NO20045192L - Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on - Google Patents
Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-onInfo
- Publication number
- NO20045192L NO20045192L NO20045192A NO20045192A NO20045192L NO 20045192 L NO20045192 L NO 20045192L NO 20045192 A NO20045192 A NO 20045192A NO 20045192 A NO20045192 A NO 20045192A NO 20045192 L NO20045192 L NO 20045192L
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- carbazol
- imidazol
- tetrahydro
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- FELGMEQIXOGIFQ-UHFFFAOYSA-N Ondansetron Chemical compound CC1=NC=CN1CC1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-UHFFFAOYSA-N 0.000 title 1
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 abstract 3
- 229960005343 ondansetron Drugs 0.000 abstract 3
- 238000005891 transamination reaction Methods 0.000 abstract 2
- 238000006683 Mannich reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37632302P | 2002-04-29 | 2002-04-29 | |
| PCT/US2003/013221 WO2003093281A1 (en) | 2002-04-29 | 2003-04-29 | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20045192L true NO20045192L (no) | 2005-01-28 |
Family
ID=29401332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045192A NO20045192L (no) | 2002-04-29 | 2004-11-26 | Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7098345B2 (pl) |
| EP (1) | EP1499623B1 (pl) |
| JP (1) | JP2005529142A (pl) |
| KR (1) | KR20040104654A (pl) |
| CN (1) | CN1665823A (pl) |
| AT (1) | ATE364611T1 (pl) |
| AU (1) | AU2003223764A1 (pl) |
| CA (1) | CA2483566A1 (pl) |
| DE (1) | DE60314400T2 (pl) |
| DK (1) | DK1499623T3 (pl) |
| ES (1) | ES2288606T3 (pl) |
| HR (1) | HRP20041070A2 (pl) |
| IL (1) | IL164904A0 (pl) |
| MX (1) | MXPA04010846A (pl) |
| NO (1) | NO20045192L (pl) |
| PL (1) | PL373191A1 (pl) |
| PT (1) | PT1499623E (pl) |
| WO (1) | WO2003093281A1 (pl) |
| ZA (1) | ZA200408934B (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK6182003A3 (en) * | 2000-10-30 | 2004-03-02 | Teva Pharma | Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof |
| HRP20041136A2 (en) * | 2002-04-30 | 2005-04-30 | Teva Gy�gyszergy�r R�szv�nyt�rsas�g | Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them |
| US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
| US7696356B2 (en) * | 2004-08-17 | 2010-04-13 | Taro Pharmaceutical Industries Limited | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom |
| WO2006046253A1 (en) * | 2004-10-26 | 2006-05-04 | Ipca Laboratories Limited | A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
| PH22672A (en) | 1984-01-25 | 1988-11-14 | Glaxo Group Ltd | Imidazolylmethyltetrahydrocarbazolone derivatives, composition and method of use thereof |
| EP0385517B1 (en) | 1985-03-14 | 1993-04-14 | BEECHAM GROUP plc | Medicaments for the treatment of emesis |
| GB8518742D0 (en) | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
| GB8518741D0 (en) | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
| GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8518745D0 (en) | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
| US4859662A (en) | 1986-11-28 | 1989-08-22 | Glaxo Group Limited | Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances |
| GB8630071D0 (en) | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
| GB8816187D0 (en) * | 1988-07-07 | 1988-08-10 | Glaxo Group Ltd | Medicaments |
| GB8914804D0 (en) | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
| US5344658A (en) | 1989-06-28 | 1994-09-06 | Glaxo Group Limited | Process and composition using ondansetron |
| WO1993000074A1 (en) | 1991-06-26 | 1993-01-07 | Sepracor, Inc. | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
| CA2106642C (en) | 1992-10-14 | 2005-08-16 | Peter Bod | Carbazolone derivatives and process for preparing the same |
| GB9423588D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| GB9423511D0 (en) | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
| CN1045437C (zh) | 1994-12-29 | 1999-10-06 | 中国科学院上海有机化学研究所 | 恩丹西酮及其生理盐的合成 |
| SK6182003A3 (en) | 2000-10-30 | 2004-03-02 | Teva Pharma | Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof |
| EP1207160A1 (en) | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
| ES2219201T1 (es) | 2001-01-11 | 2004-12-01 | Teva Pharmaceutical Industries Ltd. | Procedimiento mejorado para la preparacion de ondansetron clorhidrato dihidrato puro. |
| AU2002251329A1 (en) | 2002-04-25 | 2003-11-10 | Generics (Uk) Limited | Novel crystalline forms of celecoxib and other compounds |
| HRP20041136A2 (en) | 2002-04-30 | 2005-04-30 | Teva Gy�gyszergy�r R�szv�nyt�rsas�g | Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them |
-
2003
- 2003-04-29 AT AT03719968T patent/ATE364611T1/de not_active IP Right Cessation
- 2003-04-29 US US10/425,450 patent/US7098345B2/en not_active Expired - Fee Related
- 2003-04-29 ES ES03719968T patent/ES2288606T3/es not_active Expired - Lifetime
- 2003-04-29 WO PCT/US2003/013221 patent/WO2003093281A1/en not_active Ceased
- 2003-04-29 PL PL03373191A patent/PL373191A1/pl not_active Application Discontinuation
- 2003-04-29 MX MXPA04010846A patent/MXPA04010846A/es unknown
- 2003-04-29 EP EP03719968A patent/EP1499623B1/en not_active Expired - Lifetime
- 2003-04-29 CN CN038154684A patent/CN1665823A/zh active Pending
- 2003-04-29 DK DK03719968T patent/DK1499623T3/da active
- 2003-04-29 JP JP2004501420A patent/JP2005529142A/ja active Pending
- 2003-04-29 CA CA002483566A patent/CA2483566A1/en not_active Abandoned
- 2003-04-29 PT PT03719968T patent/PT1499623E/pt unknown
- 2003-04-29 DE DE60314400T patent/DE60314400T2/de not_active Expired - Fee Related
- 2003-04-29 AU AU2003223764A patent/AU2003223764A1/en not_active Abandoned
- 2003-04-29 KR KR10-2004-7017346A patent/KR20040104654A/ko not_active Ceased
- 2003-04-29 HR HR20041070A patent/HRP20041070A2/hr not_active Application Discontinuation
-
2004
- 2004-10-28 IL IL16490404A patent/IL164904A0/xx unknown
- 2004-11-04 ZA ZA200408934A patent/ZA200408934B/xx unknown
- 2004-11-26 NO NO20045192A patent/NO20045192L/no not_active Application Discontinuation
-
2006
- 2006-07-07 US US11/482,486 patent/US20060252942A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20041070A2 (en) | 2005-02-28 |
| AU2003223764A1 (en) | 2003-11-17 |
| KR20040104654A (ko) | 2004-12-10 |
| ES2288606T3 (es) | 2008-01-16 |
| IL164904A0 (en) | 2005-12-18 |
| CN1665823A (zh) | 2005-09-07 |
| PL373191A1 (pl) | 2005-08-22 |
| ZA200408934B (en) | 2006-07-26 |
| US20060252942A1 (en) | 2006-11-09 |
| EP1499623B1 (en) | 2007-06-13 |
| WO2003093281A1 (en) | 2003-11-13 |
| DK1499623T3 (da) | 2007-10-08 |
| DE60314400T2 (de) | 2008-02-07 |
| CA2483566A1 (en) | 2003-11-13 |
| US20050020655A1 (en) | 2005-01-27 |
| PT1499623E (pt) | 2007-08-10 |
| DE60314400D1 (de) | 2007-07-26 |
| JP2005529142A (ja) | 2005-09-29 |
| US7098345B2 (en) | 2006-08-29 |
| ATE364611T1 (de) | 2007-07-15 |
| MXPA04010846A (es) | 2005-01-25 |
| EP1499623A1 (en) | 2005-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |