PL373191A1 - Sposób wytwarzania 1,2,3,9-tetrahydro-9-metylo-3-[(2-metylo-1H-imidazol-1-ilo)metylo]-4H-karbazol-4-onu - Google Patents

Sposób wytwarzania 1,2,3,9-tetrahydro-9-metylo-3-[(2-metylo-1H-imidazol-1-ilo)metylo]-4H-karbazol-4-onu

Info

Publication number
PL373191A1
PL373191A1 PL03373191A PL37319103A PL373191A1 PL 373191 A1 PL373191 A1 PL 373191A1 PL 03373191 A PL03373191 A PL 03373191A PL 37319103 A PL37319103 A PL 37319103A PL 373191 A1 PL373191 A1 PL 373191A1
Authority
PL
Poland
Prior art keywords
methyl
preparing
carbazol
imidazol
tetrahydro
Prior art date
Application number
PL03373191A
Other languages
English (en)
Inventor
Sandor Molnar
Csaba Szabo
Sos Erzsebet Meszaros
Szabolcs Salyi
Tivadar Tamas
Original Assignee
Teva Gyogyszergyar Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Reszvenytarsasag filed Critical Teva Gyogyszergyar Reszvenytarsasag
Publication of PL373191A1 publication Critical patent/PL373191A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
PL03373191A 2002-04-29 2003-04-29 Sposób wytwarzania 1,2,3,9-tetrahydro-9-metylo-3-[(2-metylo-1H-imidazol-1-ilo)metylo]-4H-karbazol-4-onu PL373191A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37632302P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
PL373191A1 true PL373191A1 (pl) 2005-08-22

Family

ID=29401332

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03373191A PL373191A1 (pl) 2002-04-29 2003-04-29 Sposób wytwarzania 1,2,3,9-tetrahydro-9-metylo-3-[(2-metylo-1H-imidazol-1-ilo)metylo]-4H-karbazol-4-onu

Country Status (19)

Country Link
US (2) US7098345B2 (pl)
EP (1) EP1499623B1 (pl)
JP (1) JP2005529142A (pl)
KR (1) KR20040104654A (pl)
CN (1) CN1665823A (pl)
AT (1) ATE364611T1 (pl)
AU (1) AU2003223764A1 (pl)
CA (1) CA2483566A1 (pl)
DE (1) DE60314400T2 (pl)
DK (1) DK1499623T3 (pl)
ES (1) ES2288606T3 (pl)
HR (1) HRP20041070A2 (pl)
IL (1) IL164904A0 (pl)
MX (1) MXPA04010846A (pl)
NO (1) NO20045192L (pl)
PL (1) PL373191A1 (pl)
PT (1) PT1499623E (pl)
WO (1) WO2003093281A1 (pl)
ZA (1) ZA200408934B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK6182003A3 (en) * 2000-10-30 2004-03-02 Teva Pharma Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
HRP20041136A2 (en) * 2002-04-30 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
WO2006046253A1 (en) * 2004-10-26 2006-05-04 Ipca Laboratories Limited A one-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1h-imidazole-1-yl)methyl]-4h-carbazol-4-o

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
PH22672A (en) 1984-01-25 1988-11-14 Glaxo Group Ltd Imidazolylmethyltetrahydrocarbazolone derivatives, composition and method of use thereof
EP0385517B1 (en) 1985-03-14 1993-04-14 BEECHAM GROUP plc Medicaments for the treatment of emesis
GB8518742D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518741D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US4859662A (en) 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
GB8630071D0 (en) 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8816187D0 (en) * 1988-07-07 1988-08-10 Glaxo Group Ltd Medicaments
GB8914804D0 (en) 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5344658A (en) 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
WO1993000074A1 (en) 1991-06-26 1993-01-07 Sepracor, Inc. Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
CA2106642C (en) 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
GB9423588D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1045437C (zh) 1994-12-29 1999-10-06 中国科学院上海有机化学研究所 恩丹西酮及其生理盐的合成
SK6182003A3 (en) 2000-10-30 2004-03-02 Teva Pharma Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
EP1207160A1 (en) 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
ES2219201T1 (es) 2001-01-11 2004-12-01 Teva Pharmaceutical Industries Ltd. Procedimiento mejorado para la preparacion de ondansetron clorhidrato dihidrato puro.
AU2002251329A1 (en) 2002-04-25 2003-11-10 Generics (Uk) Limited Novel crystalline forms of celecoxib and other compounds
HRP20041136A2 (en) 2002-04-30 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them

Also Published As

Publication number Publication date
HRP20041070A2 (en) 2005-02-28
AU2003223764A1 (en) 2003-11-17
KR20040104654A (ko) 2004-12-10
ES2288606T3 (es) 2008-01-16
IL164904A0 (en) 2005-12-18
NO20045192L (no) 2005-01-28
CN1665823A (zh) 2005-09-07
ZA200408934B (en) 2006-07-26
US20060252942A1 (en) 2006-11-09
EP1499623B1 (en) 2007-06-13
WO2003093281A1 (en) 2003-11-13
DK1499623T3 (da) 2007-10-08
DE60314400T2 (de) 2008-02-07
CA2483566A1 (en) 2003-11-13
US20050020655A1 (en) 2005-01-27
PT1499623E (pt) 2007-08-10
DE60314400D1 (de) 2007-07-26
JP2005529142A (ja) 2005-09-29
US7098345B2 (en) 2006-08-29
ATE364611T1 (de) 2007-07-15
MXPA04010846A (es) 2005-01-25
EP1499623A1 (en) 2005-01-26

Similar Documents

Publication Publication Date Title
AU2003202585A1 (en) Disubstituted thiazolyl carboxanilides and their use as microbicides
TW200626580A (en) Synthesis of (5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
BG105177A (en) Novel substituted pyrazole derivatives
EP1427411A4 (en) (-) - 1- (3,4-DICHLORPHENYL) -3-AZABICYCLO ç3.1.0! HEXAN, COMPOSITIONS OF THESE, AND USE AS DOPAMINE RECOVERY INHIBITORS
YU59002A (sh) Upotreba antagonista centralnog kanabionid receptora za dobijanje medicinskih proizvoda koji pomažu u odvikavanju od pušenja
MX9707706A (es) Compuestos intermediarios novedosos y proceso para la manufactura de derivados de la camptotecina (cpt-11) y compuestos relacionados.
NO20071629L (no) Fremgangsmate for fremstilling av 2,7-oktadienylderivater
ZA202204277B (en) Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid
WO2002092564A3 (en) Synthesis of cyclopentadiene derivatives
WO2008021491A3 (en) Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
NO20045192L (no) Prosess for fremstilling av 1,2,3,9-tetrahydro-9-metyl-3-[(2-metyl-1H-imidazol-1-yl)metyl]-4H-karbazol-4-on
HRP931292B1 (en) Carbazolone derivatives and the process for preparing the same
EP1153919A4 (en) SUBSTITUTED ACETYLPYRIDINE DERIVATIVES AND PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR OPTICALLY ACTIVE BETA3 ADRENERGIC RECEPTOR AGONIST USING THE SAME
WO2004026267A3 (en) Tri(alkylcarboxylato) gallium (iii) products and pharmaceutical compositions containing them
NO20060417L (no) Fremgangsmate til fremstilling av 1-okten fra krakk-C4
BG105198A (en) Process for the synthesis of (1h)-benzo[c]quinolizin-3-ones derivatives
IL156141A0 (en) A process for the preparation of taxan derivatives
WO2003064617A3 (en) Pestalotiopsis microsporia isolates and compounds derived therefrom
MX2022004636A (es) Metodos para la preparacion del acido 5-bromo-2-(3-cloropiridin-2- il)-2h-pirazol-3-carboxilico.
EP1627650A3 (de) Bicarbonatbehälter mit Zweikanal-Steckverbinder zum Einmalgebrauch in Hämodialysegeräten
AU3814800A (en) Enantiomers of mercapto lactones and processes for their synthesis
MX2023013305A (es) Compuesto polimorfo de imidazolidinona, método de preparación del mismo y uso del mismo.
IL158933A0 (en) Method for the production of biperiden ii
TW200626555A (en) A process for the preparation of 1, 3, 5-trisubstituted pyrazoles via [3+2] cycloaddition
WO2005047215A3 (en) Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)