NO20051025L - Injiserbare, multimodale polymerdepotpreparater og anvendelser derav - Google Patents

Injiserbare, multimodale polymerdepotpreparater og anvendelser derav

Info

Publication number
NO20051025L
NO20051025L NO20051025A NO20051025A NO20051025L NO 20051025 L NO20051025 L NO 20051025L NO 20051025 A NO20051025 A NO 20051025A NO 20051025 A NO20051025 A NO 20051025A NO 20051025 L NO20051025 L NO 20051025L
Authority
NO
Norway
Prior art keywords
polymer
polymers
compositions
injectable
applications
Prior art date
Application number
NO20051025A
Other languages
English (en)
Inventor
Jeremy Corwin Wright
Lothar W Kleiner
Guohua Chen
Paul Ricky Houston
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of NO20051025L publication Critical patent/NO20051025L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det er beskrevet injiserbare depotpreparater som omfatter en polymermatriks som har et flertall av bionedbiytbare, biokompatible polymerer hvor hver polymer av flertallet av polymerer har en spesifisert vektmidlere molekylvekt; og polymermafriksen har en bred molekylvektsfordeling av flertallet av polymerer; et oppløsningsmiddel som har en blandbarhet i vann på mindre enn eller lik 7 vekt-% ved 25°e, i en mengde effektiv for å mykne polymeren ved å danne en gel med denne og et fordelaktig middel. Preparatene har vesentlig forbedret skjærfortynningsoppførsel og redusert injeksjonskraft, hvilket gjør preparatene lett implanterbare under en pasients kroppsoverflate ved injeksjon.
NO20051025A 2002-07-31 2005-02-25 Injiserbare, multimodale polymerdepotpreparater og anvendelser derav NO20051025L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39983202P 2002-07-31 2002-07-31
PCT/US2003/023439 WO2004011054A2 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof

Publications (1)

Publication Number Publication Date
NO20051025L true NO20051025L (no) 2005-02-25

Family

ID=31188625

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051025A NO20051025L (no) 2002-07-31 2005-02-25 Injiserbare, multimodale polymerdepotpreparater og anvendelser derav

Country Status (19)

Country Link
US (2) US8501215B2 (no)
EP (2) EP1539101B1 (no)
JP (1) JP4639400B2 (no)
KR (1) KR20050083605A (no)
CN (2) CN1684663A (no)
AR (1) AR040753A1 (no)
AT (1) ATE419831T1 (no)
AU (2) AU2003256849A1 (no)
BR (1) BR0313539A (no)
CA (1) CA2494400A1 (no)
DE (1) DE60325742D1 (no)
DK (1) DK1539101T3 (no)
ES (1) ES2321505T3 (no)
IL (1) IL166463A0 (no)
MX (1) MXPA05001244A (no)
NO (1) NO20051025L (no)
NZ (1) NZ537953A (no)
WO (1) WO2004011054A2 (no)
ZA (1) ZA200501645B (no)

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WO2004011054A3 (en) 2004-04-01
IL166463A0 (en) 2006-01-15
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US20040022859A1 (en) 2004-02-05
DK1539101T3 (da) 2009-04-27
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