NO20060494L - Regioselektiv syntese av CCI-779 - Google Patents

Regioselektiv syntese av CCI-779

Info

Publication number
NO20060494L
NO20060494L NO20060494A NO20060494A NO20060494L NO 20060494 L NO20060494 L NO 20060494L NO 20060494 A NO20060494 A NO 20060494A NO 20060494 A NO20060494 A NO 20060494A NO 20060494 L NO20060494 L NO 20060494L
Authority
NO
Norway
Prior art keywords
cci
regioselective synthesis
regioselective
synthesis
boronate
Prior art date
Application number
NO20060494A
Other languages
English (en)
Norwegian (no)
Inventor
Warren Chew
Chia-Cheng Shaw
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20060494L publication Critical patent/NO20060494L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
NO20060494A 2003-08-07 2006-01-31 Regioselektiv syntese av CCI-779 NO20060494L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49324903P 2003-08-07 2003-08-07
PCT/US2004/022860 WO2005016935A2 (en) 2003-08-07 2004-07-15 Regioselective synthesis of cci-779

Publications (1)

Publication Number Publication Date
NO20060494L true NO20060494L (no) 2006-03-06

Family

ID=34193170

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060494A NO20060494L (no) 2003-08-07 2006-01-31 Regioselektiv syntese av CCI-779

Country Status (26)

Country Link
US (1) US7153957B2 (de)
EP (1) EP1658295B1 (de)
JP (1) JP4227649B2 (de)
KR (1) KR20060057605A (de)
CN (1) CN1829722B (de)
AR (1) AR045217A1 (de)
AT (1) ATE365169T1 (de)
AU (1) AU2004265267A1 (de)
BR (1) BRPI0412667A (de)
CA (1) CA2532988A1 (de)
CO (1) CO5650251A2 (de)
CR (1) CR8189A (de)
DE (1) DE602004007145T2 (de)
DK (1) DK1658295T3 (de)
EC (1) ECSP066413A (de)
ES (1) ES2287772T3 (de)
IL (1) IL173134A0 (de)
MX (1) MXPA06000951A (de)
NO (1) NO20060494L (de)
PL (1) PL1658295T3 (de)
PT (1) PT1658295E (de)
RU (1) RU2339639C2 (de)
TW (1) TW200508241A (de)
UA (1) UA83245C2 (de)
WO (1) WO2005016935A2 (de)
ZA (1) ZA200601055B (de)

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KR20040106547A (ko) * 2002-05-15 2004-12-17 엔도사이트, 인코포레이티드 비타민-마이토마이신 공액체
RU2344821C2 (ru) * 2002-07-30 2009-01-27 Уайт Парентеральные композиции, содержащие гидроксиэфиры рапамицина
US7601332B2 (en) 2003-01-27 2009-10-13 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1660081A1 (de) * 2003-09-03 2006-05-31 Wyeth Amorphe rapamycin 42-ester mit 3-hydroxy-2-(hydroxymethyl)-2-methylpropionsäure und diese enthaltende pharmazeutische zusammensetzungen
DE602004011398T2 (de) * 2004-01-08 2009-01-15 Wyeth Direkt komprimierbare pharmazeutische zusammensetzung für die orale verabreichung von cci-779
KR20070015544A (ko) 2004-04-14 2007-02-05 와이어쓰 라파마이신 42-에스테르 유도체의 위치특이성 합성
PL1735321T3 (pl) 2004-04-14 2009-04-30 Wyeth Corp Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała
EP1751168A1 (de) 2004-04-14 2007-02-14 Wyeth Prolin cci-779 (prolin-rapamycin 42-ester mit 2,2-bis(hydroxymethyl)propionsäure) und zweistufige enzymatische synthese von prolin cci-779 und cci-779 mit mikrobieller lipase
CN1946852A (zh) * 2004-04-27 2007-04-11 惠氏公司 利用雷帕霉素特异性甲基化酶标记雷帕霉素
CN101098854B (zh) 2004-07-23 2012-12-05 恩多塞特公司 二价连接体及其轭合物
TW200616633A (en) * 2004-08-10 2006-06-01 Wyeth Corp CCI-779 derivatives and methods of making same
EP1804779A1 (de) 2004-10-28 2007-07-11 Wyeth Verwendung eines mto-inhibitors bei der behandlung von gebärmutter-leiomyomen
JP2008530090A (ja) * 2005-02-09 2008-08-07 ワイス Ｃｃｉ−７７９多形及びその使用
BRPI0607390A2 (pt) 2005-03-02 2017-08-22 Wyeth Corp Processo para recuperar cci-779 de licores mâe
AU2006218918A1 (en) * 2005-03-02 2006-09-08 Wyeth Purification of rapamycin
CN101175757B (zh) 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
RU2470668C2 (ru) 2005-08-19 2012-12-27 Эндосайт, Инк. Конъюгаты лиганда с несколькими лекарственными средствами
JP2009504783A (ja) * 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド ビンカアルカロイド、類似体および誘導体のリガンド結合体
US7538119B2 (en) * 2005-11-04 2009-05-26 Wyeth 41-Methoxy isotope labeled rapamycin 42-ester
EP3488866A1 (de) 2005-11-04 2019-05-29 Wyeth LLC Antineoplastische kombinationen mit mtor-inhibitor, herceptin und/oder hki-272
AR058282A1 (es) * 2005-12-07 2008-01-30 Wyeth Corp Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer.
PE20070748A1 (es) 2005-12-07 2007-08-08 Wyeth Corp Proceso ajustable a escala para la preparacion de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina
JP2009518648A (ja) * 2005-12-07 2009-05-07 ワイス 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法
JP2009520818A (ja) * 2005-12-20 2009-05-28 ワイス 薬物物質不純物の制御によるｃｃｉ−７７９製剤安定性の制御
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN104127878A (zh) * 2007-03-14 2014-11-05 恩多塞特公司 结合配体连接的微管溶素递药缀合物
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
TW200901989A (en) 2007-04-10 2009-01-16 Wyeth Corp Anti-tumor activity of CCI-779 in papillary renal cell cancer
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
BRPI0812970A2 (pt) * 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
EP2209374B1 (de) 2007-10-25 2014-12-03 Endocyte, Inc. Tubulysine und verfahren zu ihrer herstellung
US8754207B2 (en) 2009-09-25 2014-06-17 Cadila Healthcare Limited Process for the preparation of rapamycin derivatives
AU2011210227A1 (en) * 2010-01-28 2012-08-30 Fresenius Kabi Oncology Ltd. Process for the preparation of Temsirolimus and its intermediates
CN102020662B (zh) 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔制备方法
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
RU2603261C2 (ru) * 2011-04-01 2016-11-27 Сандоз Аг Региоселективное ацилирование рапамицина в положении с-42
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
EA201590622A1 (ru) 2012-10-16 2015-10-30 Эндосайт, Инк. Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения
CN104086564B (zh) * 2014-07-30 2019-02-05 江苏奥赛康药业股份有限公司 一种高纯度坦罗莫司的制备方法

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DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives

Also Published As

Publication number Publication date
DE602004007145T2 (de) 2008-02-28
BRPI0412667A (pt) 2006-09-26
HK1085482A1 (en) 2006-08-25
DK1658295T3 (da) 2007-09-24
JP2007501783A (ja) 2007-02-01
DE602004007145D1 (de) 2007-08-02
CN1829722A (zh) 2006-09-06
EP1658295B1 (de) 2007-06-20
WO2005016935A3 (en) 2005-04-07
TW200508241A (en) 2005-03-01
CR8189A (es) 2006-10-04
AR045217A1 (es) 2005-10-19
ES2287772T3 (es) 2007-12-16
ATE365169T1 (de) 2007-07-15
WO2005016935A2 (en) 2005-02-24
KR20060057605A (ko) 2006-05-26
AU2004265267A1 (en) 2005-02-24
PT1658295E (pt) 2007-09-25
RU2339639C2 (ru) 2008-11-27
US20050033046A1 (en) 2005-02-10
CA2532988A1 (en) 2005-02-24
MXPA06000951A (es) 2006-03-30
JP4227649B2 (ja) 2009-02-18
EP1658295A2 (de) 2006-05-24
ECSP066413A (es) 2006-09-18
CN1829722B (zh) 2010-10-27
CO5650251A2 (es) 2006-06-30
PL1658295T3 (pl) 2007-11-30
IL173134A0 (en) 2006-06-11
ZA200601055B (en) 2008-07-30
UA83245C2 (en) 2008-06-25
US7153957B2 (en) 2006-12-26
RU2006106910A (ru) 2007-09-20

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