NO20060900L - Nitroosyderivater av Losartan, Valsartan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-reseptorblokkere for behandling av kardiovaskulaer sykdom - Google Patents

Nitroosyderivater av Losartan, Valsartan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-reseptorblokkere for behandling av kardiovaskulaer sykdom

Info

Publication number: NO20060900L
Authority: NO; Norway
Prior art keywords: olmesartan; eprosartan; telmisartan; candesartan; valsartan
Prior art date: 2003-07-31

Application number

NO20060900A

Other languages

English (en)

Norwegian (no)

Inventor

Piero Del Soldato

Ennio Ongini

Nicoletta Almirante

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-31

Filing date

2006-02-24

Publication date

2006-02-24

2006-02-24 Application filed by Nicox Sa filed Critical Nicox Sa

2006-02-24 Publication of NO20060900L publication Critical patent/NO20060900L/no

Links

RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 title abstract 4
102000008873 Angiotensin II receptor Human genes 0.000 title abstract 2
108050000824 Angiotensin II receptor Proteins 0.000 title abstract 2
239000002080 C09CA02 - Eprosartan Substances 0.000 title abstract 2
239000004072 C09CA03 - Valsartan Substances 0.000 title abstract 2
239000002053 C09CA06 - Candesartan Substances 0.000 title abstract 2
239000005537 C09CA07 - Telmisartan Substances 0.000 title abstract 2
239000005480 Olmesartan Substances 0.000 title abstract 2
229960000932 candesartan Drugs 0.000 title abstract 2
SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 title abstract 2
229960004563 eprosartan Drugs 0.000 title abstract 2
OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 title abstract 2
229960005117 olmesartan Drugs 0.000 title abstract 2
VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 title abstract 2
229960005187 telmisartan Drugs 0.000 title abstract 2
229960004699 valsartan Drugs 0.000 title abstract 2
SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 title abstract 2
208000024172 Cardiovascular disease Diseases 0.000 title 1
150000004106 losartan derivatives Chemical class 0.000 title 1
239000002083 C09CA01 - Losartan Substances 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960004773 losartan Drugs 0.000 abstract 1
KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20060900A 2003-07-31 2006-02-24 Nitroosyderivater av Losartan, Valsartan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-reseptorblokkere for behandling av kardiovaskulaer sykdom NO20060900L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03102379		2003-07-31
PCT/EP2004/051550 WO2005011646A2 (en)	2003-07-31	2004-07-20	Nitrooxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-ii receptor blockers for the treatment of cardiovascular diseases

Publications (1)

Publication Number	Publication Date
NO20060900L true NO20060900L (no)	2006-02-24

Family

ID=34112476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20060900A NO20060900L (no)	2003-07-31	2006-02-24	Nitroosyderivater av Losartan, Valsartan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-reseptorblokkere for behandling av kardiovaskulaer sykdom

Country Status (29)

Country	Link
US (1)	US20060276523A1 (da)
EP (1)	EP1653950B1 (da)
JP (1)	JP2007500684A (da)
KR (1)	KR20060056352A (da)
CN (1)	CN100496490C (da)
AR (1)	AR045145A1 (da)
AT (1)	ATE383155T1 (da)
AU (1)	AU2004260830B2 (da)
BR (1)	BRPI0413028A (da)
CA (1)	CA2534451A1 (da)
CY (1)	CY1110447T1 (da)
DE (1)	DE602004011230T2 (da)
DK (1)	DK1653950T3 (da)
EC (1)	ECSP066334A (da)
ES (1)	ES2299861T3 (da)
HR (1)	HRP20060084A2 (da)
IL (1)	IL172703A0 (da)
IS (1)	IS2534B (da)
MA (1)	MA27987A1 (da)
MX (1)	MXPA06001263A (da)
NO (1)	NO20060900L (da)
NZ (1)	NZ544463A (da)
PL (2)	PL379420A1 (da)
PT (1)	PT1653950E (da)
RU (1)	RU2374240C2 (da)
SI (1)	SI1653950T1 (da)
UA (1)	UA87983C2 (da)
WO (1)	WO2005011646A2 (da)
ZA (1)	ZA200600856B (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7723529B2 (en)	2004-07-20	2010-05-25	Nicox S.A.	Process for preparing nitrooxy esters, nitrooxy thioesters nitrooxy carbonates and nitrooxy thiocarbinates, intermediates useful in said process and preparation thereof
WO2006079610A1 (en) *	2005-01-31	2006-08-03	Nicox S.A.	Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
RU2306930C1 (ru) *	2005-12-28	2007-09-27	Михаил Владимирович Покровский	Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
CN101024643A (zh)	2006-02-20	2007-08-29	上海艾力斯医药科技有限公司	咪唑－5－羧酸类衍生物、制备方法及其应用
TW200821303A (en) *	2006-08-08	2008-05-16	Speedel Experimenta Ag	Organic compounds
CA2668744C (en)	2006-11-17	2015-09-15	Queen's University At Kingston	Compounds and methods for treating protein folding disorders
JP5290190B2 (ja) *	2006-12-06	2013-09-18	サルブリス・アセット・マネイジメント・カンパニー・リミテッド	イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物
JP2010513273A (ja) *	2006-12-13	2010-04-30	メルクアンドカンパニーインク．	アンジオテンシンｉｉ受容体拮抗薬
TW200831079A (en) *	2006-12-13	2008-08-01	Merck & Co Inc	Angiotensin II receptor antagonists
CN101214242A (zh) *	2007-01-05	2008-07-09	上海艾力斯医药科技有限公司	新的药用组合物
EP1980559A1 (en) *	2007-04-10	2008-10-15	CTG Pharma S.r.l.	Cardiovascular agents
CN101317842A (zh)	2007-06-07	2008-12-10	上海艾力斯医药科技有限公司	一种咪唑-5-羧酸衍生物的治疗用途
CN101407511B (zh) *	2007-10-11	2013-01-09	上海艾力斯生物医药有限公司	一种结晶型的咪唑-5-羧酸衍生物
AR069340A1 (es)	2007-11-26	2010-01-13	Merck & Co Inc	Antagonistas del receptor de angiotensina ii
EP2534957B1 (en)	2007-12-14	2015-05-27	AeroDesigns, Inc	Delivering aerosolizable products
WO2009094242A1 (en) *	2008-01-24	2009-07-30	Merck & Co., Inc.	Angiotensin ii receptor antagonists
AU2009210484A1 (en)	2008-02-08	2009-08-13	Merck Sharp & Dohme Corp.	Angiotensin II receptor antagonists
CA2712689A1 (en) *	2008-02-26	2009-09-03	Nicoletta Almirante	Angiotensin ii receptor antagonists
CA2712695A1 (en) *	2008-02-26	2009-09-03	Nicoletta Almirante	New angiotensin ii receptor blocker derivatives
US8207208B2 (en) *	2008-05-15	2012-06-26	Merck Sharp & Dohme Corp.	Angiotensin II receptor antagonists
CN101596189A (zh) *	2008-06-05	2009-12-09	上海艾力斯生物医药有限公司	含有咪唑-5-羧酸类衍生物的药用组合物
WO2009150007A1 (en) *	2008-06-09	2009-12-17	Nicox S.A.	Angiotensin ii receptor antagonists
AR073259A1 (es) *	2008-07-29	2010-10-28	Merck & Co Inc	Derivados de furosemida utiles como diureticos
WO2010015447A1 (en) *	2008-08-08	2010-02-11	Nicox S.A.	Angiotensin ii receptor antagonists
EP2194048A1 (en)	2008-12-02	2010-06-09	Dirk Sartor	Nitrate esters for the treatment of vascular and metabolic diseases
CA2745095A1 (en) *	2008-12-05	2010-06-10	Merck Sharp & Dohme Corp.	Nitrooxy derivatives as angiotensin ii receptor antagonists
MA33056B1 (fr)	2009-01-23	2012-02-01	Hanmi Holding Co Ltd	Composition pharmaceutique solide comprenant de l'amlodipine et du losartan et son procede de fabrication
WO2011131613A1 (en)	2010-04-19	2011-10-27	Cardiolynx Ag	Valsartan derivatives carrying nitrogen oxide donors for the treatment of vascular and metabolic diseases
EP2560634A1 (en) *	2010-04-23	2013-02-27	Piramal Enterprises Limited	Nitric oxide releasing prodrugs of therapeutic agents
WO2011160974A2 (en)	2010-06-21	2011-12-29	Nicox S.A.	Statin derivatives
JO3350B1 (ar)	2011-03-07	2019-03-13	Merck Sharp & Dohme	مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CN103275074B (zh) *	2013-06-21	2016-08-10	黄冈鲁班药业股份有限公司	一种奥美沙坦衍生物及其制备方法
CN105820125B (zh) *	2015-01-09	2018-12-07	北京中医药大学	一种用于治疗高血压的化合物及其制备方法和用途
JP2018526448A (ja)	2015-09-07	2018-09-13	浙江華海薬業股▲フン▼有限公司	一酸化窒素を放出可能なプロドラッグ分子
CN106800537B (zh)	2017-01-18	2019-02-01	广东隆赋药业股份有限公司	丁苯酞-替米沙坦杂合物及其制备方法和用途
CN108892624B (zh) *	2018-06-20	2020-12-15	重庆威鹏药业有限公司	沙库巴曲硝基氧衍生物及其制备方法和应用
CN114105881B (zh) *	2020-08-31	2024-01-26	沈阳海诺威医药科技有限公司	血小板聚集抑制剂及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1338238C (en) *	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DK0403159T3 (da) *	1989-06-14	2000-08-14	Smithkline Beecham Corp	Imidazolylalkensyrer
SG52709A1 (en) *	1989-06-30	1998-09-28	Du Pont	Substituted imidazoles
RU2067581C1 (ru) *	1989-06-30	1996-10-10	Е.И.Дюпон Де Немур Энд Компани	Аралкилзамещенные имидазолы, обладающие противогипертоническим действием, способ их получения и фармацевтический состав, обладающий ингибирующей активностью в отношении ангиотензина ii
AT398202B (de) *	1991-10-04	1994-10-25	Chem Pharm Forsch Gmbh	Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
FR2725987B1 (fr) *	1994-10-19	1997-01-10	Sanofi Sa	Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
IT1311924B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
CA2420055C (en) *	2000-08-25	2010-06-01	Takeda Chemical Industries, Ltd.	Fibrinogen-lowering agent
ITMI20011744A1 (it) *	2001-08-09	2003-02-09	Nicox Sa	Farmaci per le vasculopatie

2004
- 2004-07-20 PL PL379420A patent/PL379420A1/pl not_active Application Discontinuation
- 2004-07-20 HR HR20060084A patent/HRP20060084A2/hr not_active Application Discontinuation
- 2004-07-20 KR KR1020067001893A patent/KR20060056352A/ko not_active Ceased
- 2004-07-20 PT PT04766269T patent/PT1653950E/pt unknown
- 2004-07-20 UA UAA200600273A patent/UA87983C2/ru unknown
- 2004-07-20 CN CNB200480022483XA patent/CN100496490C/zh not_active Expired - Fee Related
- 2004-07-20 NZ NZ544463A patent/NZ544463A/en unknown
- 2004-07-20 EP EP04766269A patent/EP1653950B1/en not_active Expired - Lifetime
- 2004-07-20 MX MXPA06001263A patent/MXPA06001263A/es active IP Right Grant
- 2004-07-20 BR BRPI0413028-6A patent/BRPI0413028A/pt not_active IP Right Cessation
- 2004-07-20 RU RU2006105804/04A patent/RU2374240C2/ru not_active IP Right Cessation
- 2004-07-20 ES ES04766269T patent/ES2299861T3/es not_active Expired - Lifetime
- 2004-07-20 JP JP2006521571A patent/JP2007500684A/ja active Pending
- 2004-07-20 CA CA002534451A patent/CA2534451A1/en not_active Abandoned
- 2004-07-20 AT AT04766269T patent/ATE383155T1/de not_active IP Right Cessation
- 2004-07-20 WO PCT/EP2004/051550 patent/WO2005011646A2/en not_active Ceased
- 2004-07-20 DE DE602004011230T patent/DE602004011230T2/de not_active Expired - Lifetime
- 2004-07-20 DK DK04766269T patent/DK1653950T3/da active
- 2004-07-20 SI SI200430655T patent/SI1653950T1/sl unknown
- 2004-07-20 AU AU2004260830A patent/AU2004260830B2/en not_active Ceased
- 2004-07-20 US US10/566,292 patent/US20060276523A1/en not_active Abandoned
- 2004-07-20 PL PL04766269T patent/PL1653950T3/pl unknown
- 2004-07-28 AR ARP040102685A patent/AR045145A1/es unknown
2005
- 2005-12-20 IL IL172703A patent/IL172703A0/en not_active IP Right Cessation
2006
- 2006-01-30 EC EC2006006334A patent/ECSP066334A/es unknown
- 2006-01-30 ZA ZA200600856A patent/ZA200600856B/en unknown
- 2006-02-13 MA MA28789A patent/MA27987A1/fr unknown
- 2006-02-24 NO NO20060900A patent/NO20060900L/no not_active Application Discontinuation
- 2006-02-27 IS IS8332A patent/IS2534B/is unknown
2008
- 2008-04-07 CY CY20081100385T patent/CY1110447T1/el unknown

Also Published As

Publication number	Publication date
DE602004011230T2 (de)	2009-01-02
CA2534451A1 (en)	2005-02-10
ZA200600856B (en)	2007-05-30
ES2299861T3 (es)	2008-06-01
WO2005011646A2 (en)	2005-02-10
CY1110447T1 (el)	2015-04-29
PL379420A1 (pl)	2006-09-04
MA27987A1 (fr)	2006-07-03
IS2534B (is)	2009-08-15
CN100496490C (zh)	2009-06-10
IL172703A0 (en)	2006-04-10
KR20060056352A (ko)	2006-05-24
SI1653950T1 (sl)	2008-06-30
DE602004011230D1 (de)	2008-02-21
EP1653950A2 (en)	2006-05-10
AR045145A1 (es)	2005-10-19
HRP20060084A2 (hr)	2006-04-30
ECSP066334A (es)	2006-07-28
MXPA06001263A (es)	2006-04-11
UA87983C2 (ru)	2009-09-10
CN1832742A (zh)	2006-09-13
PL1653950T3 (pl)	2008-08-29
HK1095093A1 (zh)	2007-04-27
US20060276523A1 (en)	2006-12-07
NZ544463A (en)	2009-10-30
JP2007500684A (ja)	2007-01-18
WO2005011646A3 (en)	2005-04-21
EP1653950B1 (en)	2008-01-09
RU2374240C2 (ru)	2009-11-27
IS8332A (is)	2006-02-27
DK1653950T3 (da)	2008-05-26
AU2004260830A1 (en)	2005-02-10
AU2004260830B2 (en)	2010-04-29
BRPI0413028A (pt)	2006-10-03
RU2006105804A (ru)	2007-09-20
PT1653950E (pt)	2008-04-11
ATE383155T1 (de)	2008-01-15

Legal Events

Date	Code	Title	Description
2012-02-20	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20060900L (no)	2006-02-24	Nitroosyderivater av Losartan, Valsartan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-reseptorblokkere for behandling av kardiovaskulaer sykdom
NO20081476L (no)	2008-03-26	Substituerte benzimidazoler og fremgangsmater for fremstilling
NO20054407L (no)	2005-12-15	Cannabinoid reseptor ligander og deres anvendelser
BRPI0605921A2 (pt)	2009-05-26	compostos orgánicos
NO20071254L (no)	2007-03-22	Fremgangsmate for fremstilling av irbesartan og mellomprodukter derav.
SV2009002876A (es)	2009-02-19	Derivados de triazol como inhibidores de 11-beta-hidroxiesteroide-deshidrogenasa-1
IL208059A0 (en)	2010-12-30	Novel hsp90 inhibitory carbazole derivatives, compositions containing same and use thereof
ATE522523T1 (de)	2011-09-15	1,3,5-trisubstituiertes triazolderivat
NO20075399L (no)	2007-12-19	Benzimidazolerivat og anvendelse derav
DE602007009865D1 (de)	2010-11-25	5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin-7-olderivate als cxcr2-antagonisten
TN2010000045A1 (en)	2011-09-26	Novel herbicides
DE602006013878D1 (de)	2010-06-02	Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
BRPI0821357A2 (pt)	2017-05-23	derivados de oxadiazois de triazol
ATE538787T1 (de)	2012-01-15	Benzimidazol-derivative als raf-kinase-hemmer
NO20084543L (no)	2008-10-21	Benzimidazolderivater
ZA200709240B (en)	2009-06-24	Solid forms of 1-(5-(IH-1,2,4-triazol-5-yl)(IH-indazol-3-yl)-3-(2-piperidylethoxy)benzene
MXPA05013149A (es)	2006-03-17	Derivados de imidazol como antagonistas del receptor de glutamato.
UY29709A1 (es)	2007-02-28	"compuestos quimicos"
ZA200800213B (en)	2008-12-31	Benzimidazole derivatives as 5-HT6, 5-HT24
NO20070550L (no)	2007-03-26	Fremgangsmate for fremstilling av pyrrolotriazinforbindelser
WO2006069159A3 (en)	2006-12-21	Pharmaceutical compositions comprising amorphous benzimidazole compounds
TW200501953A (en)	2005-01-16	Combination therapy for hypertension using lercanidipine and an angiotensin II receptor blocker
NL1031384A1 (nl)	2006-09-20	Gesubstitueerde aryl-1,4-pyrazinederivaten.
IL188273A (en)	2015-03-31	The process of producing benzimidazole compounds which includes one-stage cyclization
UA92485C2 (ru)	2010-11-10	Производная бензамида и ее применение как антагониста ангиотензина ии