NO20065443L - HIV-Integraseinhibitorer: Sykliske pyrimidinonforbindelser - Google Patents
HIV-Integraseinhibitorer: Sykliske pyrimidinonforbindelserInfo
- Publication number
- NO20065443L NO20065443L NO20065443A NO20065443A NO20065443L NO 20065443 L NO20065443 L NO 20065443L NO 20065443 A NO20065443 A NO 20065443A NO 20065443 A NO20065443 A NO 20065443A NO 20065443 L NO20065443 L NO 20065443L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- hiv integrase
- integrase inhibitors
- pyrimidinone compounds
- hiv
- Prior art date
Links
- -1 Cyclic pyrimidinone compounds Chemical class 0.000 title 1
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 abstract 1
- 150000008318 pyrimidones Chemical class 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57034804P | 2004-05-12 | 2004-05-12 | |
| PCT/US2005/013911 WO2005113562A1 (en) | 2004-05-12 | 2005-04-22 | Hiv integrase inhibitors: cyclic pyrimidinone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20065443L true NO20065443L (no) | 2006-11-27 |
Family
ID=34967012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20065443A NO20065443L (no) | 2004-05-12 | 2006-11-27 | HIV-Integraseinhibitorer: Sykliske pyrimidinonforbindelser |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7273859B2 (de) |
| EP (1) | EP1745052B9 (de) |
| JP (1) | JP2007537251A (de) |
| KR (1) | KR20070014173A (de) |
| CN (1) | CN1984917A (de) |
| AR (1) | AR049498A1 (de) |
| AT (1) | ATE405570T1 (de) |
| AU (1) | AU2005245789A1 (de) |
| BR (1) | BRPI0511078A (de) |
| CA (1) | CA2566755A1 (de) |
| DE (1) | DE602005009172D1 (de) |
| DK (1) | DK1745052T3 (de) |
| ES (1) | ES2310823T3 (de) |
| HR (1) | HRP20080531T3 (de) |
| IL (1) | IL179161A0 (de) |
| MX (1) | MXPA06013023A (de) |
| NO (1) | NO20065443L (de) |
| NZ (1) | NZ550698A (de) |
| PE (1) | PE20060238A1 (de) |
| PL (1) | PL1745052T3 (de) |
| PT (1) | PT1745052E (de) |
| RU (1) | RU2006143683A (de) |
| SI (1) | SI1745052T1 (de) |
| TW (1) | TW200540173A (de) |
| WO (1) | WO2005113562A1 (de) |
| ZA (1) | ZA200609181B (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115601B2 (en) | 2004-05-18 | 2006-10-03 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| AU2006228278C1 (en) * | 2005-03-31 | 2011-06-23 | Msd Italia S.R.L. | HIV integrase inhibitors |
| US7494984B2 (en) * | 2005-08-31 | 2009-02-24 | Bristol-Myers Squibb Company | Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors |
| WO2007058646A1 (en) * | 2005-11-15 | 2007-05-24 | Bristol-Myers Squibb Company | Hiv integrase inhibitors: cyclic pyrimidinone compounds |
| US7897592B2 (en) * | 2005-11-15 | 2011-03-01 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7902182B2 (en) * | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| WO2007064502A1 (en) * | 2005-12-01 | 2007-06-07 | Bristol-Myers Squibb Company | Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide |
| US7897593B2 (en) * | 2006-05-30 | 2011-03-01 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7893055B2 (en) * | 2006-06-28 | 2011-02-22 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7763630B2 (en) * | 2007-06-06 | 2010-07-27 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| BRPI0913934A2 (pt) * | 2008-07-02 | 2015-10-20 | Avexa Ltd | compostos tendo propriedades antivirais |
| EP2291377B1 (de) * | 2008-07-02 | 2015-02-18 | Avexa Limited | Imidazopyrimidinone und ihre verwendungen |
| AU2009302663B2 (en) * | 2008-10-06 | 2012-11-08 | Merck Sharp & Dohme Corp. | HIV integrase inhibitors |
| EP2391212A4 (de) * | 2009-01-28 | 2012-08-08 | Verbrückte verbindungen als hiv-integrase-hemmer | |
| US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
| US20120220571A1 (en) * | 2009-08-26 | 2012-08-30 | Wai John S | Hiv integrase inhibitors |
| US8383639B2 (en) | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| WO2011075747A1 (en) * | 2009-12-18 | 2011-06-23 | Glaxosmithkline Llc | Therapeutic compounds |
| WO2012151567A1 (en) * | 2011-05-05 | 2012-11-08 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
| US10699038B2 (en) | 2012-03-30 | 2020-06-30 | Litmus Blue Technology LLC | Configurable representation of domain models |
| WO2014008636A1 (en) * | 2012-07-11 | 2014-01-16 | Merck Sharp & Dohme Corp. | Macrocyclic compounds as hiv integrase inhibitors |
| WO2014099586A1 (en) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| CA2893843C (en) | 2012-12-21 | 2018-09-04 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| HK1214817A1 (en) | 2012-12-27 | 2016-08-05 | Japan Tobacco Inc. | Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as hiv integrase inhibitor |
| WO2014172188A2 (en) | 2013-04-16 | 2014-10-23 | Merck Sharp & Dohme Corp. | 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors |
| PT2997033T (pt) | 2013-05-17 | 2018-01-25 | Merck Sharp & Dohme | Compostos heterocíclicos tricíclicos fundidos como inibidores de vih integrase |
| WO2014200880A1 (en) | 2013-06-13 | 2014-12-18 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| NO2865735T3 (de) | 2013-07-12 | 2018-07-21 | ||
| MX367057B (es) | 2013-09-27 | 2019-08-02 | Merck Sharp & Dohme | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih. |
| WO2015096651A1 (en) | 2013-12-23 | 2015-07-02 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as pde2 inhibitors |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (de) | 2014-06-20 | 2018-06-23 | ||
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| WO2016154081A1 (en) | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as pde2 inhibitors |
| TR201905009T4 (tr) | 2015-04-02 | 2019-05-21 | Gilead Sciences Inc | Polisiklik-karbamoilpiridon bileşikleri ve bunların farmasötik kullanımları. |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| US10647727B2 (en) | 2015-06-25 | 2020-05-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors |
| WO2017000277A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| WO2017087257A1 (en) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors |
| WO2017106071A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| AU2017367714B2 (en) | 2016-12-02 | 2020-11-12 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as HIV integrase inhibitors |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| WO2018140368A1 (en) | 2017-01-26 | 2018-08-02 | Merck Sharp & Dohme Corp. | Substituted quinolizine derivatives useful as hiv integrase inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9201803D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Corp | Methods |
| SI1441734T1 (sl) | 2001-10-26 | 2007-08-31 | Angeletti P Ist Richerche Bio | Dihidropirimidin karboksamidni inhibitorji HIV-integraze |
| DE60209381T2 (de) | 2001-10-26 | 2006-10-05 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase |
| US7094783B2 (en) | 2002-06-26 | 2006-08-22 | Bristol-Myers Squibb Company | Bicyclic pyrimidinones as coagulation cascade inhibitors |
| BR0317749A (pt) | 2002-12-27 | 2005-11-22 | Angeletti P Ist Richerche Bio | Composto, composição farmacêutica, e, uso de um composto |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| CN1934093A (zh) | 2004-01-12 | 2007-03-21 | 吉里德科学公司 | 嘧啶基膦酸酯抗病毒化合物和使用方法 |
| US7173022B2 (en) * | 2004-05-28 | 2007-02-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| AU2006228278C1 (en) * | 2005-03-31 | 2011-06-23 | Msd Italia S.R.L. | HIV integrase inhibitors |
| PT1874117E (pt) * | 2005-04-28 | 2013-10-17 | Shionogi & Co | Derivado policíclico de carbamoílpiridona possuindo actividade inibidora de hiv-integrasse |
-
2005
- 2005-04-20 US US11/110,589 patent/US7273859B2/en not_active Expired - Lifetime
- 2005-04-22 NZ NZ550698A patent/NZ550698A/en unknown
- 2005-04-22 PT PT05738619T patent/PT1745052E/pt unknown
- 2005-04-22 KR KR1020067023555A patent/KR20070014173A/ko not_active Withdrawn
- 2005-04-22 ES ES05738619T patent/ES2310823T3/es not_active Expired - Lifetime
- 2005-04-22 RU RU2006143683/04A patent/RU2006143683A/ru not_active Application Discontinuation
- 2005-04-22 DK DK05738619T patent/DK1745052T3/da active
- 2005-04-22 EP EP05738619A patent/EP1745052B9/de not_active Expired - Lifetime
- 2005-04-22 HR HR20080531T patent/HRP20080531T3/xx unknown
- 2005-04-22 DE DE602005009172T patent/DE602005009172D1/de not_active Expired - Fee Related
- 2005-04-22 CA CA002566755A patent/CA2566755A1/en not_active Abandoned
- 2005-04-22 WO PCT/US2005/013911 patent/WO2005113562A1/en not_active Ceased
- 2005-04-22 BR BRPI0511078-5A patent/BRPI0511078A/pt not_active IP Right Cessation
- 2005-04-22 JP JP2007513169A patent/JP2007537251A/ja active Pending
- 2005-04-22 PL PL05738619T patent/PL1745052T3/pl unknown
- 2005-04-22 CN CNA2005800236418A patent/CN1984917A/zh active Pending
- 2005-04-22 AT AT05738619T patent/ATE405570T1/de not_active IP Right Cessation
- 2005-04-22 AU AU2005245789A patent/AU2005245789A1/en not_active Abandoned
- 2005-04-22 SI SI200530425T patent/SI1745052T1/sl unknown
- 2005-04-22 MX MXPA06013023A patent/MXPA06013023A/es not_active Application Discontinuation
- 2005-05-09 TW TW094114913A patent/TW200540173A/zh unknown
- 2005-05-11 AR ARP050101931A patent/AR049498A1/es not_active Application Discontinuation
- 2005-05-11 PE PE2005000520A patent/PE20060238A1/es not_active Application Discontinuation
- 2005-11-14 US US11/273,671 patent/US7419969B2/en not_active Expired - Lifetime
-
2006
- 2006-11-03 ZA ZA200609181A patent/ZA200609181B/en unknown
- 2006-11-09 IL IL179161A patent/IL179161A0/en unknown
- 2006-11-27 NO NO20065443A patent/NO20065443L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1745052A1 (de) | 2007-01-24 |
| RU2006143683A (ru) | 2008-06-20 |
| MXPA06013023A (es) | 2006-12-20 |
| DK1745052T3 (da) | 2009-01-05 |
| US7273859B2 (en) | 2007-09-25 |
| US20060106007A1 (en) | 2006-05-18 |
| ZA200609181B (en) | 2008-06-25 |
| HRP20080531T3 (en) | 2009-03-31 |
| BRPI0511078A (pt) | 2007-12-26 |
| ATE405570T1 (de) | 2008-09-15 |
| US7419969B2 (en) | 2008-09-02 |
| ES2310823T3 (es) | 2009-01-16 |
| DE602005009172D1 (de) | 2008-10-02 |
| PE20060238A1 (es) | 2006-03-31 |
| WO2005113562A1 (en) | 2005-12-01 |
| CA2566755A1 (en) | 2005-12-01 |
| KR20070014173A (ko) | 2007-01-31 |
| NZ550698A (en) | 2009-05-31 |
| IL179161A0 (en) | 2007-03-08 |
| PL1745052T3 (pl) | 2009-01-30 |
| SI1745052T1 (sl) | 2009-04-30 |
| AR049498A1 (es) | 2006-08-09 |
| US20050256109A1 (en) | 2005-11-17 |
| EP1745052B1 (de) | 2008-08-20 |
| TW200540173A (en) | 2005-12-16 |
| PT1745052E (pt) | 2008-11-14 |
| AU2005245789A1 (en) | 2005-12-01 |
| CN1984917A (zh) | 2007-06-20 |
| EP1745052B9 (de) | 2009-10-28 |
| JP2007537251A (ja) | 2007-12-20 |
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