NO20073655L - Antistoffer mot IL-13 reseptor alfa 1 og anvendelser derav - Google Patents

Antistoffer mot IL-13 reseptor alfa 1 og anvendelser derav

Info

Publication number
NO20073655L
NO20073655L NO20073655A NO20073655A NO20073655L NO 20073655 L NO20073655 L NO 20073655L NO 20073655 A NO20073655 A NO 20073655A NO 20073655 A NO20073655 A NO 20073655A NO 20073655 L NO20073655 L NO 20073655L
Authority
NO
Norway
Prior art keywords
antibodies
receptor alpha
antibody
heavy chain
variable
Prior art date
Application number
NO20073655A
Other languages
English (en)
Norwegian (no)
Inventor
Adelbert Grossmann
Ralf Schumacher
Paul Parren
Yvo Graus
Frank Rebers
Martine Van Vugt
Kay-Gunnar Stubenrauch
Jan Van De Winkel
Josef Endl
Maria Elena Fuentes
Jorg Regula
Sebastian Neumann
Stefan Seeber
Jan Stracke
Sandra Vereecken-Verploegen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20073655L publication Critical patent/NO20073655L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20073655A 2005-01-03 2007-07-17 Antistoffer mot IL-13 reseptor alfa 1 og anvendelser derav NO20073655L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05000003 2005-01-03
EP05002229 2005-02-03
PCT/EP2006/000005 WO2006072564A1 (fr) 2005-01-03 2006-01-02 Anticorps contre le recepteur alpha-1 de l'il-13 et leurs utilisations

Publications (1)

Publication Number Publication Date
NO20073655L true NO20073655L (no) 2007-08-02

Family

ID=36199730

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073655A NO20073655L (no) 2005-01-03 2007-07-17 Antistoffer mot IL-13 reseptor alfa 1 og anvendelser derav

Country Status (19)

Country Link
US (2) US7807158B2 (fr)
EP (1) EP1836226B1 (fr)
JP (1) JP5086098B2 (fr)
KR (1) KR100934894B1 (fr)
AR (1) AR051888A1 (fr)
AT (1) ATE513855T1 (fr)
AU (1) AU2006204480B2 (fr)
BR (1) BRPI0606368A2 (fr)
CA (1) CA2592614C (fr)
CR (1) CR9209A (fr)
IL (1) IL184205A0 (fr)
MA (1) MA29226B1 (fr)
MX (1) MX2007008128A (fr)
NO (1) NO20073655L (fr)
NZ (1) NZ556126A (fr)
RU (1) RU2413736C2 (fr)
SG (1) SG172504A1 (fr)
TW (2) TWI306862B (fr)
WO (1) WO2006072564A1 (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
CA2664343C (fr) 2006-10-02 2016-04-26 Regeneron Pharmaceuticals, Inc. Anticorps humains a haute affinite vis-a-vis du recepteur il-4 humain
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
PL2068922T3 (pl) 2006-10-19 2012-11-30 Csl Ltd Przeciwciała anty-IL-13R alfa1 i ich zastosowania
EP2076285A4 (fr) * 2006-10-19 2010-06-30 Merck Sharp & Dohme Antagonistes d'anticorps du récepteur 1 de l'interleukine-13
ES2501947T3 (es) 2006-10-19 2014-10-02 Csl Limited Antagonistas de anticuerpos de alta afinidad del receptor alfa 1 de interleucina
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
JP2010531340A (ja) * 2007-07-10 2010-09-24 エフ.ホフマン−ラ ロシュ アーゲー 新規処方物
PT2592148T (pt) * 2007-10-12 2018-11-12 Hoffmann La Roche Expressão proteica de múltiplos ácidos nucleicos
EP2050764A1 (fr) * 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
AU2008337904B2 (en) 2007-12-15 2014-02-13 F. Hoffmann-La Roche Ag Distinguishing assay
ES2549769T3 (es) * 2009-03-25 2015-11-02 Genentech, Inc. Anticuerpos anti-FGFR3 y métodos que emplean los mismos
US8530392B2 (en) * 2009-05-13 2013-09-10 Shionogi & Co., Ltd. Test agent for visceral obesity and use thereof
BR112012001843A2 (pt) 2009-07-30 2016-03-15 Hoffmann La Roche separador de coluna de cromatografia móvel
WO2011038894A1 (fr) 2009-10-01 2011-04-07 F. Hoffmann-La Roche Ag Chromatographie sur protéine a
KR101653471B1 (ko) 2009-10-01 2016-09-01 에프. 호프만-라 로슈 아게 다단계 최종 여과
WO2011048043A1 (fr) 2009-10-19 2011-04-28 F. Hoffmann-La Roche Ag Anticorps anti igg non à réactivité croisée
EP2516460B1 (fr) 2009-12-22 2015-03-04 F.Hoffmann-La Roche Ag Agrégation dépendant de la séquence
EP2606071B1 (fr) 2010-08-17 2019-12-18 F.Hoffmann-La Roche Ag Anticorps anti-igg1 humaine
WO2012104278A1 (fr) 2011-02-02 2012-08-09 F. Hoffmann-La Roche Ag Support de colonne chromatographique
EP2699256B1 (fr) * 2011-04-21 2017-09-27 The Regents of the University of Colorado, a body corporate Compositions et méthodes de traitement de maladie de devic
KR102502640B1 (ko) 2012-08-21 2023-02-23 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법
CN118286417A (zh) 2012-09-07 2024-07-05 瑞泽恩制药公司 以il-4r拮抗剂治疗特应性皮炎的方法
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
RS59354B1 (sr) 2013-06-21 2019-10-31 Sanofi Biotechnology Postupci lečenja nosne polipoze davanjem il-4r antagonista
JP6563910B2 (ja) 2013-07-04 2019-08-21 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
AU2014368453B2 (en) 2013-12-20 2020-04-16 Intervet International B.V. Caninized murine anti-canine PD-1 antibodies
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
PT3110848T (pt) 2014-09-24 2024-03-05 Regeneron Pharma Métodos para tratamento de infeção cutânea por administração de um antagonista do il-4r
ES2853823T3 (es) 2014-09-30 2021-09-17 Intervet Int Bv Anticuerpos de PD-L1 que se unen a PD-L1 canino
CA3246946A1 (en) 2014-11-14 2025-11-29 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
MX388197B (es) 2015-08-21 2025-03-19 Hoffmann La Roche Método para la reducción de proteínas de células hospederas en cromatografía de afinidad.
HRP20211737T1 (hr) * 2015-08-21 2022-02-18 F. Hoffmann - La Roche Ag Postupak za smanjenje proteina stanice domaćina u afinitetnoj kromatografiji
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
ES3014160T3 (en) 2015-12-18 2025-04-21 Intervet Int Bv Caninized human antibodies to human and canine il-4r alpha
WO2018011405A1 (fr) * 2016-07-15 2018-01-18 Universität Zürich Anticorps il-13r alpha1 pour dans le traitement de l'inflammation atopique, de la septicémie et de la neutropénie.
KR102872485B1 (ko) 2016-09-01 2025-10-20 리제너론 파아마슈티컬스, 인크. Il-4r 길항제를 투여함에 의해 알레르기를 예방하거나 치료하기 위한 방법
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
TWI784988B (zh) 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
CA3045944A1 (fr) 2016-12-07 2018-06-14 Progenity, Inc. Procedes, dispositifs et systemes de detection du tractus gastro-intestinal
WO2018183932A1 (fr) 2017-03-30 2018-10-04 Progenity Inc. Traitement d'une maladie du tractus gastro-intestinal à l'aide d'un inhibiteur d'il-13
WO2019028367A1 (fr) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. Méthodes de traitement de l'oesophagite à éosinophiles active
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
US11034768B2 (en) 2017-10-30 2021-06-15 Sanofi Biotechnology Methods for treating or preventing asthma by administering an IL-4R antagonist
WO2019183266A1 (fr) 2018-03-21 2019-09-26 ALX Oncology Inc. Anticorps contre la protéine régulatrice de signal alpha et procédés d'utilisation
MX2020012064A (es) 2018-05-13 2021-04-13 Regeneron Pharma Metodos para tratar la dermatitis atopica administrando un inhibidor de il-4r.
CN113348011B (zh) 2018-11-19 2023-04-18 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
KR20210143246A (ko) 2019-03-21 2021-11-26 리제너론 파아마슈티컬스, 인크. 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용
WO2020197502A1 (fr) 2019-03-26 2020-10-01 Aslan Pharmaceuticals Pte Ltd Traitement faisant intervenir un anticorps anti-il-13r ou un fragment de liaison de celui-ci
KR20220034878A (ko) 2019-07-16 2022-03-18 사노피 바이오테크놀로지 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
US11504426B2 (en) 2019-08-05 2022-11-22 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
JP7736667B2 (ja) 2019-08-05 2025-09-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Il-4rアンタゴニストを投与することによるアトピー性皮膚炎の治療方法
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
WO2022186772A1 (fr) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TRAITEMENT DE LA DERMATITE ATOPIQUE À L'AIDE D'UN ANTICORPS ANTI-IL-13Rα1 OU D'UN FRAGMENT DE LIAISON ASSOCIÉ
WO2022186773A1 (fr) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TRAITEMENT DE LA DERMATITE ATOPIQUE À L'AIDE D'UN ANTICORPS ANTI-IL-13Rα1 OU D'UN FRAGMENT DE LIAISON ASSOCIÉ CHEZ UNE POPULATION ALLERGIQUE
WO2023048650A1 (fr) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd TRAITEMENT DU PRURIT FAISANT INTERVENIR UN ANTICORPS ANTI-IL13Rα1 OU UN FRAGMENT DE LIAISON DE CELUI-CI
JP2024534717A (ja) 2021-09-27 2024-09-24 アスラン ファーマシューティカルズ ピーティーイー リミテッド 中等症から重症のアトピー性皮膚炎の処置のための方法
WO2023075702A1 (fr) 2021-10-29 2023-05-04 Aslan Pharmaceuticals Pte Ltd Formulation d'anticorps anti-il-13r
KR20250075749A (ko) 2022-08-26 2025-05-28 아슬란 파마슈티컬스 피티이 엘티디 항-il13r 항체의 고농도 제형
CN120077070A (zh) 2022-09-06 2025-05-30 亚狮康私人有限公司 皮炎患者的睡眠缺失或睡眠障碍的治疗

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5614191A (en) 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
ES2334408T3 (es) 1995-10-23 2010-03-09 Zenyth Operations Pty Ltd Receptor de hematopoyetina y secuencias geneticas que lo codifican.
US5843659A (en) * 1996-03-21 1998-12-01 Apoptosis Technology, Inc. Apoptosis gene EI24, compositions, and methods of use
EP1449851A4 (fr) 2001-11-27 2005-11-16 Mochida Pharm Co Ltd Anticorps de neutralisation du recepteur alpha 1 de l'il13
AR037756A1 (es) * 2001-12-17 2004-12-01 Bayer Corp Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma.
CA2480059C (fr) 2002-03-22 2015-11-24 Amrad Operations Pty. Ltd. Anticorps monoclonal contre le recepteur alpha1 de l'interleukine 13 (il-13ra1)
WO2004081186A2 (fr) * 2003-03-10 2004-09-23 Applera Corporation Polymorphismes genetiques associes a la stenose, procedes de detection et utilisations associees
UA97086C2 (uk) * 2003-07-15 2012-01-10 Емджен, Інк. Виділене людське антитіло, яке специфічно зв'язується з фактором росту нервової тканини (ngf)

Also Published As

Publication number Publication date
KR20070091180A (ko) 2007-09-07
MX2007008128A (es) 2007-07-20
TW200902555A (en) 2009-01-16
MA29226B1 (fr) 2008-02-01
RU2007129676A (ru) 2009-02-10
CA2592614C (fr) 2015-04-14
AU2006204480A1 (en) 2006-07-13
EP1836226B1 (fr) 2011-06-22
ATE513855T1 (de) 2011-07-15
TWI306862B (en) 2009-03-01
EP1836226A1 (fr) 2007-09-26
TW200635945A (en) 2006-10-16
RU2413736C2 (ru) 2011-03-10
US20060263356A1 (en) 2006-11-23
NZ556126A (en) 2008-09-26
SG172504A1 (en) 2011-07-28
KR100934894B1 (ko) 2010-01-07
WO2006072564A1 (fr) 2006-07-13
JP5086098B2 (ja) 2012-11-28
BRPI0606368A2 (pt) 2009-06-23
IL184205A0 (en) 2007-10-31
AU2006204480B2 (en) 2011-06-09
AR051888A1 (es) 2007-02-14
US7807158B2 (en) 2010-10-05
US20110086026A1 (en) 2011-04-14
CR9209A (es) 2007-08-28
HK1112006A1 (en) 2008-08-22
CA2592614A1 (fr) 2006-07-13
JP2008526187A (ja) 2008-07-24

Similar Documents

Publication Publication Date Title
TW200635945A (en) Antibodies against IL-13 receptor alpha 1 and uses thereof
NO20074867L (no) Antistoffer mot CCR5 og anvendelser derav
RU2015147300A (ru) Гуманизированные антитела к cxcr5, их производные и их применение
CY1117702T1 (el) Πρωτεϊνες δεσμευομενες με αντιγονο ικανες να δεσμευονται με θυμικη στρωματικη λεμφοποιητινη
LTPA2017038I1 (lt) Didelio giminingumo antikūnai prieš žmogaus IL-6 receptorių
NZ607711A (en) Antibodies directed to her-3 and uses thereof
WO2007117577A3 (fr) Anticorps humains à haute affinité dirigés contre le récepteur de l'il-18 humaine
PE20110801A1 (es) Anticuerpos con reactividad cruzada y biespecificos anti-il-17a/f
RU2013138469A (ru) АНТИТЕЛА К ИНТЕРЛЕЙКИНУ-1α И СПОСОБЫ ПРИМЕНЕНИЯ
NO20090224L (no) Anti-IL-6 monoklonale antistoffer og anvendelser derav
CO6231009A2 (es) Anticuerpos ox40 antagonistas y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes
ATE395364T1 (de) Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung
BRPI0821168B8 (pt) anticorpo isolado que se liga ao il-21 humano, ou um fragmento deste, usos de dito anticorpo ou fragmento, e, hibridoma
JP2012507294A5 (fr)
PE20120429A1 (es) Proteinas de enlace de miostatina
NZ700473A (en) Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof
NO20084650L (no) Modifiserte humaniserte anti-interleukin-18 antistoffer
ES2572177T3 (es) Anticuerpos neutralizantes anti-B7RP1 humanos
NZ602780A (en) Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
EA201190132A1 (ru) Гуманизированные антитела, связывающиеся с cd19, и их применение
PE20080036A1 (es) Anticuerpos humanos para la interleucina-13 (il13)
RU2011144166A (ru) Способы применения антител к il-22 человека
ATE512986T1 (de) Antikörper gegen clostridium difficile-toxine und ihre verwendung
NO20063026L (no) Antistoffer
EA032189B9 (ru) Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application