NO20075298L - Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists - Google Patents

Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists

Info

Publication number: NO20075298L
Authority: NO; Norway
Prior art keywords: sphingosine; phosphate; thiophene derivatives; receptor agonists; novel thiophene
Prior art date: 2005-03-23

Application number

NO20075298A

Other languages

English (en)

Norwegian (no)

Inventor

Martin Bolli

Thomas Weller

Oliver Nayler

Claus Mueller

Joerg Velker

David Lehmann

Boris Mathys

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-23

Filing date

2007-10-17

Publication date

2007-12-20

2007-10-17 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2007-12-20 Publication of NO20075298L publication Critical patent/NO20075298L/no

Links

150000003577 thiophenes Chemical class 0.000 title abstract 2
239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20075298A 2005-03-23 2007-10-17 Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists NO20075298L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP2005003070		2005-03-23
PCT/IB2006/050850 WO2006100633A1 (en)	2005-03-23	2006-03-20	NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS

Publications (1)

Publication Number	Publication Date
NO20075298L true NO20075298L (no)	2007-12-20

Family

ID=36699202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20075298A NO20075298L (no)	2005-03-23	2007-10-17	Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists

Country Status (25)

Country	Link
US (1)	US7605269B2 (pt)
EP (1)	EP1863474B1 (pt)
JP (1)	JP5072825B2 (pt)
KR (1)	KR20070116645A (pt)
CN (1)	CN101146529B (pt)
AR (1)	AR055751A1 (pt)
AT (1)	ATE413874T1 (pt)
AU (1)	AU2006226020A1 (pt)
BR (1)	BRPI0609668A2 (pt)
CA (1)	CA2602475C (pt)
CY (1)	CY1108750T1 (pt)
DE (1)	DE602006003642D1 (pt)
DK (1)	DK1863474T3 (pt)
ES (1)	ES2316062T3 (pt)
IL (1)	IL186150A0 (pt)
MX (1)	MX2007011672A (pt)
NO (1)	NO20075298L (pt)
NZ (1)	NZ562561A (pt)
PL (1)	PL1863474T3 (pt)
PT (1)	PT1863474E (pt)
RU (1)	RU2404178C2 (pt)
SI (1)	SI1863474T1 (pt)
TW (1)	TW200700406A (pt)
WO (1)	WO2006100633A1 (pt)
ZA (1)	ZA200709087B (pt)

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DE602005020036D1 (de)	2004-09-27	2010-04-29	Avon Protection Systems Inc	Ausatmungseinheit eines beatmungsgeräts
AU2006226018B2 (en)	2005-03-23	2012-07-12	Idorsia Pharmaceuticals Ltd	Hydrogenated benzo (C) thiophene derivatives as immunomodulators
KR20080002850A (ko)	2005-03-23	2008-01-04	액테리온 파마슈티칼 리미티드	신규한 티오펜 유도체
BRPI0609668A2 (pt)	2005-03-23	2011-10-18	Actelion Pharmaceuticals Ltd	composto, composição farmacêutica, e, uso de um composto
AR057894A1 (es)	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
KR20080092385A (ko)	2006-01-24	2008-10-15	액테리온 파마슈티칼 리미티드	신규한 피리딘 유도체

2006
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- 2006-03-20 RU RU2007138869/04A patent/RU2404178C2/ru not_active IP Right Cessation
- 2006-03-20 PL PL06727683T patent/PL1863474T3/pl unknown
- 2006-03-20 DK DK06727683T patent/DK1863474T3/da active
- 2006-03-20 EP EP06727683A patent/EP1863474B1/en not_active Expired - Lifetime
- 2006-03-20 ES ES06727683T patent/ES2316062T3/es not_active Expired - Lifetime
- 2006-03-20 MX MX2007011672A patent/MX2007011672A/es active IP Right Grant
- 2006-03-20 US US11/909,436 patent/US7605269B2/en not_active Expired - Fee Related
- 2006-03-20 SI SI200630178T patent/SI1863474T1/sl unknown
- 2006-03-20 JP JP2008502540A patent/JP5072825B2/ja not_active Expired - Fee Related
- 2006-03-20 PT PT06727683T patent/PT1863474E/pt unknown
- 2006-03-20 KR KR1020077024345A patent/KR20070116645A/ko not_active Ceased
- 2006-03-20 CN CN2006800092312A patent/CN101146529B/zh not_active Expired - Fee Related
- 2006-03-20 AT AT06727683T patent/ATE413874T1/de active
- 2006-03-20 NZ NZ562561A patent/NZ562561A/en not_active IP Right Cessation
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- 2006-03-20 WO PCT/IB2006/050850 patent/WO2006100633A1/en not_active Ceased
- 2006-03-20 DE DE602006003642T patent/DE602006003642D1/de not_active Expired - Lifetime
- 2006-03-20 AU AU2006226020A patent/AU2006226020A1/en not_active Abandoned
- 2006-03-22 TW TW095109955A patent/TW200700406A/zh unknown
- 2006-03-22 AR ARP060101135A patent/AR055751A1/es not_active Application Discontinuation
2007
- 2007-09-20 IL IL186150A patent/IL186150A0/en unknown
- 2007-10-17 NO NO20075298A patent/NO20075298L/no not_active Application Discontinuation
- 2007-10-22 ZA ZA200709087A patent/ZA200709087B/xx unknown
2009
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Also Published As

Publication number	Publication date
US7605269B2 (en)	2009-10-20
AU2006226020A1 (en)	2006-09-28
CA2602475A1 (en)	2006-09-28
ZA200709087B (en)	2008-09-25
CY1108750T1 (el)	2014-04-09
ES2316062T3 (es)	2009-04-01
RU2007138869A (ru)	2009-04-27
JP2008534491A (ja)	2008-08-28
MX2007011672A (es)	2007-11-15
SI1863474T1 (sl)	2009-04-30
DK1863474T3 (da)	2009-02-09
EP1863474A1 (en)	2007-12-12
US20080318955A1 (en)	2008-12-25
CN101146529B (zh)	2012-08-29
IL186150A0 (en)	2008-01-20
EP1863474B1 (en)	2008-11-12
BRPI0609668A2 (pt)	2011-10-18
CA2602475C (en)	2014-11-04
WO2006100633A1 (en)	2006-09-28
AR055751A1 (es)	2007-09-05
TW200700406A (en)	2007-01-01
NZ562561A (en)	2010-11-26
PT1863474E (pt)	2009-01-20
RU2404178C2 (ru)	2010-11-20
KR20070116645A (ko)	2007-12-10
DE602006003642D1 (en)	2008-12-24
CN101146529A (zh)	2008-03-19
PL1863474T3 (pl)	2009-04-30
ATE413874T1 (de)	2008-11-15
JP5072825B2 (ja)	2012-11-14

Legal Events

Date	Code	Title	Description
2012-10-22	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
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