NO20075723L - Tiazolforbindelser og fremgangsmater for anvendelse - Google Patents
Tiazolforbindelser og fremgangsmater for anvendelseInfo
- Publication number
- NO20075723L NO20075723L NO20075723A NO20075723A NO20075723L NO 20075723 L NO20075723 L NO 20075723L NO 20075723 A NO20075723 A NO 20075723A NO 20075723 A NO20075723 A NO 20075723A NO 20075723 L NO20075723 L NO 20075723L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compounds
- methods
- compound
- administering
- Prior art date
Links
- 150000003557 thiazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 9
- 208000035473 Communicable disease Diseases 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000711549 Hepacivirus C Species 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67913305P | 2005-05-09 | 2005-05-09 | |
| PCT/US2006/017692 WO2006122011A2 (fr) | 2005-05-09 | 2006-05-09 | Composes thiazole et procedes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075723L true NO20075723L (no) | 2008-02-05 |
Family
ID=36968742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075723A NO20075723L (no) | 2005-05-09 | 2007-11-09 | Tiazolforbindelser og fremgangsmater for anvendelse |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8088806B2 (fr) |
| EP (1) | EP1879575A2 (fr) |
| JP (1) | JP2008540537A (fr) |
| KR (1) | KR20080019213A (fr) |
| CN (1) | CN101247807A (fr) |
| AP (1) | AP2358A (fr) |
| AU (1) | AU2006244203B2 (fr) |
| BR (1) | BRPI0608910A2 (fr) |
| CA (1) | CA2607617A1 (fr) |
| EA (1) | EA200702445A1 (fr) |
| IL (1) | IL186970A0 (fr) |
| MX (1) | MX2007013955A (fr) |
| NO (1) | NO20075723L (fr) |
| NZ (1) | NZ563866A (fr) |
| SG (1) | SG159561A1 (fr) |
| UA (1) | UA92746C2 (fr) |
| WO (1) | WO2006122011A2 (fr) |
| ZA (1) | ZA200709751B (fr) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1909910A1 (fr) * | 2005-08-04 | 2008-04-16 | Sirtris Pharmaceuticals, Inc. | Dérivés de benzimidazole en tant que modulateur du sirtuin |
| JP2009529059A (ja) * | 2006-03-08 | 2009-08-13 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 抗ｃ型肝炎ウイルス活性を有する置換アミノチアゾール誘導体 |
| WO2007123269A1 (fr) | 2006-04-19 | 2007-11-01 | Astellas Pharma Inc. | DÉRIVÉ d'azolecarboxamide |
| CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
| AU2007281212B8 (en) | 2006-08-03 | 2013-02-28 | Trustees Of Tufts College | Non-flushing niacin analogues, and methods of use thereof |
| RU2009110254A (ru) | 2006-08-24 | 2010-09-27 | Новартис АГ (CH) | Производные 2-(пиразин-2-ил)тиазола и 2-(1н-пиразол-3-ил)тиразола и связанные с ним соединения в качестве ингибиторов стеароил-соа десатуразы для лечения метаболических, сердечно-сосудистых и других нарушений |
| CN101516877B (zh) | 2006-09-22 | 2013-09-11 | 诺瓦提斯公司 | 杂环有机化合物 |
| US20100055071A1 (en) * | 2006-11-21 | 2010-03-04 | Martin Robert Leivers | Anti-Viral Compounds |
| EP2121671A1 (fr) | 2006-12-20 | 2009-11-25 | Novartis AG | Hétérocycles à 5 chaînons substitués en position 2 comme inhibiteurs de scd |
| WO2008124300A1 (fr) | 2007-04-10 | 2008-10-16 | National Health Research Institutes | Inhibiteurs du virus de l'hépatite c |
| CA2683948A1 (fr) * | 2007-04-20 | 2008-10-30 | Merck Frosst Canada Ltd. | Nouveaux composes heteroaromatiques comme inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase |
| US8183263B2 (en) | 2007-05-22 | 2012-05-22 | Achillion Pharmaceuticals, Inc. | Heteroaryl substituted thiazoles |
| US20100152208A1 (en) * | 2007-05-23 | 2010-06-17 | Merck Frosst Canada Ltd. | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2008154091A1 (fr) | 2007-06-08 | 2008-12-18 | National Health Research Institutes | Dérivés de thiourée |
| TW200918542A (en) | 2007-06-20 | 2009-05-01 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| US20100144756A1 (en) | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| GB2455111A (en) * | 2007-11-28 | 2009-06-03 | Addex Pharmaceuticals Sa | Metabotropic glutamate receptor (mGluR4) modulators having 5- or 6-membered N-heteroaryl ring substituted by both N-cyclylamino & 5-membered N-heteroaryl ring |
| CN101801942B (zh) | 2007-07-17 | 2013-03-27 | 美国艾森生物科学公司 | 杂环化合物和作为抗癌剂的用途 |
| JP2010533658A (ja) * | 2007-07-20 | 2010-10-28 | メルク フロスト カナダ リミテツド | ステアロイル補酵素ａデルタ−９デサチュラーゼ阻害剤としての二環性へテロ芳香族化合物 |
| CN101808995A (zh) * | 2007-07-27 | 2010-08-18 | 百时美施贵宝公司 | 新颖的葡糖激酶激活剂及其使用方法 |
| US8124632B2 (en) * | 2007-08-03 | 2012-02-28 | Romark Laboratories, L.C. | Alkylsulfonyl-substituted thiazolide compounds |
| EA201000561A1 (ru) * | 2007-10-09 | 2010-10-29 | Мерк Патент Гмбх | Производные пиридина, пригодные в качестве активаторов глюкокиназы |
| WO2009051909A1 (fr) * | 2007-10-16 | 2009-04-23 | The Regents Of The University Of California | Composés présentant une activité de correction du traitement cellulaire cftr mutante, et utilisations de ceux-ci |
| RU2461551C2 (ru) | 2007-10-24 | 2012-09-20 | Астеллас Фарма Инк. | Азолкарбоксамидное соединение или его фармацевтически приемлемая соль |
| EP2070924A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nouveaux dérivés de 2-hetarylthiazol-4-amides d'acide carboxylique, leur fabrication et leur utilisation en tant que médicament |
| EP2070916A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dérivés de 2-aryl-thiazol-4-amides d'acide carboxylique, leur fabrication et leur utilisation en tant que médicament |
| EP2070925A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nouveaux dérivés de 2-thiazol-4-amides d'acide carboxylique substitués, leur fabrication et leur utilisation en tant que médicament |
| TWI361808B (en) | 2008-01-08 | 2012-04-11 | Nat Health Research Institutes | Imidazolidinone and imidazolidinethione derivatives |
| EP2101173A1 (fr) | 2008-03-14 | 2009-09-16 | Vivalis | Procédé in vitro pour déterminer si un candidat destiné à un médicament pour une protéine cible est actif contre une variante de cette protéine |
| US8198284B2 (en) | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
| US8106209B2 (en) * | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
| WO2010008831A2 (fr) * | 2008-06-24 | 2010-01-21 | Irm Llc | Composés et procédés pour moduler les récepteurs couplés à la protéine g |
| ES2605815T3 (es) * | 2008-07-01 | 2017-03-16 | Ptc Therapeutics, Inc. | Moduladores de la expresión de la proteína Bmi-1 |
| NZ602832A (en) | 2008-07-14 | 2014-04-30 | Gilead Sciences Inc | Fused heterocyclic hdac inhibitor compounds |
| CA2728228A1 (fr) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Composes inhibiteurs de l'oxindolyle |
| AU2009271003A1 (en) | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Imidazolylpyrimidine compounds as HDAC and/or CDK inhibitors |
| AU2009276699A1 (en) | 2008-07-28 | 2010-02-04 | Gilead Sciences, Inc. | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| WO2010018131A1 (fr) | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Dérivés purines destinés à être utilisés dans le traitement de maladies allergiques, inflammatoires et infectieuses |
| WO2010018134A1 (fr) | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Nouveaux dérivés d’adénine |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| PE20110368A1 (es) * | 2008-08-18 | 2011-06-13 | Univ Yale | Moduladores de mif |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| GB0900388D0 (en) | 2009-01-12 | 2009-02-11 | Addex Pharmaceuticals Sa | New compounds |
| EP3078377A3 (fr) | 2009-05-12 | 2017-04-05 | Romark Laboratories, L.C. | Nitazoxanide et tizoxanide en tant qu'agents antiviraux |
| ES2463826T3 (es) | 2009-06-08 | 2014-05-29 | Gilead Sciences, Inc. | Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina |
| KR20120031170A (ko) | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| CN101928283A (zh) * | 2009-06-25 | 2010-12-29 | 上海唐润医药科技有限公司 | 具有抗hcv活性的化合物及其用途 |
| MX341877B (es) | 2009-06-26 | 2016-09-06 | Romark Laboratories L C * | Compuestos y métodos para tratar influenza. |
| WO2011098451A1 (fr) | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Dérivés de purine et leurs utilisations pharmaceutiques |
| ES2525826T3 (es) | 2010-02-10 | 2014-12-30 | Glaxosmithkline Llc | Maleato de 6-amino-2-{[(1s)-1-metilbutil]-oxi}-9-[5-(1-piperidinil)pentil]-7,9-dihidro-8H-purin-8-ona |
| CN102822173A (zh) * | 2010-02-19 | 2012-12-12 | 美国艾森生物科学公司 | 杂环化合物和作为抗癌剂的用途 |
| ES2557465T3 (es) * | 2010-03-17 | 2016-01-26 | Taivex Therapeutics Inc. | Moduladores de la actividad de HEC 1 y procedimientos para ello |
| WO2012037351A1 (fr) * | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Composés |
| WO2012037349A2 (fr) * | 2010-09-17 | 2012-03-22 | Glaxosmithkline Llc | Composés |
| WO2012075393A2 (fr) * | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activateurs de la dégradation protéasomique et leurs utilisations |
| US8835456B1 (en) | 2011-03-18 | 2014-09-16 | Achillion Pharmaceuticals, Inc. | NS5A inhibitors useful for treating HCV |
| WO2012136111A1 (fr) * | 2011-04-02 | 2012-10-11 | 中国人民解放军军事医学科学院毒物药物研究所 | Composé phénylproponiate, son procédé de préparation et ses applications médicales |
| KR101931311B1 (ko) | 2011-05-27 | 2018-12-20 | 아칠리온 파르마세우티칼스 인코포레이티드 | Ｈｃｖ 감염 치료에 유용한 치환된 앨리팬, 시클로팬, 헤테라팬, 헤테로팬, 헤테로-헤테라팬 및 메탈로센 |
| WO2013033037A2 (fr) * | 2011-08-26 | 2013-03-07 | The Regents Of The University Of California | Nouveaux composés d'antiprion |
| AP2014007595A0 (en) * | 2011-09-30 | 2014-04-30 | Kineta Inc | Anti-viral compounds |
| HK1200361A1 (en) | 2011-10-04 | 2015-08-07 | 肝炎和病毒研究所 | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication |
| US9926309B2 (en) | 2011-10-05 | 2018-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Pi-kinase inhibitors with anti-infective activity |
| EP2770993A2 (fr) | 2011-10-26 | 2014-09-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Méthode de traitement d'infection par le vhc par inhibiteur de chk2 à petite molécule |
| US11071736B2 (en) | 2011-11-21 | 2021-07-27 | Taivex Therapeutics Corporation | Modulators of HEC1 activity and methods therefor |
| EP2869897A4 (fr) | 2012-07-06 | 2016-09-28 | Univ Duke | Activation du canal ionique trpv4 par stimuli physiques et rôle critique de trpv4 dans l'inflammation et la démangeaison spécifique à un organe |
| EP2882726A4 (fr) * | 2012-08-09 | 2016-04-06 | Neuropore Therapies Inc | Dérivés de benzène substitués par un aryle et hétéroaryle à titre de modulateurs des voies de signalisation de la pi-3 kinase |
| WO2014063168A1 (fr) | 2012-10-19 | 2014-04-24 | The Broad Institute, Inc. | Inhibiteurs hétérocycle - bisamide de récepteur éboueur bl |
| WO2014063167A1 (fr) * | 2012-10-19 | 2014-04-24 | The Broad Institute, Inc. | Inhibiteurs à base de thiazole de récepteur éboueur bi |
| MX2015010790A (es) * | 2013-03-05 | 2015-11-26 | Hoffmann La Roche | Derivados de anilina sustituidos con n-heteroarilo como antivirales de vhc. |
| TW201534586A (zh) | 2013-06-11 | 2015-09-16 | Orion Corp | 新穎ｃｙｐ１７抑制劑／抗雄激素劑 |
| EP3016951B1 (fr) | 2013-07-02 | 2017-05-31 | Bristol-Myers Squibb Company | Dérivés de pyrido-carboxamides tricycliques en tant qu' inhibiteurs du rock |
| ES2634628T3 (es) | 2013-07-02 | 2017-09-28 | Bristol-Myers Squibb Company | Derivados tricíclicos de pirido-carboxamida como inhibidores ROCK |
| US9353078B2 (en) * | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
| WO2015124591A1 (fr) | 2014-02-20 | 2015-08-27 | Glaxosmithkline Intellectual Property (No.2) Limited | Dérivés de pyrrolo[3,2]pyrimidine en tant qu'inducteurs d'interféron humain |
| WO2016028325A1 (fr) | 2014-08-22 | 2016-02-25 | Duke University | Inhibiteurs et de trpa1 de trpv4 et procédés pour les utiliser dans des cas d'inflammation et de prurit spécifique d'un organe |
| TW201629035A (zh) * | 2014-10-06 | 2016-08-16 | 奇尼塔公司 | 抗病毒化合物、醫藥組合物及其使用方法 |
| MX2017006302A (es) | 2014-11-13 | 2018-02-16 | Glaxosmithkline Biologicals Sa | Derivados de adenina que son utiles en el tratamiento de enfermedades alergicas u otras afecciones inflamatorias. |
| US11229628B2 (en) | 2015-01-09 | 2022-01-25 | Duke University | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| CN107531687A (zh) * | 2015-02-27 | 2018-01-02 | 加利福尼亚大学董事会 | 能够实现软骨复壮的小分子 |
| CN107690429B (zh) * | 2015-04-07 | 2022-02-25 | Ela制药有限公司 | 用于治疗和/或预防细胞或组织坏死的组合物，其特异性靶向组织蛋白酶c和/或cela1和/或cela3a和/或与其结构相关的酶 |
| JP6411676B2 (ja) | 2015-12-03 | 2018-10-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド |
| CN105524056A (zh) * | 2016-01-05 | 2016-04-27 | 中山大学肿瘤防治中心 | 一种氨基噻唑化合物及其制备方法和应用 |
| US11091472B2 (en) | 2016-02-26 | 2021-08-17 | The Regents Of The University Of California | PI-kinase inhibitors with anti-infective activity |
| CN113549110B (zh) | 2016-04-07 | 2024-08-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作蛋白质调节剂的杂环酰胺 |
| KR20180132783A (ko) | 2016-04-07 | 2018-12-12 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 단백질 조절제로서 유용한 헤테로사이클릭 아미드 |
| US11564911B2 (en) | 2016-04-07 | 2023-01-31 | Duke University | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3455219A4 (fr) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | Dégronimères de c3-glutarimide liés à une amine pour la dégradation de protéines cibles |
| EP4483875A3 (fr) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Dégronimères spirocycliques pour la dégradation de protéines cibles |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| KR20190058494A (ko) | 2016-08-26 | 2019-05-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 모낭 줄기 세포 활성화 및 모발 성장 |
| US10875861B1 (en) | 2017-05-26 | 2020-12-29 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| EP3641762B1 (fr) | 2017-06-20 | 2026-02-18 | C4 Therapeutics, Inc. | Dégrons et dégronimères à liaison n/o pour la dégradation de protéines |
| EP3692033A1 (fr) | 2017-10-05 | 2020-08-12 | GlaxoSmithKline Intellectual Property Development Limited | Modulateurs de stimulateur des gènes (sting) d'interféron utiles dans le traitement du vih |
| WO2019069270A1 (fr) | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | Modulateurs de stimulateur des gènes (sting) de l'interféron |
| EP3703675A4 (fr) | 2017-10-30 | 2021-06-16 | Neuropore Therapies, Inc. | Phénylsulfonylphényltriazolethiones substituées et utilisations associées |
| US11472781B2 (en) | 2018-02-21 | 2022-10-18 | Southern Research Institute | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases |
| EP3773589B1 (fr) | 2018-04-03 | 2023-11-01 | Blueprint Medicines Corporation | Inhibiteur de ret destiné à être utilisé dans le traitement du cancer présentant une altération du ret |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| US11718593B2 (en) * | 2018-05-17 | 2023-08-08 | Southern Research Institute | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases |
| EP3846793B1 (fr) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Inhibiteurs d'eif4e et leurs utilisations |
| EP3886848A4 (fr) | 2018-11-27 | 2022-08-17 | Rutgers, The State University of New Jersey | Composés pharmaceutiques et méthodes thérapeutiques |
| EP3941909A4 (fr) | 2019-03-21 | 2023-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibiteurs de pi4-kinase et leurs procédés d'utilisation |
| JP2022533390A (ja) | 2019-05-16 | 2022-07-22 | スティングセラ インコーポレイテッド | オキソアクリジニル酢酸誘導体および使用方法 |
| WO2020232378A1 (fr) | 2019-05-16 | 2020-11-19 | Silicon Swat, Inc. | Dérivés d'acide acétique benzo[b][1,8]naphtyridine et leur procédés d'utilisation |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| WO2021119753A1 (fr) | 2019-12-18 | 2021-06-24 | Ctxt Pty Limited | Composés |
| MX2022010944A (es) | 2020-03-03 | 2022-11-09 | Pic Therapeutics Inc | Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos. |
| CN115697979B (zh) | 2020-04-24 | 2025-06-24 | 拜耳公司 | 作为用于免疫激活的dgkzeta抑制剂的取代的氨基噻唑类 |
| CA3183728A1 (fr) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Formes solide de pralsetinib |
| JP2024532276A (ja) | 2021-08-25 | 2024-09-05 | ピク セラピューティクス， インコーポレイテッド | ｅＩＦ４Ｅ阻害剤及びその使用 |
| TW202315621A (zh) * | 2021-08-25 | 2023-04-16 | 美商皮克醫療公司 | Ｅｉｆ４ｅ抑制劑及其用途 |
| WO2023111996A1 (fr) | 2021-12-17 | 2023-06-22 | Reglagene Holding, Inc. | Compositions et procédés de fabrication et d'utilisation de petites molécules dans le traitement du cancer |
| CN114249702B (zh) * | 2022-01-12 | 2023-09-05 | 沈阳药科大学 | N-芳基-[2,4′-双噻唑]-2′-胺类化合物及其制备与用途 |
| WO2023135330A1 (fr) * | 2022-01-17 | 2023-07-20 | Centre National De La Recherche Scientifique | Inhibiteurs de désoxycytidine kinase |
| CN116531373B (zh) * | 2022-01-26 | 2025-02-25 | 上海日馨医药科技股份有限公司 | 噻唑类化合物、其药物组合物及应用 |
| US12215102B2 (en) | 2023-02-28 | 2025-02-04 | Reglagene, Inc. | Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions |
| WO2025151517A1 (fr) * | 2024-01-08 | 2025-07-17 | Wavebreak Therapeutics Limited | Composés thiazole, compositions et méthodes de traitement de troubles associés au mauvais repliement de la protéine alpha-synucléine |
| WO2025166015A2 (fr) * | 2024-02-02 | 2025-08-07 | Photys Therapeutics, Inc. | Composés bifonctionnels de liaison à l'abl1 et leurs utilisations |
| WO2026017723A1 (fr) * | 2024-07-19 | 2026-01-22 | Givaudan Sa | Composé organique |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2474194A (en) * | 1941-08-30 | 1949-06-21 | American Cyanamid Co | N-heterocyclic substituted guanamines |
| US3458526A (en) | 1966-09-26 | 1969-07-29 | Upjohn Co | Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles |
| US3467666A (en) | 1966-11-07 | 1969-09-16 | Geigy Chem Corp | 2-substituted aminothiazoles |
| BE795907A (fr) | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
| CA1051906A (fr) | 1973-10-24 | 1979-04-03 | Shionogi And Co. | Derives du thiazole et production dudit derive |
| DK150068C (da) * | 1978-06-02 | 1987-06-29 | Pfizer | Analogifremgangsmaade til fremstilling af aminothiazoler |
| JPS6339868A (ja) | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| DD271258A1 (de) | 1988-04-06 | 1989-08-30 | Univ Leipzig | Mittel zur chemotherapie von kulturpflanzenvirosen |
| DE4029771A1 (de) | 1990-09-20 | 1992-03-26 | Basf Ag | N-heteroaryl-2-nitroaniline |
| AU689972B2 (en) | 1994-11-29 | 1998-04-09 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
| WO1997024343A1 (fr) * | 1995-12-29 | 1997-07-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derives de phenylthiazole dotes de proprietes anti virus de l'herpes |
| MY128323A (en) | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
| WO2000006575A2 (fr) | 1998-07-28 | 2000-02-10 | Smithkline Beecham Plc | Nouveaux composes |
| JP2002526482A (ja) * | 1998-09-18 | 2002-08-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｐ３８のインヒビター |
| EP1135126A4 (fr) | 1998-12-07 | 2003-04-02 | Smithkline Beecham Corp | Inhibiteurs de la kinase myt1 |
| WO2001021160A2 (fr) | 1999-09-23 | 2001-03-29 | Axxima Pharmaceuticals Aktiengesellschaft | Derives de carboxamide, inhibiteurs selectifs d'agents pathogenes |
| TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| ATE414079T1 (de) | 2000-03-01 | 2008-11-15 | Janssen Pharmaceutica Nv | 2,4-disubstituierte thiazolyl derivate |
| AU2001249670A1 (en) | 2000-04-03 | 2001-10-15 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1 |
| WO2002030357A2 (fr) * | 2000-10-11 | 2002-04-18 | Chemocentryx, Inc. | Composes et procedes servant a moduler la fonction de ccr4 |
| GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| WO2002051410A2 (fr) | 2000-12-22 | 2002-07-04 | Akzo Nobel N.V. | Derives de phenylthiazole et thiazoline et leur utilisation comme antiparasites |
| EP1354603A1 (fr) | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Co-prescriptions |
| US7169931B2 (en) | 2001-01-26 | 2007-01-30 | Shionogi & Co., Ltd. | Cyclic compounds exhibiting thrombopoietin receptor agonism |
| WO2002094264A1 (fr) | 2001-05-23 | 2002-11-28 | Tularik Inc. | Antagonistes de ccr4 |
| HN2002000156A (es) * | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
| EA007717B1 (ru) | 2001-08-13 | 2006-12-29 | Янссен Фармацевтика Н.В. | 2-амино-4,5-тризамещенные производные тиазолила |
| US20040267017A1 (en) | 2001-09-26 | 2004-12-30 | Bierer Donald E | 3-pyridyl or 4-isoquinolinyl thiazoles as c17, 20 lyase inhibitors |
| WO2003027094A2 (fr) | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 3-pyridyl indoles et indazoles substitues servant d'inhibiteurs de c17,20 lyase |
| US20040236110A1 (en) | 2001-09-26 | 2004-11-25 | Ladouceur Gaetan H | Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors |
| US20040198773A1 (en) | 2001-09-26 | 2004-10-07 | Barry Hart | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
| US20040209924A1 (en) | 2001-09-26 | 2004-10-21 | Barry Hart | Substituted 3-pyridyl imidazoles as c17,20 lyase inhibitors |
| CA2462645A1 (fr) | 2001-10-03 | 2003-11-13 | Pharmacia Corporation | Composes polycycliques a 5 elements substitues pour l'inhibition selective de la cascade de reactions dans la coagulation sanguine |
| JP2005509606A (ja) | 2001-10-03 | 2005-04-14 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環式化合物のプロドラッグ |
| US6881746B2 (en) | 2001-12-03 | 2005-04-19 | Novo Nordick A/S | Glucagon antagonists/inverse agonists |
| US7163952B2 (en) | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US6936629B2 (en) | 2001-12-21 | 2005-08-30 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| US20030158199A1 (en) | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| CA2474322A1 (fr) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | (thia-/oxa-/pyra) zoles substitues 4(hetero-) aryle pour inhibition de tie-2 |
| CA2727661C (fr) | 2002-02-06 | 2013-09-10 | Jx Nippon Oil & Energy Corporation | Procede de preparation de catalyseur d'hydrogenation de purification |
| DE60316810T2 (de) | 2002-08-02 | 2008-07-17 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren |
| AU2003253364B2 (en) * | 2002-08-07 | 2007-06-07 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| CN102558155A (zh) | 2003-01-14 | 2012-07-11 | 阿伦纳药品公司 | 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗 |
| EP1603878B1 (fr) | 2003-02-10 | 2013-01-02 | Vertex Pharmaceuticals Incorporated | Procedes de preparation de n-heteroaryl-n-aryl-amines par mise en reaction d'un ester d'acide n-aryl-carbamique avec un halo-heteroaryle, et procedess analogues |
| AU2004212490B2 (en) | 2003-02-10 | 2008-05-15 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| JP2006518738A (ja) | 2003-02-12 | 2006-08-17 | トランス テック ファーマ，インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
| BRPI0407456A (pt) | 2003-02-12 | 2006-01-31 | Pfizer | Derivados antiproliferativos de 2-(sulfo-fenil)-aminotiazole e composições farmacêuticas, e métodos para o seu uso |
| CA2517308A1 (fr) | 2003-02-27 | 2004-09-10 | Ab Science | Traitement individualise pour differentes formes de mastocytose |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| EA200501462A1 (ru) | 2003-04-15 | 2006-04-28 | Пфайзер Инк. | Альфа-замещенные карбоновые кислоты в качестве модуляторов ppar |
| FR2854158B1 (fr) * | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
| US20070191267A1 (en) | 2003-04-28 | 2007-08-16 | Ab Science | Use of tyrosine kinase inhibitors for treating cerebral ischemia |
| WO2004098612A2 (fr) | 2003-05-07 | 2004-11-18 | Ab Science | Nouveaux analogues de calcitriol et leur utilisation |
| EP1628666B1 (fr) | 2003-05-14 | 2015-09-23 | NeuroGenetic Pharmaceuticals, Inc. | Composes et leurs utilisations pour la modulation de l'amyloide-beta |
| AU2004251668B2 (en) | 2003-06-03 | 2008-03-20 | Triad Therapeutics, Inc | 5-membered heterocycle-based p-38 inhibitors |
| WO2005000309A2 (fr) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Composes chimiques |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| CA2535242A1 (fr) | 2003-08-15 | 2005-02-24 | Ab Science | Utilisation d'inhibiteurs de c-kit pour le traitement du diabete de type ii |
| ES2297467T3 (es) | 2003-09-30 | 2008-05-01 | Tibotec Pharmaceuticals Ltd. | Sulfonamidas de inhibicion de vhc. |
| EP1686949A2 (fr) | 2003-11-24 | 2006-08-09 | Viropharma Incorporated | Composes, compositions et procedes pour le traitement et la prophylaxie d'infections de l'hepatite c virale et de maladies associees |
| CA2554925A1 (fr) | 2004-01-30 | 2005-08-11 | Ab Science | 2-(3-substitues aryle)amino-4-aryle-thiazoles en tant qu'inhibiteurs de tyrosine kinase |
| WO2005077368A2 (fr) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Nouveau traitement du reflux gastro-oesophagien pathologique iii |
| TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
| US20050227989A1 (en) | 2004-04-13 | 2005-10-13 | Icagen, Inc. | Polycyclic thiazoles as potassium ion channel modulators |
| WO2005102325A1 (fr) | 2004-04-20 | 2005-11-03 | Ab Science | Utilisation d'inhibiteurs de c-kit pour le traitement de troubles musculaires inflammatoires comprenant la myosite et la dystrophie musculaire |
| WO2005102318A1 (fr) | 2004-04-20 | 2005-11-03 | Ab Science | Utilisation d'inhibiteurs de c-kit dans le traitement des maladies liees au vih |
| EP1758654A1 (fr) | 2004-04-23 | 2007-03-07 | AB Science | Utilisation d'inhibiteurs de c-kit dans le traitement des maladies imputables au plasmodium |
| WO2005102326A2 (fr) | 2004-04-23 | 2005-11-03 | Ab Science | Utilisation d'inhibiteurs de c-kit dans le traitement des maladies renales |
| CA2564574A1 (fr) | 2004-04-23 | 2005-11-03 | Ab Science | Utilisation des inhibiteurs de c-kit pour le traitement de la fibrose |
| US20070249628A1 (en) | 2004-05-18 | 2007-10-25 | Alain Moussy | Use of Mast Cells Inhibitors for Treating Patients Exposed to Chemical or Biological Weapons |
| WO2005115304A2 (fr) | 2004-05-24 | 2005-12-08 | Ab Science | Utilisation d'inhibiteurs de c-kit pour le traitement de la fibrodysplasie |
| WO2005115385A1 (fr) | 2004-05-24 | 2005-12-08 | Ab Science | Utilisation d'inhibiteurs de c-kit pour le traitement de l'acne |
| BRPI0515571A (pt) | 2004-09-23 | 2008-07-29 | Pfizer Prod Inc | agonistas de receptor de trombopoetina |
| KR20080014024A (ko) | 2005-05-11 | 2008-02-13 | 아보트 러보러터리즈 | 바닐로이드 수용체 아형 １(ｖｒ１)의 길항제 및 이의 용도 |
| CN101384568B (zh) | 2006-02-15 | 2012-12-12 | 雅培制药有限公司 | 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用 |
| JP2009529059A (ja) * | 2006-03-08 | 2009-08-13 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 抗ｃ型肝炎ウイルス活性を有する置換アミノチアゾール誘導体 |
| US8183263B2 (en) * | 2007-05-22 | 2012-05-22 | Achillion Pharmaceuticals, Inc. | Heteroaryl substituted thiazoles |
-
2006
- 2006-05-09 SG SG201001098-1A patent/SG159561A1/en unknown
- 2006-05-09 WO PCT/US2006/017692 patent/WO2006122011A2/fr not_active Ceased
- 2006-05-09 MX MX2007013955A patent/MX2007013955A/es not_active Application Discontinuation
- 2006-05-09 EA EA200702445A patent/EA200702445A1/ru unknown
- 2006-05-09 US US11/431,155 patent/US8088806B2/en not_active Expired - Fee Related
- 2006-05-09 UA UAA200713741A patent/UA92746C2/ru unknown
- 2006-05-09 KR KR1020077028496A patent/KR20080019213A/ko not_active Ceased
- 2006-05-09 CN CNA200680025066XA patent/CN101247807A/zh active Pending
- 2006-05-09 AP AP2007004268A patent/AP2358A/xx active
- 2006-05-09 EP EP06770077A patent/EP1879575A2/fr not_active Withdrawn
- 2006-05-09 CA CA002607617A patent/CA2607617A1/fr not_active Abandoned
- 2006-05-09 JP JP2008511226A patent/JP2008540537A/ja active Pending
- 2006-05-09 BR BRPI0608910-0A patent/BRPI0608910A2/pt not_active IP Right Cessation
- 2006-05-09 NZ NZ563866A patent/NZ563866A/en not_active IP Right Cessation
- 2006-05-09 AU AU2006244203A patent/AU2006244203B2/en not_active Ceased
-
2007
- 2007-10-28 IL IL186970A patent/IL186970A0/en unknown
- 2007-11-09 NO NO20075723A patent/NO20075723L/no not_active Application Discontinuation
- 2007-11-13 ZA ZA200709751A patent/ZA200709751B/xx unknown
-
2011
- 2011-11-30 US US13/307,761 patent/US20120108576A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| UA92746C2 (en) | 2010-12-10 |
| KR20080019213A (ko) | 2008-03-03 |
| MX2007013955A (es) | 2008-02-05 |
| AU2006244203A1 (en) | 2006-11-16 |
| US8088806B2 (en) | 2012-01-03 |
| IL186970A0 (en) | 2008-02-09 |
| SG159561A1 (en) | 2010-03-30 |
| AU2006244203B2 (en) | 2012-05-03 |
| US20120108576A1 (en) | 2012-05-03 |
| WO2006122011A2 (fr) | 2006-11-16 |
| CA2607617A1 (fr) | 2006-11-16 |
| ZA200709751B (en) | 2008-11-26 |
| CN101247807A (zh) | 2008-08-20 |
| JP2008540537A (ja) | 2008-11-20 |
| WO2006122011A3 (fr) | 2007-05-03 |
| NZ563866A (en) | 2011-03-31 |
| AP2007004268A0 (en) | 2007-12-31 |
| BRPI0608910A2 (pt) | 2010-02-17 |
| US20070004711A1 (en) | 2007-01-04 |
| AP2358A (en) | 2012-01-30 |
| EA200702445A1 (ru) | 2008-04-28 |
| EP1879575A2 (fr) | 2008-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20065736L (no) | Substituerte arylacyltioureaer og relaterte forbindelser; Inhibitorer av viral reproduksjon | |
| SG159561A1 (en) | Thiazole compounds and methods of use | |
| NO20052546L (no) | Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon. | |
| NO20062928L (no) | Azabenzofuran substituerte tiourear som inhibitorer av viral replikasjon | |
| TW200510391A (en) | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | |
| ATE447573T1 (de) | Chinoxalinyl-makrocyclische hepatitis c serin protease-hemmer | |
| NO20062101L (no) | Serinproteaseinhibitorer, spesielt hcv ns3-ns4a-protease | |
| MY155851A (en) | Quinoxaline-containing compounds as hepatitis c virus inhibitors | |
| NO20060706L (no) | Inhibitorer av serinproteaser, spesielt HCV NS3-NS4A-protease | |
| WO2009053828A3 (fr) | Inhibiteurs p3-hydroxyamino macrocycliques des sérine protéases de l'hépatite c | |
| MX2010010276A (es) | Compuestos macrociclicos fluorinados como inhibidores del virus de hepatitis c. | |
| NO20060981L (no) | Pyridazinderivater og deres anvendelse som terapeutiske midler | |
| WO2008002924A3 (fr) | Inhibiteurs macrocycliques quinoxalinyliques des protéases à sérine du virus de l'hépatite c | |
| EA200500610A1 (ru) | Композиция для лечения инфекции, вызываемой вирусами семейств flaviviridae | |
| WO2005077969A3 (fr) | Inhibiteurs de proteases serines, en particulier de la protease hcv ns3-ns4a | |
| MX2010006518A (es) | Inhibidores de serina proteasa de hepatitis c de oximil macrociclica. | |
| WO2008022006A3 (fr) | Inhibiteurs de protéase du virus de l'hépatite c arylalcoxyle | |
| MX2010006210A (es) | Inhibidores de serina proteasa de hcv de tripeptido fluorado. | |
| CY1117576T1 (el) | Δινουκλεοτιδικα προφαρμακα | |
| WO2008021871A3 (fr) | Inhibiteurs triazolyle acyclique de la sérine protéase de l'hépatite c | |
| WO2007143694A3 (fr) | Inhibiteurs oximyles macrocycliques de la protéase de l'hépatite c | |
| WO2009076166A3 (fr) | Inhibiteurs oximyles de la sérine protéase de vhc | |
| WO2008021960A3 (fr) | Inhibiteurs triazolyle macrocycliques de la sérine protéase de l'hépatite c | |
| MX2010008109A (es) | Tripéptidos difluorizados como inhibidores de proteasa de serina de virus de hepatitis c (hcv). | |
| DE602005023015D1 (de) | Indolderivate als viruzide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |