AP2358A - Thiazole compounds and methods of use. - Google Patents
Thiazole compounds and methods of use.Info
- Publication number
- AP2358A AP2358A AP2007004268A AP2007004268A AP2358A AP 2358 A AP2358 A AP 2358A AP 2007004268 A AP2007004268 A AP 2007004268A AP 2007004268 A AP2007004268 A AP 2007004268A AP 2358 A AP2358 A AP 2358A
- Authority
- AP
- ARIPO
- Prior art keywords
- methods
- thiazole compounds
- thiazole
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67913305P | 2005-05-09 | 2005-05-09 | |
| PCT/US2006/017692 WO2006122011A2 (fr) | 2005-05-09 | 2006-05-09 | Composes thiazole et procedes d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2007004268A0 AP2007004268A0 (en) | 2007-12-31 |
| AP2358A true AP2358A (en) | 2012-01-30 |
Family
ID=36968742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2007004268A AP2358A (en) | 2005-05-09 | 2006-05-09 | Thiazole compounds and methods of use. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8088806B2 (fr) |
| EP (1) | EP1879575A2 (fr) |
| JP (1) | JP2008540537A (fr) |
| KR (1) | KR20080019213A (fr) |
| CN (1) | CN101247807A (fr) |
| AP (1) | AP2358A (fr) |
| AU (1) | AU2006244203B2 (fr) |
| BR (1) | BRPI0608910A2 (fr) |
| CA (1) | CA2607617A1 (fr) |
| EA (1) | EA200702445A1 (fr) |
| IL (1) | IL186970A0 (fr) |
| MX (1) | MX2007013955A (fr) |
| NO (1) | NO20075723L (fr) |
| NZ (1) | NZ563866A (fr) |
| SG (1) | SG159561A1 (fr) |
| UA (1) | UA92746C2 (fr) |
| WO (1) | WO2006122011A2 (fr) |
| ZA (1) | ZA200709751B (fr) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7345178B2 (en) * | 2005-08-04 | 2008-03-18 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| NZ570835A (en) * | 2006-03-08 | 2011-11-25 | Achillion Pharmaceuticals Inc | Substituted aminothiazole derivatives with anti-HCV activity |
| JP5182088B2 (ja) | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
| CN101096363B (zh) * | 2006-06-27 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途 |
| CN101522623B (zh) | 2006-08-03 | 2013-06-12 | 塔夫茨大学信托人 | 无潮红烟酸类似物和其使用方法 |
| BRPI0719122A2 (pt) | 2006-08-24 | 2013-12-10 | Novartis Ag | Compostos orgânicos |
| MX2009003080A (es) | 2006-09-22 | 2009-04-02 | Novartis Ag | Compuestos organicos heterociclicos. |
| EP2097405A2 (fr) * | 2006-11-21 | 2009-09-09 | Smithkline Beecham Corporation | Composés anti-viraux |
| AU2007336238A1 (en) | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as SCD inhibitors |
| WO2008124300A1 (fr) | 2007-04-10 | 2008-10-16 | National Health Research Institutes | Inhibiteurs du virus de l'hépatite c |
| AU2008241313A1 (en) * | 2007-04-20 | 2008-10-30 | Merck Frosst Canada Ltd. | Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| EA200901573A1 (ru) * | 2007-05-22 | 2010-04-30 | Ачиллион Фармасьютикалз, Инк. | Гетероарилзамещенные тиазолы |
| AU2008253512A1 (en) * | 2007-05-23 | 2008-11-27 | Merck Frosst Canada Ltd. | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme A delta-9 desaturase |
| TW200848016A (en) | 2007-06-08 | 2008-12-16 | Nat Health Research Institutes | Thiourea compound and composition of treating hepatitis C virus infection |
| TW200918542A (en) | 2007-06-20 | 2009-05-01 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| GB2455111A (en) * | 2007-11-28 | 2009-06-03 | Addex Pharmaceuticals Sa | Metabotropic glutamate receptor (mGluR4) modulators having 5- or 6-membered N-heteroaryl ring substituted by both N-cyclylamino & 5-membered N-heteroaryl ring |
| US20100144756A1 (en) * | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| JP5457344B2 (ja) * | 2007-07-17 | 2014-04-02 | アセア バイオサイエンシズ インコーポレイテッド | 複素環式化合物および抗がん剤としての使用 |
| WO2009012573A1 (fr) * | 2007-07-20 | 2009-01-29 | Merck Frosst Canada Ltd. | Composés hétéroaromatiques bicycliques en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase |
| CN101808995A (zh) * | 2007-07-27 | 2010-08-18 | 百时美施贵宝公司 | 新颖的葡糖激酶激活剂及其使用方法 |
| EP2178852B9 (fr) | 2007-08-03 | 2016-06-22 | Romark Laboratories, L.C. | Composés thiazolide à substitution alkylsulfonyle |
| KR20100090250A (ko) * | 2007-10-09 | 2010-08-13 | 메르크 파텐트 게엠베하 | 글루코키나제 활성체로서 유용한 피리딘 유도체 |
| WO2009051909A1 (fr) * | 2007-10-16 | 2009-04-23 | The Regents Of The University Of California | Composés présentant une activité de correction du traitement cellulaire cftr mutante, et utilisations de ceux-ci |
| SI2206707T1 (sl) | 2007-10-24 | 2014-11-28 | Astellas Pharma Inc. | Azolkarboksamidna spojina ali njena sol |
| EP2070925A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nouveaux dérivés de 2-thiazol-4-amides d'acide carboxylique substitués, leur fabrication et leur utilisation en tant que médicament |
| EP2070924A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nouveaux dérivés de 2-hetarylthiazol-4-amides d'acide carboxylique, leur fabrication et leur utilisation en tant que médicament |
| EP2070916A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dérivés de 2-aryl-thiazol-4-amides d'acide carboxylique, leur fabrication et leur utilisation en tant que médicament |
| TWI361808B (en) | 2008-01-08 | 2012-04-11 | Nat Health Research Institutes | Imidazolidinone and imidazolidinethione derivatives |
| EP2101173A1 (fr) | 2008-03-14 | 2009-09-16 | Vivalis | Procédé in vitro pour déterminer si un candidat destiné à un médicament pour une protéine cible est actif contre une variante de cette protéine |
| US8198284B2 (en) | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
| US8106209B2 (en) * | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
| WO2010008831A2 (fr) * | 2008-06-24 | 2010-01-21 | Irm Llc | Composés et procédés pour moduler les récepteurs couplés à la protéine g |
| EP2306836B1 (fr) * | 2008-07-01 | 2016-09-07 | PTC Therapeutics, Inc. | Modulateurs de l'expression de la protéine bmi-1 |
| EP2303841A1 (fr) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Composés inhibiteurs de l oxindolyle |
| JP5640005B2 (ja) | 2008-07-14 | 2014-12-10 | ギリアード サイエンシーズ, インコーポレイテッド | Hdacおよび/またはcdk阻害剤としてのイミダゾシルピリジン化合物 |
| EP2303881A2 (fr) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Composés inhibiteurs hétérocycliques condensés d'histone déacétylase et/ou de kinases cycline-dépendantes |
| KR20110038159A (ko) | 2008-07-28 | 2011-04-13 | 길리애드 사이언시즈, 인코포레이티드 | 사이클로알킬리덴 및 헤테로사이클로알킬리덴 히스톤 데아세틸라아제 억제제 화합물 |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| CN102176911B (zh) | 2008-08-11 | 2014-12-10 | 葛兰素史密丝克莱恩有限责任公司 | 新的腺嘌呤衍生物 |
| BRPI0917458A2 (pt) | 2008-08-11 | 2015-12-01 | Glaxosmithkline Llc | composto, método de tratamento de doenças e condições, composição farmacêutica, método para tratar ou prevenir doença, e, uso de um composto |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| MX2011001872A (es) * | 2008-08-18 | 2011-05-23 | Univ Yale | Moduladores de mif. |
| GB0900388D0 (en) | 2009-01-12 | 2009-02-11 | Addex Pharmaceuticals Sa | New compounds |
| CN105853415A (zh) | 2009-05-12 | 2016-08-17 | 罗马克实验室有限公司 | 卤代烷基杂芳基苯甲酰胺化合物 |
| CA2763786C (fr) | 2009-06-08 | 2014-09-30 | Gilead Sciences, Inc. | Composes inhibiteurs d'hdac a base d'alkanoylamino benzamide aniline |
| ES2463826T3 (es) | 2009-06-08 | 2014-05-29 | Gilead Sciences, Inc. | Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina |
| CN101928283A (zh) * | 2009-06-25 | 2010-12-29 | 上海唐润医药科技有限公司 | 具有抗hcv活性的化合物及其用途 |
| BRPI1014322A2 (pt) | 2009-06-26 | 2015-08-25 | Romark Lab Lc | Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica. |
| RS53745B1 (sr) | 2010-02-10 | 2015-06-30 | Glaxosmithkline Llc | 6-amino-2-{[(1s)-1-metilbutil]oksi}-9-[5-(1-piperidinil)pentil]-7,9-dihidro-8h-purin-8-on-maleat |
| US8575340B2 (en) | 2010-02-10 | 2013-11-05 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
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| WO2013033037A2 (fr) * | 2011-08-26 | 2013-03-07 | The Regents Of The University Of California | Nouveaux composés d'antiprion |
| AU2012315953A1 (en) * | 2011-09-30 | 2014-04-03 | Kineta, Inc. | Anti-viral compounds |
| PH12014500724A1 (en) | 2011-10-04 | 2014-05-19 | Institute For Hepatitis And Virus Res | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication |
| US9926309B2 (en) | 2011-10-05 | 2018-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Pi-kinase inhibitors with anti-infective activity |
| EP2770993A2 (fr) | 2011-10-26 | 2014-09-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Méthode de traitement d'infection par le vhc par inhibiteur de chk2 à petite molécule |
| US11071736B2 (en) | 2011-11-21 | 2021-07-27 | Taivex Therapeutics Corporation | Modulators of HEC1 activity and methods therefor |
| EP2869897A4 (fr) | 2012-07-06 | 2016-09-28 | Univ Duke | Activation du canal ionique trpv4 par stimuli physiques et rôle critique de trpv4 dans l'inflammation et la démangeaison spécifique à un organe |
| JP2015524483A (ja) * | 2012-08-09 | 2015-08-24 | ニューロポア セラピーズ,インコーポレイティド | Pi3−キナーゼシグナリング経路の調節因子としてのアリール及びヘテロアリールで置換されたベンゼン誘導体 |
| WO2014063168A1 (fr) | 2012-10-19 | 2014-04-24 | The Broad Institute, Inc. | Inhibiteurs hétérocycle - bisamide de récepteur éboueur bl |
| WO2014063167A1 (fr) * | 2012-10-19 | 2014-04-24 | The Broad Institute, Inc. | Inhibiteurs à base de thiazole de récepteur éboueur bi |
| HK1216639A1 (zh) * | 2013-03-05 | 2016-11-25 | F. Hoffmann-La Roche Ag | 作为hcv抗病毒剂的n-杂芳基取代的苯胺衍生物 |
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|---|---|
| WO2006122011A3 (fr) | 2007-05-03 |
| SG159561A1 (en) | 2010-03-30 |
| JP2008540537A (ja) | 2008-11-20 |
| BRPI0608910A2 (pt) | 2010-02-17 |
| IL186970A0 (en) | 2008-02-09 |
| KR20080019213A (ko) | 2008-03-03 |
| ZA200709751B (en) | 2008-11-26 |
| NO20075723L (no) | 2008-02-05 |
| AU2006244203A1 (en) | 2006-11-16 |
| UA92746C2 (en) | 2010-12-10 |
| US8088806B2 (en) | 2012-01-03 |
| EA200702445A1 (ru) | 2008-04-28 |
| EP1879575A2 (fr) | 2008-01-23 |
| AU2006244203B2 (en) | 2012-05-03 |
| CN101247807A (zh) | 2008-08-20 |
| US20120108576A1 (en) | 2012-05-03 |
| US20070004711A1 (en) | 2007-01-04 |
| NZ563866A (en) | 2011-03-31 |
| WO2006122011A2 (fr) | 2006-11-16 |
| MX2007013955A (es) | 2008-02-05 |
| CA2607617A1 (fr) | 2006-11-16 |
| AP2007004268A0 (en) | 2007-12-31 |
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