NO20080045L - Glykosylert UL-7, fremstilling og anvendelse av samme - Google Patents
Glykosylert UL-7, fremstilling og anvendelse av sammeInfo
- Publication number
- NO20080045L NO20080045L NO20080045A NO20080045A NO20080045L NO 20080045 L NO20080045 L NO 20080045L NO 20080045 A NO20080045 A NO 20080045A NO 20080045 A NO20080045 A NO 20080045A NO 20080045 L NO20080045 L NO 20080045L
- Authority
- NO
- Norway
- Prior art keywords
- polypeptides
- well
- relates
- preparation
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Sammendrag Det beskrives nye og forbedrete interl eukin-7 polypeptider, og likeledes sammensetninger omfattende samme, deres framstilling og anvendelser. Nærmere bestemt vedrører oppfinnelsen hyperglykosylerte IL-7 polypeptider som har forbedrete egenskaper, og likeledes framstilling og terapeutiske anvendelser av disse. Oppfinnelsen beskriver også nye IL-7 polypeptider som har modifiserte aminosyresekvenser inne- holdende artifisielt etablerte glykosyleringssete(r), og likeledes korresponderende nukleinsyremolekyler, vektorer og rekombinante vertsceller. Oppfinnelsen vedrører også anvendelse av slike polypeptider, celler eller nukleinsyrer for helbredende eller preventiv behandling av mammaiske individer, inkluderende mennesker.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05291556A EP1746161A1 (en) | 2005-07-20 | 2005-07-20 | Glycosylated IL-7, preparation and uses |
| PCT/IB2006/002663 WO2007010401A2 (en) | 2005-07-20 | 2006-07-19 | Glycosylated il-7, preparation and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20080045L true NO20080045L (no) | 2008-04-21 |
| NO344802B1 NO344802B1 (no) | 2020-05-04 |
Family
ID=35385570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080045A NO344802B1 (no) | 2005-07-20 | 2008-01-03 | Glykosylert UL-7, fremstilling og anvendelse av samme. |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7708985B2 (no) |
| EP (2) | EP1746161A1 (no) |
| JP (2) | JP5685363B2 (no) |
| CN (2) | CN105647939A (no) |
| AT (1) | ATE542901T1 (no) |
| AU (1) | AU2006271315B2 (no) |
| CA (2) | CA2859145C (no) |
| CY (1) | CY1112655T1 (no) |
| DK (1) | DK1904635T3 (no) |
| EA (1) | EA012802B1 (no) |
| ES (1) | ES2379732T3 (no) |
| IL (1) | IL188480A0 (no) |
| NO (1) | NO344802B1 (no) |
| NZ (1) | NZ564907A (no) |
| PL (1) | PL1904635T3 (no) |
| PT (1) | PT1904635E (no) |
| SI (1) | SI1904635T1 (no) |
| WO (1) | WO2007010401A2 (no) |
| ZA (1) | ZA200800533B (no) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295450B1 (en) | 2000-09-29 | 2015-01-28 | Merck Sharp & Dohme Corp. | Pegylated interleukin-10 |
| EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
| ES2305886T3 (es) | 2003-12-30 | 2008-11-01 | Merck Patent Gmbh | Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo. |
| EP2066336B1 (en) | 2006-09-28 | 2012-09-19 | Merck Sharp & Dohme Corp. | Use of pegylated il-10 to treat cancer |
| AR063975A1 (es) * | 2006-11-28 | 2009-03-04 | Centelion | Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada |
| CN101943688B (zh) * | 2009-07-10 | 2013-01-02 | 复旦大学 | 一种利用质谱靶板富集糖基化肽段的方法 |
| EP2576622A4 (en) | 2010-06-01 | 2013-11-27 | Univ Monash | ON THE UNPROCESSED RECEPTOR TYROSINE KINASE C-MET TARGETED ANTIBODIES |
| DK2596010T3 (en) * | 2010-07-19 | 2017-07-31 | Otago Innovation Ltd | SIGNAL biomarkers |
| NZ609567A (en) | 2010-11-05 | 2015-05-29 | Transbio Ltd | Markers of endothelial progenitor cells and uses thereof |
| CA2820956C (en) | 2010-12-10 | 2016-05-03 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising il-7 receptor ligands |
| WO2013017653A1 (en) | 2011-08-03 | 2013-02-07 | Cytheris | Hcv immunotherapy |
| MX2015014438A (es) | 2013-04-18 | 2016-05-18 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
| EP3010527B1 (en) | 2013-06-17 | 2018-08-08 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| CN120242030A (zh) | 2013-11-11 | 2025-07-04 | 阿尔莫生物科技股份有限公司 | 将白细胞介素-10用于治疗疾病和病症的方法 |
| CN104725484B (zh) * | 2013-12-19 | 2018-03-13 | 中国科学院微生物研究所 | 一种糖基化多肽及其制备方法和其应用 |
| WO2015140751A1 (en) | 2014-03-21 | 2015-09-24 | Boreal Invest | Terminal nanofiltration of solubilized protein compositions for removal of immunogenic aggregates |
| WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| AU2015336101A1 (en) | 2014-10-22 | 2017-04-20 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN104372021A (zh) * | 2014-11-05 | 2015-02-25 | 太仓思源生物医药有限公司 | 人白细胞介素-2蛋白质的制备方法 |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US20160361415A1 (en) | 2015-05-28 | 2016-12-15 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
| CN114853873B (zh) | 2015-06-11 | 2025-01-28 | 格纳西尼有限公司 | 经修饰的白细胞介素-7蛋白及其用途 |
| CA3002741A1 (en) | 2015-10-23 | 2017-04-27 | Apogenix Ag | Single-chain gitr-receptor agonist proteins |
| KR102386735B1 (ko) | 2015-11-06 | 2022-04-14 | 주식회사 제넥신 | 변형된 인터루킨-7 융합 단백질의 제형 |
| US11357827B2 (en) | 2015-12-04 | 2022-06-14 | Genexine, Inc. | Method for preventing or treating influenza virus infection using pharmaceutical composition comprising immunoglobulin Fc-fused interleukin-7 fusion protein |
| US11708399B2 (en) | 2015-12-04 | 2023-07-25 | Genexine, Inc. | Pharmaceutical composition comprising immunoglobulin Fc-fused interleukin-7 fusion protein for preventing or treating human papillomavirus-caused diseases |
| CN106317226B (zh) * | 2016-08-19 | 2017-09-05 | 安源医药科技(上海)有限公司 | 用于构建融合蛋白的连接肽 |
| EP4512469A3 (en) | 2017-09-11 | 2025-05-21 | Monash University | Binding proteins to the human thrombin receptor, par4 |
| BR112020010536A2 (pt) | 2018-01-25 | 2020-12-01 | I-Mab Biopharma Us Limited | molécula de fusão, proteína e célula isoladas, composição, e, método para tratar um câncer |
| CN113365650A (zh) | 2018-11-16 | 2021-09-07 | 新免疫技术有限公司 | 用il-7蛋白和免疫检查点抑制剂的组合治疗肿瘤的方法 |
| KR20210108978A (ko) | 2018-12-21 | 2021-09-03 | 오제 이뮈노테라프틱스 | 이작용성 항-pd-1/il-7 분자 |
| EP4017523A4 (en) * | 2019-08-22 | 2024-01-17 | The Regents Of The University Of California | UBE3A FOR THE TREATMENT OF ANGELMAN SYNDROME |
| KR102402276B1 (ko) * | 2019-11-15 | 2022-05-26 | 주식회사 제넥신 | 변형된 인터루킨-7 및 tgf 베타 수용체 ii를 포함하는 융합단백질 및 이의 용도 |
| US20230057939A1 (en) | 2020-01-13 | 2023-02-23 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and a bispecific antibody |
| JP2023512657A (ja) | 2020-02-05 | 2023-03-28 | ワシントン・ユニバーシティ | Il-7タンパク質とcar保有免疫細胞の組み合わせで固形腫瘍を治療する方法 |
| KR20230098201A (ko) | 2020-10-26 | 2023-07-03 | 네오이뮨텍, 인코퍼레이티드 | 줄기 세포 동원의 유도 방법 |
| EP4236989A1 (en) | 2020-11-02 | 2023-09-06 | NeoImmuneTech, Inc. | Use of interleukin-7 for the treatment of coronavirus |
| JP2023549112A (ja) | 2020-11-05 | 2023-11-22 | ネオイミューンテック, インコーポレイテッド | Il-7タンパク質とヌクレオチドワクチンの組み合わせで腫瘍を治療する方法 |
| WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
| CN113817043B (zh) * | 2021-09-22 | 2023-07-25 | 清华大学 | 制备活性铁调节激素的方法 |
| WO2023130081A1 (en) | 2021-12-30 | 2023-07-06 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and vegf antagonist |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| JP2026504619A (ja) | 2022-11-07 | 2026-02-06 | ネオイミューンテック, インコーポレイテッド | 非メチル化mgmtプロモーターを含む腫瘍を治療する方法 |
| US20240424127A1 (en) | 2023-01-11 | 2024-12-26 | Bright Peak Therapeutics Ag | Il-7 polypeptides, immunocytokines comprising same, and uses thereof |
| WO2024261027A1 (en) | 2023-06-19 | 2024-12-26 | Vector Biopharma Ag | Il-7-retargeting of adenoviruses for cell specific infection |
| CN117050178B (zh) * | 2023-10-13 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 特异性检测il-7的抗体及应用 |
| WO2025093541A1 (en) | 2023-10-31 | 2025-05-08 | Ose Immunotherapeutics | Combination of interleukin 7 and tumour associated antigen vaccine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| ZA887773B (en) * | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
| US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
| US5153310A (en) * | 1989-02-28 | 1992-10-06 | Du Pont Merck Pharmaceutical Company | Il-2 analogs containing n-linked glycosylation sites |
| CA2412882A1 (en) * | 2000-06-30 | 2002-01-10 | Maxygen Aps | Peptide extended glycosylated polypeptides |
| EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
-
2005
- 2005-07-20 EP EP05291556A patent/EP1746161A1/en not_active Withdrawn
-
2006
- 2006-07-19 CN CN201610038940.9A patent/CN105647939A/zh active Pending
- 2006-07-19 US US11/996,176 patent/US7708985B2/en active Active
- 2006-07-19 DK DK06795556.7T patent/DK1904635T3/da active
- 2006-07-19 AT AT06795556T patent/ATE542901T1/de active
- 2006-07-19 CN CN200680026503.XA patent/CN101228275B/zh not_active Expired - Fee Related
- 2006-07-19 PL PL06795556T patent/PL1904635T3/pl unknown
- 2006-07-19 CA CA2859145A patent/CA2859145C/en active Active
- 2006-07-19 ES ES06795556T patent/ES2379732T3/es active Active
- 2006-07-19 WO PCT/IB2006/002663 patent/WO2007010401A2/en not_active Ceased
- 2006-07-19 NZ NZ564907A patent/NZ564907A/en not_active IP Right Cessation
- 2006-07-19 EA EA200800368A patent/EA012802B1/ru not_active IP Right Cessation
- 2006-07-19 PT PT06795556T patent/PT1904635E/pt unknown
- 2006-07-19 CA CA2615562A patent/CA2615562C/en active Active
- 2006-07-19 JP JP2008522097A patent/JP5685363B2/ja active Active
- 2006-07-19 AU AU2006271315A patent/AU2006271315B2/en active Active
- 2006-07-19 EP EP06795556A patent/EP1904635B1/en active Active
- 2006-07-19 SI SI200631263T patent/SI1904635T1/sl unknown
-
2007
- 2007-12-27 IL IL188480A patent/IL188480A0/en active IP Right Grant
-
2008
- 2008-01-03 NO NO20080045A patent/NO344802B1/no not_active IP Right Cessation
- 2008-01-18 ZA ZA200800533A patent/ZA200800533B/xx unknown
-
2010
- 2010-02-24 US US12/711,675 patent/US8034327B2/en active Active
-
2011
- 2011-08-24 US US13/216,331 patent/US8153114B2/en active Active
-
2012
- 2012-02-16 CY CY20121100161T patent/CY1112655T1/el unknown
-
2014
- 2014-10-01 JP JP2014202828A patent/JP2015057392A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20080045L (no) | Glykosylert UL-7, fremstilling og anvendelse av samme | |
| MX2009012650A (es) | Secuencias de aminoacido dirigidas contra rank-l y polipeptidos que comprenden lo mismo para el tratamiento de enfermedades y trastornos de huesos. | |
| ES2353814T3 (es) | Proteinas n-glicosiladas recombinantes de celulas procariotas. | |
| MX2010005783A (es) | Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas. | |
| DE60330923D1 (de) | Menschliche Koagulationsfaktor VII Polypeptide | |
| WO2007104529A3 (en) | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling | |
| MX362028B (es) | Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos. | |
| MX2009002816A (es) | Proteinas de fusion de albumina. | |
| EP2470559A4 (en) | COAGULATION FACTOR IX COMPOSITIONS AND METHODS OF MAKING AND USING THEM | |
| PL2157192T3 (pl) | Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin) | |
| MX2009004243A (es) | Nuevas proteinas h5, moleculas de acido nucleico y vectores que las codifican y su uso medicinal. | |
| DK0902085T3 (da) | Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil | |
| IL212653A0 (en) | Polypeptides of leishmania major and polynucleotides encoding same and vaccinal, therapeutical and diagnostic applications thereof | |
| ATE501728T1 (de) | Therapeutische verwendung von lpi, einem inhibitor des lectinwegs in staphylokokken bei entzündungskrankheiten | |
| HK1161887A (en) | Extended recombinant polypeptides and compositions comprising same | |
| HK1172631A (en) | Coagulation factor ix compositions and methods of making and using same | |
| BRPI0406656A (pt) | Espécies de polipeptìdeos secretadas (fragmentos de quitotriosidase) reduzidas nos distúrbios cardiovasculares | |
| DE602007009797D1 (de) | Antitumorheilmittel, Medikament, Zusammensetzung und Verwendung davon | |
| HK1172653A (en) | Coagulation factor vii compositions and methods of making and using same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |