PL2157192T3 - Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin) - Google Patents
Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin)Info
- Publication number
- PL2157192T3 PL2157192T3 PL09170230T PL09170230T PL2157192T3 PL 2157192 T3 PL2157192 T3 PL 2157192T3 PL 09170230 T PL09170230 T PL 09170230T PL 09170230 T PL09170230 T PL 09170230T PL 2157192 T3 PL2157192 T3 PL 2157192T3
- Authority
- PL
- Poland
- Prior art keywords
- futrin
- spondin
- diagnosis
- diseases associated
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03023000 | 2003-10-10 | ||
| EP04765894A EP1673475B1 (en) | 2003-10-10 | 2004-10-08 | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt |
| EP09170230.8A EP2157192B1 (en) | 2003-10-10 | 2004-10-08 | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2157192T3 true PL2157192T3 (pl) | 2014-01-31 |
Family
ID=34486059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09170230T PL2157192T3 (pl) | 2003-10-10 | 2004-10-08 | Kompozycje do diagnozowania i terapii chorób związanych z nieprawidłową ekspresją futrin (R-spondin) |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US9081011B2 (pl) |
| EP (3) | EP1673475B1 (pl) |
| AT (1) | ATE466106T1 (pl) |
| CY (1) | CY1114679T1 (pl) |
| DE (1) | DE602004026898D1 (pl) |
| DK (2) | DK2157192T3 (pl) |
| ES (2) | ES2437337T3 (pl) |
| PL (1) | PL2157192T3 (pl) |
| PT (1) | PT2157192E (pl) |
| SI (1) | SI2157192T1 (pl) |
| WO (1) | WO2005040418A2 (pl) |
Families Citing this family (29)
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|---|---|---|---|---|
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| EP1673475B1 (en) | 2003-10-10 | 2010-04-28 | Deutsches Krebsforschungszentrum | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt |
| JP2007526248A (ja) | 2004-01-27 | 2007-09-13 | ヌベロ インコーポレーティッド | 胃腸増殖因子およびその使用方法 |
| US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
| DK2081586T4 (en) * | 2006-10-20 | 2019-01-21 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| WO2008088524A2 (en) * | 2006-12-28 | 2008-07-24 | Nuvelo, Inc. | Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor |
| AU2013203352B2 (en) * | 2007-07-02 | 2016-10-27 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| EP3009148B1 (en) * | 2007-07-02 | 2018-08-22 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| PL3441458T3 (pl) | 2009-02-03 | 2023-11-06 | Koninklijke Nederlandse Akademie Van Wetenschappen | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste |
| US20120039912A1 (en) * | 2009-04-15 | 2012-02-16 | Galapagos Sasu | Rspondin-3 inhibition in bone disorders |
| CN102859356B (zh) * | 2009-09-29 | 2016-01-06 | 达特神经科学(开曼)有限公司 | 与神经发生及其调节相关的基因、方法和组合物 |
| WO2011076932A1 (en) * | 2009-12-23 | 2011-06-30 | Deutsches Krebsforschungszentrum | Receptors of rspo2 and rspo3 |
| EP3401329A1 (en) * | 2011-07-15 | 2018-11-14 | OncoMed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
| AU2013204484B2 (en) * | 2011-07-15 | 2016-05-12 | Oncomed Pharmaceuticals, Inc. | RSPO binding agents and uses thereof |
| MX366804B (es) | 2012-02-11 | 2019-07-25 | Genentech Inc | Translocaciones de la r-espondina y sus metodos de uso. |
| JP6335896B2 (ja) | 2012-07-13 | 2018-05-30 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Rspo3結合剤およびその使用法 |
| CN105142641A (zh) | 2013-03-12 | 2015-12-09 | 广州源生医药科技有限公司 | 用于治疗癌症的化合物 |
| CN105744954B (zh) | 2013-10-18 | 2021-03-05 | 豪夫迈·罗氏有限公司 | 抗rspo2和/或抗rspo3抗体及其用途 |
| CA2961374A1 (en) | 2014-09-16 | 2016-03-24 | Oncomed Pharmaceuticals, Inc. | Treatment of fibrotic diseases |
| WO2017095918A2 (en) * | 2015-12-01 | 2017-06-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer using rspo3 antagonists |
| EP3443004A1 (en) | 2016-04-14 | 2019-02-20 | H. Hoffnabb-La Roche Ag | Anti-rspo3 antibodies and methods of use |
| US11993645B2 (en) | 2017-01-11 | 2024-05-28 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions comprising R-Spondin (RSPO) surrogate molecules |
| JP7305543B2 (ja) * | 2017-01-26 | 2023-07-10 | スロゼン オペレーティング, インコーポレイテッド | 組織特異的Wntシグナル増強分子およびその使用 |
| GB201721615D0 (en) | 2017-12-21 | 2018-02-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Immune cell organoid co-cultures |
| WO2020014271A1 (en) | 2018-07-09 | 2020-01-16 | Surrozen, Inc. | Tissue-specific wnt signal enhancing molecules and uses |
| CN110218740A (zh) * | 2019-05-17 | 2019-09-10 | 深圳先进技术研究院 | 一种用于快速检测经典Wnt信号通路活性的脑血管内皮细胞系 |
| JP2023549854A (ja) | 2020-11-16 | 2023-11-29 | スロゼン オペレーティング, インコーポレイテッド | 肝臓特異的Wntシグナル増強分子およびその使用 |
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| DK2081586T4 (en) | 2006-10-20 | 2019-01-21 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
| EP3009148B1 (en) * | 2007-07-02 | 2018-08-22 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| US20120039912A1 (en) | 2009-04-15 | 2012-02-16 | Galapagos Sasu | Rspondin-3 inhibition in bone disorders |
| WO2010129284A1 (en) | 2009-04-27 | 2010-11-11 | The Trustees Of The University Of Pennsylvania | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
| WO2011076932A1 (en) | 2009-12-23 | 2011-06-30 | Deutsches Krebsforschungszentrum | Receptors of rspo2 and rspo3 |
| GB201106395D0 (en) * | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| EP3401329A1 (en) * | 2011-07-15 | 2018-11-14 | OncoMed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
-
2004
- 2004-10-08 EP EP04765894A patent/EP1673475B1/en not_active Expired - Lifetime
- 2004-10-08 EP EP09170230.8A patent/EP2157192B1/en not_active Revoked
- 2004-10-08 DK DK09170230.8T patent/DK2157192T3/da active
- 2004-10-08 DE DE602004026898T patent/DE602004026898D1/de not_active Expired - Lifetime
- 2004-10-08 WO PCT/EP2004/011269 patent/WO2005040418A2/en not_active Ceased
- 2004-10-08 US US10/575,217 patent/US9081011B2/en not_active Expired - Fee Related
- 2004-10-08 PT PT91702308T patent/PT2157192E/pt unknown
- 2004-10-08 EP EP09002213A patent/EP2093298A3/en not_active Withdrawn
- 2004-10-08 AT AT04765894T patent/ATE466106T1/de active
- 2004-10-08 DK DK04765894.3T patent/DK1673475T3/da active
- 2004-10-08 SI SI200432095T patent/SI2157192T1/sl unknown
- 2004-10-08 ES ES09170230.8T patent/ES2437337T3/es not_active Expired - Lifetime
- 2004-10-08 ES ES04765894T patent/ES2345256T3/es not_active Expired - Lifetime
- 2004-10-08 PL PL09170230T patent/PL2157192T3/pl unknown
-
2013
- 2013-06-28 US US13/931,481 patent/US20130337533A1/en not_active Abandoned
- 2013-07-19 US US13/946,907 patent/US20140134703A1/en not_active Abandoned
- 2013-07-25 US US13/951,152 patent/US20140186917A1/en not_active Abandoned
- 2013-11-27 CY CY20131101060T patent/CY1114679T1/el unknown
-
2014
- 2014-04-04 US US14/245,897 patent/US8951745B2/en not_active Expired - Fee Related
- 2014-04-04 US US14/245,807 patent/US8921056B2/en not_active Expired - Fee Related
-
2015
- 2015-12-23 US US14/757,390 patent/US20160376349A1/en not_active Abandoned
-
2018
- 2018-12-18 US US16/224,230 patent/US20190194306A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2437337T3 (es) | 2014-01-10 |
| ES2345256T3 (es) | 2010-09-20 |
| US20190194306A1 (en) | 2019-06-27 |
| US20140357510A1 (en) | 2014-12-04 |
| WO2005040418A3 (en) | 2005-11-10 |
| PT2157192E (pt) | 2013-11-28 |
| EP1673475B1 (en) | 2010-04-28 |
| US20140227713A1 (en) | 2014-08-14 |
| US20140186917A1 (en) | 2014-07-03 |
| DE602004026898D1 (de) | 2010-06-10 |
| US9081011B2 (en) | 2015-07-14 |
| EP2157192B1 (en) | 2013-08-28 |
| SI2157192T1 (sl) | 2013-11-29 |
| US8921056B2 (en) | 2014-12-30 |
| US20140134703A1 (en) | 2014-05-15 |
| DK1673475T3 (da) | 2010-07-19 |
| US8951745B2 (en) | 2015-02-10 |
| EP2157192A1 (en) | 2010-02-24 |
| EP1673475A2 (en) | 2006-06-28 |
| EP2093298A2 (en) | 2009-08-26 |
| EP2093298A3 (en) | 2009-09-23 |
| ATE466106T1 (de) | 2010-05-15 |
| US20130337533A1 (en) | 2013-12-19 |
| WO2005040418A2 (en) | 2005-05-06 |
| US20070244061A1 (en) | 2007-10-18 |
| DK2157192T3 (da) | 2013-11-25 |
| US20160376349A1 (en) | 2016-12-29 |
| CY1114679T1 (el) | 2016-10-05 |
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