NO20080457L - Kjemiske forbindelser - Google Patents

Kjemiske forbindelser

Info

Publication number: NO20080457L
Authority: NO; Norway
Prior art keywords: compound; ikk2; directed; compounds; formula
Prior art date: 2005-06-30

Application number

NO20080457A

Other languages

English (en)

Norwegian (no)

Inventor

Qi Jin

Christopher E Neipp

Sonia M Thomas

Jeffrey K Kerns

Michael Lindenmuth

Xichen Lin

Hong Nie

Jianghe Deng

Guoliang Lin

Katherine L Widdowson

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-30

Filing date

2008-01-24

Publication date

2008-01-29

2008-01-24 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2008-01-29 Publication of NO20080457L publication Critical patent/NO20080457L/no

Links

150000001875 compounds Chemical class 0.000 abstract 5
102100021854 Inhibitor of nuclear factor kappa-B kinase subunit beta Human genes 0.000 abstract 3
101710205525 Inhibitor of nuclear factor kappa-B kinase subunit beta Proteins 0.000 abstract 3
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Molecular Biology (AREA)

NO20080457A 2005-06-30 2008-01-24 Kjemiske forbindelser NO20080457L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US69525605P	2005-06-30	2005-06-30
PCT/US2006/025402 WO2007005534A2 (en)	2005-06-30	2006-06-28	Chemical compounds

Publications (1)

Publication Number	Publication Date
NO20080457L true NO20080457L (no)	2008-01-29

Family

ID=37605008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20080457A NO20080457L (no)	2005-06-30	2008-01-24	Kjemiske forbindelser

Country Status (19)

Country	Link
EP (1)	EP1896014A4 (de)
JP (1)	JP5059756B2 (de)
KR (1)	KR20080021077A (de)
CN (1)	CN101247804B (de)
AR (1)	AR055343A1 (de)
AU (1)	AU2006266028B2 (de)
BR (1)	BRPI0611674A2 (de)
CA (1)	CA2613068A1 (de)
EA (1)	EA014083B1 (de)
IL (1)	IL187786A0 (de)
MA (1)	MA29566B1 (de)
MX (1)	MX2007016541A (de)
NO (1)	NO20080457L (de)
NZ (1)	NZ563687A (de)
PE (1)	PE20070173A1 (de)
TW (1)	TWI380973B (de)
UA (1)	UA99699C2 (de)
WO (1)	WO2007005534A2 (de)
ZA (1)	ZA200709948B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0315950D0 (en)	2003-06-11	2003-08-13	Xention Discovery Ltd	Compounds
TW200626142A (en)	2004-09-21	2006-08-01	Glaxo Group Ltd	Chemical compounds
GB0525164D0 (en) *	2005-12-09	2006-01-18	Xention Discovery Ltd	Compounds
EP1959737A4 (de) *	2005-12-16	2010-12-08	Glaxosmithkline Llc	Chemische verbindungen
AR065804A1 (es)	2007-03-23	2009-07-01	Smithkline Beecham Corp	Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
EP2370407B1 (de) *	2008-12-19	2014-06-18	Bristol-Myers Squibb Company	Carbazole und carboline als kinaseinhibitoren
US8354539B2 (en)	2009-03-10	2013-01-15	Glaxo Group Limited	Indole derivatives as IKK2 inhibitors
EP3483167A1 (de) *	2013-06-26	2019-05-15	AbbVie Inc.	Primäre carboxamide als btk-hemmer
MX393057B (es) *	2014-10-24	2025-03-24	Bristol Myers Squibb Co	Compuestos de indol carboxamida útiles como inhibidores de cinasas.

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20010022581A (ko) *	1997-08-06	2001-03-26	피터 지. 스트링거	타키키닌 수용체 길항제인 2-아실아미노프로판아민
DE19807993A1 (de)	1998-02-26	1999-09-02	Bayer Ag	Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten
HK1047582B (zh)	1999-06-23	2005-03-04	萨诺费－阿文蒂斯德国有限公司	取代的苯並咪唑
DE19928424A1 (de)	1999-06-23	2000-12-28	Aventis Pharma Gmbh	Substituierte Benzimidazole
DE19951360A1 (de)	1999-10-26	2001-05-03	Aventis Pharma Gmbh	Substituierte Indole
GB0003154D0 (en)	2000-02-12	2000-04-05	Astrazeneca Uk Ltd	Novel compounds
EP1134221A1 (de)	2000-03-15	2001-09-19	Aventis Pharma Deutschland GmbH	Substituierte beta-Carboline als lkB-Kinasehemmer
EP1209158A1 (de)	2000-11-18	2002-05-29	Aventis Pharma Deutschland GmbH	Substitutierte beta-Carboline
EP1268477B1 (de)	2000-03-15	2010-04-21	Sanofi-Aventis Deutschland GmbH	Substituierte beta-carboline mit ikb-kinase hemmender wirkung
JP2001278886A (ja) *	2000-03-28	2001-10-10	Dai Ichi Seiyaku Co Ltd	ベンゾオキサジン誘導体及びこれを含有する医薬
US6414013B1 (en)	2000-06-19	2002-07-02	Pharmacia & Upjohn S.P.A.	Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
JP4272338B2 (ja)	2000-09-22	2009-06-03	バイエルアクチェンゲゼルシャフト	ピリジン誘導体
US6869956B2 (en)	2000-10-03	2005-03-22	Bristol-Myers Squibb Company	Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
AU1182702A (en)	2000-10-03	2002-04-15	Bristol Myers Squibb Co	Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
EP1328272A1 (de)	2000-10-12	2003-07-23	SmithKline Beecham Corporation	Nf-kappa-b-inhibitoren
AU2002211663A1 (en)	2000-10-12	2002-04-22	Smith Kline Beecham Corporation	Nf-$g(k)b inhibitors
CN1503673A (zh)	2000-10-26	2004-06-09	�㽭�пؼ��ɷ��޹�˾	消炎药
JP2002193938A (ja)	2000-12-01	2002-07-10	Bayer Ag	４−アリールピリジン誘導体
US7122544B2 (en)	2000-12-06	2006-10-17	Signal Pharmaceuticals, Llc	Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
CZ20032287A3 (cs)	2001-02-01	2004-02-18	Bristol-Myers Squibb Company	Způsoby léčení zánětlivých a imunitních nemocí za použití inhibitorů IkB kinázy (IKK)
US20030045515A1 (en)	2001-05-24	2003-03-06	Lise Binderup	Combination medicament for treatment of neoplastic diseases
US7304066B2 (en)	2001-05-24	2007-12-04	Bjoerkling Fredrik	Pyridyl cyanoguanidine compounds
WO2002094265A1 (en)	2001-05-24	2002-11-28	Leo Pharma A/S	A method of modulating nf-$g(k)b activity
US6638679B2 (en)	2001-07-12	2003-10-28	Kodak Polychrome Graphics, Llc	Photosensitive compositions having mixtures of alkoxy and non-alkoxy diazonium salt containing compounds
SE0102616D0 (sv)	2001-07-25	2001-07-25	Astrazeneca Ab	Novel compounds
SE0102617D0 (sv)	2001-07-25	2001-07-25	Astrazeneca Ab	Novel compounds
JP2005507892A (ja)	2001-09-19	2005-03-24	ファルマシア・コーポレーション	炎症の治療のための置換されたピラゾリルベンゼンスルファミド化合物
CA2460939C (en)	2001-09-19	2008-07-29	Pharmacia Corporation	Substituted pyrazolyl compounds for the treatment of inflammation
EP1444207A2 (de)	2001-09-19	2004-08-11	Pharmacia Corporation	Substituierte pyrazolylverbindungen zur behandlung von entzündungen
US20030109550A1 (en)	2001-09-19	2003-06-12	Michael Clare	Substituted indazole compounds for the treatment of inflammation
AU2002356871A1 (en)	2001-10-30	2003-05-12	Pharmacia Corporation	Heteroaromatic carboxamide derivatives for the treatment of inflammation
AU2003222106A1 (en)	2002-04-03	2003-10-20	Bristol-Myers Squibb Company	Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same
EP1501805A1 (de)	2002-05-09	2005-02-02	Pharmacia Corporation	Substituierte pyrazolylverbindungen zur behandlung von entzündungen
BR0311605A (pt)	2002-06-06	2005-02-22	Boehringer Ingelheim Pharma	Compostos de amida de ácido 3-aminotieno[2,3-b]piridina-2-carboxìlico substituìdo e processos para preparação e seus usos
GB0217757D0 (en) *	2002-07-31	2002-09-11	Glaxo Group Ltd	Novel compounds
CA2494962C (en) *	2002-08-09	2011-06-14	Merck & Co., Inc.	Tyrosine kinase inhibitors
DE10237722A1 (de)	2002-08-17	2004-08-19	Aventis Pharma Deutschland Gmbh	Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
US7329668B2 (en)	2003-02-25	2008-02-12	Bristol-Myers Squibb Company	Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
US7176214B2 (en)	2003-05-21	2007-02-13	Bristol-Myers Squibb Company	Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
JP2007533602A (ja) *	2003-07-31	2007-11-22	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	置換ベンゾチオフェン化合物及びそれらの使用
US7265148B2 (en) *	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7291733B2 (en)	2003-10-10	2007-11-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Substituted tricyclic heterocycles and their uses
CA2541667A1 (en)	2003-10-14	2005-04-21	Pharmacia Corporation	Substituted pyrazinone compounds for the treatment of inflammation
GB0400895D0 (en) *	2004-01-15	2004-02-18	Smithkline Beecham Corp	Chemical compounds
TW200616967A (en) *	2004-06-24	2006-06-01	Smithkline Beecham Corp	Novel indazole carboxamides and their use
CN101060842A (zh) *	2004-09-21	2007-10-24	葛兰素集团有限公司	化合物
TW200626142A (en) *	2004-09-21	2006-08-01	Glaxo Group Ltd	Chemical compounds

2006
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- 2006-06-28 MX MX2007016541A patent/MX2007016541A/es active IP Right Grant
- 2006-06-28 BR BRPI0611674-4A patent/BRPI0611674A2/pt not_active IP Right Cessation
- 2006-06-28 JP JP2008519569A patent/JP5059756B2/ja not_active Expired - Fee Related
- 2006-06-28 AU AU2006266028A patent/AU2006266028B2/en not_active Ceased
- 2006-06-28 KR KR1020077030656A patent/KR20080021077A/ko not_active Ceased
- 2006-06-28 WO PCT/US2006/025402 patent/WO2007005534A2/en not_active Ceased
- 2006-06-28 EA EA200800183A patent/EA014083B1/ru not_active IP Right Cessation
- 2006-06-28 EP EP06785861A patent/EP1896014A4/de not_active Withdrawn
- 2006-06-28 TW TW095123240A patent/TWI380973B/zh not_active IP Right Cessation
- 2006-06-28 PE PE2006000761A patent/PE20070173A1/es not_active Application Discontinuation
- 2006-06-28 CN CN2006800304481A patent/CN101247804B/zh not_active Expired - Fee Related
- 2006-06-28 AR ARP060102790A patent/AR055343A1/es not_active Application Discontinuation
- 2006-06-28 UA UAA200714940A patent/UA99699C2/ru unknown
- 2006-06-28 CA CA002613068A patent/CA2613068A1/en not_active Abandoned
2007
- 2007-11-19 ZA ZA2007/09948A patent/ZA200709948B/en unknown
- 2007-11-29 IL IL187786A patent/IL187786A0/en unknown
- 2007-12-26 MA MA30513A patent/MA29566B1/fr unknown
2008
- 2008-01-24 NO NO20080457A patent/NO20080457L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1896014A4 (de)	2010-07-21
NZ563687A (en)	2011-07-29
TWI380973B (zh)	2013-01-01
KR20080021077A (ko)	2008-03-06
WO2007005534A8 (en)	2008-01-17
MA29566B1 (fr)	2008-06-02
PE20070173A1 (es)	2007-03-14
IL187786A0 (en)	2008-08-07
BRPI0611674A2 (pt)	2009-04-28
WO2007005534A3 (en)	2007-04-26
MX2007016541A (es)	2008-03-07
CN101247804A (zh)	2008-08-20
EA200800183A1 (ru)	2008-08-29
EA014083B1 (ru)	2010-08-30
AR055343A1 (es)	2007-08-22
CN101247804B (zh)	2012-09-26
AU2006266028B2 (en)	2012-03-15
ZA200709948B (en)	2009-03-25
CA2613068A1 (en)	2007-01-11
AU2006266028A1 (en)	2007-01-11
EP1896014A2 (de)	2008-03-12
WO2007005534A2 (en)	2007-01-11
JP5059756B2 (ja)	2012-10-31
TW200738588A (en)	2007-10-16
JP2009500338A (ja)	2009-01-08
UA99699C2 (ru)	2012-09-25

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Date	Code	Title	Description
2015-01-26	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
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