NO20081075L - Macrocykliske inhibitorer av hepatitt C virus - Google Patents

Macrocykliske inhibitorer av hepatitt C virus

Info

Publication number: NO20081075L
Authority: NO; Norway
Prior art keywords: alkylene; alkyl; carbocyclyl; hydrogen; heterocyclyl
Prior art date: 2005-07-29

Application number

NO20081075A

Other languages

English (en)

Norwegian (no)

Inventor

Herman Augustinus De Kock

Hans Wallberg

Pierre Jean-Marie Raboisson

Kenneth Alan Simmen

Lili Hu

Karl Magnus Nilsson

Bengt Bertil Samuelsson

Asa Annicka Kristina Rosenquist

Anna Karin Gertrud Linnea Belfrage

Mats Stefan Lindstrom

Pia Cecilia Kahnberg

Karin Charlotta Lindquist

Horst Juergen Wahling

Sven Christer Sahlberg

Bjorn Olof Classon

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-29

Filing date

2008-02-29

Publication date

2008-04-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37708968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081075(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-02-29 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2008-04-25 Publication of NO20081075L publication Critical patent/NO20081075L/no

Links

241000711549 Hepacivirus C Species 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
206010057199 Flaviviral infections Diseases 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
-1 haloC 1 -C 6 alkyl Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

NO20081075A 2005-07-29 2008-02-29 Macrocykliske inhibitorer av hepatitt C virus NO20081075L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05107057		2005-07-29
EP06113097		2006-04-25
PCT/EP2006/064822 WO2007014927A2 (en)	2005-07-29	2006-07-28	Macrocyclic inhibitors of hepatitis c virus

Publications (1)

Publication Number	Publication Date
NO20081075L true NO20081075L (no)	2008-04-25

Family

ID=37708968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20081075A NO20081075L (no)	2005-07-29	2008-02-29	Macrocykliske inhibitorer av hepatitt C virus

Country Status (31)

Country	Link
US (1)	US7659245B2 (sr)
EP (1)	EP1912981B1 (sr)
JP (1)	JP5230418B2 (sr)
KR (1)	KR101083631B1 (sr)
AP (1)	AP2585A (sr)
AR (1)	AR057702A1 (sr)
AT (1)	ATE455775T1 (sr)
AU (1)	AU2006274866B2 (sr)
BR (1)	BRPI0614153A2 (sr)
CA (1)	CA2617103C (sr)
CY (1)	CY1110008T1 (sr)
DE (1)	DE602006011905D1 (sr)
DK (1)	DK1912981T3 (sr)
EA (1)	EA014188B1 (sr)
ES (1)	ES2339702T3 (sr)
GT (1)	GT200600343A (sr)
HR (1)	HRP20100209T1 (sr)
IL (1)	IL188320A (sr)
ME (1)	ME01454B (sr)
MY (1)	MY151026A (sr)
NO (1)	NO20081075L (sr)
NZ (1)	NZ564540A (sr)
PE (1)	PE20070343A1 (sr)
PL (1)	PL1912981T3 (sr)
PT (1)	PT1912981E (sr)
RS (1)	RS51227B (sr)
SI (1)	SI1912981T1 (sr)
SV (1)	SV2008002641A (sr)
TW (1)	TWI387597B (sr)
UY (1)	UY29704A1 (sr)
WO (1)	WO2007014927A2 (sr)

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MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
KR20120090077A (ko)	2004-01-30	2012-08-16	얀센 알 앤드 디 아일랜드	Ｈｃｖｎｓ?３ 세린 프로테아제 저해제
PE20070211A1 (es)	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
TWI412535B (zh)	2005-07-29	2013-10-21	Tibotec Pharm Ltd	Ｃ型肝炎病毒之大環抑制劑（五）
JO2768B1 (en) *	2005-07-29	2014-03-15	تيبوتيك فارماسيوتيكالز ليمتد	Large cyclic inhibitors of hepatitis C virus
ES2373685T3 (es)	2005-07-29	2012-02-07	Tibotec Pharmaceuticals	Inhibidores macrocíclicos del virus de la hepatitis c.
GEP20104956B (en)	2005-10-11	2010-04-12	Array Biopharma Inc	Compounds for inhibiting hepatitis c viral replication and use thereof
US7741281B2 (en)	2005-11-03	2010-06-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
KR20090024834A (ko)	2006-07-05	2009-03-09	인터뮨, 인크.	Ｃ형 간염 바이러스 복제의 신규 억제제
EP2049474B1 (en)	2006-07-11	2015-11-04	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
CA2657618C (en)	2006-07-13	2016-10-11	Achillion Pharmaceuticals, Inc.	4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US8343477B2 (en)	2006-11-01	2013-01-01	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
US7772180B2 (en)	2006-11-09	2010-08-10	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7888464B2 (en)	2006-11-16	2011-02-15	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7763584B2 (en)	2006-11-16	2010-07-27	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8003604B2 (en)	2006-11-16	2011-08-23	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CA2661338C (en) *	2006-11-17	2015-05-12	Tibotec Pharmaceuticals Ltd.	Macrocyclic inhibitors of hepatitis c virus
PL2121674T3 (pl) *	2007-02-01	2010-10-29	Janssen Sciences Ireland Uc	Sposoby i związki pośrednie do wytwarzania makrocyklicznego inhibitora proteazy HCV
US8937080B2 (en) *	2007-02-08	2015-01-20	Medivir Ab	Pyrimidine substituted macrocyclic HCV inhibitors
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EP2190858A4 (en) *	2007-09-24	2013-02-13	Achillion Pharmaceuticals Inc	PEPTIDES CONTAINING UREA AS INHIBITORS OF VIRAL REPLICATION
US8383583B2 (en)	2007-10-26	2013-02-26	Enanta Pharmaceuticals, Inc.	Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
US8426360B2 (en) *	2007-11-13	2013-04-23	Enanta Pharmaceuticals, Inc.	Carbocyclic oxime hepatitis C virus serine protease inhibitors
WO2009070692A1 (en)	2007-11-29	2009-06-04	Enanta Pharmaceuticals, Inc.	C5-substituted, proline-derived, macrocyclic hepatitis c serine protease inhibitors
US8202996B2 (en)	2007-12-21	2012-06-19	Bristol-Myers Squibb Company	Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
EP2226315A4 (en)	2007-12-28	2012-01-25	Carna Biosciences Inc	2-aminoquinazoline DERIVATIVE
CA2719008A1 (en)	2008-03-20	2009-09-24	Enanta Pharmaceuticals, Inc.	Fluorinated macrocyclic compounds as hepatitis c virus inhibitors
US8163921B2 (en)	2008-04-16	2012-04-24	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7964560B2 (en)	2008-05-29	2011-06-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8044023B2 (en)	2008-05-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8563505B2 (en)	2008-09-29	2013-10-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8044087B2 (en)	2008-09-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
ES2527166T3 (es)	2008-12-10	2015-01-21	Achillion Pharmaceuticals, Inc.	Nuevos péptidos de 4-amino-4-oxobutanoílo como inhibidores de la replicación viral
US8283310B2 (en)	2008-12-15	2012-10-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
MX340792B (es)	2009-02-27	2016-07-25	Ortho-Mcneil-Janssen Pharmaceuticals Inc *	Sal amorfa de un inhibidor macrociclico de virus de hepatitis c.
US8377962B2 (en)	2009-04-08	2013-02-19	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors
WO2010136475A1 (en) *	2009-05-29	2010-12-02	Syngenta Participations Ag	Substituted quinazolines as fungicides
US9284307B2 (en)	2009-08-05	2016-03-15	Idenix Pharmaceuticals Llc	Macrocyclic serine protease inhibitors
WO2012092411A2 (en)	2010-12-30	2012-07-05	Enanta Pharmaceuticals, Inc.	Phenanthridine macrocyclic hepatitis c serine protease inhibitors
CN103534256B (zh)	2010-12-30	2016-08-10	益安药业	大环丙型肝炎丝氨酸蛋白酶抑制剂
US9353100B2 (en)	2011-02-10	2016-05-31	Idenix Pharmaceuticals Llc	Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
BR112014016157A8 (pt)	2011-12-28	2017-07-04	Janssen R&D Ireland	derivados heterobicíclicos como inibidores de vhc
CA2886973C (en) *	2012-10-15	2017-08-15	Albemarle Corporation	Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds
SI2909205T1 (sl)	2012-10-19	2017-02-28	Bristol-Myers Squibb Company	9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
EP2914598B1 (en)	2012-11-02	2017-10-18	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
EP2914613B1 (en)	2012-11-02	2017-11-22	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US9409943B2 (en)	2012-11-05	2016-08-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9580463B2 (en)	2013-03-07	2017-02-28	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9006423B2 (en)	2013-03-15	2015-04-14	Achillion Pharmaceuticals Inc.	Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
WO2014145600A1 (en)	2013-03-15	2014-09-18	Achillion Pharmaceuticals, Inc.	Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof
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JP2005535574A (ja)	2002-04-11	2005-11-24	バーテックス　ファーマシューティカルズ　インコーポレイテッド	セリンプロテアーゼ、特にｈｃｖｎｓ３−ｎｓ４ａプロテアーゼのインヒビター
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US20040180815A1 (en) *	2003-03-07	2004-09-16	Suanne Nakajima	Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
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DK1919904T3 (da) *	2005-07-29	2014-04-07	Janssen R & D Ireland	Makrocykliske inhibitorer af hepatitis-c-virus
US20100120855A1 (en) *	2005-07-29	2010-05-13	Tibotec Pharmaceuticals Ltd.	Macrocylic inhibitors of hepatitis c virus
PE20070211A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c

2006
- 2006-07-26 PE PE2006000903A patent/PE20070343A1/es not_active Application Discontinuation
- 2006-07-28 JP JP2008523383A patent/JP5230418B2/ja not_active Expired - Fee Related
- 2006-07-28 DE DE602006011905T patent/DE602006011905D1/de active Active
- 2006-07-28 MY MYPI20063670 patent/MY151026A/en unknown
- 2006-07-28 WO PCT/EP2006/064822 patent/WO2007014927A2/en not_active Ceased
- 2006-07-28 UY UY29704A patent/UY29704A1/es unknown
- 2006-07-28 BR BRPI0614153-6A patent/BRPI0614153A2/pt not_active Application Discontinuation
- 2006-07-28 EP EP06764268A patent/EP1912981B1/en active Active
- 2006-07-28 ME MEP-2012-119A patent/ME01454B/me unknown
- 2006-07-28 SI SI200630627T patent/SI1912981T1/sl unknown
- 2006-07-28 RS RSP-2010/0183A patent/RS51227B/sr unknown
- 2006-07-28 KR KR1020087004894A patent/KR101083631B1/ko not_active Expired - Fee Related
- 2006-07-28 PT PT06764268T patent/PT1912981E/pt unknown
- 2006-07-28 DK DK06764268.6T patent/DK1912981T3/da active
- 2006-07-28 ES ES06764268T patent/ES2339702T3/es active Active
- 2006-07-28 TW TW095127585A patent/TWI387597B/zh not_active IP Right Cessation
- 2006-07-28 US US11/995,900 patent/US7659245B2/en not_active Expired - Fee Related
- 2006-07-28 HR HR20100209T patent/HRP20100209T1/hr unknown
- 2006-07-28 GT GT200600343A patent/GT200600343A/es unknown
- 2006-07-28 AR ARP060103303A patent/AR057702A1/es not_active Application Discontinuation
- 2006-07-28 CA CA2617103A patent/CA2617103C/en not_active Expired - Fee Related
- 2006-07-28 AP AP2008004306A patent/AP2585A/xx active
- 2006-07-28 PL PL06764268T patent/PL1912981T3/pl unknown
- 2006-07-28 AU AU2006274866A patent/AU2006274866B2/en not_active Ceased
- 2006-07-28 EA EA200800482A patent/EA014188B1/ru not_active IP Right Cessation
- 2006-07-28 AT AT06764268T patent/ATE455775T1/de active
- 2006-07-28 NZ NZ564540A patent/NZ564540A/en not_active IP Right Cessation
- 2006-07-29 SV SV2006002641A patent/SV2008002641A/es unknown
2007
- 2007-12-20 IL IL188320A patent/IL188320A/en not_active IP Right Cessation
2008
- 2008-02-29 NO NO20081075A patent/NO20081075L/no not_active Application Discontinuation
2010
- 2010-04-20 CY CY20101100355T patent/CY1110008T1/el unknown

Also Published As

Publication number	Publication date
AP2585A (en)	2013-02-04
MY151026A (en)	2014-03-31
IL188320A (en)	2014-07-31
CA2617103A1 (en)	2007-02-08
US20090118312A1 (en)	2009-05-07
AR057702A1 (es)	2007-12-12
HK1116488A1 (en)	2008-12-24
ES2339702T3 (es)	2010-05-24
WO2007014927A3 (en)	2007-11-29
BRPI0614153A2 (pt)	2011-03-15
ME01454B (me)	2014-04-20
SI1912981T1 (sl)	2010-05-31
DE602006011905D1 (de)	2010-03-11
AU2006274866A1 (en)	2007-02-08
RS51227B (sr)	2010-12-31
IL188320A0 (en)	2008-04-13
JP5230418B2 (ja)	2013-07-10
KR20080033475A (ko)	2008-04-16
EA014188B1 (ru)	2010-10-29
AU2006274866B2 (en)	2012-04-12
UY29704A1 (es)	2007-05-31
NZ564540A (en)	2010-03-26
PE20070343A1 (es)	2007-05-12
SV2008002641A (es)	2008-07-23
EP1912981B1 (en)	2010-01-20
DK1912981T3 (da)	2010-05-25
CY1110008T1 (el)	2015-01-14
GT200600343A (es)	2007-08-06
ATE455775T1 (de)	2010-02-15
EP1912981A2 (en)	2008-04-23
PL1912981T3 (pl)	2010-07-30
JP2009502890A (ja)	2009-01-29
WO2007014927A2 (en)	2007-02-08
TW200745116A (en)	2007-12-16
CA2617103C (en)	2015-01-06
KR101083631B1 (ko)	2011-11-16
PT1912981E (pt)	2010-04-16
EA200800482A1 (ru)	2008-06-30
US7659245B2 (en)	2010-02-09
TWI387597B (zh)	2013-03-01
HRP20100209T1 (hr)	2010-05-31

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Publication	Publication Date	Title
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