NO20081787L - Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet - Google Patents

Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Info

Publication number: NO20081787L
Authority: NO; Norway
Prior art keywords: group; hydrogen atom; new; binding activity; receptor binding
Prior art date: 2005-09-14

Application number

NO20081787A

Other languages

English (en)

Norwegian (no)

Inventor

Mamoru Matsuda

Toshiyuki Mori

Kenji Kawashima

Masato Nagatsuka

Sachiko Kobayashi

Minoru Yamamoto

Masatomo Kato

Miwa Takai

Tomoko Oda

Original Assignee

Santen Pharmaceutical Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-14

Filing date

2008-04-11

Publication date

2008-06-10

2008-04-11 Application filed by Santen Pharmaceutical Co Inc filed Critical Santen Pharmaceutical Co Inc

2008-06-10 Publication of NO20081787L publication Critical patent/NO20081787L/no

Links

230000027455 binding Effects 0.000 title 1
239000003862 glucocorticoid Substances 0.000 title 1
102000005962 receptors Human genes 0.000 title 1
108020003175 receptors Proteins 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
IRFSXVIRXMYULF-UHFFFAOYSA-N 1,2-dihydroquinoline Chemical class C1=CC=C2C=CCNC2=C1 IRFSXVIRXMYULF-UHFFFAOYSA-N 0.000 abstract 1
102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Immunology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)

NO20081787A 2005-09-14 2008-04-11 Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet NO20081787L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2005266622		2005-09-14
JP2006027128		2006-02-03
PCT/JP2006/318674 WO2007032556A1 (ja)	2005-09-14	2006-09-14	グルココルチコイド受容体結合活性を有する新規１，２−ジヒドロキノリン誘導体

Publications (1)

Publication Number	Publication Date
NO20081787L true NO20081787L (no)	2008-06-10

Family

ID=37865125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20081787A NO20081787L (no)	2005-09-14	2008-04-11	Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Country Status (12)

Country	Link
US (2)	US8017775B2 (pt)
EP (1)	EP1944290B1 (pt)
KR (1)	KR101390094B1 (pt)
CN (4)	CN102229562B (pt)
AU (1)	AU2006289751A1 (pt)
BR (1)	BRPI0615892A2 (pt)
CA (1)	CA2621292C (pt)
ES (1)	ES2455142T3 (pt)
NO (1)	NO20081787L (pt)
PL (1)	PL1944290T3 (pt)
RU (1)	RU2008114369A (pt)
WO (1)	WO2007032556A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL1944290T3 (pl)	2005-09-14	2014-07-31	Ayumi Pharmaceutical Corp	Nowa pochodna 1-2-dihydrochinoliny mająca aktywność wiązania glukokortykoidowego receptora
SI1995242T1 (sl)	2006-03-14	2013-01-31	Santen Pharmaceutical Co., Ltd.	Nov derivat 1,2,3,4-tetrahidrokinoksalina z aktivnostjo vezanja glukokortikoidnega receptorja
ES2391910T3 (es)	2006-11-14	2012-12-03	Santen Pharmaceutical Co., Ltd	Derivado de 1,2-dihidroquinolina que tiene un grupo (fenil sustituido o heterociclil sustituido)carboniloxi-alquilo inferior y un grupo fenilo introducido por éster como sustituyentes
JP2008255112A (ja) *	2007-03-13	2008-10-23	Santen Pharmaceut Co Ltd	２，２，４−トリメチル−６−フェニル−１，２−ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト
AU2008255733B8 (en) *	2007-05-29	2013-06-13	Santen Pharmaceutical Co., Ltd.	Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
US20090042936A1 (en) *	2007-08-10	2009-02-12	Ward Keith W	Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
JP2009084273A (ja) *	2007-09-13	2009-04-23	Santen Pharmaceut Co Ltd	１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
JP2009084274A (ja) *	2007-09-13	2009-04-23	Santen Pharmaceut Co Ltd	新規１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体
CA2724055C (en)	2008-05-12	2016-08-02	Santen Pharmaceutical Co., Ltd.	Glucocorticoid receptor agonist comprising 2,2,4-trimethyl-6-phenyl-1,2 -dihydroquinoline derivatives having substituted oxy group
US8664221B2 (en) *	2008-09-12	2014-03-04	Santen Pharmaceutical Co., Ltd.	Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent
WO2012108455A1 (ja)	2011-02-09	2012-08-16	参天製薬株式会社	３－ヒドロキシ－６Ｈ－ベンゾ［ｃ］クロメン－６－オン誘導体およびその製造方法
US20120316199A1 (en)	2011-06-07	2012-12-13	Ward Keith W	Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
WO2013108921A1 (ja) *	2012-01-20	2013-07-25	参天製薬株式会社	１，２－ジヒドロキノリン誘導体またはその塩の工業的製造方法およびその製造中間体
RU2644944C1 (ru) *	2017-04-06	2018-02-15	Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет"	Способ получения (Z)-этил 2-(4-(4-хлорфенил)-2,4-диоксо-3-(3-оксо-3,4-дигидрохиноксалин-2(1Н)-илиден)бутанамидо)-4-метил-5-фенилтиофен-3-карбоксилата
US11433090B2 (en)	2017-06-16	2022-09-06	The Doshisha	mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
WO2018230713A1 (ja)	2017-06-16	2018-12-20	学校法人同志社	カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5696130A (en) *	1994-12-22	1997-12-09	Ligand Pharmaceuticals Incorporated	Tricyclic steroid receptor modulator compounds and methods
EP1043325B1 (en)	1994-12-22	2004-06-16	Ligand Pharmaceuticals Incorporated	Steroid receptor modulator compounds and methods
BR9907788A (pt) *	1998-02-13	2001-10-30	Abbott Lab	Agentes antiinflamatórios seletivos paraglicocorticóides
ES2246292T3 (es) *	2000-10-30	2006-02-16	Pfizer Products Inc.	Moduladores de receptor glucocorticoide.
JP2006504678A (ja) *	2002-08-21	2006-02-09	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用
US7135575B2 (en) *	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
CN101018552A (zh)	2004-07-14	2007-08-15	利亘制药公司	细胞内受体调节剂化合物和方法
PL1944290T3 (pl)	2005-09-14	2014-07-31	Ayumi Pharmaceutical Corp	Nowa pochodna 1-2-dihydrochinoliny mająca aktywność wiązania glukokortykoidowego receptora
ES2391910T3 (es) *	2006-11-14	2012-12-03	Santen Pharmaceutical Co., Ltd	Derivado de 1,2-dihidroquinolina que tiene un grupo (fenil sustituido o heterociclil sustituido)carboniloxi-alquilo inferior y un grupo fenilo introducido por éster como sustituyentes
JP2008255112A (ja)	2007-03-13	2008-10-23	Santen Pharmaceut Co Ltd	２，２，４−トリメチル−６−フェニル−１，２−ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト

2006
- 2006-09-14 PL PL06798171T patent/PL1944290T3/pl unknown
- 2006-09-14 EP EP06798171.2A patent/EP1944290B1/en not_active Not-in-force
- 2006-09-14 AU AU2006289751A patent/AU2006289751A1/en not_active Abandoned
- 2006-09-14 RU RU2008114369/04A patent/RU2008114369A/ru not_active Application Discontinuation
- 2006-09-14 KR KR1020087008299A patent/KR101390094B1/ko not_active Expired - Fee Related
- 2006-09-14 CN CN2011101034745A patent/CN102229562B/zh not_active Expired - Fee Related
- 2006-09-14 ES ES06798171.2T patent/ES2455142T3/es active Active
- 2006-09-14 CA CA2621292A patent/CA2621292C/en active Active
- 2006-09-14 CN CN200680033078.7A patent/CN101263119B/zh not_active Expired - Fee Related
- 2006-09-14 WO PCT/JP2006/318674 patent/WO2007032556A1/ja not_active Ceased
- 2006-09-14 BR BRPI0615892-7A patent/BRPI0615892A2/pt not_active Application Discontinuation
- 2006-09-14 CN CN201110320070.1A patent/CN102311385B/zh not_active Expired - Fee Related
- 2006-09-14 CN CN201110316386.3A patent/CN102304124B/zh not_active Expired - Fee Related
- 2006-09-14 US US11/992,088 patent/US8017775B2/en active Active
2008
- 2008-04-11 NO NO20081787A patent/NO20081787L/no not_active Application Discontinuation
2011
- 2011-06-28 US US13/135,164 patent/US8420635B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL1944290T3 (pl)	2014-07-31
US8420635B2 (en)	2013-04-16
CA2621292C (en)	2014-05-27
US8017775B2 (en)	2011-09-13
KR20080046230A (ko)	2008-05-26
CN102229562A (zh)	2011-11-02
US20110263589A1 (en)	2011-10-27
EP1944290A1 (en)	2008-07-16
BRPI0615892A2 (pt)	2011-05-31
HK1165800A1 (en)	2012-10-12
CN102311385B (zh)	2015-01-14
EP1944290B1 (en)	2013-12-04
RU2008114369A (ru)	2009-10-27
WO2007032556A1 (ja)	2007-03-22
KR101390094B1 (ko)	2014-04-28
AU2006289751A1 (en)	2007-03-22
CA2621292A1 (en)	2007-03-22
CN102311385A (zh)	2012-01-11
HK1166072A1 (en)	2012-10-19
ES2455142T3 (es)	2014-04-14
EP1944290A4 (en)	2011-01-12
US20090326009A1 (en)	2009-12-31
CN102304124B (zh)	2014-10-22
CN101263119A (zh)	2008-09-10
CN102304124A (zh)	2012-01-04
CN102229562B (zh)	2013-11-13
CN101263119B (zh)	2014-04-09

Legal Events

Date	Code	Title	Description
2010-04-26	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20081787L (no)	2008-06-10	Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet
NO20084262L (no)	2008-10-10	Nye 1,2,3,4-tetrahydrokinoksalinderivater som har glukokortikoidreseptorbindende aktivitet
NO20084127L (no)	2009-04-30	Benzylfenylglukopyranosidderivat
NO20072409L (no)	2007-06-11	Substituerte n-sulfonylaminobenzyl-2-fenoksy acetamid-forbindelser
NO20073663L (no)	2007-09-03	Tiazol-4-karboksamid-derivater som mGluR5 antagonister
PE20080839A1 (es)	2008-08-23	Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas
AR054024A1 (es)	2007-05-30	Derivados de piridina -3- carboxamida como agonistas inversos de cb1
NO20072605L (no)	2007-09-05	Nytt antranilinsyrederivat eller et salt derav
NO20090760L (no)	2009-04-14	Nye tricykliske spiropiperidinforbindelser, deres synteser og deres anvendelser som modulatorer av kemokinreseptor-aktivitet
NO20065929L (no)	2007-02-19	Sykliske amidderivater, deres fremstilling og anvendelse
NO20065694L (no)	2007-01-29	Indolderivat med piperidinring
NO20063470L (no)	2006-11-17	Tetrazolforbindelser og deres anvendelse av metabotrofe glutamatreseptorantagonister
PE20081059A1 (es)	2008-10-22	Derivados de pirimidinas como inhibidores de la actividad de la tirosina quinasa de bruton (btk)
DE60335869D1 (de)	2011-03-10	1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren
MX2009008465A (es)	2009-08-20	Nuevas 2-aminooxazolinas como ligandos de taar1.
PE20090420A1 (es)	2009-05-08	Compuestos de piperazina con accion herbicida
NO20041531L (no)	2004-04-15	Alkyleterderivater eller salter derav
NO20080717L (no)	2008-04-09	Oksimderivat og fremgangsmate for fremstilling av dette
NO20076010L (no)	2008-01-21	Heterosyklisk forbindelse
NO20083248L (no)	2008-07-23	Imidazoler som GABA-B reseptormodulatorer
NO20070583L (no)	2007-03-08	Isoindolonforbindelser og anvendelse derav som metabotrofe glutamatreseptorforsterker
NO20076479L (no)	2008-01-29	Nye oksadiazolderivater og anvendelse derav som positive allosteriske metabotropiske modulatorer av glutamatreseptorer
MX2009006024A (es)	2009-06-30	Derivados de heteroaril piridopirimidona sustituidos.
DE602005008558D1 (de)	2008-09-11	Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen reznkungen
PE20081227A1 (es)	2008-11-08	Derivados indazolil sulfonamidas como moduladores de glucocorticoides