NO20081787L - Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet - Google Patents

Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Info

Publication number: NO20081787L
Authority: NO; Norway
Prior art keywords: group; hydrogen atom; new; binding activity; receptor binding
Prior art date: 2005-09-14

Application number

NO20081787A

Other languages

English (en)

Norwegian (no)

Inventor

Mamoru Matsuda

Toshiyuki Mori

Kenji Kawashima

Masato Nagatsuka

Sachiko Kobayashi

Minoru Yamamoto

Masatomo Kato

Miwa Takai

Tomoko Oda

Original Assignee

Santen Pharmaceutical Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-14

Filing date

2008-04-11

Publication date

2008-06-10

2008-04-11 Application filed by Santen Pharmaceutical Co Inc filed Critical Santen Pharmaceutical Co Inc

2008-06-10 Publication of NO20081787L publication Critical patent/NO20081787L/no

Links

230000027455 binding Effects 0.000 title 1
239000003862 glucocorticoid Substances 0.000 title 1
102000005962 receptors Human genes 0.000 title 1
108020003175 receptors Proteins 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
IRFSXVIRXMYULF-UHFFFAOYSA-N 1,2-dihydroquinoline Chemical class C1=CC=C2C=CCNC2=C1 IRFSXVIRXMYULF-UHFFFAOYSA-N 0.000 abstract 1
102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Neurology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)

NO20081787A 2005-09-14 2008-04-11 Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet NO20081787L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2005266622		2005-09-14
JP2006027128		2006-02-03
PCT/JP2006/318674 WO2007032556A1 (ja)	2005-09-14	2006-09-14	グルココルチコイド受容体結合活性を有する新規１，２−ジヒドロキノリン誘導体

Publications (1)

Publication Number	Publication Date
NO20081787L true NO20081787L (no)	2008-06-10

Family

ID=37865125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20081787A NO20081787L (no)	2005-09-14	2008-04-11	Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Country Status (12)

Country	Link
US (2)	US8017775B2 (pt)
EP (1)	EP1944290B1 (pt)
KR (1)	KR101390094B1 (pt)
CN (4)	CN101263119B (pt)
AU (1)	AU2006289751A1 (pt)
BR (1)	BRPI0615892A2 (pt)
CA (1)	CA2621292C (pt)
ES (1)	ES2455142T3 (pt)
NO (1)	NO20081787L (pt)
PL (1)	PL1944290T3 (pt)
RU (1)	RU2008114369A (pt)
WO (1)	WO2007032556A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8017775B2 (en)	2005-09-14	2011-09-13	Santen Pharmaceutical Co., Ltd.	1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity
CN101400659B (zh)	2006-03-14	2012-02-29	参天制药株式会社	具有糖皮质激素受体结合活性的新型1，2，3，4-四氢喹喔啉衍生物
KR20090086539A (ko)	2006-11-14	2009-08-13	산텐 세이야꾸 가부시키가이샤	(치환 페닐 또는 치환 복소환) 카르보닐옥시 저급 알킬기와 에스테르 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2-디히드로퀴놀린 유도체
WO2008111632A1 (ja) *	2007-03-13	2008-09-18	Santen Pharmaceutical Co., Ltd.	２，２，４－トリメチル－６－フェニル－１，２－ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト
EP2151436B1 (en) *	2007-05-29	2013-04-24	Santen Pharmaceutical Co., Ltd	Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
US20090042936A1 (en) *	2007-08-10	2009-02-12	Ward Keith W	Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
JP2009084273A (ja) *	2007-09-13	2009-04-23	Santen Pharmaceut Co Ltd	１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
WO2009035068A1 (ja) *	2007-09-13	2009-03-19	Santen Pharmaceutical Co., Ltd.	新規１，３，３－トリメチル－７－フェニル－３，４－ジヒドロ－１ｈ－キノキサリン－２－オン誘導体
TWI510240B (zh) *	2008-05-12	2015-12-01		由具有取代氧基之２，２，４－三甲基－６－苯基－１，２－二氫喹啉衍生物組成之糖皮質激素受體激動劑
GEP20135804B (en) *	2008-09-12	2013-04-10	Santen Pharmaceutical Co Ltd	Glucocorticoid receptor agonist comprising novel 1,2,3,4-tetrahydroquinoxaline derivative containing phenyl group having sulfonic acid ester introduced therein as substituent
JP5921235B2 (ja)	2011-02-09	2016-05-24	あゆみ製薬株式会社	３−ヒドロキシ−６Ｈ−ベンゾ［ｃ］クロメン−６−オン誘導体およびその製造方法
US20120316199A1 (en)	2011-06-07	2012-12-13	Ward Keith W	Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
EP2805948A4 (en) *	2012-01-20	2015-05-27	Santen Pharmaceutical Co Ltd	INDUSTRIAL METHOD FOR PRODUCING A 1,2-DIHYDROCHINOLINE DERIVATIVE OR SALT, AND INTERMEDIATE PRODUCTS FOR THE PREPARATION THEREOF
RU2644944C1 (ru) *	2017-04-06	2018-02-15	Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет"	Способ получения (Z)-этил 2-(4-(4-хлорфенил)-2,4-диоксо-3-(3-оксо-3,4-дигидрохиноксалин-2(1Н)-илиден)бутанамидо)-4-метил-5-фенилтиофен-3-карбоксилата
EP3639854B1 (en)	2017-06-16	2026-01-07	The Doshisha	Mtor-inhibitor-containing medicine for treating or preventing fuchs' endothelial corneal dystrophy
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2006
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- 2006-09-14 ES ES06798171.2T patent/ES2455142T3/es active Active
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Also Published As

Publication number	Publication date
CN102229562A (zh)	2011-11-02
RU2008114369A (ru)	2009-10-27
HK1166072A1 (en)	2012-10-19
EP1944290A1 (en)	2008-07-16
EP1944290A4 (en)	2011-01-12
WO2007032556A1 (ja)	2007-03-22
US8017775B2 (en)	2011-09-13
US20110263589A1 (en)	2011-10-27
AU2006289751A1 (en)	2007-03-22
US20090326009A1 (en)	2009-12-31
ES2455142T3 (es)	2014-04-14
CA2621292A1 (en)	2007-03-22
CN102311385A (zh)	2012-01-11
CA2621292C (en)	2014-05-27
BRPI0615892A2 (pt)	2011-05-31
CN102304124B (zh)	2014-10-22
US8420635B2 (en)	2013-04-16
PL1944290T3 (pl)	2014-07-31
KR101390094B1 (ko)	2014-04-28
HK1165800A1 (en)	2012-10-12
CN102304124A (zh)	2012-01-04
CN102229562B (zh)	2013-11-13
EP1944290B1 (en)	2013-12-04
CN101263119A (zh)	2008-09-10
CN101263119B (zh)	2014-04-09
CN102311385B (zh)	2015-01-14
KR20080046230A (ko)	2008-05-26

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