NO20083642L - Dibenzylaminderivater som CETP-inhibitorer - Google Patents

Dibenzylaminderivater som CETP-inhibitorer

Info

Publication number: NO20083642L
Authority: NO; Norway
Prior art keywords: compounds; derivatives; dibenzylamine; cetp inhibitors; triglycerides
Prior art date: 2006-03-10

Application number

NO20083642A

Other languages

English (en)

Norwegian (no)

Inventor

David Austen Perry

Bruce Allen Lefker

Chang George

Ravi Shanker Gangipati

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-10

Filing date

2008-08-22

Publication date

2008-09-29

2008-08-22 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2008-09-29 Publication of NO20083642L publication Critical patent/NO20083642L/no

Links

BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical class C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 title abstract 2
239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
102000015779 HDL Lipoproteins Human genes 0.000 abstract 2
238000008214 LDL Cholesterol Methods 0.000 abstract 2
235000012000 cholesterol Nutrition 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000002632 lipids Chemical class 0.000 abstract 2
150000003626 triacylglycerols Chemical class 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20083642A 2006-03-10 2008-08-22 Dibenzylaminderivater som CETP-inhibitorer NO20083642L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US78148806P	2006-03-10	2006-03-10
US11/619,299 US8383660B2 (en)	2006-03-10	2007-01-03	Dibenzyl amine compounds and derivatives
PCT/IB2007/000524 WO2007105049A1 (fr)	2006-03-10	2007-02-28	Dérivés de dibenzylamine en tant qu'inhibiteurs de cetp

Publications (1)

Publication Number	Publication Date
NO20083642L true NO20083642L (no)	2008-09-29

Family

ID=38085975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20083642A NO20083642L (no)	2006-03-10	2008-08-22	Dibenzylaminderivater som CETP-inhibitorer

Country Status (23)

Country	Link
US (1)	US8383660B2 (fr)
EP (1)	EP1994015B1 (fr)
JP (1)	JP4959731B2 (fr)
KR (1)	KR101059274B1 (fr)
AP (1)	AP2008004603A0 (fr)
AR (1)	AR059802A1 (fr)
AU (1)	AU2007226260B2 (fr)
BR (1)	BRPI0708753A2 (fr)
CA (2)	CA2645291C (fr)
CR (1)	CR10265A (fr)
DK (1)	DK1994015T3 (fr)
DO (1)	DOP2007000044A (fr)
ES (1)	ES2410859T3 (fr)
IL (1)	IL193572A (fr)
MA (1)	MA30272B1 (fr)
MX (1)	MX2008011045A (fr)
NL (1)	NL2000527C2 (fr)
NO (1)	NO20083642L (fr)
PE (1)	PE20071022A1 (fr)
RS (1)	RS20080409A (fr)
TW (1)	TW200736235A (fr)
UY (1)	UY30197A1 (fr)
WO (1)	WO2007105049A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2008249744A1 (en) *	2007-05-10	2008-11-20	Pfizer Limited	Azetidine derivatives and their use as prostaglandin E2 antagonists
BRPI0923225A2 (pt)	2008-12-02	2016-10-04	Chiralgen Ltd	metodo para sintese de acidos nucleicos modificados no atomo de fosforo
EP2451461A4 (fr)	2009-07-06	2013-05-29	Ontorii Inc	Nouveaux précurseurs d'acide nucléique et leurs méthodes d'utilisation
CN102241667B (zh)	2010-05-14	2013-10-23	中国人民解放军军事医学科学院毒物药物研究所	1-[(4-羟基哌啶-4基)甲基]吡啶-2(1h)-酮衍生物及其制备方法和用途
CN103298469A (zh)	2010-08-31	2013-09-11	首尔大学校产学协力财团	PPARδ激动剂的胎儿重编程的用途
DK2620428T3 (da) *	2010-09-24	2019-07-01	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
CN103648495A (zh)	2011-07-08	2014-03-19	诺华股份有限公司	在高甘油三酯对象中治疗动脉粥样硬化的方法
CN107365339A (zh)	2011-07-19	2017-11-21	波涛生命科学有限公司	合成官能化核酸的方法
DK2872147T3 (da)	2012-07-13	2023-02-20	Wave Life Sciences Ltd	Fremgangsmåde til fremstilling af kirale oligonukleotider
WO2014010250A1 (fr)	2012-07-13	2014-01-16	Chiralgen, Ltd.	Groupe auxiliaire asymétrique
SG11201500243WA (en)	2012-07-13	2015-04-29	Shin Nippon Biomedical Lab Ltd	Chiral nucleic acid adjuvant
CN103351354B (zh) *	2013-06-09	2015-08-12	西安近代化学研究所	1-甲基-5-氨基四唑合成方法
EP3095461A4 (fr)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
WO2015108046A1 (fr)	2014-01-15	2015-07-23	株式会社新日本科学	Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique
EP3095459A4 (fr)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral
EP3094728B1 (fr)	2014-01-16	2022-03-09	Wave Life Sciences Ltd.	Conception chirale
WO2017030367A1 (fr) *	2015-08-17	2017-02-23	인제대학교 산학협력단	Nouveau composé d'isonitramine et composition le contenant pour prévenir ou traiter des maladies métaboliques
KR101799793B1 (ko)	2015-08-17	2017-11-21	인제대학교 산학협력단	신규한 이소나이트라민 화합물 및 이를 포함하는 대사성 질환 예방 또는 치료용 조성물
WO2025125486A1 (fr)	2023-12-14	2025-06-19	Syngenta Crop Protection Ag	Procédé de préparation de dérivés de pipéridinyl 1,2,4-oxadiazole

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2161938A (en)	1934-07-31	1939-06-13	Soc Of Chemical Ind	Imidazolines
US2970082A (en)	1958-10-07	1961-01-31	Walker Lab Inc	Aluminum nicotinate compositions for hypercholesteremia
DE1518133B1 (de)	1961-10-05	1970-08-20	Farmaceutici Italia	Verfahren zur Herstellung eines neuen hypotensiv wirkenden Hendekapeptids
US3228943A (en)	1962-06-11	1966-01-11		Lumilysergol derivatives
US3338899A (en)	1962-07-09	1967-08-29	Aron Samuel	3-phenyl-5-amino-1, 2, 4-oxadiazole compounds
US3238215A (en)	1963-10-17	1966-03-01	Sterling Drug Inc	1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
NL127065C (fr)	1964-04-22
FR1460571A (fr)	1965-06-10	1966-03-04	Innothera Lab Sa	Composés thiényl acétiques et leur préparation
FR6087M (fr)	1967-01-10	1968-06-04
US3511836A (en)	1967-12-13	1970-05-12	Pfizer & Co C	2,4,6,7-tetra substituted quinazolines
FR2003097A1 (en)	1968-03-02	1969-11-07	Takeda Chemical Industries Ltd	Cpds. of general formula (I) A=CH or N Spasmolytics and peripheral vasodilators. Dose: 100-200 mg/d. (p.o). Z and X are OH or reactive
GB1218591A (en)	1968-04-03	1971-01-06	Delalande Sa	Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
CH507249A (de)	1968-05-31	1971-05-15	Sandoz Ag	Verfahren zur Herstellung von 2-Brom-a-ergokryptin
FR2092133B1 (fr)	1970-05-06	1974-03-22	Orsymonde
GB1435139A (en)	1972-08-17	1976-05-12	Sumitomo Chemical Co	Thiazole derivatives
US4146643A (en)	1973-12-18	1979-03-27	Sandoz Ltd.	Increasing vigilance or treating cerebral insufficiency with substituted vincamines
NL175059C (nl)	1974-02-23		Boehringer Mannheim Gmbh	Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
DE2733747C2 (de)	1977-07-27	1979-09-27	Hoechst Ag, 6000 Frankfurt	Verfahren zur Herstellung von 2,2 Dichlorhydrazobenzol
US4188390A (en)	1977-11-05	1980-02-12	Pfizer Inc.	Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
IT1094076B (it)	1978-04-18	1985-07-26	Acraf	Cicloalchiltriazoli
JPS56110665A (en)	1980-02-08	1981-09-01	Yamanouchi Pharmaceut Co Ltd	Sulfamoyl-substituted phenetylamine derivative and its preparation
US5061798A (en)	1985-01-18	1991-10-29	Smith Kline & French Laboratories, Ltd.	Benzyl pyridyl and pyridazinyl compounds
GB8501372D0 (en)	1985-01-18	1985-02-20	Smith Kline French Lab	Chemical compounds
GB8531071D0 (en)	1985-12-17	1986-01-29	Boots Co Plc	Therapeutic compound
US5284971A (en)	1992-07-16	1994-02-08	Syntex (U.S.A.) Inc.	4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
EP0580550B1 (fr)	1992-07-21	1997-10-22	Novartis AG	Dérivés de l'acide oxamique utilisés comme agents hypocholestérémiques
DE4435477A1 (de)	1994-10-04	1996-04-11	Bayer Ag	Cycloalkano-indol- und -azaindol-derivate
AU697744C (en)	1994-10-27	2002-08-22	Elanco Animal Health Ireland Limited	Apolipoprotein-B synthesis inhibitors
US5521186A (en)	1994-10-27	1996-05-28	Janssen Pharmaceutica N.V.	Apolipoprotein-β synthesis inhibitors
WO1996040640A1 (fr)	1995-06-07	1996-12-19	Pfizer Inc.	DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)
TR199901180T2 (xx)	1996-11-27	1999-08-23	Pfizer Inc.	Apo B-Salg�lama/MTP inhibit�r amidler.
JP2894445B2 (ja) *	1997-02-12	1999-05-24	日本たばこ産業株式会社	Ｃｅｔｐ活性阻害剤として有効な化合物
BR0210616A (pt)	2001-06-28	2004-09-28	Pfizer Prod Inc	Indóis, benzofuranos e benzotiofenos substituìdos com triamida, composição farmacêutica, uso dos referidos compostos, bem como processo para preparação dos mesmos
JP2003221376A (ja)	2001-11-21	2003-08-05	Japan Tobacco Inc	Ｃｅｔｐ活性阻害剤
US6875780B2 (en)	2002-04-05	2005-04-05	Warner-Lambert Company	Compounds that modulate PPAR activity and methods for their preparation
US7332514B2 (en) *	2002-08-30	2008-02-19	Japan Tobacco Inc.	Dibenzylamine compound and medicinal use thereof
US6653334B1 (en) *	2002-12-27	2003-11-25	Kowa Co., Ltd.	Benzoxazole compound and pharmaceutical composition containing the same
CN1942428A (zh)	2004-04-13	2007-04-04	默克公司	Cetp抑制剂
DOP2005000123A (es)	2004-07-02	2011-07-15	Merck Sharp & Dohme	Inhibidores de cetp
AP2007003980A0 (en)	2004-11-23	2007-06-30	Pfizer Prod Inc	Dibenzylamine compounds and derivatives
MX2007007919A (es) *	2004-12-31	2008-01-22	Reddy Us Therapeutics Inc	Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp).
JP2009513573A (ja) *	2005-09-30	2009-04-02	メルクエンドカムパニーインコーポレーテッド	コレステリルエステル転送蛋白阻害剤
US7919506B2 (en) *	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives

2007
- 2007-01-03 US US11/619,299 patent/US8383660B2/en not_active Expired - Fee Related
- 2007-02-28 EP EP07705669.5A patent/EP1994015B1/fr active Active
- 2007-02-28 MX MX2008011045A patent/MX2008011045A/es active IP Right Grant
- 2007-02-28 ES ES07705669T patent/ES2410859T3/es active Active
- 2007-02-28 AU AU2007226260A patent/AU2007226260B2/en not_active Ceased
- 2007-02-28 WO PCT/IB2007/000524 patent/WO2007105049A1/fr not_active Ceased
- 2007-02-28 AP AP2008004603A patent/AP2008004603A0/xx unknown
- 2007-02-28 JP JP2008558923A patent/JP4959731B2/ja not_active Expired - Fee Related
- 2007-02-28 RS RSP-2008/0409A patent/RS20080409A/sr unknown
- 2007-02-28 CA CA2645291A patent/CA2645291C/fr not_active Expired - Fee Related
- 2007-02-28 CA CA2717242A patent/CA2717242A1/fr not_active Abandoned
- 2007-02-28 BR BRPI0708753-5A patent/BRPI0708753A2/pt not_active Application Discontinuation
- 2007-02-28 DK DK07705669.5T patent/DK1994015T3/da active
- 2007-02-28 KR KR1020087022081A patent/KR101059274B1/ko not_active Expired - Fee Related
- 2007-03-07 NL NL2000527A patent/NL2000527C2/nl not_active IP Right Cessation
- 2007-03-07 DO DO2007000044A patent/DOP2007000044A/es unknown
- 2007-03-08 UY UY30197A patent/UY30197A1/es not_active Application Discontinuation
- 2007-03-09 PE PE2007000259A patent/PE20071022A1/es not_active Application Discontinuation
- 2007-03-09 TW TW096108178A patent/TW200736235A/zh unknown
- 2007-03-09 AR ARP070100979A patent/AR059802A1/es unknown
2008
- 2008-08-20 IL IL193572A patent/IL193572A/en not_active IP Right Cessation
- 2008-08-22 NO NO20083642A patent/NO20083642L/no not_active Application Discontinuation
- 2008-08-29 CR CR10265A patent/CR10265A/es not_active Application Discontinuation
- 2008-09-10 MA MA31226A patent/MA30272B1/fr unknown

Also Published As

Publication number	Publication date
KR20080093156A (ko)	2008-10-20
TW200736235A (en)	2007-10-01
AU2007226260B2 (en)	2012-02-09
NL2000527C2 (nl)	2008-02-06
AU2007226260A1 (en)	2007-09-20
CA2645291C (fr)	2011-06-28
WO2007105049A1 (fr)	2007-09-20
KR101059274B1 (ko)	2011-08-24
IL193572A0 (en)	2009-05-04
JP4959731B2 (ja)	2012-06-27
DOP2007000044A (es)	2007-09-15
US8383660B2 (en)	2013-02-26
MA30272B1 (fr)	2009-03-02
RS20080409A (sr)	2009-07-15
CR10265A (es)	2008-09-23
PE20071022A1 (es)	2007-10-06
NL2000527A1 (nl)	2007-09-11
US20070213314A1 (en)	2007-09-13
AP2008004603A0 (en)	2008-10-31
AR059802A1 (es)	2008-04-30
CA2717242A1 (fr)	2007-09-20
JP2009529573A (ja)	2009-08-20
ES2410859T3 (es)	2013-07-03
CA2645291A1 (fr)	2007-09-20
IL193572A (en)	2013-02-28
EP1994015A1 (fr)	2008-11-26
EP1994015B1 (fr)	2013-04-24
BRPI0708753A2 (pt)	2011-06-28
UY30197A1 (es)	2007-10-31
MX2008011045A (es)	2008-09-08
DK1994015T3 (da)	2013-06-24

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Date	Code	Title	Description
2015-09-28	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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