NO20084471L - Nasolakrimalt dreneringssystemimplantater for legemiddelterapi - Google Patents

Nasolakrimalt dreneringssystemimplantater for legemiddelterapi

Info

Publication number
NO20084471L
NO20084471L NO20084471A NO20084471A NO20084471L NO 20084471 L NO20084471 L NO 20084471L NO 20084471 A NO20084471 A NO 20084471A NO 20084471 A NO20084471 A NO 20084471A NO 20084471 L NO20084471 L NO 20084471L
Authority
NO
Norway
Prior art keywords
drug core
tear
drainage system
drug therapy
implant
Prior art date
Application number
NO20084471A
Other languages
English (en)
Inventor
Jr Eugene De Juan
Cary Reich
Stephen Boyd
Hanson S Gifford
Mark Deem
Alan Rapacki
Original Assignee
Qlt Plug Delivery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38564290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20084471(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Qlt Plug Delivery Inc filed Critical Qlt Plug Delivery Inc
Publication of NO20084471L publication Critical patent/NO20084471L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00772—Apparatus for restoration of tear ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0085—Identification means; Administration of patients
    • A61F2250/0087—Identification means; Administration of patients colour-coded

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Implanteringsinnretninger, systemer og fremgangsmåter for innføring i et tårepunkt i en pasient omfatter om ønskelig en medikamentkjerne og et kappelegeme som ligger over medikamentkjernen. Medikamentkjernen omfatter et terapeutisk middel som kan tilføres til øyet og kappen definerer minst én eksponert overflate på medikamentkjernen. Den eller de eksponerte overflatene på medikamentkjernen kan komme i kontakt med en tårevæske eller tårefilm og frigjøre det terapeutiske middelet i et terapeutisk nivå over et vedvarende tidsrom når implantatet er implantert for anvendelse. Implantatet kan omfatte et tilbakeholdelseselement som holder medikamentkjernen og kappelegemet tilbake nær tårepunktet og som om ønskelig omfatter en legering med formhukommelse som kan ekspandere elastisk. Et okklusivt element kan være festet til tilbakeholdelseselementet og i det minste delvis okkludere tårestrømmen gjennom tårekanalens lumen.
NO20084471A 2006-03-31 2008-10-23 Nasolakrimalt dreneringssystemimplantater for legemiddelterapi NO20084471L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78777506P 2006-03-31 2006-03-31
US87186406P 2006-12-26 2006-12-26
PCT/US2007/065789 WO2007115259A2 (en) 2006-03-31 2007-04-02 Nasolacrimal drainage system implants for drug therapy

Publications (1)

Publication Number Publication Date
NO20084471L true NO20084471L (no) 2008-12-29

Family

ID=38564290

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20084275A NO20084275L (no) 2006-03-31 2008-10-13 Legemiddel leveringsmetoder, strukturer og sammensetninger for nasolakrimalsystem
NO20084471A NO20084471L (no) 2006-03-31 2008-10-23 Nasolakrimalt dreneringssystemimplantater for legemiddelterapi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20084275A NO20084275L (no) 2006-03-31 2008-10-13 Legemiddel leveringsmetoder, strukturer og sammensetninger for nasolakrimalsystem

Country Status (18)

Country Link
US (17) US8795711B2 (no)
EP (3) EP2004172B1 (no)
JP (10) JP5208916B2 (no)
KR (4) KR20090006153A (no)
CN (2) CN103393483B (no)
AU (2) AU2007234447B2 (no)
BR (2) BRPI0709663A2 (no)
CA (2) CA2648421C (no)
DK (2) DK2004172T3 (no)
ES (2) ES2640458T3 (no)
IL (5) IL194515A (no)
MX (2) MX2008012601A (no)
NO (2) NO20084275L (no)
NZ (4) NZ572193A (no)
RU (4) RU2413480C2 (no)
SG (2) SG170806A1 (no)
WO (2) WO2007115259A2 (no)
ZA (2) ZA200808401B (no)

Families Citing this family (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
EP1765454B1 (en) 2004-07-02 2016-04-13 Mati Therapeutics Inc. Treatment medium delivery device for the eye
EP2594259A1 (en) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
EP1933810B1 (en) 2005-08-11 2012-10-10 Massachusetts Institute of Technology Intravesical drug delivery device and method
WO2007028005A2 (en) * 2005-09-01 2007-03-08 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US8900620B2 (en) 2005-10-13 2014-12-02 DePuy Synthes Products, LLC Drug-impregnated encasement
EP1979023B1 (en) 2006-01-17 2015-07-22 Transcend Medical, Inc. Glaucoma treatment device
EP1978892B1 (en) 2006-01-17 2017-11-15 Novartis Ag Drug delivery treatment device
EP2319558B1 (en) 2006-03-14 2014-05-21 University Of Southern California Mems device for delivery of therapeutic agents
EP2004172B1 (en) * 2006-03-31 2019-03-13 Mati Therapeutics Inc. Drug delivery structures and compositions for nasolacrimal system
SG138567A1 (en) * 2006-06-21 2008-01-28 Johnson & Johnson Vision Care Punctal plugs for the delivery of active agents
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
JP5340161B2 (ja) * 2006-11-09 2013-11-13 アルコン リサーチ， リミテッド 水不溶性ポリマーマトリックスを含む涙点プラグ
TWI409081B (zh) 2006-11-09 2013-09-21 Alcon Res Ltd 用於藥物輸送之水不溶性聚合物基質
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
EP2173289A4 (en) * 2007-07-17 2010-11-24 Transcend Medical Inc EYE IMPLANT WITH HYDROGEL EXPANSION CAPABILITIES
ES2732555T3 (es) 2007-09-07 2019-11-25 Mati Therapeutics Inc Implantes lagrimales y métodos relacionados
US9011361B2 (en) 2007-09-07 2015-04-21 Mati Therapeutics Inc. Lacrimal implant detection
MX2010002618A (es) * 2007-09-07 2010-11-10 Qlt Plug Delivery Inc Herramientas de insercion y extraccion para implantes lagrimales.
EP2207529B1 (en) * 2007-09-07 2014-12-31 Mati Therapeutics Inc. Drug cores for sustained release of therapeutic agents
US9849027B2 (en) 2007-11-08 2017-12-26 Alimera Sciences, Inc. Ocular implantation device
EA201070703A1 (ru) * 2007-12-11 2010-12-30 Массачусетс Инститьют Оф Текнолоджи Имплантируемое устройство для доставки лекарства и способы лечения мочевого пузыря и других полостей тела или трубчатых органов
WO2009079559A1 (en) * 2007-12-17 2009-06-25 University Of Florida Research Foundation, Inc. Dry eye treatment by puncta plugs
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
CA2715489C (en) * 2008-02-18 2017-09-19 Qlt Plug Delivery, Inc. Lacrimal implants and their use in the treatment of eye disorders
WO2009134371A2 (en) * 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
CN102202719B (zh) 2008-05-08 2014-11-26 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
EP2323716B1 (en) 2008-05-08 2015-03-04 MiniPumps, LLC Drug-delivery pumps
MX2010012022A (es) * 2008-05-09 2011-03-15 Qlt Plug Delivery Inc Suministro de liberacion sostenida de agentes activos para tratar glaucoma e hipertension ocular.
CA2728623A1 (en) * 2008-06-24 2010-01-21 Qlt Plug Delivery, Inc. Combination treatment of glaucoma
WO2009158524A2 (en) 2008-06-25 2009-12-30 Transcend Medical, Inc. Ocular implant with shape change capabilities
WO2010006053A1 (en) * 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Lacrimal implant body including comforting agent
EA201170297A1 (ru) 2008-08-09 2011-08-30 Массачусетс Инститьют Оф Текнолоджи Имплантируемое устройство для доставки лекарственных средств и способ лечения мужской мочеполовой системы и окружающих тканей
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
CN102300517A (zh) * 2008-12-19 2011-12-28 Qlt股份有限公司 物质输送泪点植入物和方法
CA2750381C (en) 2009-01-23 2021-03-16 Qlt Inc. Sustained released delivery of one or more agents
EP2548538B1 (en) 2009-01-28 2020-04-01 Alcon Inc. Implantation systems for ocular implants with stiffness qualities
CA3045436C (en) 2009-01-29 2025-10-07 Forsight Vision4, Inc. ADMINISTRATION OF A MEDICATION IN THE POSTERIOR SEGMENT
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US20100204325A1 (en) * 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
JP5890182B2 (ja) * 2009-02-12 2016-03-22 インセプト エルエルシー ヒドロゲルプラグによる薬物送達
WO2010096822A2 (en) 2009-02-23 2010-08-26 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
EP2408409B8 (en) * 2009-03-16 2016-06-08 Endoshape, Inc. Reliably retained shape memory ophthal-mological implants
US9421127B2 (en) 2009-03-31 2016-08-23 Johnson & Johnson Vision Care, Inc. Punctal plugs
TWI495459B (zh) * 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
AU2010246067B2 (en) * 2009-05-04 2016-07-07 Eyepoint Pharmaceuticals Us, Inc. Porous silicon drug-eluting particles
JP5937004B2 (ja) 2009-05-18 2016-06-22 ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ 薬剤溶出眼内インプラント
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
AU2010256558B2 (en) * 2009-06-03 2013-10-03 Forsight Labs, Llc Anterior segment drug delivery
CA2765630C (en) 2009-06-26 2016-07-05 Taris Biomedical, Inc. Solid drug tablets for implantable drug delivery devices
KR101697388B1 (ko) 2009-08-18 2017-01-17 미니펌프스, 엘엘씨 적응 제어기를 갖춘 전해 약품 운반 펌프
US8808257B2 (en) 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
US20120245539A1 (en) 2009-11-27 2012-09-27 Qlt Inc. Lacrimal implants including split and insertable drug core
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US9259352B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US9259351B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US20110251568A1 (en) * 2010-04-08 2011-10-13 Beeley Nathan R F Punctal plugs for controlled release of therapeutic agents
WO2012019136A2 (en) 2010-08-05 2012-02-09 Forsight Vision 4, Inc. Injector apparatus and method for drug delivery
CN103153316B (zh) 2010-08-05 2015-08-19 弗赛特影像4股份有限公司 组合药物递送方法和设备
ES2822118T3 (es) 2010-08-05 2021-04-29 Taris Biomedical Llc Dispositivos de administración de fármacos implantables para sitios genitourinarios
CN103209664A (zh) 2010-08-05 2013-07-17 弗赛特影像4股份有限公司 可植入的治疗装置
US8821457B2 (en) * 2010-09-08 2014-09-02 Johnson & Johnson Vision Care, Inc. Punctal plug containing drug formulation
US8591484B2 (en) 2010-09-15 2013-11-26 AlphaMed, Inc. Lacrimal punctum measurement and occlusion
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
RU2640918C2 (ru) 2010-11-01 2018-01-12 Псивида Юэс, Инк. Биоразлагаемые устройства на основе кремния для доставки терапевтических агентов
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US20140023692A1 (en) * 2010-11-26 2014-01-23 Lisa Claire Du Toit Drug delivery device
US20120157938A1 (en) * 2010-12-16 2012-06-21 Tokarski Jason M Punctal plug with drug core retention features
JP2014503554A (ja) 2011-01-10 2014-02-13 タリス バイオメディカル，インコーポレイテッド 膀胱痛及び刺激性排尿の持続的治療の使用のためのリドカインレジメン
ES2637388T3 (es) 2011-02-04 2017-10-13 Taris Biomedical, Inc. Dispositivo implantable para la liberación controlada de un fármaco de baja solubilidad
EP3967297A1 (en) 2011-04-29 2022-03-16 Allergan, Inc. Sustained release latanoprost implant
US10245178B1 (en) * 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
ES2727203T3 (es) 2011-08-29 2019-10-14 Mati Therapeutics Inc Administración por liberación sostenida de agentes activos para tratar glaucoma e hipertensión ocular
RU2740680C2 (ru) 2011-09-14 2021-01-19 Форсайт Вижн5, Инк. Глазное вкладочное устройство и способы
SI2755600T1 (sl) 2011-09-16 2021-08-31 Forsight Vision4, Inc. Naprava za izmenjavo tekočine
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
GB201120771D0 (en) * 2011-12-02 2012-01-11 Ljt Projects Ltd tear duct resistance measuring system
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US10342700B2 (en) * 2012-02-22 2019-07-09 Ira H. Schachar Device and method for treatment of retinal detachment and other maladies of the eye
RU2630601C2 (ru) * 2012-02-29 2017-09-11 Джонсон Энд Джонсон Вижн Кэа, Инк. Пробка для слезной точки с подключенной к источнику питания матрицей из удерживающих ячеек
EP2836170B1 (en) 2012-04-11 2018-02-14 Sinopsys Surgical, Inc. Implantation tools, tool assemblies and kits
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
CA2872338C (en) 2012-05-03 2021-09-14 Qlt Inc. Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
KR101969594B1 (ko) * 2012-05-11 2019-04-16 서강대학교산학협력단 안내 약물 전달 임플란트
ES2633185T3 (es) 2012-09-17 2017-09-19 Novartis Ag Dispositivos de implante ocular expansibles
EP2911623B1 (en) * 2012-10-26 2019-08-14 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
WO2014078288A1 (en) 2012-11-14 2014-05-22 Transcend Medical, Inc. Flow promoting ocular implant
CA2892322C (en) 2013-01-25 2017-05-30 Sinopsys Surgical, Inc. Paranasal sinus access implant devices and related tools and kits
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
AU2014236455B2 (en) 2013-03-14 2018-07-12 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP2968571A4 (en) 2013-03-15 2016-09-07 Psivida Inc BIODEGRADABLE SILICONE BASED COMPOSITIONS FOR THE DELIVERY OF THERAPEUTIC AGENTS
PL2968880T3 (pl) 2013-03-15 2025-06-23 Taris Biomedical Llc Urządzenia do dostarczania leku ze składnikiem przepuszczalnym dla leku
AU2014241163B2 (en) 2013-03-28 2018-09-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
AU2014281010B2 (en) 2013-06-21 2018-05-10 DePuy Synthes Products, Inc. Films and methods of manufacture
IL299897B2 (en) 2013-08-19 2024-02-01 Taris Biomedical Llc Devices and methods for administering multiple units of drug
CN105828755B (zh) 2013-10-16 2019-01-22 西诺普西斯外科股份有限公司 与鼻窦的流体操纵治疗相关的设备、工具、套件和方法
US9585790B2 (en) 2013-11-14 2017-03-07 Aquesys, Inc. Intraocular shunt inserter
HU231309B1 (hu) 2014-02-25 2022-11-28 Darholding Kft. Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
RU2695563C2 (ru) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Способ и устройство для доставки глазного имплантата
WO2016015002A1 (en) 2014-07-24 2016-01-28 Sinopsys Surgical, Inc. Paranasal sinus access implant devices and related products and methods
MY182793A (en) 2014-08-08 2021-02-05 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
EP3183026B1 (en) 2014-08-19 2019-10-30 The Regents of The University of California Implants for localized drug delivery and methods of use thereof
RU2562515C1 (ru) * 2014-08-19 2015-09-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Интубационный набор для биканаликулярного дренирования слезоотводящих путей
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
JP7037360B2 (ja) 2014-11-10 2022-03-16 フォーサイト・ビジョン フォー・インコーポレーテッド 拡張可能な薬物送達デバイス
JP6686023B2 (ja) * 2014-11-25 2020-04-22 エキシモア・リミテッドＥｘｉｍｏｒｅ Ｌｔｄ． 生物活性剤または生物活性剤類を送達する組成物および方法
WO2016099946A1 (en) 2014-12-17 2016-06-23 Paul Gavaris Canalicular plug, method and kit for treating dry eye
RU2581823C1 (ru) * 2015-03-17 2016-04-20 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Дренаж для хирургического лечения глаукомы
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
US11291377B2 (en) 2015-03-31 2022-04-05 California Institute Of Technology Biocompatible packaging for long term implantable sensors and electronics
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
EP4744688A2 (en) 2015-04-23 2026-05-20 Janssen Biotech Inc DRUG DELIVERY DEVICES WITH A DRUG-PERMEABLE COMPONENT AND METHODS
WO2016187355A1 (en) * 2015-05-20 2016-11-24 Glaukos Corporation Therapeutic drug compositions and implants for delivery of same
EP3310433A1 (en) 2015-06-16 2018-04-25 The Regents of The University of Colorado, A Body Corporate Nasolacrimal implants and related methods for tear stimulation
US20180193193A1 (en) * 2015-07-06 2018-07-12 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drainage system diagnostic implant
AU2016297642A1 (en) 2015-07-22 2018-02-15 Incept, Llc Coated punctal plug
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) * 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017062770A1 (en) 2015-10-08 2017-04-13 Silverberg Noah Punctal plug and bioadhesives
KR20180084104A (ko) 2015-11-20 2018-07-24 포사이트 비젼4, 인크. 연장 방출 약물 전달 장치를 위한 다공성 구조물
RU2613435C1 (ru) * 2015-12-17 2017-03-16 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Дренаж для хирургического лечения глаукомы
RU2620249C1 (ru) * 2015-12-17 2017-05-23 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Многослойный биодеградируемый глазной имплантат с дозированным высвобождением лекарственного вещества и способ его изготовления
EP3393452B1 (en) * 2015-12-21 2021-08-04 Bayer Oy Method for manufacturing a drug delivery device
BR112018070383A2 (pt) 2016-04-05 2019-02-05 Forsight Vision4 Inc dispositivos para aplicação de fármaco oculares implantáveis
US11318043B2 (en) 2016-04-20 2022-05-03 Dose Medical Corporation Bioresorbable ocular drug delivery device
US11207211B2 (en) 2016-05-20 2021-12-28 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drug delivery device
GB2555373A (en) * 2016-08-23 2018-05-02 Reproductive Medicine And Gynaecology Associates Ltd Implant
EP4046609B1 (en) 2016-09-30 2025-02-26 Mati Therapeutics Inc. Ophthalmic drug sustained release formulation and uses thereof
US10722335B1 (en) * 2016-11-15 2020-07-28 Proximate Concepts Llc Device for the delivery of a prosthetic implant and method of use thereof
US9925028B1 (en) * 2016-11-15 2018-03-27 Proximate Concepts Llc Device for the delivery of a prosthetic implant and method of use thereof
US11523940B2 (en) 2017-03-17 2022-12-13 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
CN110520031B (zh) * 2017-05-12 2023-02-21 加州理工学院 可植入腔室外压力传感器
EP3630042A4 (en) * 2017-05-30 2021-06-23 Eximore Ltd. COMPOSITIONS AND METHODS OF TREATMENT OF DRY EYE BY RELEASE OF ANTIBIOTIC MACROLIDE
CN111065359A (zh) 2017-06-16 2020-04-24 埃斯库莱泰克股份有限公司 热反应性聚合物及其用途
US11332773B2 (en) 2017-07-31 2022-05-17 Keio University Rapid tumorigenicity screening system
AU2018338092B2 (en) 2017-09-20 2024-06-13 Sinopsys Surgical, Inc. Paranasal sinus fluid access implantation tools, assemblies, kits and methods
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス， インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
CN115607358A (zh) 2017-11-21 2023-01-17 弗赛特影像4股份有限公司 用于可扩展端口递送系统的流体交换装置及使用方法
EP3737433A1 (en) 2018-01-08 2020-11-18 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
JP7296446B2 (ja) * 2018-03-22 2023-06-22 アルファメッド インコーポレイテッド 小管内溶解性涙点プラグ挿入器
WO2019221853A1 (en) 2018-05-12 2019-11-21 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
EP3843710A1 (en) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymer implants
US12239573B2 (en) 2018-08-29 2025-03-04 W. L. Gore & Associates, Inc. Drug therapy delivery systems and methods
US11980574B2 (en) 2018-09-04 2024-05-14 University Hospitals Health System, Inc. Ocular device for treating glaucoma and related minimally invasive glaucoma surgery method
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
MA54325A (fr) 2019-06-05 2022-05-11 Regeneron Pharma Dispositifs et procédés pour l'administration précise de doses
US11850135B2 (en) 2019-08-01 2023-12-26 Paul H. Rosenberg Family Trust Prosthetic implant delivery device utilizing surface active agents
US12447045B2 (en) 2019-10-02 2025-10-21 Segal Innovations LLC Bio-adhesive dissolving compounds and device
US11207267B2 (en) 2019-10-02 2021-12-28 Segal Innovations LLC Bio-adhesive dissolving compounds and device
US12213916B2 (en) 2020-01-17 2025-02-04 Quest Medical, Inc. Nasolacrimal duct stent assembly and method
US11701504B2 (en) 2020-01-17 2023-07-18 California Institute Of Technology Implantable intracranial pressure sensor
WO2021158968A1 (en) 2020-02-06 2021-08-12 Ocular Therapeutix, Inc. Compositions and methods for treating ocular diseases
US11338119B2 (en) 2020-03-20 2022-05-24 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11173291B2 (en) 2020-03-20 2021-11-16 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11344526B2 (en) 2020-03-20 2022-05-31 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
EP4100075A4 (en) 2020-03-20 2024-01-31 The Regents of University of California IMPLANTABLE DRUG RELEASE DEVICES FOR LOCALIZED DRUG RELEASE
PT3884929T (pt) 2020-03-25 2023-08-09 Ocular Therapeutix Inc Implante ocular contendo um inibidor da tirosina cinase
US20210338481A1 (en) * 2020-04-20 2021-11-04 Bruce B. Becker Lacrimal gland implant for drug delivery and method
CA3177005A1 (en) 2020-04-27 2021-11-04 Michael Goldstein Methods of treating allergic conjunctivitis
JP2023542939A (ja) 2020-09-24 2023-10-12 オキュラ セラピューティクス，インコーポレイテッド ヒドロゲル及び活性薬剤を含む徐放性生分解性小管内挿入物
KR102893953B1 (ko) 2020-09-24 2025-12-02 오큘라 테라퓨틱스, 인코포레이티드 하이드로겔 및 사이클로스포린을 포함하는 지속 방출 생분해성 소관내 삽입체
CN120694804A (zh) 2021-02-24 2025-09-26 视尔普斯眼科公司 小管内储器插入器装置
US12527691B2 (en) 2021-11-05 2026-01-20 W. L. Gore & Associates, Inc. Fluid drainage devices, systems, and methods
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
AU2024251447A1 (en) 2023-04-11 2025-08-21 Ocular Therapeutix, Inc. Ocular implant comprising axitinib polymorph iv
CN117281687A (zh) * 2023-09-22 2023-12-26 海思盖德(苏州)生物医学科技有限公司 一种眼用引流管及其制备方法与应用
CN118190718B (zh) * 2024-03-15 2025-02-11 广州市纳爱生物科技有限公司 一种眼用中药制剂及其活性成分的提取方法

Family Cites Families (318)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2962023A (en) 1955-10-28 1960-11-29 Chappaz Gaston Medicator
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3880991A (en) * 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US3626940A (en) 1969-05-02 1971-12-14 Alza Corp Ocular insert
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3832252A (en) 1970-09-29 1974-08-27 T Higuchi Method of making a drug-delivery device
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3960150A (en) 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3993071A (en) 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3826258A (en) 1972-02-07 1974-07-30 S Abraham Gradual release medicine carrier
US3845201A (en) 1972-04-24 1974-10-29 S Loucas Solid state ophthalmic medication delivery method
US3962414A (en) 1972-04-27 1976-06-08 Alza Corporation Structured bioerodible drug delivery device
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4093708A (en) 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4052505A (en) 1975-05-30 1977-10-04 Alza Corporation Ocular therapeutic system manufactured from copolymer
US4121648A (en) 1977-03-07 1978-10-24 Boris Izrailevich Medovar Apparatus for electroslag castings of semicircular blanks
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4281654A (en) 1980-04-07 1981-08-04 Alza Corporation Drug delivery system for controlled ocular therapy
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4322323A (en) 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
NZ200429A (en) * 1981-04-30 1984-10-19 Smith & Nephew Ass Applicator for placing pharmaceutically active agent in contact with moist surface,e.g.,eye
US5512329A (en) 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4521210A (en) 1982-12-27 1985-06-04 Wong Vernon G Eye implant for relieving glaucoma, and device and method for use therewith
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4660546A (en) 1984-11-07 1987-04-28 Robert S. Herrick Method for treating for deficiency of tears
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
GB8527071D0 (en) 1985-11-04 1985-12-11 Biocompatibles Ltd Plastics
US5229128A (en) 1986-06-11 1993-07-20 Haddad Heskel M Drug delivery ophthalmic insert and method of preparing same
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4747404A (en) 1986-11-10 1988-05-31 Kresge Eye Institute Of Wayne State University Foldable intraocular lens inserter
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
GB8806367D0 (en) * 1988-03-17 1988-04-13 Erba Carlo Spa Siloxane matrices with internal non-uniform drug distribution
US4915684A (en) 1988-06-21 1990-04-10 Mackeen Donald L Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5634946A (en) 1988-08-24 1997-06-03 Focal, Inc. Polymeric endoluminal paving process
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4915664A (en) 1988-12-22 1990-04-10 Erik Bakker Toy glider with wing converging mechanism
US5133159A (en) 1989-01-13 1992-07-28 Nestle S.A. Method for polishing silicone products
US4959048A (en) 1989-01-17 1990-09-25 Helix Medical, Inc. Lacrimal duct occluder
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5128058A (en) 1989-05-31 1992-07-07 Hoya Corporation Contact lens cleaner containing a microcapsular polishing agent
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
IE910450A1 (en) 1990-02-15 1991-08-28 Bausch & Lomb Soft contact lens processing aid
US6004346A (en) 1990-02-28 1999-12-21 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5760261A (en) 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US5163959A (en) 1990-03-29 1992-11-17 Herrick Robert S Method for treating an eye with a canalicular implant having a collapsible flared section
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5041081A (en) 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5116371A (en) 1990-07-06 1992-05-26 Christensen James M Prosthesis with improved biocompatibility
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
WO1993012765A1 (en) 1991-12-27 1993-07-08 Merck & Co., Inc. A controlled release drug dispersion delivery device
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5334137A (en) 1992-02-21 1994-08-02 Eagle Vision, Inc. Lacrimal fluid control device
US5254089A (en) 1992-04-02 1993-10-19 Boston Scientific Corp. Medication dispensing balloon catheter
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5469867A (en) 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5318513A (en) 1992-09-24 1994-06-07 Leib Martin L Canalicular balloon fixation stent
FR2700265B1 (fr) * 1993-01-08 1995-03-31 France Chirurgie Instr Bouchon méatique pour pathologie lacrymale.
US5707643A (en) 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
US6117907A (en) * 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
US5824048A (en) 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
US5417651A (en) 1993-07-01 1995-05-23 Guena; Nicolas Punctum plug and monocanalicular probe for lacrimal pathology
US5770589A (en) 1993-07-27 1998-06-23 The University Of Sydney Treatment of macular degeneration
US5423777A (en) 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US6350781B1 (en) * 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
ES2258495T3 (es) 1994-04-08 2006-09-01 Qlt Usa, Inc. Composiciones de administracion liquida de farmacos.
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
JP3486758B2 (ja) 1994-06-24 2004-01-13 株式会社高研 注入可能な涙小管閉鎖剤
US20020032298A1 (en) 1994-07-22 2002-03-14 Bennett Steven L. Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom
JPH0878130A (ja) 1994-09-08 1996-03-22 Wako:Kk 接地極の埋設方法
US6416760B2 (en) 1995-01-26 2002-07-09 Societe L'oreal Therapeutic/cosmetic compositions comprising CGRP antagonists for treating sensitive human skin
WO1996036377A1 (en) 1995-05-14 1996-11-21 Optonol Ltd. Intraocular implant, delivery device, and method of implantation
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5723005A (en) 1995-06-07 1998-03-03 Herrick Family Limited Partnership Punctum plug having a collapsible flared section and method
US6149684A (en) 1995-06-07 2000-11-21 Herrick; Robert S. Punctum plug having a thin elongated lip and a distal starting tip and method of using
ATE240698T1 (de) 1995-06-07 2003-06-15 Keravision Inc Radiales intrastromales hornhautimplantat
US5766243A (en) 1995-08-21 1998-06-16 Oasis Medical, Inc. Abrasive polished canalicular implant
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5741292A (en) 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US5714360A (en) 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
FR2747033B1 (fr) * 1996-04-03 1998-05-22 Parrat Michel Jesus Hubert Obturateur meatique dynamique pour canalicules lacrymaux
JP3675035B2 (ja) 1996-06-10 2005-07-27 トヨタ自動車株式会社 内燃機関の燃料噴射量制御装置
JPH1033584A (ja) 1996-07-26 1998-02-10 M L C:Kk 涙道挿管器具
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
CA2260992C (en) 1996-08-20 2004-03-09 The Regents Of The University Of California Eye treatments using synthetic thyroid hormone compositions
US5993407A (en) 1996-10-25 1999-11-30 Moazed; Kambiz Thomas Transnasal lacrimal insert
US6010391A (en) 1996-11-01 2000-01-04 Alcon Laboratories, Inc. Cryogenic polishing method for soft acrylic articles
WO1998033461A1 (fr) 1997-02-04 1998-08-06 Alain Fouere Tampon meatique vissable pour canal lacrymal
US6027470A (en) 1998-06-10 2000-02-22 Eagle Vision, Inc. Punctum plug and method for inserting the same into the punctual opening
US6082362A (en) 1997-03-27 2000-07-04 Eagle Vision, Inc. Punctum plug
US6016806A (en) 1997-03-27 2000-01-25 Eaglevision, Inc Punctum plug
US6041785A (en) 1997-03-27 2000-03-28 Eaglevision, Inc. Punctum plug
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
DE69809222T2 (de) * 1997-05-07 2003-08-14 Galen (Chemicals) Ltd., Dublin Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen
US5961370A (en) 1997-05-08 1999-10-05 Chiron Vision Corporation Intraocular lens tumbling process using coated beads
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
MY125870A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
DE69827138T2 (de) 1997-08-11 2006-02-23 Allergan, Inc., Irvine Steriles Retinoid enthaltendes biodegradierbares Implantat mit verbesserter Biokompatibilität und Verfahren zu dessen Herstellung
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5830171A (en) 1997-08-12 1998-11-03 Odyssey Medical, Inc. Punctal occluder
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6060439A (en) 1997-09-29 2000-05-09 Kyzen Corporation Cleaning compositions and methods for cleaning resin and polymeric materials used in manufacture
US5858653A (en) 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6645963B2 (en) * 1997-11-05 2003-11-11 Senju Pharmaceutical Co., Ltd. Prolonged-action eye drop
US5947974A (en) 1997-12-09 1999-09-07 Allergan Folding device and method for an intraocular lens
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
NL1008090C2 (nl) 1998-01-22 1999-07-26 Lubberman Bernardus H M Plug voor het afsluiten van een traanbuis.
US5984523A (en) 1998-02-03 1999-11-16 International Business Machines Corporation Method for recording the heat generated in a hole wall of a substrate during a drilling operation
US6290684B1 (en) 1998-03-02 2001-09-18 Herrick Family Limited Partnership Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same
WO1999044553A1 (en) 1998-03-02 1999-09-10 Herrick Family Limited Partnership A punctum plug having a collapsible flared section and method
US6512747B1 (en) 1998-03-05 2003-01-28 Nippon Telegraph And Telephone Corporation ATM transmission system
US6196993B1 (en) * 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
AU760408B2 (en) 1998-04-27 2003-05-15 Surmodics, Inc. Bioactive agent release coating
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6015433A (en) * 1998-05-29 2000-01-18 Micro Therapeutics, Inc. Rolled stent with waveform perforation pattern
US6306114B1 (en) 1998-06-16 2001-10-23 Eagle Vision, Inc. Valved canalicular plug for lacrimal duct occlusion
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
DK1037627T3 (da) 1998-07-14 2001-10-01 Alcon Lab Inc Anvendelse af 11-(3-dimethylamino-propyliden)-6, 11-dihydrodibenz[b,e]oxepin-2-eddikesyre og af farmaceutisk acceptable salte deraf til fremstillingen af et lægemiddel til behandlingen af non-allergiske...
US6225348B1 (en) * 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
JP2000070296A (ja) 1998-08-27 2000-03-07 M L C:Kk 涙道内挿管器具
US6095901A (en) 1998-12-09 2000-08-01 Alcon Laboratories, Inc. Polishing method for soft acrylic articles
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6234175B1 (en) 1999-03-23 2001-05-22 Medennium, Inc. Smart ocular plug design and method of insertion for punctal and intracanalicular implants
US6383192B1 (en) 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct
US6428502B1 (en) 1999-06-25 2002-08-06 Alcon Manufacturing, Ltd. Punctal cannula
US6706275B1 (en) 1999-09-08 2004-03-16 Matthew W. Camp Scleral plug system
ATE414494T1 (de) * 1999-10-21 2008-12-15 Alcon Inc Medikamentenzuführeinrichtung
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
US6278018B1 (en) 1999-12-14 2001-08-21 Surmodics, Inc. Surface coating agents
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6706034B1 (en) 1999-12-30 2004-03-16 Advanced Cardiovascular Systems, Inc. Process for agent retention in biological tissues
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20030096831A1 (en) 2000-01-18 2003-05-22 Stone Richard A. Ocular growth and nicotinic antagonists
US6344047B1 (en) 2000-02-02 2002-02-05 Eagle Vision Instrument for inserting a punctum plug and method for manufacturing the instrument
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20040208910A1 (en) * 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6371122B1 (en) 2000-06-20 2002-04-16 Robert M. Mandelkorn Gauge/dilator apparatus
US6629533B1 (en) 2000-06-30 2003-10-07 Eagle Vision, Inc. Punctum plug with at least one anchoring arm
EP1305061B1 (en) * 2000-08-04 2004-11-03 Medennium, Inc. Ocular plug for punctal and intracanalicular implants
FI109611B (fi) 2000-10-05 2002-09-13 Abloy Oy Sähkömekaaninen sylinterilukko-avain-yhdistelmä
US6534693B2 (en) 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
AU2002236495B2 (en) 2000-11-29 2006-05-11 Allergan, Inc. Intraocular implants for preventing transplant rejection in the eye
US7041868B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
WO2002056863A2 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
US6964781B2 (en) 2001-01-03 2005-11-15 Bausch & Lomb Incorporated Sustained release drug delivery devices with prefabricated permeable plugs
WO2002058667A2 (en) 2001-01-26 2002-08-01 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US20020193441A1 (en) 2001-02-21 2002-12-19 Robertson Stella M. Prostanoid therapies for the treatment of glaucoma
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
AU2002258754B2 (en) 2001-04-07 2006-08-17 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US6605108B2 (en) 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
US6982090B2 (en) 2001-05-10 2006-01-03 Gillespie Donald E More easily visualized punctum plug configurations
BR0210013A (pt) 2001-05-25 2004-08-10 Valley Forge Pharmaceuticals Gel oftálmico de pirenzepina
US7404825B2 (en) 2001-06-11 2008-07-29 Herrick Ii Robert S Implant capable of forming a differential image in an eye
US6743439B1 (en) * 2001-06-27 2004-06-01 Alcon, Inc. Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride
DE10133870A1 (de) 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
EP1385452B1 (en) * 2001-07-23 2006-09-13 Alcon, Inc. Ophthalmic drug delivery device
WO2003015667A1 (en) 2001-08-03 2003-02-27 David Castillejos Method and intra sclera implant for treatment of glaucoma and presbyopia
FR2829019B3 (fr) 2001-08-31 2003-10-31 Alain Fouere Bouchons lacrymaux et methodes de mise en place de ces dispositifs
EP1424994A4 (en) 2001-09-11 2004-12-01 Smart Drug Systems Inc PREPARATION OF A SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION
US20030097151A1 (en) 2001-10-25 2003-05-22 Smedley Gregory T. Apparatus and mitochondrial treatment for glaucoma
US6996063B2 (en) 2001-11-16 2006-02-07 Asustek Computer Inc. Applicable PDU range test and calculation for window-based polling
FR2833175B1 (fr) 2001-12-06 2004-05-14 Sobem Dispositif de controle de debit, a usage medical
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
US6729939B2 (en) 2001-12-17 2004-05-04 Bausch & Lomb Incorporated Polishing method for intraocular lens
FR2834446B1 (fr) 2002-01-08 2004-02-13 Ioltechnologie Production Clou meatique a expansion
US7090888B2 (en) * 2002-01-18 2006-08-15 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
JP4262601B2 (ja) 2002-01-18 2009-05-13 タカラバイオ株式会社 硫酸化フカン
TW200305424A (en) * 2002-01-29 2003-11-01 Santen Pharmaceutical Co Ltd Glaucoma-treating agent comprising bunazosin and prostaglandin
US7204995B2 (en) 2002-01-31 2007-04-17 El-Sherif Dalia M Treatment and control of dry eye by use of biodegradable polymer capsules
US20040116524A1 (en) * 2002-02-04 2004-06-17 Cohen Ben Z. Method of administering opthalmic fluids
EP1482914B1 (en) * 2002-03-11 2015-04-22 Novartis AG Implantable drug delivery device for the eye
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
CN1658836A (zh) * 2002-05-07 2005-08-24 控制传输系统公司 形成药物传递装置的方法
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20040043067A1 (en) 2002-06-19 2004-03-04 Salamone Joseph C. Fluorosiloxane matrix controlled diffusion drug delivery systems
US6866563B2 (en) 2002-06-27 2005-03-15 Bausch & Lomb Incorporated Apparatus and method for target polishing intraocular lenses
FR2841770B1 (fr) * 2002-07-05 2004-10-01 Ioltechnologie Production Clou meatique d'obturation d'un meat lacrymal
FR2844182B1 (fr) 2002-09-11 2004-12-03 Humanoptics Ag Bouchon d'obturation d'un canalicule lacrymal
US7169163B2 (en) 2002-09-30 2007-01-30 Bruce Becker Transnasal method and catheter for lacrimal system
US7785578B2 (en) 2002-10-11 2010-08-31 Aciont, Inc. Non-invasive ocular drug delivery
ATE369717T1 (de) 2002-10-16 2007-08-15 Alcatel Lucent Paketvermittlung für paketdatenübertragungssysteme in einer multikanalfunkanordnung
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7580394B2 (en) 2002-11-27 2009-08-25 Nokia Corporation System and method for collision-free transmission scheduling in a network
NZ540885A (en) 2002-12-20 2009-02-28 Chakshu Res Inc Ophthalmic formulation for the prevention and treatment of ocular conditions
US20040144392A1 (en) * 2003-01-23 2004-07-29 Mueller Richard L. Breast nipple duct protective device
BRPI0406879B1 (pt) * 2003-01-24 2015-12-22 Control Delivery Sys Inc dispositivo de liberação de droga de liberação sustentada
WO2004066980A2 (en) * 2003-01-24 2004-08-12 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US8149707B2 (en) 2003-02-12 2012-04-03 Rockstar Bidco, LP Minimization of radio resource usage in multi-hop networks with multiple routings
US20040170685A1 (en) 2003-02-26 2004-09-02 Medivas, Llc Bioactive stents and methods for use thereof
US7767429B2 (en) * 2003-03-05 2010-08-03 Halozyme, Inc. Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
US20050283109A1 (en) 2003-03-07 2005-12-22 Peyman Gholam A Method and apparatus for lacrimal canal obstruction
US7065376B2 (en) 2003-03-20 2006-06-20 Microsoft Corporation Multi-radio unification protocol
US20040193095A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
ATE476960T1 (de) 2003-05-02 2010-08-15 Surmodics Inc System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges
US7017580B2 (en) 2003-05-22 2006-03-28 Clarity Corporation Punctum plug system including a punctum plug and passive insertion tool therefor
US7204253B2 (en) 2003-05-22 2007-04-17 Clarity Corporation Punctum plug
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
CA2467410A1 (en) * 2003-05-27 2004-11-27 Synphora Ab Method for treatment of glaucoma and ocular hypertension with prostaglandin analgoues without melanogenic side-effect
JP4104137B2 (ja) 2003-05-30 2008-06-18 有限会社エム・エル・シー 涙点プラグ
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
JP4339635B2 (ja) 2003-06-12 2009-10-07 有限会社エム・エル・シー 涙点プラグ
US6994684B2 (en) 2003-06-16 2006-02-07 Alphamed Inc. Punctum plugs having fluid collecting recesses and methods of punctal occlusion
US20040265356A1 (en) 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
CA2531640C (en) 2003-07-10 2013-06-18 Galen (Chemicals) Limited Intravaginal drug delivery devices
JP4280128B2 (ja) 2003-08-19 2009-06-17 有限会社エム・エル・シー 涙点プラグ
US20050055078A1 (en) 2003-09-04 2005-03-10 Medtronic Vascular, Inc. Stent with outer slough coating
JP2007505932A (ja) * 2003-09-18 2007-03-15 マクサイト， インコーポレイテッド 経強膜送達
WO2005039619A1 (en) * 2003-10-03 2005-05-06 Allergan, Inc. Compositions and methods comprising prostaglandin-related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia
JP2005110765A (ja) 2003-10-03 2005-04-28 M L C:Kk 涙点プラグセット
JP2005110930A (ja) 2003-10-07 2005-04-28 M L C:Kk 涙点プラグセット
US20050129731A1 (en) 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US20050095269A1 (en) 2003-11-04 2005-05-05 Ainpour Parviz R. Gel plug for blockage of the canaliculus
PL1696822T3 (pl) 2003-11-13 2010-08-31 Psivida Inc Wstrzykiwane implanty o opóźnionym wydzielaniu mające matrycę rdzenia i powłokę podatne na erozję biologiczną
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US7983241B2 (en) 2003-12-17 2011-07-19 Telefonaktiebolaget Lm Ericsson (Publ) Method, system, terminal and computer program product for selecting radio access system in a multiaccess system
US7752519B2 (en) 2003-12-29 2010-07-06 Electronics And Telecommunications Research Institute Method for creating feedback message for ARQ in mobile communication system
US20050197614A1 (en) 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
US20050220882A1 (en) 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
US20050228477A1 (en) 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
JP2004202276A (ja) 2004-04-16 2004-07-22 M L C:Kk 涙道再建用挿管器具
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20060182783A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Sustained release intraocular drug delivery systems
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
JP2005312835A (ja) 2004-04-30 2005-11-10 M L C:Kk 糸で補強した涙道ステント
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
JP4644438B2 (ja) 2004-05-11 2011-03-02 有限会社エム・エル・シー ツバつき涙道ステント
JP4510511B2 (ja) 2004-05-18 2010-07-28 有限会社エム・エル・シー ツバを円盤で補強した涙道ステント及び涙道プラグ
US20050281858A1 (en) 2004-06-18 2005-12-22 Kloke Tim M Devices, articles, coatings, and methods for controlled active agent release
WO2006002366A2 (en) 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable ocular devices, methods and systems
EP1765454B1 (en) 2004-07-02 2016-04-13 Mati Therapeutics Inc. Treatment medium delivery device for the eye
AU2005269599A1 (en) * 2004-07-26 2006-02-09 Clarity Corporation Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US7117870B2 (en) * 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US7807750B2 (en) 2004-08-06 2010-10-05 Surmodics, Inc. Thermally-reactive polymers
WO2006031658A2 (en) * 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods
US20060074370A1 (en) 2004-09-24 2006-04-06 Medennium, Inc. Ocular occluder and method of insertion
RU2007115853A (ru) * 2004-10-04 2008-11-10 КьюЭлТи ЮЭсЭй, ИНК. (US) Композиция, применимая в качестве имплантата с контролируемым высвобождением
CA2588449A1 (en) 2004-11-24 2006-06-01 Therakine Corporation An implant for intraocular drug delivery
CN1790976A (zh) 2004-12-17 2006-06-21 松下电器产业株式会社 用于多天线传输中的重传方法
US7986633B2 (en) 2004-12-27 2011-07-26 Lg Electronics Inc. Method of controlling data transmission for multimedia and broadcasting services in a broadband wireless access system
US8535702B2 (en) 2005-02-01 2013-09-17 Boston Scientific Scimed, Inc. Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
CN100394900C (zh) * 2005-02-02 2008-06-18 周星 螺旋弹簧型人工泪道
ATE365432T1 (de) 2005-03-04 2007-07-15 Matsushita Electric Industrial Co Ltd Verfahren und vorrichtung zur synchronisation der physikalischen protokollschichten in heterogenen mobilkommunikationsnetzwerken
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
WO2006122414A1 (en) * 2005-05-17 2006-11-23 Matregen Corp. Depot for sustained and controlled delivery of methotrexate
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
WO2007009061A2 (en) * 2005-07-13 2007-01-18 Anthrogenesis Corporation Ocular plug formed from placenta derived collagen biofabric
JP2009503335A (ja) 2005-07-29 2009-01-29 センサータ テクノロジーズ ホランド ビー ヴイ 補償装置およびその動作方法
JP4654095B2 (ja) 2005-08-31 2011-03-16 キヤノン電子株式会社 画像処理装置、その制御方法及び制御プログラム
US7862532B2 (en) 2005-10-07 2011-01-04 Delta Life Sciences, Inc. Punctum plugs having insertion guides and strengthening beams
US20070088444A1 (en) * 2005-10-13 2007-04-19 Robert A Hodorek Method for repairing a bone defect using a formable implant which hardens in vivo
US20070132125A1 (en) 2005-12-08 2007-06-14 Bausch & Lomb Incorporated Use of a super-cooled fluid in lens processing
JP4667233B2 (ja) 2005-12-27 2011-04-06 パナソニック株式会社 乾式超音波探傷方法と超音波探傷装置
JP4078371B2 (ja) 2006-01-27 2008-04-23 章弘 小栗 涙点プラグ
EP2004172B1 (en) 2006-03-31 2019-03-13 Mati Therapeutics Inc. Drug delivery structures and compositions for nasolacrimal system
US9173773B2 (en) 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
WO2008011125A2 (en) * 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
FR2908042B1 (fr) 2006-11-08 2009-06-05 Bruno Fayet Ensemble d'intubation monocanaliculonasal et/ou monocanaliculaire,notamment pour l'imperforation lacrymonasale.
US20100114309A1 (en) * 2006-12-26 2010-05-06 De Juan Jr Eugene Drug delivery implants for inhibition of optical defects
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US20080299176A1 (en) 2007-05-30 2008-12-04 Yu-Chin Lai Drug delivery device comprising crosslinked polyurethane-siloxane-containing copolymers
MX2010002618A (es) 2007-09-07 2010-11-10 Qlt Plug Delivery Inc Herramientas de insercion y extraccion para implantes lagrimales.
WO2009035565A1 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
EP2207529B1 (en) 2007-09-07 2014-12-31 Mati Therapeutics Inc. Drug cores for sustained release of therapeutic agents
ES2732555T3 (es) * 2007-09-07 2019-11-25 Mati Therapeutics Inc Implantes lagrimales y métodos relacionados
US9011361B2 (en) 2007-09-07 2015-04-21 Mati Therapeutics Inc. Lacrimal implant detection
AU2008333339A1 (en) 2007-12-07 2009-06-11 F. Hoffmann-La Roche Ag HCV NS3 protease replicon shuttle vectors
US8211846B2 (en) 2007-12-14 2012-07-03 Lam Research Group Materials for particle removal by single-phase and two-phase media
CA2715489C (en) 2008-02-18 2017-09-19 Qlt Plug Delivery, Inc. Lacrimal implants and their use in the treatment of eye disorders
BRPI0910253A2 (pt) 2008-03-07 2015-09-29 Hoffmann La Roche derivados de 2-aminoquinolina
WO2009134371A2 (en) 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
MX2010012022A (es) 2008-05-09 2011-03-15 Qlt Plug Delivery Inc Suministro de liberacion sostenida de agentes activos para tratar glaucoma e hipertension ocular.
MX2010013010A (es) 2008-05-30 2011-05-03 Qlt Plug Delivery Inc Articulos implantables tratados en la superficie y metodos relacionados.
CA2728623A1 (en) 2008-06-24 2010-01-21 Qlt Plug Delivery, Inc. Combination treatment of glaucoma
WO2010006053A1 (en) 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Lacrimal implant body including comforting agent
CN102300517A (zh) 2008-12-19 2011-12-28 Qlt股份有限公司 物质输送泪点植入物和方法
CA2750381C (en) 2009-01-23 2021-03-16 Qlt Inc. Sustained released delivery of one or more agents
WO2010096822A2 (en) 2009-02-23 2010-08-26 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
JP6588228B2 (ja) 2015-05-08 2019-10-09 シャープ株式会社 電池システム及び充電槽

Also Published As

Publication number Publication date
US20230165791A1 (en) 2023-06-01
IL212114A0 (en) 2011-06-30
JP2017060789A (ja) 2017-03-30
NZ571758A (en) 2012-06-29
KR20090006153A (ko) 2009-01-14
HK1190908A1 (zh) 2014-07-18
US8795711B2 (en) 2014-08-05
WO2007115261A2 (en) 2007-10-11
CN103393496B (zh) 2016-08-17
WO2007115259A2 (en) 2007-10-11
CN103393483B (zh) 2016-08-24
CA2648421A1 (en) 2007-10-11
US8691265B2 (en) 2014-04-08
EP2010096B1 (en) 2017-07-19
ES2717607T3 (es) 2019-06-24
JP2014087650A (ja) 2014-05-15
JP2012228571A (ja) 2012-11-22
US20190054017A1 (en) 2019-02-21
AU2007234445B2 (en) 2011-07-21
BRPI0709663A2 (pt) 2011-07-26
US9168222B2 (en) 2015-10-27
CN103393496A (zh) 2013-11-20
KR20110038144A (ko) 2011-04-13
US20070243230A1 (en) 2007-10-18
WO2007115259A3 (en) 2008-10-16
US20180133150A1 (en) 2018-05-17
RU2413480C2 (ru) 2011-03-10
JP2018187396A (ja) 2018-11-29
US9849082B2 (en) 2017-12-26
JP2009532132A (ja) 2009-09-10
US20150224200A1 (en) 2015-08-13
EP2010096A4 (en) 2012-11-21
ES2640458T3 (es) 2017-11-03
JP6279421B2 (ja) 2018-02-14
MX2008012603A (es) 2009-02-10
IL194515A0 (en) 2011-08-01
DK2010096T3 (en) 2017-10-02
US12226525B2 (en) 2025-02-18
US20190054018A1 (en) 2019-02-21
CA2648066C (en) 2012-07-03
EP2010096A2 (en) 2009-01-07
CA2648421C (en) 2016-01-12
US20160008171A1 (en) 2016-01-14
JP2019213885A (ja) 2019-12-19
KR101062796B1 (ko) 2011-09-06
IL225842A0 (en) 2013-06-27
US8747884B2 (en) 2014-06-10
US11406592B2 (en) 2022-08-09
CA2648066A1 (en) 2007-10-11
RU2008143224A (ru) 2010-05-10
JP2015037542A (ja) 2015-02-26
US20170128361A1 (en) 2017-05-11
ZA200809003B (en) 2009-10-28
ZA200808401B (en) 2009-06-24
US20140161863A1 (en) 2014-06-12
RU2010149066A (ru) 2012-06-10
NZ595349A (en) 2013-01-25
NO20084275L (no) 2008-12-30
US7998497B2 (en) 2011-08-16
US20140236293A1 (en) 2014-08-21
US20130101658A1 (en) 2013-04-25
RU2010149861A (ru) 2012-06-10
US20110276131A1 (en) 2011-11-10
KR101270113B1 (ko) 2013-06-07
RU2414199C2 (ru) 2011-03-20
HK1190909A1 (zh) 2014-07-18
US10874606B2 (en) 2020-12-29
NZ595623A (en) 2013-01-25
JP5208916B2 (ja) 2013-06-12
KR20090014268A (ko) 2009-02-09
NZ572193A (en) 2011-10-28
BRPI0709672B8 (pt) 2021-06-22
AU2007234445A1 (en) 2007-10-11
KR20120041272A (ko) 2012-04-30
IL225842B (en) 2018-01-31
JP2021176523A (ja) 2021-11-11
JP2017148605A (ja) 2017-08-31
US20140328894A1 (en) 2014-11-06
IL212114A (en) 2017-02-28
US20090092654A1 (en) 2009-04-09
US20210212941A1 (en) 2021-07-15
IL212113A (en) 2017-04-30
JP7273891B2 (ja) 2023-05-15
US20070269487A1 (en) 2007-11-22
US20200000715A1 (en) 2020-01-02
IL212113A0 (en) 2011-06-30
SG170816A1 (en) 2011-05-30
US9549852B2 (en) 2017-01-24
AU2007234447A1 (en) 2007-10-11
US10383817B2 (en) 2019-08-20
WO2007115261A3 (en) 2009-01-22
EP2004172A2 (en) 2008-12-24
EP3449873A1 (en) 2019-03-06
JP2009532133A (ja) 2009-09-10
MX2008012601A (es) 2009-02-10
US10300014B2 (en) 2019-05-28
IL194515A (en) 2013-09-30
US9610194B2 (en) 2017-04-04
SG170806A1 (en) 2011-05-30
EP2004172A4 (en) 2013-01-02
DK2004172T3 (en) 2019-04-23
AU2007234447B2 (en) 2011-07-14
BRPI0709672B1 (pt) 2019-07-02
BRPI0709672A2 (pt) 2011-07-19
CN103393483A (zh) 2013-11-20
RU2008143223A (ru) 2010-05-10
EP2004172B1 (en) 2019-03-13
IL194514A0 (en) 2011-08-01

Similar Documents

Publication Publication Date Title
SG170806A1 (en) Nasolacrimal drainage system implants for drug therapy
WO2008027371A3 (en) Low profile bioactive agent delivery device
US12121415B2 (en) Inner ear plug
CN107027288B (zh) 耳朵治疗
US8216603B2 (en) Method, device, and system for delivery of therapeutic agents to the eye
WO2007021964A3 (en) Intravesical drug delivery device and method
WO2009055347A3 (en) Technology delivery, position and sound management system and method for use in the ear canal
DE60219607D1 (de) Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
NO20072318L (no) Okular levering av polymere leveringsformuleringer
MX385821B (es) Reduccion de la presion intraocular con implantes de bimatoprost intracamerales.
MX2009006146A (es) Dispositivos y metodos para la administracion de farmacos oftalmicos.
CN201977965U (zh) 泪小管支架
JP2014128739A5 (no)
MX2009007394A (es) Tapones puntuales y metodos de entrega de agentes terapeuticos.
CO6450672A2 (es) Implantes lagrimales y métodos relacionados
NO20013094L (no) Biokompatible, okulore, legemiddelavgivende implantatanordninger med regulert frigivningsvirkning, ogfremgangsmaater
ATE458508T1 (de) Stent mit antimikrobieller drainagelumen- oberfläche
WO2007126768A3 (en) Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
WO2005099628A3 (en) Implantable frame with variable compliance
WO2008024982A2 (en) Ophthalmic insert
WO2007133776A3 (en) Active delivery and flow redirection: novel devices and method of delivery of materials to patients
Paasche et al. Technical report: modification of a cochlear implant electrode for drug delivery to the inner ear
WO2009073754A3 (en) Implantation methods, systems and tools for intravascular implantable devices
WO2007030512A3 (en) Graft implant containing drug crystals
WO2007084396A3 (en) Halofuginone delivering vascular medical devices

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application