NO20090177L - Vaksiner for malaria - Google Patents

Vaksiner for malaria

Info

Publication number
NO20090177L
NO20090177L NO20090177A NO20090177A NO20090177L NO 20090177 L NO20090177 L NO 20090177L NO 20090177 A NO20090177 A NO 20090177A NO 20090177 A NO20090177 A NO 20090177A NO 20090177 L NO20090177 L NO 20090177L
Authority
NO
Norway
Prior art keywords
protein
vivax
derived
vaccines
hybrid
Prior art date
Application number
NO20090177A
Other languages
English (en)
Inventor
Martine Marchand
Joseph D Cohen
Christian F Ockenhouse
Anjali Yadava
Original Assignee
Us Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0614254.1A external-priority patent/GB0614254D0/en
Priority claimed from GB0614476A external-priority patent/GB0614476D0/en
Priority claimed from GB0614473A external-priority patent/GB0614473D0/en
Priority claimed from GB0615115A external-priority patent/GB0615115D0/en
Application filed by Us Army filed Critical Us Army
Publication of NO20090177L publication Critical patent/NO20090177L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Foreliggende oppfinnelse angår et nytt hybrid/fusjonsprotein avledet fra CS-proteinet fra Plasmodium vivax (P. vivax), fremgangsmåter for fremstilling og rensing av dette, anvendelse av dette i medisin, spesielt for forebygging av malariainfeksjoner, for eksempel de forårsaket av P. vivax, sammensetninger/vaksiner inneholdende proteinet eller antistoffer mot proteinet slik som monoklonale eller polyklonale antistoffer og anvendelse av disse, spesielt i terapi. Oppfinnelsen omfatter også lipoproteinpartikler av nevnte hybridprotein og formuleringer/vaksiner omfattende disse og anvendelse derav. Spesielt angår den et immunogent hybrid fusjonsprotein omfattende: a) minst én repetert enhet avledet fra den repeterte regionen fra et type I circumsporozoite protein fra P. vivax, b) minst én repetert enhet avledet fra den repeterte regionen fra et type II circumsporozoite protein fra P. vivax, og overflateantigen S avledet fra Hepatitt B virus, eller et fragment derav.
NO20090177A 2006-07-18 2009-01-13 Vaksiner for malaria NO20090177L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0614254.1A GB0614254D0 (en) 2006-07-18 2006-07-18 Vaccine
GB0614476A GB0614476D0 (en) 2006-07-20 2006-07-20 Vaccine
GB0614473A GB0614473D0 (en) 2006-07-20 2006-07-20 Vaccines
GB0615115A GB0615115D0 (en) 2006-07-28 2006-07-28 Vaccines
PCT/EP2007/057301 WO2008009652A2 (en) 2006-07-18 2007-07-16 Vaccines for malaria

Publications (1)

Publication Number Publication Date
NO20090177L true NO20090177L (no) 2009-02-16

Family

ID=38957130

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20090178A NO20090178L (no) 2006-07-18 2009-01-13 Vaksiner for malaria
NO20090177A NO20090177L (no) 2006-07-18 2009-01-13 Vaksiner for malaria

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20090178A NO20090178L (no) 2006-07-18 2009-01-13 Vaksiner for malaria

Country Status (22)

Country Link
US (2) US9592282B2 (no)
EP (2) EP2040742B1 (no)
JP (2) JP5222289B2 (no)
KR (2) KR20090092752A (no)
AR (1) AR061894A1 (no)
AU (2) AU2007276217B2 (no)
BR (2) BRPI0714326A2 (no)
CA (2) CA2657279A1 (no)
CO (2) CO6150187A2 (no)
CR (2) CR10555A (no)
EA (2) EA200900033A1 (no)
ES (2) ES2437082T3 (no)
IL (2) IL196410A0 (no)
MA (2) MA30671B1 (no)
MX (2) MX2009000655A (no)
NO (2) NO20090178L (no)
NZ (2) NZ574238A (no)
PE (1) PE20080428A1 (no)
SG (2) SG173377A1 (no)
TW (1) TW200819462A (no)
WO (2) WO2008009652A2 (no)
ZA (1) ZA200900386B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040136963A1 (en) * 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
MXPA04004876A (es) 2001-11-21 2004-07-30 Univ Pennsylvania Secuencias de acido nucleico y de aminoacido de adenovirus de simio, vectores que contienen los mismos y metodos de uso.
JP5222289B2 (ja) * 2006-07-18 2013-06-26 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム マラリア用ワクチン
CA2707245A1 (en) * 2007-12-06 2009-06-11 Glaxosmithkline Biologicals S.A. Vaccine
AP2010005294A0 (en) 2007-12-24 2010-06-30 Glaxosmithkline Biolog Sa Vaccines for malaria
WO2010036293A1 (en) * 2008-09-24 2010-04-01 The Johns Hokins University Malaria vaccine
EA019928B1 (ru) 2008-11-03 2014-07-30 Круселл Холланд Б.В. Способ получения аденовирусных векторов
US8784832B2 (en) 2011-08-19 2014-07-22 University Of South Florida (A Florida Non-Profit Corporation) Synthetic antigen based on the ligand domain of the Plasmodium vivax duffy binding protein
GB201116248D0 (en) 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
US9580482B2 (en) 2012-02-17 2017-02-28 Children's Medical Center Corporation Conformation-stabilized TRAP antigens
WO2014111733A1 (en) * 2013-01-21 2014-07-24 Isis Innovation Limited Composition and uses thereof
EP3213638A1 (en) 2016-03-01 2017-09-06 Coöperatie Avebe U.A. Vegan cheese analogue
GB201608821D0 (en) 2016-05-19 2016-07-06 Isis Innovation Vaccines
CA3045952A1 (en) 2016-12-07 2018-06-14 Glaxosmithkline Biologicals Sa Novel process
BR112019012843A2 (pt) * 2016-12-23 2019-12-17 The Walter And Eliza Hall Institute Of Medical Research teste de diagnóstico, e, aparelho, sistema e método para o diagnóstico de p. vivax ou p. ovale.

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
US4826957A (en) * 1985-07-12 1989-05-02 New York University Immunogenic recombinant yeast expression product and method for purifying it
AU590599B2 (en) * 1985-07-12 1989-11-09 New York University Immunogenic peptide antigen corresponding to plasmodium vivax circumsporozoite protein
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
JPH0222300A (ja) * 1987-02-02 1990-01-25 Swiss Serum & Vaccine Inst Bern 免疫原性接合体およびその製法ならびに免疫を生ぜしめる方法
US4997647A (en) * 1987-03-30 1991-03-05 New York University Vaccine against the sporozoite stage of malaria
WO1988009797A1 (en) 1987-06-05 1988-12-15 The United States Of America, As Represented By Th Autocrine motility factors in cancer diagnosis and management
US5278302A (en) 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US4977647A (en) * 1989-10-27 1990-12-18 D.B. Industries, Inc. Double locking snap hook
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
JP3954643B2 (ja) * 1991-11-16 2007-08-08 グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニム マラリア原虫由来のＣＳおよびＨＢｓＡＧ間のハイブリッド蛋白質
DE69313134T2 (de) 1992-06-25 1998-02-26 Smithkline Beecham Biolog Adjuvantien enthaltende impfstoffzusammensetzung
KR100310510B1 (ko) 1993-03-23 2002-07-04 장 스테판느 3-0-탈아세틸화모노포스포릴지질a를함유하는백신조성물
DE69434221T2 (de) 1993-09-10 2006-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Bindungsdomänen von Plasmodius Vivax und Plasmodium Falciparum Erythrozyten bindenden Proteinen
PT729473E (pt) 1993-11-17 2001-02-28 Deutsche Om Arzneimittel Gmbh Dissacaridos de glucosamina metodo para a sua preparacao composicao farmaceutica contendo os mesmos e sua utilizacao
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
WO1995026204A1 (en) 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
GB9620795D0 (en) 1996-10-05 1996-11-20 Smithkline Beecham Plc Vaccines
US5666153A (en) 1995-10-03 1997-09-09 Virtual Shopping, Inc. Retractable teleconferencing apparatus
US20030133944A1 (en) 2001-04-05 2003-07-17 Smithkline Beecham Biologicals S.A. Vaccine composition against malaria
GB9616351D0 (en) * 1996-08-02 1996-09-11 Smithkline Beecham Biolog Vaccine composition
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US6303347B1 (en) 1997-05-08 2001-10-16 Corixa Corporation Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
US6764840B2 (en) 1997-05-08 2004-07-20 Corixa Corporation Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
SK287073B6 (sk) 1998-06-30 2009-11-05 Om Pharma N-Acyldipeptidový derivát, spôsob jeho prípravy a farmaceutický prostriedok, ktorý ho obsahuje
KR20000020497A (ko) 1998-09-21 2000-04-15 임채승 말라리아의 검출방법
DK1187629T3 (da) 1999-04-19 2005-01-17 Glaxosmithkline Biolog Sa Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
AU1600401A (en) * 1999-11-12 2001-06-06 Chinese University Of Hong Kong, The Malaria vaccine
AU1581400A (en) 1999-12-22 2001-07-03 Om Pharma Acyl pseudopeptides bearing a functionalised auxiliary spacer
GB0027088D0 (en) 2000-11-06 2000-12-20 Glaxo Group Ltd DNA expression vectors
US6942866B2 (en) 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine
EP1201250A1 (en) * 2000-10-25 2002-05-02 SMITHKLINE BEECHAM BIOLOGICALS s.a. Immunogenic compositions comprising liver stage malarial antigens
AU2002308713B2 (en) 2001-06-22 2008-05-15 The Trustees Of The University Of Pennsylvania Methods of inducing a cytotoxic immune response and recombinant simian adenovirus compositions useful therein
US8232255B2 (en) 2002-10-23 2012-07-31 Glaxosmithkline Biologicals S.A. Methods for vaccinating against malaria
EP1573012B1 (en) 2002-12-17 2011-11-30 Crucell Holland B.V. Recombinant viral-based malaria vaccines
WO2005001103A2 (en) 2003-06-20 2005-01-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
ES2385481T3 (es) 2003-06-20 2012-07-25 Siemens Healthcare Diagnostics Products Gmbh Nueva variante de proteína de superficie (HbsAg) del virus de hepatitis B
US20050233435A1 (en) * 2003-09-04 2005-10-20 Nyu Medical Center Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
US20060041248A1 (en) * 2004-08-23 2006-02-23 Patton David L Pharmaceutical compositions delivery system and methods
GB0420634D0 (en) 2004-09-16 2004-10-20 Glaxosmithkline Biolog Sa Vaccines
US7790186B2 (en) * 2005-01-18 2010-09-07 The United States Of America As Represented By The Secretary Of The Army Plasmodium vivax hybrid circumsporozoite protein and vaccine
GB0513421D0 (en) * 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
JP5222289B2 (ja) * 2006-07-18 2013-06-26 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム マラリア用ワクチン
AP2010005294A0 (en) * 2007-12-24 2010-06-30 Glaxosmithkline Biolog Sa Vaccines for malaria

Also Published As

Publication number Publication date
CO6150189A2 (es) 2010-04-20
CA2657353A1 (en) 2008-01-24
NZ574238A (en) 2012-02-24
PE20080428A1 (es) 2008-05-15
AU2007276219A1 (en) 2008-01-24
US9364525B2 (en) 2016-06-14
WO2008009650A2 (en) 2008-01-24
BRPI0715581A2 (pt) 2013-04-24
EP2040743A2 (en) 2009-04-01
CA2657279A1 (en) 2008-01-24
EP2040742B1 (en) 2014-10-29
MA30670B1 (fr) 2009-08-03
ES2437082T3 (es) 2014-01-08
AU2007276217A1 (en) 2008-01-24
JP2009543846A (ja) 2009-12-10
IL196471A0 (en) 2011-08-01
JP2009543569A (ja) 2009-12-10
NO20090178L (no) 2009-02-09
MX2009000655A (es) 2009-07-02
MA30671B1 (fr) 2009-08-03
TW200819462A (en) 2008-05-01
MX2009000650A (es) 2009-07-02
NZ574239A (en) 2011-12-22
BRPI0714326A2 (pt) 2013-05-07
SG173363A1 (en) 2011-08-29
JP5222289B2 (ja) 2013-06-26
US9592282B2 (en) 2017-03-14
CR10561A (es) 2009-04-29
WO2008009652A3 (en) 2008-05-08
IL196410A0 (en) 2011-08-01
KR20090094213A (ko) 2009-09-04
ZA200900386B (en) 2014-03-26
AU2007276219B2 (en) 2013-10-03
AU2007276217B2 (en) 2013-08-29
WO2008009650A3 (en) 2008-04-10
US20100062028A1 (en) 2010-03-11
KR20090092752A (ko) 2009-09-01
CO6150187A2 (es) 2010-04-20
EP2040743B1 (en) 2013-10-02
EA200900033A1 (ru) 2009-12-30
US20100150998A1 (en) 2010-06-17
AR061894A1 (es) 2008-10-01
ES2525732T3 (es) 2014-12-29
WO2008009652A2 (en) 2008-01-24
AU2007276217A8 (en) 2009-02-26
CR10555A (es) 2009-04-29
EP2040742A2 (en) 2009-04-01
SG173377A1 (en) 2011-08-29
JP5592110B2 (ja) 2014-09-17
EA200900032A1 (ru) 2011-02-28

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