NO20091720L - Azaindol-derivate som CFTR-modulatorer - Google Patents

Azaindol-derivate som CFTR-modulatorer

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Publication number
NO20091720L
NO20091720L NO20091720A NO20091720A NO20091720L NO 20091720 L NO20091720 L NO 20091720L NO 20091720 A NO20091720 A NO 20091720A NO 20091720 A NO20091720 A NO 20091720A NO 20091720 L NO20091720 L NO 20091720L
Authority
NO
Norway
Prior art keywords
modulators
cftr modulators
azaindole derivatives
relates
present
Prior art date
Application number
NO20091720A
Other languages
English (en)
Inventor
Brian Bear
Sara Hadida Ruah
Jinglan Zhou
Mark Miller
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20091720L publication Critical patent/NO20091720L/no

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen angår modulatorer av ATP-bindingkassett ("ABC") transportører eller fragmenter derav av formel (I), inkludert cystisk fibrose transmembran led konduktansmodulator ("CFTR"), sammensetninger derav og fremgangsmåte dermed. Den foreliggende oppfinnelsen angår også fremgangsmåter for å behandle ABC-transportør medierte sykdommer ved å anvende slike modulatorer.
NO20091720A 2006-11-03 2009-04-30 Azaindol-derivate som CFTR-modulatorer NO20091720L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85658406P 2006-11-03 2006-11-03
PCT/US2007/083464 WO2008127399A2 (en) 2006-11-03 2007-11-02 Azaindole derivatives as cftr modulators

Publications (1)

Publication Number Publication Date
NO20091720L true NO20091720L (no) 2009-07-21

Family

ID=39864541

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091720A NO20091720L (no) 2006-11-03 2009-04-30 Azaindol-derivate som CFTR-modulatorer

Country Status (14)

Country Link
EP (2) EP2118103B1 (no)
JP (3) JP5284268B2 (no)
KR (1) KR20090082456A (no)
CN (2) CN101715450B (no)
AU (1) AU2007351454B2 (no)
CA (1) CA2668305C (no)
ES (2) ES2471890T3 (no)
HU (1) HUE034579T2 (no)
IL (1) IL198509A0 (no)
MX (1) MX2009004702A (no)
NO (1) NO20091720L (no)
NZ (1) NZ576642A (no)
RU (1) RU2009120976A (no)
WO (1) WO2008127399A2 (no)

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NZ727015A (en) 2012-01-25 2017-12-22 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
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ITMI20122065A1 (it) 2012-12-03 2014-06-04 Univ Padova Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato
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