NO2945632T3 - - Google Patents

Info

Publication number
NO2945632T3
NO2945632T3 NO13866588A NO13866588A NO2945632T3 NO 2945632 T3 NO2945632 T3 NO 2945632T3 NO 13866588 A NO13866588 A NO 13866588A NO 13866588 A NO13866588 A NO 13866588A NO 2945632 T3 NO2945632 T3 NO 2945632T3
Authority
NO
Norway
Application number
NO13866588A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO2945632T3 publication Critical patent/NO2945632T3/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
NO13866588A 2012-12-28 2013-12-20 NO2945632T3 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2012/087865 WO2014101120A1 (fr) 2012-12-28 2012-12-28 Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution hétérobicyclo présentant des propriétés d'antagoniste d'a2a
PCT/CN2013/076853 WO2014101373A1 (fr) 2012-12-28 2013-06-06 Composés hétérobicyclo-substitués-[1,2,4]triazolo[1,5-c]quinazolin-5-amine pour le traitement d'un trouble du système nerveux central
PCT/US2013/076781 WO2014105666A1 (fr) 2012-12-28 2013-12-20 Composés [1,2,4]triazolo[1,5-c]quinazolin-5-amines à substitution hétérobicyclique ayant des propriétés d'antagonistes du récepteur a2a

Publications (1)

Publication Number Publication Date
NO2945632T3 true NO2945632T3 (fr) 2018-08-04

Family

ID=51019745

Family Applications (1)

Application Number Title Priority Date Filing Date
NO13866588A NO2945632T3 (fr) 2012-12-28 2013-12-20

Country Status (22)

Country Link
US (2) US9708347B2 (fr)
EP (1) EP2945632B1 (fr)
JP (1) JP6306049B2 (fr)
KR (1) KR102165113B1 (fr)
AU (1) AU2013370977B2 (fr)
BR (1) BR112015015468B8 (fr)
CA (1) CA2896056C (fr)
CY (1) CY1120258T1 (fr)
DK (1) DK2945632T3 (fr)
ES (1) ES2667477T3 (fr)
HR (1) HRP20180678T1 (fr)
HU (1) HUE037950T2 (fr)
LT (1) LT2945632T (fr)
ME (1) ME03034B (fr)
MX (1) MX370017B (fr)
NO (1) NO2945632T3 (fr)
PL (1) PL2945632T3 (fr)
PT (1) PT2945632T (fr)
RS (1) RS57162B1 (fr)
RU (2) RU2018136104A (fr)
SI (1) SI2945632T1 (fr)
WO (3) WO2014101120A1 (fr)

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US10138212B2 (en) 2015-02-06 2018-11-27 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as A2A antagonist
EP3307067B1 (fr) * 2015-06-11 2022-11-02 Merck Sharp & Dohme LLC Composés d'aminopyrazine ayant des propriétés d'antagoniste a2a
WO2017008205A1 (fr) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Composés d'aminoquinazoline substitués a titre d'antagonistes du récepteur a2a
WO2017034990A1 (fr) 2015-08-21 2017-03-02 Portola Pharmaceuticals, Inc. Composition et procédés d'utilisation de petites molécules de type tétrahydroisoquinoline pour se lier à pcsk9 et moduler l'activité protéique de pcsk9
EP3337497B1 (fr) 2015-08-21 2023-07-12 SRX Cardio, LLC Composition et procédés d'utilisation de nouveaux petits composés organiques de phénylalanine pour moduler directement l'activité de la protéine pcsk9
HK1257102A1 (zh) 2015-08-21 2019-10-11 Portola Pharmaceuticals, Inc. 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用
WO2017107089A1 (fr) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. Modulateurs allostériques 3-(1h-pyrazol-4-yl)pyridine du récepteur muscarinique m4 de l'acétylcholine
ES2789756T3 (es) 2015-12-23 2020-10-26 Merck Sharp & Dohme Moduladores alostéricos de 6,7-dihidro-5H-pirrolo[3,4-b]piridin-5-ona del receptor de acetilcolina muscarínico M4
WO2017107087A1 (fr) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. Modulateurs allostériques 6,7-dihydro -5h-pyrrolo[3,4-b]pyridin-5-one du récepteur de l'acétylcholine muscarinique m4
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
WO2018112843A1 (fr) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Modulateurs allostériques d'éther hétéroarylpipéridine du récepteur muscarinique de l'acétylcholine m4
WO2018112842A1 (fr) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Modulateurs allostériques d'éther hétéroarylpipéridine 6,6-fusionné du récepteur muscarinique de l'acétylcholine m4
TW201827422A (zh) 2017-01-13 2018-08-01 大陸商江蘇恆瑞醫藥股份有限公司 1,2,4-三嗪-3-胺類衍生物、其製備方法及其在醫藥上的應用
CN110382499B (zh) 2017-02-27 2023-01-03 贝达药业股份有限公司 Fgfr抑制剂及其应用
WO2018166493A1 (fr) 2017-03-16 2018-09-20 江苏恒瑞医药股份有限公司 Dérivé d'hétéroaryl[4,3-c]pyrimidine-5-amine, son procédé de préparation et ses utilisations médicales
AU2018341781B2 (en) 2017-09-28 2023-03-30 Cstone Pharmaceuticals Fused ring derivative as A2A receptor inhibitor
US11498923B2 (en) 2017-12-13 2022-11-15 Merck Sharp & Dohme Llc Substituted imidazo[1,2-c]quinazolines as A2A antagonists
JP2021512959A (ja) 2018-02-06 2021-05-20 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Jiangsu Hengrui Medicine Co., Ltd. ピラゾロ[1,5−a][1,3,5]トリアジン−2−アミン誘導体、その製造法、およびその医薬用途
WO2020106558A1 (fr) 2018-11-20 2020-05-28 Merck Sharp & Dohme Corp. Amino-triazolopyrimidine et amino-triazolopyrazine substitués antagoniste du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
WO2020106560A1 (fr) 2018-11-20 2020-05-28 Merck Sharp & Dohme Corp. Composés amino-triazolopyrimidine et amino-triazolopyrazine substitués utilisés en tant qu'antagonistes de récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
JP2022511778A (ja) 2018-11-30 2022-02-01 メルク・シャープ・アンド・ドーム・コーポレーション アデノシン受容体拮抗薬としての7-、8-及び10-置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用
CR20210271A (es) 2018-11-30 2021-07-14 Merck Sharp & Dohme Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso
CN113727999A (zh) 2019-01-11 2021-11-30 奥默罗斯公司 用于治疗癌症的方法和组合物
AR117844A1 (es) 2019-01-22 2021-09-01 Merck Patent Gmbh Derivados de tiazolopiridina como antagonistas del receptor de adenosina
CA3102364A1 (fr) 2019-03-26 2020-10-01 Novel Pharma Inc. Derive de gnrh de liaison aux acides gras a action prolongee et composition pharmaceutique contenant celui-ci
PE20231066A1 (es) 2020-02-07 2023-07-17 Gasherbrum Bio Inc Agonistas heterociclicos de glp-1
US20240076297A1 (en) * 2020-07-24 2024-03-07 Merck Sharp & Dohme Llc Adenosine a2a and a2b receptor dual antagonists for immuno-oncology
EP4185296A4 (fr) * 2020-07-24 2025-03-05 Merck Sharp & Dohme LLC Antagonistes doubles du récepteur a2a et du récepteur a2b de l'adénosine pour l'immuno-oncologie
JP7858636B2 (ja) 2020-09-10 2026-05-14 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環glp-1アゴニスト
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
KR20250004779A (ko) 2022-04-13 2025-01-08 길리애드 사이언시즈, 인코포레이티드 Trop-2 발현 암을 치료하기 위한 병용 요법
IL322686A (en) 2023-02-16 2025-10-01 Gasherbrum Bio Inc Heterocyclic glp-1 agonists
WO2025137640A1 (fr) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Inhibiteurs azaspiro de wrn

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Also Published As

Publication number Publication date
RU2018136104A (ru) 2018-11-21
WO2014101373A1 (fr) 2014-07-03
BR112015015468B8 (pt) 2023-04-25
US10011615B2 (en) 2018-07-03
AU2013370977B2 (en) 2017-12-14
HRP20180678T1 (hr) 2018-06-01
RU2018136104A3 (fr) 2022-04-05
JP2016504363A (ja) 2016-02-12
RS57162B1 (sr) 2018-07-31
PT2945632T (pt) 2018-05-22
US9708347B2 (en) 2017-07-18
CA2896056A1 (fr) 2014-07-03
EP2945632A1 (fr) 2015-11-25
KR20150100879A (ko) 2015-09-02
RU2015131148A (ru) 2017-02-03
EP2945632B1 (fr) 2018-03-07
LT2945632T (lt) 2018-05-25
PL2945632T3 (pl) 2018-07-31
WO2014101120A1 (fr) 2014-07-03
RU2671628C2 (ru) 2018-11-06
US20150361098A1 (en) 2015-12-17
US20170197991A1 (en) 2017-07-13
ES2667477T3 (es) 2018-05-11
MX2015008481A (es) 2015-09-23
SI2945632T1 (en) 2018-05-31
DK2945632T3 (en) 2018-05-22
EP2945632A4 (fr) 2016-09-14
MX370017B (es) 2019-11-28
CY1120258T1 (el) 2019-07-10
BR112015015468A2 (pt) 2017-07-11
WO2014105666A1 (fr) 2014-07-03
JP6306049B2 (ja) 2018-04-04
ME03034B (fr) 2018-10-20
CA2896056C (fr) 2020-11-10
KR102165113B1 (ko) 2020-10-13
AU2013370977A1 (en) 2015-07-09
HUE037950T2 (hu) 2018-09-28
BR112015015468B1 (pt) 2021-10-26

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