NO300086B1 - Polyisobutylenklebemiddel for anvendelse i en anordning for transdermal avgivelse av et aktivt middel, samt en slik anordning - Google Patents

Polyisobutylenklebemiddel for anvendelse i en anordning for transdermal avgivelse av et aktivt middel, samt en slik anordning Download PDF

Info

Publication number: NO300086B1
Authority: NO; Norway
Prior art keywords: pib; adhesive; nicotine; molecular weight; accordance
Prior art date: 1990-04-16

Application number

NO923954A

Other languages

English (en)

Norwegian (no)

Other versions

NO923954L (no

NO923954D0 (no

Inventor

Karly S Wang

James L Osborne

James A Hunt

Melinda K Nelson

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-16

Filing date

1992-10-12

Publication date

1997-04-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24027514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO300086(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-12 Application filed by Alza Corp filed Critical Alza Corp

1992-10-12 Publication of NO923954D0 publication Critical patent/NO923954D0/no

1992-12-16 Publication of NO923954L publication Critical patent/NO923954L/no

1997-04-07 Publication of NO300086B1 publication Critical patent/NO300086B1/no

Links

230000001070 adhesive effect Effects 0.000 title claims abstract description 123
239000000853 adhesive Substances 0.000 title claims abstract description 111
229920002367 Polyisobutene Polymers 0.000 title claims abstract description 86
230000037317 transdermal delivery Effects 0.000 title claims abstract description 32
239000013543 active substance Substances 0.000 title claims description 23
239000003795 chemical substances by application Substances 0.000 claims abstract description 47
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 36
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 35
229960002715 nicotine Drugs 0.000 claims abstract description 35
239000000203 mixture Substances 0.000 claims abstract description 27
239000004014 plasticizer Substances 0.000 claims abstract description 19
HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 claims abstract description 16
GIJXKZJWITVLHI-PMOLBWCYSA-N benzatropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(C=1C=CC=CC=1)C1=CC=CC=C1 GIJXKZJWITVLHI-PMOLBWCYSA-N 0.000 claims abstract description 8
229960001081 benzatropine Drugs 0.000 claims abstract description 8
WAVYHSURRZBQKO-SFHVURJKSA-N 1-cyclohexyl-4-[ethyl-[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]butan-1-one Chemical compound CCN([C@@H](C)CC=1C=CC(OC)=CC=1)CCCC(=O)C1CCCCC1 WAVYHSURRZBQKO-SFHVURJKSA-N 0.000 claims abstract description 5
WAVYHSURRZBQKO-UHFFFAOYSA-N 1-cyclohexyl-4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butan-1-one Chemical compound C=1C=C(OC)C=CC=1CC(C)N(CC)CCCC(=O)C1CCCCC1 WAVYHSURRZBQKO-UHFFFAOYSA-N 0.000 claims abstract description 5
229950004088 dexsecoverine Drugs 0.000 claims abstract description 5
229950004117 secoverine Drugs 0.000 claims abstract description 5
239000000463 material Substances 0.000 claims description 19
229920000642 polymer Polymers 0.000 claims description 8
239000007788 liquid Substances 0.000 claims description 5
239000005038 ethylene vinyl acetate Substances 0.000 claims description 4
229920001903 high density polyethylene Polymers 0.000 claims description 4
239000004700 high-density polyethylene Substances 0.000 claims description 4
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 2
239000012790 adhesive layer Substances 0.000 description 14
229940079593 drug Drugs 0.000 description 14
239000003814 drug Substances 0.000 description 14
239000012528 membrane Substances 0.000 description 12
210000004379 membrane Anatomy 0.000 description 12
239000002480 mineral oil Substances 0.000 description 10
235000010446 mineral oil Nutrition 0.000 description 10
230000035699 permeability Effects 0.000 description 9
230000001276 controlling effect Effects 0.000 description 8
238000000034 method Methods 0.000 description 8
238000009472 formulation Methods 0.000 description 7
239000010410 layer Substances 0.000 description 6
238000000338 in vitro Methods 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
150000001875 compounds Chemical class 0.000 description 3
230000000694 effects Effects 0.000 description 3
229920001083 polybutene Polymers 0.000 description 3
229920005989 resin Polymers 0.000 description 3
239000011347 resin Substances 0.000 description 3
239000012453 solvate Substances 0.000 description 3
239000004821 Contact adhesive Substances 0.000 description 2
239000000654 additive Substances 0.000 description 2
239000000499 gel Substances 0.000 description 2
230000007794 irritation Effects 0.000 description 2
229920001684 low density polyethylene Polymers 0.000 description 2
239000004702 low-density polyethylene Substances 0.000 description 2
230000005012 migration Effects 0.000 description 2
238000013508 migration Methods 0.000 description 2
-1 polyethylene terephthalate Polymers 0.000 description 2
239000005020 polyethylene terephthalate Substances 0.000 description 2
229920000139 polyethylene terephthalate Polymers 0.000 description 2
239000000758 substrate Substances 0.000 description 2
238000013271 transdermal drug delivery Methods 0.000 description 2
206010020751 Hypersensitivity Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
239000000006 Nitroglycerin Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
229920001328 Polyvinylidene chloride Polymers 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
230000002411 adverse Effects 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
239000000975 dye Substances 0.000 description 1
239000010408 film Substances 0.000 description 1
230000004907 flux Effects 0.000 description 1
239000011888 foil Substances 0.000 description 1
229960003711 glyceryl trinitrate Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000011140 metalized polyester Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
229920003052 natural elastomer Polymers 0.000 description 1
239000000025 natural resin Substances 0.000 description 1
229920001194 natural rubber Polymers 0.000 description 1
231100000344 non-irritating Toxicity 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
239000003921 oil Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
229920006267 polyester film Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
229920000307 polymer substrate Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
239000005033 polyvinylidene chloride Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
239000003223 protective agent Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000001235 sensitizing effect Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
229920003051 synthetic elastomer Polymers 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
239000005061 synthetic rubber Substances 0.000 description 1
239000010409 thin film Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Materials Engineering (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Materials For Medical Uses (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO923954A 1990-04-16 1992-10-12 Polyisobutylenklebemiddel for anvendelse i en anordning for transdermal avgivelse av et aktivt middel, samt en slik anordning NO300086B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/509,644 US5508038A (en)	1990-04-16	1990-04-16	Polyisobutylene adhesives for transdermal devices
PCT/US1991/002516 WO1991016085A1 (en)	1990-04-16	1991-04-12	Polyisobutylene adhesives for transdermal devices

Publications (3)

Publication Number	Publication Date
NO923954D0 NO923954D0 (no)	1992-10-12
NO923954L NO923954L (no)	1992-12-16
NO300086B1 true NO300086B1 (no)	1997-04-07

Family

ID=24027514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO923954A NO300086B1 (no)	1990-04-16	1992-10-12	Polyisobutylenklebemiddel for anvendelse i en anordning for transdermal avgivelse av et aktivt middel, samt en slik anordning

Country Status (18)

Country	Link
US (1)	US5508038A (pt)
EP (1)	EP0525105B1 (pt)
JP (1)	JP3035346B2 (pt)
KR (1)	KR0150228B1 (pt)
AT (1)	ATE134512T1 (pt)
AU (1)	AU630817B2 (pt)
CA (1)	CA2040352A1 (pt)
DE (1)	DE69117505T2 (pt)
DK (1)	DK0525105T3 (pt)
ES (1)	ES2084161T3 (pt)
FI (1)	FI112171B (pt)
GR (1)	GR3019157T3 (pt)
IE (1)	IE74862B1 (pt)
NO (1)	NO300086B1 (pt)
NZ (1)	NZ237810A (pt)
PT (1)	PT97357B (pt)
WO (1)	WO1991016085A1 (pt)
ZA (1)	ZA912753B (pt)

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US8361553B2 (en)	2004-07-30	2013-01-29	Kimberly-Clark Worldwide, Inc.	Methods and compositions for metal nanoparticle treated surfaces
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JP4824963B2 (ja) *	2004-08-12	2011-11-30	日東電工株式会社	貼付材及び貼付製剤
JP4745747B2 (ja) *	2004-08-12	2011-08-10	日東電工株式会社	フェンタニル含有貼付製剤
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JP5058531B2 (ja)	2005-09-09	2012-10-24	日東電工株式会社	ビソプロロール含有貼付製剤
US8383149B2 (en) *	2005-09-23	2013-02-26	Alza Corporation	High enhancer-loading polyacrylate formulation for transdermal applications
US9056061B2 (en) *	2005-09-23	2015-06-16	Alza Corporation	Transdermal nicotine salt delivery system
EP1774964B1 (en)	2005-10-13	2014-08-06	Nitto Denko Corporation	Nicotine transdermal preparation and production method thereof
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AU2008261901A1 (en)	2007-06-08	2008-12-18	University Of Virginia Patent Foundation	Topical poloxamer formulations for enhancing microvascular flow: compositions and uses thereof
CN104398496B (zh) *	2007-10-15	2018-03-20	阿尔扎公司	芬太尼的一天更换一次透皮施用
MX2011005436A (es)	2008-11-24	2011-11-04	Kimberly Clark Co	Constructos laminados antimicrobianos.
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DE102011100619A1 (de)	2010-05-05	2012-01-05	Amw Gmbh	Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum
WO2012084969A1 (en)	2010-12-22	2012-06-28	Hexal Ag	Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition
WO2012105620A1 (ja) *	2011-02-02	2012-08-09	日東電工株式会社	貼付剤および貼付製剤
JP5698018B2 (ja) *	2011-02-02	2015-04-08	日東電工株式会社	貼付剤および貼付製剤
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US20140271923A1 (en)	2013-03-14	2014-09-18	Christopher Brian Reid	Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
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1990
- 1990-04-16 US US07/509,644 patent/US5508038A/en not_active Expired - Lifetime
1991
- 1991-04-12 IE IE124491A patent/IE74862B1/en not_active IP Right Cessation
- 1991-04-12 KR KR1019920702548A patent/KR0150228B1/ko not_active Expired - Lifetime
- 1991-04-12 WO PCT/US1991/002516 patent/WO1991016085A1/en not_active Ceased
- 1991-04-12 EP EP91908912A patent/EP0525105B1/en not_active Expired - Lifetime
- 1991-04-12 ES ES91908912T patent/ES2084161T3/es not_active Expired - Lifetime
- 1991-04-12 AU AU78521/91A patent/AU630817B2/en not_active Expired
- 1991-04-12 PT PT97357A patent/PT97357B/pt not_active IP Right Cessation
- 1991-04-12 JP JP03508812A patent/JP3035346B2/ja not_active Expired - Lifetime
- 1991-04-12 NZ NZ237810A patent/NZ237810A/en unknown
- 1991-04-12 CA CA002040352A patent/CA2040352A1/en not_active Abandoned
- 1991-04-12 DK DK91908912.8T patent/DK0525105T3/da active
- 1991-04-12 AT AT91908912T patent/ATE134512T1/de not_active IP Right Cessation
- 1991-04-12 DE DE69117505T patent/DE69117505T2/de not_active Expired - Lifetime
- 1991-04-21 ZA ZA912753A patent/ZA912753B/xx unknown
1992
- 1992-10-12 NO NO923954A patent/NO300086B1/no not_active IP Right Cessation
- 1992-10-15 FI FI924676A patent/FI112171B/fi active
1996
- 1996-02-29 GR GR960400405T patent/GR3019157T3/el unknown

Also Published As

Publication number	Publication date
NZ237810A (en)	1992-03-26
FI924676L (fi)	1992-10-15
PT97357A (pt)	1992-01-31
US5508038A (en)	1996-04-16
ES2084161T3 (es)	1996-05-01
FI112171B (fi)	2003-11-14
PT97357B (pt)	1998-08-31
IE911244A1 (en)	1991-10-23
ATE134512T1 (de)	1996-03-15
DK0525105T3 (da)	1996-06-24
EP0525105A1 (en)	1993-02-03
JPH05507682A (ja)	1993-11-04
ZA912753B (en)	1992-01-29
AU7852191A (en)	1991-11-11
IE74862B1 (en)	1997-08-13
EP0525105B1 (en)	1996-02-28
NO923954L (no)	1992-12-16
NO923954D0 (no)	1992-10-12
KR0150228B1 (ko)	1998-10-01
JP3035346B2 (ja)	2000-04-24
DE69117505T2 (de)	1996-07-11
DE69117505D1 (de)	1996-04-04
WO1991016085A1 (en)	1991-10-31
GR3019157T3 (en)	1996-05-31
AU630817B2 (en)	1992-11-05
FI924676A0 (fi)	1992-10-15
CA2040352A1 (en)	1991-10-17

Legal Events

Date	Code	Title	Description
2011-05-16	MK1K	Patent expired

Publication	Publication Date	Title
NO300086B1 (no)	1997-04-07	Polyisobutylenklebemiddel for anvendelse i en anordning for transdermal avgivelse av et aktivt middel, samt en slik anordning
US4908027A (en)	1990-03-13	Subsaturated transdermal therapeutic system having improved release characteristics
US5342623A (en)	1994-08-30	Subsaturated transdermal therapeutic system having improved release characteristics
US4559222A (en)	1985-12-17	Matrix composition for transdermal therapeutic system
US5683711A (en)	1997-11-04	Active ingredient patch
JP4745747B2 (ja)	2011-08-10	フェンタニル含有貼付製剤
MX2010011196A (es)	2010-12-15	Sistema terapeutico transdermico para administracion de fentanilo o un analogo de este.
KR101942677B1 (ko)	2019-01-25	첩부제
PH26276A (en)	1992-04-10	Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances
US20070202156A1 (en)	2007-08-30	Adhesive preparation comprising sufentanil and methods of using same
AU630614B2 (en)	1992-11-05	Subsaturated transdermal delivery device
JPH08337521A (ja)	1996-12-24	経皮薬剤放出デバイス
JP2007520480A (ja)	2007-07-26	少なくとも一つの脂肪酸を含むジヒドロピリジンタイプのカルシウムアンタゴニスト用の経皮的デリバリー器具
AU666208B2 (en)	1996-02-01	Transdermal delivery device
CN118103036A (zh)	2024-05-28	用于透皮施用替扎尼定的透皮治疗系统