NO923954L - Polyisobutylenklebemiddel til anordning for transdermal avgivelse - Google Patents
Polyisobutylenklebemiddel til anordning for transdermal avgivelseInfo
- Publication number
- NO923954L NO923954L NO92923954A NO923954A NO923954L NO 923954 L NO923954 L NO 923954L NO 92923954 A NO92923954 A NO 92923954A NO 923954 A NO923954 A NO 923954A NO 923954 L NO923954 L NO 923954L
- Authority
- NO
- Norway
- Prior art keywords
- transdermal delivery
- polyisobutylene
- delivery device
- cleaning agent
- pib
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/509,644 US5508038A (en) | 1990-04-16 | 1990-04-16 | Polyisobutylene adhesives for transdermal devices |
| PCT/US1991/002516 WO1991016085A1 (en) | 1990-04-16 | 1991-04-12 | Polyisobutylene adhesives for transdermal devices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO923954D0 NO923954D0 (no) | 1992-10-12 |
| NO923954L true NO923954L (no) | 1992-12-16 |
| NO300086B1 NO300086B1 (no) | 1997-04-07 |
Family
ID=24027514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO923954A NO300086B1 (no) | 1990-04-16 | 1992-10-12 | Polyisobutylenklebemiddel for anvendelse i en anordning for transdermal avgivelse av et aktivt middel, samt en slik anordning |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5508038A (no) |
| EP (1) | EP0525105B1 (no) |
| JP (1) | JP3035346B2 (no) |
| KR (1) | KR0150228B1 (no) |
| AT (1) | ATE134512T1 (no) |
| AU (1) | AU630817B2 (no) |
| CA (1) | CA2040352A1 (no) |
| DE (1) | DE69117505T2 (no) |
| DK (1) | DK0525105T3 (no) |
| ES (1) | ES2084161T3 (no) |
| FI (1) | FI112171B (no) |
| GR (1) | GR3019157T3 (no) |
| IE (1) | IE74862B1 (no) |
| NO (1) | NO300086B1 (no) |
| NZ (1) | NZ237810A (no) |
| PT (1) | PT97357B (no) |
| WO (1) | WO1991016085A1 (no) |
| ZA (1) | ZA912753B (no) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1251469B (it) * | 1991-07-15 | 1995-05-15 | Zambon Spa | Sistema terapeutico transdermale per la somministrazione di farmaci ad attivita' broncodilatante. |
| CA2166869A1 (en) * | 1993-07-09 | 1995-01-19 | Ooi Wong | Method and device for providing nicotine replacement therapy transdermally/transbuccally |
| GB2281036A (en) * | 1993-08-02 | 1995-02-22 | Agri Tech | Topical compositions containing polybutenes |
| WO1995031190A1 (en) * | 1994-05-18 | 1995-11-23 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable preparation for treating urination disorder |
| AU4657896A (en) * | 1995-01-19 | 1996-08-07 | Cygnus, Inc. | Polyisobutylene adhesives containing high TG tackifier for transdermal devices |
| JP3534775B2 (ja) * | 1995-06-07 | 2004-06-07 | オーソ―マクニール ファーマシューティカル,インコーポレイテッド | 17−デアセチルノルゲスチマートを単独でまたはエストロゲンと組み合わせて投与するための経皮パッチおよび方法 |
| JP3545532B2 (ja) * | 1996-05-08 | 2004-07-21 | 鐘淵化学工業株式会社 | 複合ゴム粒子および複合ゴム系グラフト共重合体粒子 |
| US6011116A (en) * | 1996-05-08 | 2000-01-04 | Kaneka Corporation | Thermoplastic resin composition |
| US6007837A (en) * | 1996-07-03 | 1999-12-28 | Alza Corporation | Drug delivery devices and process of manufacture |
| US6174545B1 (en) | 1997-07-01 | 2001-01-16 | Alza Corporation | Drug delivery devices and process of manufacture |
| US5948433A (en) * | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| US6605751B1 (en) * | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
| US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| HK1040915B (en) | 1998-12-18 | 2010-05-07 | Alza Corporation | Transparent transdermal nicotine delivery devices |
| US8679523B2 (en) | 1999-12-30 | 2014-03-25 | Kimberly-Clark Worldwide, Inc. | Oxygen-delivery closed cell foam matrix for wound treatment |
| DE10003767A1 (de) | 2000-01-28 | 2001-10-04 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika |
| DE10056009A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe |
| US8486426B2 (en) | 2002-07-29 | 2013-07-16 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for treatment of dermal conditions |
| TWI296531B (en) | 2002-10-18 | 2008-05-11 | Hisamitsu Pharmaceutical Co | Transdermal adhesive preparations for topical administration of fentanyl |
| CN101010003B (zh) | 2004-07-30 | 2012-07-04 | 金佰利-克拉克国际公司 | 抗微生物的银组合物 |
| US8361553B2 (en) | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
| CN101010004B (zh) * | 2004-07-30 | 2012-10-03 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
| JP4824963B2 (ja) * | 2004-08-12 | 2011-11-30 | 日東電工株式会社 | 貼付材及び貼付製剤 |
| JP4745747B2 (ja) * | 2004-08-12 | 2011-08-10 | 日東電工株式会社 | フェンタニル含有貼付製剤 |
| WO2006034249A2 (en) * | 2004-09-20 | 2006-03-30 | Acrymed, Inc. | Antimicrobial amorphous compositions |
| JP5058531B2 (ja) | 2005-09-09 | 2012-10-24 | 日東電工株式会社 | ビソプロロール含有貼付製剤 |
| US8383149B2 (en) * | 2005-09-23 | 2013-02-26 | Alza Corporation | High enhancer-loading polyacrylate formulation for transdermal applications |
| US9056061B2 (en) * | 2005-09-23 | 2015-06-16 | Alza Corporation | Transdermal nicotine salt delivery system |
| EP1774964B1 (en) | 2005-10-13 | 2014-08-06 | Nitto Denko Corporation | Nicotine transdermal preparation and production method thereof |
| EP2015722B1 (en) * | 2006-04-28 | 2016-11-16 | Avent, Inc. | Antimicrobial site dressings |
| ES2388355T3 (es) | 2006-11-03 | 2012-10-11 | Durect Corporation | Sistemas de suministro transdémico que comprenden bupivacaína |
| US20080154230A1 (en) * | 2006-12-20 | 2008-06-26 | Janardhanan Anand Subramony | Anode for electrotransport of cationic drug |
| US20100041704A1 (en) * | 2007-01-12 | 2010-02-18 | Aberg A K Gunnar | Dermal compositions of substituted amides and the use thereof as medication for pain and pruritus |
| EP2119437A4 (en) * | 2007-03-08 | 2013-07-03 | Nitto Denko Corp | DEVICE FOR THE TRANSDERMAL ADMINISTRATION OF BISOPROLOL |
| AU2008261901A1 (en) | 2007-06-08 | 2008-12-18 | University Of Virginia Patent Foundation | Topical poloxamer formulations for enhancing microvascular flow: compositions and uses thereof |
| CN104398496B (zh) * | 2007-10-15 | 2018-03-20 | 阿尔扎公司 | 芬太尼的一天更换一次透皮施用 |
| MX2011005436A (es) | 2008-11-24 | 2011-11-04 | Kimberly Clark Co | Constructos laminados antimicrobianos. |
| MX2012000947A (es) | 2009-07-21 | 2012-02-29 | Mylan Inc | Proceso para la manufactura continua de un parche transdermico basado en polisobutileno. |
| DE102009048973A1 (de) * | 2009-10-09 | 2011-04-14 | Beiersdorf Ag | Transdermale therapeutische Systeme enthaltend 4-n-Butylresorcin |
| DE102011100619A1 (de) | 2010-05-05 | 2012-01-05 | Amw Gmbh | Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum |
| WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
| WO2012105620A1 (ja) * | 2011-02-02 | 2012-08-09 | 日東電工株式会社 | 貼付剤および貼付製剤 |
| JP5698018B2 (ja) * | 2011-02-02 | 2015-04-08 | 日東電工株式会社 | 貼付剤および貼付製剤 |
| US9072682B2 (en) | 2012-12-31 | 2015-07-07 | Mylan Inc. | Transdermal dosage form for low-melting point active agent |
| US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
| EP3010545A2 (en) * | 2013-06-20 | 2016-04-27 | Mylan Technologies, Inc. | Storage stable transdermal patch of rotigotine |
| DE102017104026A1 (de) | 2017-02-27 | 2018-08-30 | Lts Lohmann Therapie-Systeme Ag | Nicotin enthaltendes transparentes transdermales therapeutisches System |
| US10406114B2 (en) * | 2017-06-11 | 2019-09-10 | Masoumeh Nasrollahzadeh Abyazani | Antibiotic-loaded transdermal patch |
| DE102017115701B4 (de) * | 2017-07-12 | 2022-03-03 | Lts Lohmann Therapie-Systeme Ag | Fampridin-TTS |
| WO2021226470A1 (en) * | 2020-05-08 | 2021-11-11 | WeCool Toys Inc. | Modular and customizable toy systems comprising building blocks, removable non-adhesive graphics, and built-in instructions |
| US20240149185A1 (en) * | 2022-11-04 | 2024-05-09 | Charlie-Kao Industry Co., Ltd. | Building block assembly |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3252802A (en) * | 1964-06-11 | 1966-05-24 | Canadian Patents Dev | Method of supplementing the feed of growing swine with nicotine |
| US3433775A (en) * | 1966-01-12 | 1969-03-18 | Exxon Research Engineering Co | Process of making butyl rubber whereby a broad molecular weight distribution is obtained under controlled conditions |
| GB1163339A (en) * | 1966-01-25 | 1969-09-04 | Montedison Spa | Polyisobutene |
| US3734097A (en) * | 1969-04-01 | 1973-05-22 | Alza Corp | Therapeutic adhesive tape |
| US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3877468A (en) * | 1970-07-22 | 1975-04-15 | Leo Ab | Chewable tobacco substitute composition |
| US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US3845217A (en) * | 1972-11-16 | 1974-10-29 | Helsingborg L Ab | Buffered smoking substitute compositions |
| US3870794A (en) * | 1974-02-20 | 1975-03-11 | Foundation For Behavioral Rese | Treatment of certain emotional disorders with nicotine compounds |
| US4125623A (en) * | 1974-04-08 | 1978-11-14 | U.S. Philips Corporation | Spasmolytics |
| NL178686C (nl) * | 1974-04-08 | 1986-05-01 | Duphar Int Res | Werkwijze ter bereiding of vervaardiging van spasmolytisch werkzame preparaten en werkwijze ter bereiding van n-alkyl-n-gesubstitueerd alkylbeta-fenylethylaminen met spasmolytische werking. |
| US3923939A (en) * | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
| US3926188A (en) * | 1974-11-14 | 1975-12-16 | Alza Corp | Laminated drug dispenser |
| US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
| US4562075A (en) * | 1982-05-20 | 1985-12-31 | Nelson Research & Development Co. | Penetration enhancers for transdermal drug delivery of systemic agents |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| US4262003A (en) * | 1975-12-08 | 1981-04-14 | Alza Corporation | Method and therapeutic system for administering scopolamine transdermally |
| US4060084A (en) * | 1976-09-07 | 1977-11-29 | Alza Corporation | Method and therapeutic system for providing chemotherapy transdermally |
| DE2702604C2 (de) * | 1977-01-22 | 1984-08-30 | Basf Ag, 6700 Ludwigshafen | Polyisobutene |
| US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| US4748181A (en) * | 1979-08-28 | 1988-05-31 | Foundation For Behavioral Research | Method for treating hypertension with nicotine |
| US4286592A (en) * | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
| US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| US4425337A (en) * | 1981-12-30 | 1984-01-10 | Merck & Co., Inc. | Adjuvants for rectal delivery of drug |
| US4440740A (en) * | 1982-04-26 | 1984-04-03 | Merck & Co., Inc. | α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption |
| IE54286B1 (en) * | 1983-01-18 | 1989-08-16 | Elan Corp Plc | Drug delivery device |
| DE3344691A1 (de) * | 1983-12-10 | 1985-06-20 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgasesysteme |
| DE3347278A1 (de) * | 1983-12-28 | 1985-07-11 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgabesysteme |
| EP0177329B1 (en) * | 1984-10-05 | 1992-09-30 | Hercon Laboratories Corporation | Device for transdermal drug administration |
| US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
| DE3438284A1 (de) * | 1984-10-16 | 1985-03-07 | Hans-Harald von 2400 Lübeck Tilly | Nikotinhaltiges depotpflaster |
| US4752478A (en) * | 1984-12-17 | 1988-06-21 | Merck & Co., Inc. | Transdermal system for timolol |
| DE3685227D1 (de) * | 1985-01-04 | 1992-06-17 | Squibb & Sons Inc | Wundverband. |
| US4597961A (en) * | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| US4680172A (en) * | 1985-03-05 | 1987-07-14 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
| US4665069A (en) * | 1985-04-02 | 1987-05-12 | Barnett Rosenberg | Analgesic composition and method of relieving pain |
| EP0204968B1 (de) * | 1985-05-24 | 1989-09-27 | Beiersdorf Aktiengesellschaft | Nitro-Pflaster |
| DE3518707A1 (de) * | 1985-05-24 | 1986-11-27 | Beiersdorf Ag, 2000 Hamburg | Nitro-pflaster |
| US4647580A (en) * | 1985-07-18 | 1987-03-03 | Syntex (U.S.A.) Inc. | Treatment of Alzheimer's disease |
| US4715387A (en) * | 1985-08-23 | 1987-12-29 | The Regents Of The Univ. Of California | Aerosol for use in the reduction of tobacco smoking |
| EP0245480A1 (en) * | 1985-11-14 | 1987-11-19 | ROSEN, David I. | Transdermal application of nicotine |
| US4797284A (en) * | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| DE3786199T2 (de) * | 1986-04-03 | 1993-09-23 | Hercon Lab | Artikel fuer die verabreichung pharmakologisch aktiver substanzen. |
| DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
| PT86138B (pt) * | 1986-11-20 | 1993-09-30 | Ciba Geigy Ag | Processo para a activacao transdermica ou topica utilizando um sistema terapeutico transdermico activado pelo utente |
| US4839174A (en) * | 1987-10-05 | 1989-06-13 | Pharmetrix Corporation | Novel transdermal nicotine patch |
| JPH01251619A (ja) * | 1988-03-30 | 1989-10-06 | Nec Corp | 半導体装置の製造方法 |
| JPH0725669B2 (ja) * | 1988-12-23 | 1995-03-22 | 日東電工株式会社 | 経皮投与用医薬製剤 |
-
1990
- 1990-04-16 US US07/509,644 patent/US5508038A/en not_active Expired - Lifetime
-
1991
- 1991-04-12 IE IE124491A patent/IE74862B1/en not_active IP Right Cessation
- 1991-04-12 KR KR1019920702548A patent/KR0150228B1/ko not_active Expired - Lifetime
- 1991-04-12 WO PCT/US1991/002516 patent/WO1991016085A1/en not_active Ceased
- 1991-04-12 EP EP91908912A patent/EP0525105B1/en not_active Expired - Lifetime
- 1991-04-12 ES ES91908912T patent/ES2084161T3/es not_active Expired - Lifetime
- 1991-04-12 AU AU78521/91A patent/AU630817B2/en not_active Expired
- 1991-04-12 PT PT97357A patent/PT97357B/pt not_active IP Right Cessation
- 1991-04-12 JP JP03508812A patent/JP3035346B2/ja not_active Expired - Lifetime
- 1991-04-12 NZ NZ237810A patent/NZ237810A/en unknown
- 1991-04-12 CA CA002040352A patent/CA2040352A1/en not_active Abandoned
- 1991-04-12 DK DK91908912.8T patent/DK0525105T3/da active
- 1991-04-12 AT AT91908912T patent/ATE134512T1/de not_active IP Right Cessation
- 1991-04-12 DE DE69117505T patent/DE69117505T2/de not_active Expired - Lifetime
- 1991-04-21 ZA ZA912753A patent/ZA912753B/xx unknown
-
1992
- 1992-10-12 NO NO923954A patent/NO300086B1/no not_active IP Right Cessation
- 1992-10-15 FI FI924676A patent/FI112171B/fi active
-
1996
- 1996-02-29 GR GR960400405T patent/GR3019157T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ237810A (en) | 1992-03-26 |
| NO300086B1 (no) | 1997-04-07 |
| FI924676L (fi) | 1992-10-15 |
| PT97357A (pt) | 1992-01-31 |
| US5508038A (en) | 1996-04-16 |
| ES2084161T3 (es) | 1996-05-01 |
| FI112171B (fi) | 2003-11-14 |
| PT97357B (pt) | 1998-08-31 |
| IE911244A1 (en) | 1991-10-23 |
| ATE134512T1 (de) | 1996-03-15 |
| DK0525105T3 (da) | 1996-06-24 |
| EP0525105A1 (en) | 1993-02-03 |
| JPH05507682A (ja) | 1993-11-04 |
| ZA912753B (en) | 1992-01-29 |
| AU7852191A (en) | 1991-11-11 |
| IE74862B1 (en) | 1997-08-13 |
| EP0525105B1 (en) | 1996-02-28 |
| NO923954D0 (no) | 1992-10-12 |
| KR0150228B1 (ko) | 1998-10-01 |
| JP3035346B2 (ja) | 2000-04-24 |
| DE69117505T2 (de) | 1996-07-11 |
| DE69117505D1 (de) | 1996-04-04 |
| WO1991016085A1 (en) | 1991-10-31 |
| GR3019157T3 (en) | 1996-05-31 |
| AU630817B2 (en) | 1992-11-05 |
| FI924676A0 (fi) | 1992-10-15 |
| CA2040352A1 (en) | 1991-10-17 |
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