NO304023B1 - AnalogifremgangsmÕte for fremstilling av terapeutisk aktive acylforbindelser - Google Patents

AnalogifremgangsmÕte for fremstilling av terapeutisk aktive acylforbindelser Download PDF

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Publication number
NO304023B1
NO304023B1 NO910630A NO910630A NO304023B1 NO 304023 B1 NO304023 B1 NO 304023B1 NO 910630 A NO910630 A NO 910630A NO 910630 A NO910630 A NO 910630A NO 304023 B1 NO304023 B1 NO 304023B1
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NO
Norway
Prior art keywords
compound
formula
methyl
salt
carboxy
Prior art date
Application number
NO910630A
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English (en)
Norwegian (no)
Other versions
NO910630L (no
NO910630D0 (no
Inventor
Hlmayer Peter B
Franz Ostermayer
Tibur Schmidlin
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO910630D0 publication Critical patent/NO910630D0/no
Publication of NO910630L publication Critical patent/NO910630L/no
Publication of NO304023B1 publication Critical patent/NO304023B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Magnetic Record Carriers (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO910630A 1990-02-19 1991-02-18 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive acylforbindelser NO304023B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH51890 1990-02-19
CH223490 1990-07-05

Publications (3)

Publication Number Publication Date
NO910630D0 NO910630D0 (no) 1991-02-18
NO910630L NO910630L (no) 1991-08-20
NO304023B1 true NO304023B1 (no) 1998-10-12

Family

ID=25684817

Family Applications (5)

Application Number Title Priority Date Filing Date
NO910630A NO304023B1 (no) 1990-02-19 1991-02-18 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive acylforbindelser
NO2007009C NO2007009I2 (no) 1990-02-19 1991-02-18 Valsartan og Amlodipin
NO1999001C NO1999001I2 (no) 1990-02-19 1991-02-18 Analogifremgangsmaate for fremstilling av terapeutisk aktive acylforbindelser
NO1998024C NO1998024I1 (no) 1990-02-19 1998-10-21 Valsartan
NO2010008C NO2010008I1 (no) 1990-02-19 2010-04-14 Valsartan, amlodipin, hydroklortiazid og farmasøytiske akseptable salter derav

Family Applications After (4)

Application Number Title Priority Date Filing Date
NO2007009C NO2007009I2 (no) 1990-02-19 1991-02-18 Valsartan og Amlodipin
NO1999001C NO1999001I2 (no) 1990-02-19 1991-02-18 Analogifremgangsmaate for fremstilling av terapeutisk aktive acylforbindelser
NO1998024C NO1998024I1 (no) 1990-02-19 1998-10-21 Valsartan
NO2010008C NO2010008I1 (no) 1990-02-19 2010-04-14 Valsartan, amlodipin, hydroklortiazid og farmasøytiske akseptable salter derav

Country Status (26)

Country Link
US (2) US5399578A (fr)
EP (1) EP0443983B1 (fr)
JP (1) JP2749458B2 (fr)
KR (1) KR0171409B1 (fr)
AT (1) ATE134624T1 (fr)
AU (1) AU644844B2 (fr)
CA (2) CA2036427C (fr)
CY (2) CY1978A (fr)
DE (4) DE122007000050I1 (fr)
DK (1) DK0443983T3 (fr)
ES (1) ES2084801T3 (fr)
FI (2) FI980787L (fr)
GR (1) GR3019155T3 (fr)
HK (1) HK219996A (fr)
HU (2) HU219343B (fr)
IE (1) IE71155B1 (fr)
IL (1) IL97219A (fr)
LU (4) LU90100I2 (fr)
LV (1) LV5773B4 (fr)
NL (3) NL970001I2 (fr)
NO (5) NO304023B1 (fr)
NZ (1) NZ237126A (fr)
PH (1) PH30484A (fr)
PT (1) PT96799B (fr)
SA (1) SA93140130A (fr)
UY (1) UY23835A1 (fr)

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