NO305397B1 - Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem - Google Patents
Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende demInfo
- Publication number
- NO305397B1 NO305397B1 NO940905A NO940905A NO305397B1 NO 305397 B1 NO305397 B1 NO 305397B1 NO 940905 A NO940905 A NO 940905A NO 940905 A NO940905 A NO 940905A NO 305397 B1 NO305397 B1 NO 305397B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- kinuclidine
- intermediates
- preparation
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000008584 quinuclidines Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001022 anti-muscarinic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000000168 bronchodilator agent Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919119705A GB9119705D0 (en) | 1991-09-14 | 1991-09-14 | Therapeutic compounds |
| PCT/EP1992/002067 WO1993006098A1 (en) | 1991-09-14 | 1992-09-03 | Quinuclidine esters process and intermediate for their preparation and pharmaceutical compositions containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO940905D0 NO940905D0 (no) | 1994-03-14 |
| NO940905L NO940905L (no) | 1994-03-14 |
| NO305397B1 true NO305397B1 (no) | 1999-05-25 |
Family
ID=10701448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO940905A NO305397B1 (no) | 1991-09-14 | 1994-03-14 | Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5543419A (de) |
| EP (1) | EP0603229B1 (de) |
| JP (2) | JP2672030B2 (de) |
| KR (1) | KR0135784B1 (de) |
| CN (1) | CN1037269C (de) |
| AT (1) | ATE167187T1 (de) |
| AU (1) | AU659487B2 (de) |
| BR (1) | BR9206499A (de) |
| CA (1) | CA2116356C (de) |
| CZ (1) | CZ281752B6 (de) |
| DE (1) | DE69225897T2 (de) |
| DK (1) | DK0603229T3 (de) |
| EG (1) | EG20072A (de) |
| ES (1) | ES2116343T3 (de) |
| FI (1) | FI114707B (de) |
| GB (1) | GB9119705D0 (de) |
| GR (1) | GR3027667T3 (de) |
| HU (1) | HU220594B1 (de) |
| IL (1) | IL103078A (de) |
| MX (1) | MX9205221A (de) |
| MY (1) | MY108602A (de) |
| NO (1) | NO305397B1 (de) |
| NZ (1) | NZ244324A (de) |
| PL (1) | PL170627B1 (de) |
| PT (1) | PT100863B (de) |
| RU (1) | RU2117669C1 (de) |
| SG (1) | SG50414A1 (de) |
| TW (1) | TW251285B (de) |
| UA (1) | UA42686C2 (de) |
| WO (1) | WO1993006098A1 (de) |
| ZA (1) | ZA926939B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT785198E (pt) * | 1996-01-19 | 2000-11-30 | Lonza Ag | Processo para a producao de 3-quinuclidinol opticamente activo. |
| CZ54498A3 (cs) * | 1997-03-07 | 1998-11-11 | Lonza Ag | Katalyzátorová směs na bázi amorfního částečně dehydratovaného hydroxidu zirkoničitého a způsob její výroby a použití |
| DE69833665T2 (de) * | 1997-08-08 | 2006-11-09 | Duke University | Zusammensetzungen zur vereinfachung von chirurgischen verfahren |
| US6711436B1 (en) | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| HUP0303529A3 (en) * | 2000-12-22 | 2008-03-28 | Almirall Ag | New quinuclidine carbamate derivatives, process for their preparation and pharmaceutical compositions containing them and their use |
| CN1250545C (zh) | 2000-12-28 | 2006-04-12 | 阿尔米雷尔普罗迪斯制药有限公司 | 新的奎宁环衍生物类及含有这类衍生物的药物组合物 |
| GB0424284D0 (en) * | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| DE102004057995A1 (de) * | 2004-12-01 | 2006-06-08 | Wacker Chemie Ag | Verfahren zur Herstellung von α,α-Dialkyl-α-Hydroxymethyl-Carbonsäurederivaten |
| ES2298049B1 (es) * | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| EP2114972A2 (de) * | 2006-12-13 | 2009-11-11 | Gilead Sciences, Inc. | Monophosphate als gemeinsame prodrugs für muskarinrezeptorantagonisten und beta-agonisten für die behandlung von copd und chronischer bronchitis |
| EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2100598A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
| EP2510928A1 (de) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4843074A (en) * | 1988-05-17 | 1989-06-27 | Marion Laboratories, Inc. | 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts |
| GB8923590D0 (en) * | 1989-10-19 | 1989-12-06 | Pfizer Ltd | Antimuscarinic bronchodilators |
-
1991
- 1991-09-14 GB GB919119705A patent/GB9119705D0/en active Pending
-
1992
- 1992-09-03 KR KR1019940700816A patent/KR0135784B1/ko not_active Expired - Fee Related
- 1992-09-03 CZ CS923953A patent/CZ281752B6/cs not_active IP Right Cessation
- 1992-09-03 WO PCT/EP1992/002067 patent/WO1993006098A1/en not_active Ceased
- 1992-09-03 CA CA002116356A patent/CA2116356C/en not_active Expired - Fee Related
- 1992-09-03 DK DK92918526T patent/DK0603229T3/da active
- 1992-09-03 JP JP5505734A patent/JP2672030B2/ja not_active Expired - Fee Related
- 1992-09-03 DE DE69225897T patent/DE69225897T2/de not_active Expired - Fee Related
- 1992-09-03 AU AU24823/92A patent/AU659487B2/en not_active Ceased
- 1992-09-03 PL PL92302771A patent/PL170627B1/pl unknown
- 1992-09-03 UA UA94005520A patent/UA42686C2/uk unknown
- 1992-09-03 HU HU9400729A patent/HU220594B1/hu not_active IP Right Cessation
- 1992-09-03 AT AT92918526T patent/ATE167187T1/de not_active IP Right Cessation
- 1992-09-03 RU RU94019411/04A patent/RU2117669C1/ru not_active IP Right Cessation
- 1992-09-03 BR BR9206499A patent/BR9206499A/pt not_active Application Discontinuation
- 1992-09-03 ES ES92918526T patent/ES2116343T3/es not_active Expired - Lifetime
- 1992-09-03 EP EP92918526A patent/EP0603229B1/de not_active Expired - Lifetime
- 1992-09-03 SG SG1996000871A patent/SG50414A1/en unknown
- 1992-09-03 US US08/204,260 patent/US5543419A/en not_active Expired - Fee Related
- 1992-09-07 IL IL10307892A patent/IL103078A/en not_active IP Right Cessation
- 1992-09-10 TW TW081107184A patent/TW251285B/zh active
- 1992-09-11 PT PT100863A patent/PT100863B/pt active IP Right Grant
- 1992-09-11 ZA ZA926939A patent/ZA926939B/xx unknown
- 1992-09-11 MX MX9205221A patent/MX9205221A/es not_active IP Right Cessation
- 1992-09-14 EG EG54292A patent/EG20072A/xx active
- 1992-09-14 MY MYPI92001642A patent/MY108602A/en unknown
- 1992-09-14 CN CN92110746A patent/CN1037269C/zh not_active Expired - Fee Related
- 1992-09-14 NZ NZ244324A patent/NZ244324A/en unknown
-
1994
- 1994-03-11 FI FI941170A patent/FI114707B/fi not_active IP Right Cessation
- 1994-03-14 NO NO940905A patent/NO305397B1/no unknown
-
1997
- 1997-02-18 JP JP9033807A patent/JP2955533B2/ja not_active Expired - Fee Related
-
1998
- 1998-08-19 GR GR980401846T patent/GR3027667T3/el unknown
Also Published As
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