NO305397B1 - Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem - Google Patents

Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem

Info

Publication number: NO305397B1
Authority: NO; Norway
Prior art keywords: pct; kinuclidine; intermediates; preparation; alkyl
Prior art date: 1991-09-14

Application number

NO940905A

Other languages

English (en)

Norwegian (no)

Other versions

NO940905D0 (no

NO940905L (no

Inventor

Peter Edward Cross

Alan Stobie

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-14

Filing date

1994-03-14

Publication date

1999-05-25

1994-03-14 Application filed by Pfizer filed Critical Pfizer

1994-03-14 Publication of NO940905D0 publication Critical patent/NO940905D0/no

1994-03-14 Publication of NO940905L publication Critical patent/NO940905L/no

1999-05-25 Publication of NO305397B1 publication Critical patent/NO305397B1/no

Links

150000001875 compounds Chemical class 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
150000008584 quinuclidines Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001022 anti-muscarinic effect Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
239000000168 bronchodilator agent Substances 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Quinoline Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO940905A 1991-09-14 1994-03-14 Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem NO305397B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919119705A GB9119705D0 (en)	1991-09-14	1991-09-14	Therapeutic compounds
PCT/EP1992/002067 WO1993006098A1 (en)	1991-09-14	1992-09-03	Quinuclidine esters process and intermediate for their preparation and pharmaceutical compositions containing them

Publications (3)

Publication Number	Publication Date
NO940905D0 NO940905D0 (no)	1994-03-14
NO940905L NO940905L (no)	1994-03-14
NO305397B1 true NO305397B1 (no)	1999-05-25

Family

ID=10701448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO940905A NO305397B1 (no)	1991-09-14	1994-03-14	Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem

Country Status (31)

Country	Link
US (1)	US5543419A (de)
EP (1)	EP0603229B1 (de)
JP (2)	JP2672030B2 (de)
KR (1)	KR0135784B1 (de)
CN (1)	CN1037269C (de)
AT (1)	ATE167187T1 (de)
AU (1)	AU659487B2 (de)
BR (1)	BR9206499A (de)
CA (1)	CA2116356C (de)
CZ (1)	CZ281752B6 (de)
DE (1)	DE69225897T2 (de)
DK (1)	DK0603229T3 (de)
EG (1)	EG20072A (de)
ES (1)	ES2116343T3 (de)
FI (1)	FI114707B (de)
GB (1)	GB9119705D0 (de)
GR (1)	GR3027667T3 (de)
HU (1)	HU220594B1 (de)
IL (1)	IL103078A (de)
MX (1)	MX9205221A (de)
MY (1)	MY108602A (de)
NO (1)	NO305397B1 (de)
NZ (1)	NZ244324A (de)
PL (1)	PL170627B1 (de)
PT (1)	PT100863B (de)
RU (1)	RU2117669C1 (de)
SG (1)	SG50414A1 (de)
TW (1)	TW251285B (de)
UA (1)	UA42686C2 (de)
WO (1)	WO1993006098A1 (de)
ZA (1)	ZA926939B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2147889T3 (es)	1996-01-19	2000-10-01	Lonza Ag	Metodo para preparar 3-hidroxiquinuclidinol opticamente activo.
CZ54498A3 (cs) *	1997-03-07	1998-11-11	Lonza Ag	Katalyzátorová směs na bázi amorfního částečně dehydratovaného hydroxidu zirkoničitého a způsob její výroby a použití
DE69833665T2 (de)	1997-08-08	2006-11-09	Duke University	Zusammensetzungen zur vereinfachung von chirurgischen verfahren
US6711436B1 (en)	1997-08-08	2004-03-23	Duke University	Compositions, apparatus and methods for facilitating surgical procedures
ES2165768B1 (es) *	1999-07-14	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
RU2296762C2 (ru) *	2000-12-22	2007-04-10	Альмиралль Продесфарма Аг	Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе
DK1353919T3 (da)	2000-12-28	2006-11-20	Almirall Prodesfarma Ag	Hidtil ukendte quinuclidinderivater og medicinale sammensætninger indeholdende samme
GB0424284D0 (en) *	2004-11-02	2004-12-01	Novartis Ag	Organic compounds
DE102004057995A1 (de) *	2004-12-01	2006-06-08	Wacker Chemie Ag	Verfahren zur Herstellung von α,α-Dialkyl-α-Hydroxymethyl-Carbonsäurederivaten
ES2298049B1 (es) *	2006-07-21	2009-10-20	Laboratorios Almirall S.A.	Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
US20100112061A1 (en) *	2006-12-13	2010-05-06	William Baker	Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
EP2100599A1 (de)	2008-03-13	2009-09-16	Laboratorios Almirall, S.A.	Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2100598A1 (de)	2008-03-13	2009-09-16	Laboratorios Almirall, S.A.	Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2510928A1 (de)	2011-04-15	2012-10-17	Almirall, S.A.	Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4843074A (en) *	1988-05-17	1989-06-27	Marion Laboratories, Inc.	1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
GB8923590D0 (en) *	1989-10-19	1989-12-06	Pfizer Ltd	Antimuscarinic bronchodilators

1991
- 1991-09-14 GB GB919119705A patent/GB9119705D0/en active Pending
1992
- 1992-09-03 ES ES92918526T patent/ES2116343T3/es not_active Expired - Lifetime
- 1992-09-03 AU AU24823/92A patent/AU659487B2/en not_active Ceased
- 1992-09-03 DE DE69225897T patent/DE69225897T2/de not_active Expired - Fee Related
- 1992-09-03 CZ CS923953A patent/CZ281752B6/cs not_active IP Right Cessation
- 1992-09-03 RU RU94019411/04A patent/RU2117669C1/ru not_active IP Right Cessation
- 1992-09-03 SG SG1996000871A patent/SG50414A1/en unknown
- 1992-09-03 BR BR9206499A patent/BR9206499A/pt not_active Application Discontinuation
- 1992-09-03 WO PCT/EP1992/002067 patent/WO1993006098A1/en not_active Ceased
- 1992-09-03 UA UA94005520A patent/UA42686C2/uk unknown
- 1992-09-03 JP JP5505734A patent/JP2672030B2/ja not_active Expired - Fee Related
- 1992-09-03 KR KR1019940700816A patent/KR0135784B1/ko not_active Expired - Fee Related
- 1992-09-03 PL PL92302771A patent/PL170627B1/pl unknown
- 1992-09-03 US US08/204,260 patent/US5543419A/en not_active Expired - Fee Related
- 1992-09-03 DK DK92918526T patent/DK0603229T3/da active
- 1992-09-03 CA CA002116356A patent/CA2116356C/en not_active Expired - Fee Related
- 1992-09-03 HU HU9400729A patent/HU220594B1/hu not_active IP Right Cessation
- 1992-09-03 AT AT92918526T patent/ATE167187T1/de not_active IP Right Cessation
- 1992-09-03 EP EP92918526A patent/EP0603229B1/de not_active Expired - Lifetime
- 1992-09-07 IL IL10307892A patent/IL103078A/en not_active IP Right Cessation
- 1992-09-10 TW TW081107184A patent/TW251285B/zh active
- 1992-09-11 ZA ZA926939A patent/ZA926939B/xx unknown
- 1992-09-11 MX MX9205221A patent/MX9205221A/es not_active IP Right Cessation
- 1992-09-11 PT PT100863A patent/PT100863B/pt active IP Right Grant
- 1992-09-14 MY MYPI92001642A patent/MY108602A/en unknown
- 1992-09-14 NZ NZ244324A patent/NZ244324A/en unknown
- 1992-09-14 EG EG54292A patent/EG20072A/xx active
- 1992-09-14 CN CN92110746A patent/CN1037269C/zh not_active Expired - Fee Related
1994
- 1994-03-11 FI FI941170A patent/FI114707B/fi not_active IP Right Cessation
- 1994-03-14 NO NO940905A patent/NO305397B1/no unknown
1997
- 1997-02-18 JP JP9033807A patent/JP2955533B2/ja not_active Expired - Fee Related
1998
- 1998-08-19 GR GR980401846T patent/GR3027667T3/el unknown

Also Published As

Publication number	Publication date
PL170627B1 (en)	1997-01-31
JP2672030B2 (ja)	1997-11-05
PT100863A (pt)	1993-10-29
SG50414A1 (en)	1998-07-20
UA42686C2 (uk)	2001-11-15
HU220594B1 (hu)	2002-03-28
PT100863B (pt)	1999-07-30
FI941170L (fi)	1994-03-11
TW251285B (de)	1995-07-11
CZ281752B6 (cs)	1997-01-15
CN1037269C (zh)	1998-02-04
GB9119705D0 (en)	1991-10-30
MX9205221A (es)	1993-03-01
AU2482392A (en)	1993-04-27
DE69225897T2 (de)	1998-10-15
RU2117669C1 (ru)	1998-08-20
FI114707B (fi)	2004-12-15
WO1993006098A1 (en)	1993-04-01
JPH09315970A (ja)	1997-12-09
CA2116356A1 (en)	1993-04-01
EP0603229A1 (de)	1994-06-29
BR9206499A (pt)	1995-11-21
FI941170A0 (fi)	1994-03-11
KR0135784B1 (ko)	1998-04-23
HU9400729D0 (en)	1994-06-28
NO940905D0 (no)	1994-03-14
NZ244324A (en)	1993-12-23
ATE167187T1 (de)	1998-06-15
NO940905L (no)	1994-03-14
JPH06510991A (ja)	1994-12-08
IL103078A (en)	1996-07-23
US5543419A (en)	1996-08-06
HUT66772A (en)	1994-12-28
EG20072A (en)	1999-06-30
ZA926939B (en)	1994-03-11
EP0603229B1 (de)	1998-06-10
DE69225897D1 (de)	1998-07-16
AU659487B2 (en)	1995-05-18
CA2116356C (en)	1998-03-31
IL103078A0 (en)	1993-02-21
MY108602A (en)	1996-10-31
DK0603229T3 (da)	1998-10-12
CN1070911A (zh)	1993-04-14
ES2116343T3 (es)	1998-07-16
GR3027667T3 (en)	1998-11-30
JP2955533B2 (ja)	1999-10-04
CZ395392A3 (en)	1994-07-13

Publication	Publication Date	Title
NO305397B1 (no)	1999-05-25	Kinuklidinesterprosess og mellomprodukter ved fremstilling av kinuklidinestere og farmas°ytiske sammensetninger inneholdende dem
HU906495D0 (en)	1991-04-29	Process for producing compounds and pharmaceutical preparatives of anti-muscarinic effect
NZ335363A (en)	2000-11-24	Naphthyridine derivatives
AU659279B2 (en)	1995-05-11	Pyrimidine derivatives
GR3034769T3 (en)	2001-02-28	Triazole antifungal agents.
KR960704536A (ko)	1996-10-09	안트라사이클리논 유도체 및 유전분증에서의 이의 용도(Anthracyclinone derivatives and their use in amyloidosis)
RU94019411A (ru)	1995-11-27	Эфиры хинук лидина, промежуточные соединения для их синтеза, фармацевтическая композиция и способ лечения
GB2063874A (en)	1981-06-10	Triazole derivatives processes for the preparation thereof and pharmaceutical compositions containing them
FI102679B1 (fi)	1999-01-29	Menetelmä uusien terapeuttisesti käyttökelpoisten sertindoli-prodrugjohdannaisten valmistamiseksi
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
BR9307091A (pt)	1999-03-30	Acido benzenoalcanóicos para doenças cardiovasculares
CA2384018A1 (en)	2001-03-29	Muscarinic antagonists
YU9199A (en)	1999-11-22	Naphtyl compounds, intermediates, compositions, and metods for use
ATE113958T1 (de)	1994-11-15	Organische ester der alkoholischen derivate der 19-nor-steroide und die salze davon, verfahren zu deren herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und pharmazeutische präparate davon.
NO933241L (no)	1993-09-10	Aminosyrer nyttige ved terapi av osteoartikulaere paavirkninger
NO944577L (no)	1995-06-02	Hemming av effekten av amyloidogene proteiner
AU703163B2 (en)	1999-03-18	Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions
SE8406046D0 (sv)	1984-11-29	New azabiocyclic compounds and a process for the preparation thereof
AU7130496A (en)	1997-04-30	Disubstituted piperidine derivatives
HUP0100407A2 (hu)	2001-07-30	Eljárás kinolin-karbamoil- és kinolin-tiokarbamoil-származékok előállítására és az eljárás intermedierjei
SE8401064L (sv)	1984-08-29	Nya isoxazoler och forfarande for framstellning derav
ES8504699A1 (es)	1985-04-16	Procedimiento para la obtencion de nuevos acidos aceticos heterociclicos