NO308074B1 - FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider - Google Patents

FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider

Info

Publication number
NO308074B1
NO308074B1 NO971358A NO971358A NO308074B1 NO 308074 B1 NO308074 B1 NO 308074B1 NO 971358 A NO971358 A NO 971358A NO 971358 A NO971358 A NO 971358A NO 308074 B1 NO308074 B1 NO 308074B1
Authority
NO
Norway
Prior art keywords
pct
compound
carboxanilides
racemization
date
Prior art date
Application number
NO971358A
Other languages
English (en)
Norwegian (no)
Other versions
NO971358D0 (no
NO971358L (no
Inventor
Ulrich Conrad Dyer
Christopher James Lock
Martin Woods
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9504927.6A external-priority patent/GB9504927D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of NO971358D0 publication Critical patent/NO971358D0/no
Publication of NO971358L publication Critical patent/NO971358L/no
Publication of NO308074B1 publication Critical patent/NO308074B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measurement Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO971358A 1994-09-23 1997-03-21 FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider NO308074B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94306962 1994-09-23
GBGB9504927.6A GB9504927D0 (en) 1995-03-10 1995-03-10 Racemisation and asymmetric transformation
PCT/GB1995/002247 WO1996009290A1 (fr) 1994-09-23 1995-09-22 Procedes d'obtention de racemiques et de transformation asymetrique utilises dans la preparation de levobupivacaine et de ses analogues

Publications (3)

Publication Number Publication Date
NO971358D0 NO971358D0 (no) 1997-03-21
NO971358L NO971358L (no) 1997-03-21
NO308074B1 true NO308074B1 (no) 2000-07-17

Family

ID=26137306

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971358A NO308074B1 (no) 1994-09-23 1997-03-21 FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider

Country Status (18)

Country Link
US (1) US5786484A (fr)
EP (1) EP0782569B1 (fr)
JP (1) JP3898220B2 (fr)
KR (1) KR100393133B1 (fr)
CN (1) CN1104416C (fr)
AT (1) ATE214695T1 (fr)
AU (1) AU695479B2 (fr)
CA (1) CA2200490C (fr)
DE (1) DE69525950T2 (fr)
DK (1) DK0782569T3 (fr)
ES (1) ES2173194T3 (fr)
FI (1) FI117436B (fr)
HU (1) HU216291B (fr)
MX (1) MX9702210A (fr)
NO (1) NO308074B1 (fr)
PL (1) PL183204B1 (fr)
PT (1) PT782569E (fr)
WO (1) WO1996009290A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384227B2 (en) 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
JP2000256359A (ja) * 1999-03-11 2000-09-19 Japan Science & Technology Corp 面性キラリティーを有する分子群の高選択的不斉変換法
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
BR0002246A (pt) * 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
WO2001096301A1 (fr) 2000-06-14 2001-12-20 Toray Industries, Inc. Procedes de production de derive de piperidine racemique et de production de derive de piperidine a activite optique
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE482695T1 (de) * 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
BRPI0515372B8 (pt) 2004-09-17 2021-05-25 Durect Corp composição líquida para fornecer anestesia local prolongada após administração a um indivíduo, e, uso de bupivacaína, acetato isobutirato de sacarose e álcool benzílico
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
PL2117521T3 (pl) 2006-11-03 2012-11-30 Durect Corp Transdermalne systemy dostarczania zawierające bupiwakainę
WO2009075782A1 (fr) * 2007-12-06 2009-06-18 Durect Corporation Procédés utiles dans le traitement de la douleur, d'états rhumatismaux ou d'inflammations associées à un état chronique
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法
CA2905131A1 (fr) 2013-03-15 2014-09-18 Durect Corporation Compositions ayant un agent de modification rheologique pour reduire une variabilite de dissolution
CN103664744B (zh) * 2013-11-30 2015-07-15 山东永泰化工有限公司 一种左布比卡因的制备方法
US12274794B2 (en) 2016-07-06 2025-04-15 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
EP3793966A1 (fr) * 2018-05-18 2021-03-24 Kura Oncology, Inc. Synthèse de tipifarnib
CA3167217A1 (fr) 2020-01-13 2021-07-22 Durect Corporation Systemes d'administration de medicament a liberation prolongee avec impuretes reduites et procedes associes
CN116940358A (zh) 2021-01-12 2023-10-24 度勒科特公司 持续释放药物递送系统和有关的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Also Published As

Publication number Publication date
HU216291B (hu) 1999-06-28
US5786484A (en) 1998-07-28
HUT77055A (hu) 1998-03-02
CN1104416C (zh) 2003-04-02
DK0782569T3 (da) 2002-07-22
JP3898220B2 (ja) 2007-03-28
FI117436B (fi) 2006-10-13
DE69525950D1 (de) 2002-04-25
DE69525950T2 (de) 2002-09-19
MX9702210A (es) 1998-05-31
ATE214695T1 (de) 2002-04-15
PL183204B1 (pl) 2002-06-28
FI971202A0 (fi) 1997-03-21
PL319368A1 (en) 1997-08-04
EP0782569A1 (fr) 1997-07-09
AU3527995A (en) 1996-04-09
CA2200490A1 (fr) 1996-03-28
ES2173194T3 (es) 2002-10-16
NO971358D0 (no) 1997-03-21
AU695479B2 (en) 1998-08-13
WO1996009290A1 (fr) 1996-03-28
EP0782569B1 (fr) 2002-03-20
CN1159184A (zh) 1997-09-10
FI971202L (fi) 1997-03-21
PT782569E (pt) 2002-09-30
CA2200490C (fr) 2007-01-09
KR100393133B1 (ko) 2003-11-17
JPH10505855A (ja) 1998-06-09
NO971358L (no) 1997-03-21

Similar Documents

Publication Publication Date Title
DE69525950D1 (de) Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen
ATE204162T1 (de) Verfahren zur herstellung von wirkstoffzubereitungen in form einer festen lösung des wirkstoffs in einer polymermatrix
DE69520920D1 (de) Optisches Informationsmedium, sowie Einheit und Verfahren zu dessen Herstellung
DE69531624D1 (de) Verfahren zur herstellung von levobupivacaine und analoge
DE69527617D1 (de) Verfahren zur racematspaltung von etodolac unter verwendung von glucamin-derivaten
GEP20022798B (en) Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline
DK0804417T3 (da) Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler
DE69727977D1 (de) Verfahren zur simultanen herstellung von acrylnitril und acrylsäure
ATE182879T1 (de) Neuartig substituierte dtpa-derivate, deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie, sowie verfahren zur herstellung der komplexe und mittel
BR9509176A (pt) Processo de preparação de ácidos 4-metiltio butíricos substituídos alpha racêmicos
ATE206407T1 (de) Verfahren zur herstellung von hiv proteasinhibitoren
DE69506900D1 (de) Enzymatisches verfahren zur herstellung von chiralen alpha-tertiären carbonsäureestern
ATE111455T1 (de) 3-substituierte 1,2,3,4-oxatriazol-5- iminderivate, verfahren zur herstellung sowie diese enthaltende arzneimittel.
DE69507355D1 (de) Verfahren zur Herstellung von optisch aktiven Carbonsäuren sowie chirale Liganten hierfür
DE69717076D1 (de) Verfahren zur herstellung von galanthanin
ATE370242T1 (de) Verfahren zur herstellung von dipeptiden
DE69607113D1 (de) Verfahren zur Racemisierung von optisch aktiven 1-Phenylethylamin-Derivaten
ATE218545T1 (de) Verfahren zur herstellung von enantiomerisch angereicherten n-acylazetidin-2-carbonsäuren
DE69526519D1 (de) Silylierungsprocess
DE59604613D1 (de) Verfahren zur herstellung von optisch aktiven alpha-aminosäuren und alpha-aminosäure-derivaten
DK0808306T3 (da) Hidtil ukendte pyridin- eller pyridazinderivater, fremgangsmåder til fremstilling deraf og lægemidler indeholdende disse fo
ATE288901T1 (de) Verfahren zur herstellung von 5-hydroxymethyl-2- oxazolidinon und neues zwischenprodukt
DE59808082D1 (de) Verfahren zur herstellung von langkettigen glycin-n,n-diessigsäure-derivaten
DE3769442D1 (de) Neues verfahren zur herstellung von optisch aktiven carbacyclin-zwischenprodukten.
DK0784603T3 (da) Racemisering af forstadier for levobupivacain og analoge forstadier heraf

Legal Events

Date Code Title Description
MK1K Patent expired