NO314761B1 - Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav - Google Patents

Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav Download PDF

Info

Publication number: NO314761B1
Authority: NO; Norway
Prior art keywords: acid; salt according; iron; salt; bile acid
Prior art date: 1997-10-09

Application number

NO20001812A

Other languages

English (en)

Norwegian (no)

Other versions

NO20001812L (no

NO20001812D0 (no

Inventor

Beniamino Palmieri

Alessandro Medici

Enzo Bartoli

Original Assignee

Alessandro Medici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-09

Filing date

2000-04-07

Publication date

2003-05-19

2000-04-07 Application filed by Alessandro Medici filed Critical Alessandro Medici

2000-04-07 Priority to NO20001812A priority Critical patent/NO314761B1/no

2000-04-07 Publication of NO20001812L publication Critical patent/NO20001812L/no

2000-04-07 Publication of NO20001812D0 publication Critical patent/NO20001812D0/no

2003-05-19 Publication of NO314761B1 publication Critical patent/NO314761B1/no

Links

229910052751 metal Inorganic materials 0.000 title claims abstract description 11
239000002184 metal Substances 0.000 title claims abstract description 11
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title claims abstract description 9
230000001225 therapeutic effect Effects 0.000 title abstract description 4
150000002739 metals Chemical class 0.000 title description 3
230000001766 physiological effect Effects 0.000 title 1
150000003839 salts Chemical class 0.000 claims abstract description 22
239000003613 bile acid Substances 0.000 claims abstract description 14
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 21
239000002253 acid Substances 0.000 claims description 10
229910052742 iron Inorganic materials 0.000 claims description 9
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims description 4
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 4
KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims description 4
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 3
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
229910017052 cobalt Inorganic materials 0.000 claims description 3
239000010941 cobalt Substances 0.000 claims description 3
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 3
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 3
229910052750 molybdenum Inorganic materials 0.000 claims description 3
239000011733 molybdenum Substances 0.000 claims description 3
229910052711 selenium Inorganic materials 0.000 claims description 3
239000011669 selenium Substances 0.000 claims description 3
229910052725 zinc Inorganic materials 0.000 claims description 3
239000011701 zinc Substances 0.000 claims description 3
BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims description 2
RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 2
239000004380 Cholic acid Substances 0.000 claims description 2
VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical compound [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 claims description 2
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 2
DGABKXLVXPYZII-UHFFFAOYSA-N Hyodeoxycholic acid Natural products C1C(O)C2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 DGABKXLVXPYZII-UHFFFAOYSA-N 0.000 claims description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 2
JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 2
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
229960001091 chenodeoxycholic acid Drugs 0.000 claims description 2
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 claims description 2
BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 2
229960002471 cholic acid Drugs 0.000 claims description 2
235000019416 cholic acid Nutrition 0.000 claims description 2
QYQADNCHXSEGJT-UHFFFAOYSA-N cyclohexane-1,1-dicarboxylate;hydron Chemical compound OC(=O)C1(C(O)=O)CCCCC1 QYQADNCHXSEGJT-UHFFFAOYSA-N 0.000 claims description 2
KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims description 2
229960003964 deoxycholic acid Drugs 0.000 claims description 2
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
229910052737 gold Inorganic materials 0.000 claims description 2
239000010931 gold Substances 0.000 claims description 2
DGABKXLVXPYZII-SIBKNCMHSA-N hyodeoxycholic acid Chemical compound C([C@H]1[C@@H](O)C2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 DGABKXLVXPYZII-SIBKNCMHSA-N 0.000 claims description 2
125000000468 ketone group Chemical group 0.000 claims description 2
229910052759 nickel Inorganic materials 0.000 claims description 2
239000008194 pharmaceutical composition Substances 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
229910052697 platinum Inorganic materials 0.000 claims description 2
235000002906 tartaric acid Nutrition 0.000 claims description 2
239000011975 tartaric acid Substances 0.000 claims description 2
239000011135 tin Substances 0.000 claims description 2
229910052718 tin Inorganic materials 0.000 claims description 2
RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims description 2
229960001661 ursodiol Drugs 0.000 claims description 2
229910052720 vanadium Inorganic materials 0.000 claims description 2
229940126601 medicinal product Drugs 0.000 claims 2
VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
239000012050 conventional carrier Substances 0.000 claims 1
238000002560 therapeutic procedure Methods 0.000 claims 1
LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 1
239000000203 mixture Substances 0.000 abstract description 7
208000007502 anemia Diseases 0.000 abstract 1
150000001768 cations Chemical class 0.000 description 4
-1 constipation Chemical class 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000007796 conventional method Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
BQQVEASFNMRTBA-UHFFFAOYSA-N 2-[4-(3-aminopropyl)piperazin-1-yl]ethanol Chemical compound NCCCN1CCN(CCO)CC1 BQQVEASFNMRTBA-UHFFFAOYSA-N 0.000 description 1
OHXPGWPVLFPUSM-KLRNGDHRSA-N 3,7,12-trioxo-5beta-cholanic acid Chemical compound C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC(O)=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C OHXPGWPVLFPUSM-KLRNGDHRSA-N 0.000 description 1
206010000087 Abdominal pain upper Diseases 0.000 description 1
206010010774 Constipation Diseases 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
206010022971 Iron Deficiencies Diseases 0.000 description 1
229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
208000002720 Malnutrition Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
239000002775 capsule Substances 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
150000003841 chloride salts Chemical class 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
230000002950 deficient Effects 0.000 description 1
229960002997 dehydrocholic acid Drugs 0.000 description 1
229940009976 deoxycholate Drugs 0.000 description 1
230000037213 diet Effects 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
235000015872 dietary supplement Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
206010016766 flatulence Diseases 0.000 description 1
238000009472 formulation Methods 0.000 description 1
159000000014 iron salts Chemical class 0.000 description 1
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
238000005907 ketalization reaction Methods 0.000 description 1
229910000000 metal hydroxide Inorganic materials 0.000 description 1
150000004692 metal hydroxides Chemical class 0.000 description 1
238000000034 method Methods 0.000 description 1
235000018343 nutrient deficiency Nutrition 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000004064 recycling Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
108091005992 succinylated proteins Proteins 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20001812A 1997-10-09 2000-04-07 Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav NO314761B1 (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO20001812A NO314761B1 (no)	1997-10-09	2000-04-07	Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/EP1997/005555 WO1999019342A1 (fr)	1997-10-09	1997-10-09	Sels d'acides biliaires de metaux comportant une action physiologique, et utilisation de ceux-ci en therapie
NO20001812A NO314761B1 (no)	1997-10-09	2000-04-07	Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav

Publications (3)

Publication Number	Publication Date
NO20001812L NO20001812L (no)	2000-04-07
NO20001812D0 NO20001812D0 (no)	2000-04-07
NO314761B1 true NO314761B1 (no)	2003-05-19

Family

ID=8166756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20001812A NO314761B1 (no)	1997-10-09	2000-04-07	Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav

Country Status (13)

Country	Link
US (1)	US6342489B1 (fr)
EP (1)	EP1023314B1 (fr)
JP (1)	JP2001519438A (fr)
AT (1)	ATE232541T1 (fr)
AU (1)	AU747019B2 (fr)
CA (1)	CA2305764C (fr)
DE (1)	DE69719095T2 (fr)
DK (1)	DK1023314T3 (fr)
ES (1)	ES2191825T3 (fr)
IL (2)	IL135499A0 (fr)
NO (1)	NO314761B1 (fr)
NZ (1)	NZ503800A (fr)
WO (1)	WO1999019342A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060127468A1 (en)	2004-05-19	2006-06-15	Kolodney Michael S	Methods and related compositions for reduction of fat and skin tightening
US8101593B2 (en)	2009-03-03	2012-01-24	Kythera Biopharmaceuticals, Inc.	Formulations of deoxycholic acid and salts thereof
WO2012097155A1 (fr) *	2011-01-14	2012-07-19	Chiasma Inc.	Compositions pharmaceutiques améliorées utilisables en vue de l'administration de composés de fer ferrique et leurs procédés d'utilisation
MX363465B (es)	2011-02-18	2019-03-25	Kythera Biopharmaceuticals Inc	Tratamiento de la grasa submental.
US8653058B2 (en)	2011-04-05	2014-02-18	Kythera Biopharmaceuticals, Inc.	Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1468922A1 (de) *	1965-06-30	1969-06-19	Riedel De Haen Ag	Verfahren zur Herstellung choleretisch wirksamer Derivate der 3-alpha-Hydroxy-7,12-diketocholansaeure
US3620831A (en) *	1968-12-30	1971-11-16	Honeywell Inc	Electrographic recording medium
GB1592791A (en) *	1977-01-07	1981-07-08	Radiochemical Centre Ltd	Selenium- or tellurium-containing bile acids and derivatives thereof
US5079240A (en) *	1990-03-15	1992-01-07	The Regents Of The University Of California	Synthetic conjugated bile acid and method of use thereof
US5174897A (en) *	1991-09-24	1992-12-29	The United States Of America As Represented By The Secretary Of Agriculture	Constructed wetlands to control nonpoint source pollution
US5578304A (en) *	1992-06-22	1996-11-26	Digestive Care Inc.	Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5460812A (en) *	1992-06-22	1995-10-24	Digestive Care Inc.	Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5415872A (en) *	1992-06-22	1995-05-16	Digestive Care Inc.	Compositions of gastric acid-resistant microspheres containing salts of bile acids

1997
- 1997-10-09 DE DE69719095T patent/DE69719095T2/de not_active Expired - Fee Related
- 1997-10-09 EP EP97909372A patent/EP1023314B1/fr not_active Expired - Lifetime
- 1997-10-09 NZ NZ503800A patent/NZ503800A/xx unknown
- 1997-10-09 JP JP2000515913A patent/JP2001519438A/ja active Pending
- 1997-10-09 DK DK97909372T patent/DK1023314T3/da active
- 1997-10-09 IL IL13549997A patent/IL135499A0/xx active IP Right Grant
- 1997-10-09 AT AT97909372T patent/ATE232541T1/de not_active IP Right Cessation
- 1997-10-09 ES ES97909372T patent/ES2191825T3/es not_active Expired - Lifetime
- 1997-10-09 WO PCT/EP1997/005555 patent/WO1999019342A1/fr not_active Ceased
- 1997-10-09 AU AU47081/97A patent/AU747019B2/en not_active Ceased
- 1997-10-09 CA CA002305764A patent/CA2305764C/fr not_active Expired - Fee Related
- 1997-10-09 US US09/509,891 patent/US6342489B1/en not_active Expired - Fee Related
2000
- 2000-04-06 IL IL135499A patent/IL135499A/en not_active IP Right Cessation
- 2000-04-07 NO NO20001812A patent/NO314761B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1023314T3 (da)	2003-05-12
ATE232541T1 (de)	2003-02-15
JP2001519438A (ja)	2001-10-23
US6342489B1 (en)	2002-01-29
NO20001812L (no)	2000-04-07
CA2305764A1 (fr)	1999-04-22
DE69719095D1 (de)	2003-03-20
NZ503800A (en)	2001-03-30
NO20001812D0 (no)	2000-04-07
IL135499A0 (en)	2001-05-20
AU4708197A (en)	1999-05-03
CA2305764C (fr)	2008-04-08
EP1023314B1 (fr)	2003-02-12
EP1023314A1 (fr)	2000-08-02
HK1032064A1 (en)	2001-07-06
DE69719095T2 (de)	2003-07-24
AU747019B2 (en)	2002-05-09
ES2191825T3 (es)	2003-09-16
WO1999019342A1 (fr)	1999-04-22
IL135499A (en)	2006-10-31

Legal Events

Date	Code	Title	Description
2010-05-31	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
US7375243B2 (en)	2008-05-20	Method for preparation of amino acid chelate
US4225592A (en)	1980-09-30	Complexes of oligo- and polygalacturonic acids formed with essential metal ions and pharmaceutical preparations containing the same
AU2010249227B2 (en)	2011-06-30	Controlled release composition containing a strontium salt
US5075499A (en)	1991-12-24	Calcium supplementation by dicalcium citrate-lactate
NO172273B (no)	1993-03-22	Fremgangsmaate for fremstilling av flytende kalsiumsupplement
ES2236300T3 (es)	2005-07-16	Composiciones de hierro.
EP0293751B1 (fr)	1993-02-10	Acide taurohyodeoxycholique pour la thérapie du calcul du canal biliaire et de la dyspepsie biliaire
NO314761B1 (no)	2003-05-19	Gallesyresalter av metaller med fysiologisk virkning, samt terapeutisk anvendelse derav
CA3182363A1 (fr)	2021-11-11	Composition de prevention et de traitement d'etats de carence en folate et/ou vitamine b12, particulierement d'hyperhomocysteinemie
US20040048925A1 (en)	2004-03-11	Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US3591687A (en)	1971-07-06	Bile acids and derivatives thereof as anorectic agents
JPH0998738A (ja)	1997-04-15	易吸収性カルシウム組成物
JPH09121811A (ja)	1997-05-13	易吸収性カルシウム組成物
MXPA00003406A (en)	2001-12-04	Bile acid salts of metals with physiological action and the use thereof in therapy
CN1153778C (zh)	2004-06-16	具有生理作用的胆汁酸金属盐及其在治疗中的应用
JP3348849B2 (ja)	2002-11-20	３−ヒドロキシ−４−ピロンのガリウム錯体の医薬組成物
EP0426098B1 (fr)	1994-06-08	Agent liant de phosphate pour l'administration orale
ES2276834T3 (es)	2007-07-01	Compuestos que comprenden una fraccion de fitosterol y/o de fitostanol y acido ascorbico y su utilizacion como agentes reguladores de peso.
HK1032064B (en)	2005-03-18	Bile acid salts of metals with physiological action and the use thereof in therapy
CN109311837A (zh)	2019-02-05	用于由氢氧化亚铁产生麦芽酚铁组合物的方法
ITMI960708A1 (it)	1997-10-12	Sali metallici di acidi biliari e loro uso in terapia
JPH11255642A (ja)	1999-09-21	骨組織傷害の予防又は処置のため及び骨構造要素の強化のための医薬品ならびに該医薬品の製法
JPH04266822A (ja)	1992-09-22	システノール酸又はその胆汁酸抱合体を含有する血中コレステロール低下剤
ES2247725T3 (es)	2006-03-01	Reduccion del colesterol en sangre mediante la precipitacion in vivo de constituyentes de la bilis con sustancias metalicas de los grupos ii o iii.
JPH11346714A (ja)	1999-12-21	特異選択的脂質吸着組成物