NO319497B1 - Ekspresjonssystem for fremstilling av apolipoprotein AI-M - Google Patents

Ekspresjonssystem for fremstilling av apolipoprotein AI-M Download PDF

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Publication number
NO319497B1
NO319497B1 NO19952297A NO952297A NO319497B1 NO 319497 B1 NO319497 B1 NO 319497B1 NO 19952297 A NO19952297 A NO 19952297A NO 952297 A NO952297 A NO 952297A NO 319497 B1 NO319497 B1 NO 319497B1
Authority
NO
Norway
Prior art keywords
apo
apolipoprotein
cultivation
approx
medium
Prior art date
Application number
NO19952297A
Other languages
English (en)
Norwegian (no)
Other versions
NO952297L (no
NO952297D0 (no
Inventor
Erik Holmgren
Mats Lake
Lars Abrahmsen
Christina Kalderen
Ase Mikaelsson
Torsten Sejlitz
Original Assignee
Esperion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esperion Therapeutics Inc filed Critical Esperion Therapeutics Inc
Publication of NO952297L publication Critical patent/NO952297L/no
Publication of NO952297D0 publication Critical patent/NO952297D0/no
Publication of NO319497B1 publication Critical patent/NO319497B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
NO19952297A 1992-12-11 1995-06-09 Ekspresjonssystem for fremstilling av apolipoprotein AI-M NO319497B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9203753A SE9203753D0 (sv) 1992-12-11 1992-12-11 Expression system for producing apolipoprotein ai-m
PCT/SE1993/001061 WO1994013819A1 (fr) 1992-12-11 1993-12-09 Systeme d'expression permettant de produire une apolipoproteine ai-m

Publications (3)

Publication Number Publication Date
NO952297L NO952297L (no) 1995-06-09
NO952297D0 NO952297D0 (no) 1995-06-09
NO319497B1 true NO319497B1 (no) 2005-08-22

Family

ID=20388112

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19952297A NO319497B1 (no) 1992-12-11 1995-06-09 Ekspresjonssystem for fremstilling av apolipoprotein AI-M

Country Status (22)

Country Link
US (1) US5721114A (fr)
EP (1) EP0677109B1 (fr)
JP (1) JP3899121B2 (fr)
AT (1) ATE191930T1 (fr)
AU (1) AU5663794A (fr)
CA (1) CA2150928C (fr)
CZ (1) CZ290865B6 (fr)
DE (1) DE69328442T2 (fr)
DK (1) DK0677109T3 (fr)
ES (1) ES2146646T3 (fr)
FI (1) FI952847A7 (fr)
GR (1) GR3033966T3 (fr)
HU (1) HU220193B (fr)
IL (1) IL107896A (fr)
MX (1) MX9307855A (fr)
NO (1) NO319497B1 (fr)
PL (1) PL175955B1 (fr)
PT (1) PT677109E (fr)
SE (1) SE9203753D0 (fr)
SK (1) SK76695A3 (fr)
WO (1) WO1994013819A1 (fr)
ZA (1) ZA939266B (fr)

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SE9603068D0 (sv) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603303D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
US6306433B1 (en) 1997-08-12 2001-10-23 Pharmacia Ab Method of preparing pharmaceutical compositions
US6004925A (en) 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6518412B1 (en) 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6037323A (en) * 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
CN1297932A (zh) * 1999-11-30 2001-06-06 上海博容基因开发有限公司 一种新的多肽——人脂蛋白前体蛋白信号肽11和编码这种多肽的多核苷酸
US20020064820A1 (en) * 2000-03-13 2002-05-30 Jean-Michel Dayer Apo-A-I regulation of T-cell signaling
WO2002038609A2 (fr) * 2000-11-10 2002-05-16 Proteopharma Aps Analogues d'apolipoproteine
US7217785B2 (en) * 2001-05-09 2007-05-15 The Regents Of The University Of California Cysteine-containing peptides having antioxidant properties
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US20030229062A1 (en) * 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
US7470659B2 (en) * 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US7223726B2 (en) * 2002-01-14 2007-05-29 The Regents Of The University Of California Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same
US20100204103A1 (en) * 2002-05-08 2010-08-12 The Regents Of The University Of California Helical synthetic peptides that stimulate cellular cholesterol efflux
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EP1706131A4 (fr) * 2003-12-15 2009-08-12 Univ California Peptides synthetiques helicoidaux stimulant la sortie du cholesterol des cellules
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DE68917379T2 (de) * 1988-05-31 1994-12-01 Mitsubishi Chem Ind Verfahren zur Herstellung von Proteinen, die ähnlich dem natürlich-menschlichen Apolipoprotein-E sind.
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Also Published As

Publication number Publication date
US5721114A (en) 1998-02-24
AU5663794A (en) 1994-07-04
SK76695A3 (en) 1996-02-07
CZ148795A3 (en) 1996-01-17
WO1994013819A1 (fr) 1994-06-23
JP3899121B2 (ja) 2007-03-28
CA2150928A1 (fr) 1994-06-23
JPH08506723A (ja) 1996-07-23
NO952297L (no) 1995-06-09
EP0677109A1 (fr) 1995-10-18
PL175955B1 (pl) 1999-03-31
HU9501680D0 (en) 1995-08-28
PT677109E (pt) 2000-07-31
IL107896A0 (en) 1994-04-12
DE69328442D1 (de) 2000-05-25
MX9307855A (es) 1994-06-30
ATE191930T1 (de) 2000-05-15
CZ290865B6 (cs) 2002-11-13
CA2150928C (fr) 2005-02-08
HU220193B (hu) 2001-11-28
HUT71697A (en) 1996-01-29
GR3033966T3 (en) 2000-11-30
IL107896A (en) 2004-06-01
SE9203753D0 (sv) 1992-12-11
ES2146646T3 (es) 2000-08-16
DK0677109T3 (da) 2000-07-17
NO952297D0 (no) 1995-06-09
ZA939266B (en) 1994-08-08
FI952847A0 (fi) 1995-06-09
PL309292A1 (en) 1995-10-02
FI952847L (fi) 1995-06-09
DE69328442T2 (de) 2000-09-07
EP0677109B1 (fr) 2000-04-19
FI952847A7 (fi) 1995-06-09

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