NO319790B1 - Substituerte fenyletylsulfoner og fremgangsmate for reduksjon av TNF<alfa>-nivaene - Google Patents

Substituerte fenyletylsulfoner og fremgangsmate for reduksjon av TNF<alfa>-nivaene Download PDF

Info

Publication number: NO319790B1
Authority: NO; Norway
Prior art keywords: ethoxy; methoxyphenyl; methylsulfonylethyl; dione; isoindoline
Prior art date: 1998-10-30

Application number

NO20012021A

Other languages

English (en)

Norwegian (no)

Other versions

NO20012021D0 (no

NO20012021L (no

Inventor

George W Muller

Hon-Wah Man

Original Assignee

Celgene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-30

Filing date

2001-04-24

Publication date

2005-09-12

2001-04-24 Application filed by Celgene Corp filed Critical Celgene Corp

2001-04-24 Publication of NO20012021D0 publication Critical patent/NO20012021D0/no

2001-06-26 Publication of NO20012021L publication Critical patent/NO20012021L/no

2005-09-12 Publication of NO319790B1 publication Critical patent/NO319790B1/no

Links

238000000034 method Methods 0.000 title description 15
VBQUDDWATQWCPP-UHFFFAOYSA-N ethylsulfonylbenzene Chemical class CCS(=O)(=O)C1=CC=CC=C1 VBQUDDWATQWCPP-UHFFFAOYSA-N 0.000 title description 3
230000009467 reduction Effects 0.000 title description 2
241000124008 Mammalia Species 0.000 claims abstract description 7
BHJUWEUNUCJYER-UHFFFAOYSA-N 4-amino-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindole-1,3-dione Chemical group C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(N)C=CC=C3C2=O)=O)=C1 BHJUWEUNUCJYER-UHFFFAOYSA-N 0.000 claims abstract description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 54
108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 43
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 41
150000001875 compounds Chemical class 0.000 claims description 29
239000001257 hydrogen Substances 0.000 claims description 20
229910052739 hydrogen Inorganic materials 0.000 claims description 20
-1 methoxy, ethoxy Chemical group 0.000 claims description 19
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
125000000217 alkyl group Chemical group 0.000 claims description 11
125000004432 carbon atom Chemical group C* 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
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MQKGPVSCBKQSDG-UHFFFAOYSA-N 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-nitroisoindole-1,3-dione Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(C=CC=C3C2=O)[N+]([O-])=O)=O)=C1 MQKGPVSCBKQSDG-UHFFFAOYSA-N 0.000 claims description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
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150000003457 sulfones Chemical class 0.000 claims description 5
LKEVYMKDZMOTIM-UHFFFAOYSA-N 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindole-1,3-dione Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=CC=CC=C3C2=O)=O)=C1 LKEVYMKDZMOTIM-UHFFFAOYSA-N 0.000 claims description 4
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UMISJYALWPECMM-UHFFFAOYSA-N 2-(3-ethoxy-4-methoxyphenyl)-n,n-dimethyl-2-(3-oxo-1h-isoindol-2-yl)ethanesulfonamide Chemical compound C1=C(OC)C(OCC)=CC(C(CS(=O)(=O)N(C)C)N2C(C3=CC=CC=C3C2)=O)=C1 UMISJYALWPECMM-UHFFFAOYSA-N 0.000 claims description 3
RIKZBWUWLKCUNY-UHFFFAOYSA-N 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-3h-isoindol-1-one Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=CC=CC=C3C2)=O)=C1 RIKZBWUWLKCUNY-UHFFFAOYSA-N 0.000 claims description 3
PWWMMNXNXVWCGI-UHFFFAOYSA-N 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-methoxyisoindole-1,3-dione Chemical compound C1=C(OC)C(OCC)=CC(C(CS(C)(=O)=O)N2C(C3=C(OC)C=CC=C3C2=O)=O)=C1 PWWMMNXNXVWCGI-UHFFFAOYSA-N 0.000 claims description 3
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatment Of Water By Oxidation Or Reduction (AREA)
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NO20012021A 1998-10-30 2001-04-24 Substituerte fenyletylsulfoner og fremgangsmate for reduksjon av TNF<alfa>-nivaene NO319790B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/183,049 US6020358A (en)	1998-10-30	1998-10-30	Substituted phenethylsulfones and method of reducing TNFα levels
PCT/US1999/024376 WO2000025777A1 (fr)	1998-10-30	1999-10-19	PHENETHYLSULFONES SUBSTITUEES ET PROCEDE DE REDUCTION DES NIVEAUX DE TNF$g(a)

Publications (3)

Publication Number	Publication Date
NO20012021D0 NO20012021D0 (no)	2001-04-24
NO20012021L NO20012021L (no)	2001-06-26
NO319790B1 true NO319790B1 (no)	2005-09-12

Family

ID=22671217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20012021A NO319790B1 (no)	1998-10-30	2001-04-24	Substituerte fenyletylsulfoner og fremgangsmate for reduksjon av TNF<alfa>-nivaene

Country Status (16)

Country	Link
US (2)	US6020358A (fr)
EP (3)	EP1126839B1 (fr)
JP (1)	JP4530543B2 (fr)
AT (2)	ATE471718T1 (fr)
AU (1)	AU756308B2 (fr)
BR (2)	BRPI9915201B8 (fr)
CA (1)	CA2348993C (fr)
CY (3)	CY1107499T1 (fr)
DE (2)	DE69934708T2 (fr)
DK (3)	DK2305248T3 (fr)
ES (3)	ES2343744T3 (fr)
HK (1)	HK1038696B (fr)
NO (1)	NO319790B1 (fr)
NZ (1)	NZ511253A (fr)
PT (3)	PT1752148E (fr)
WO (1)	WO2000025777A1 (fr)

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CY1110752T1 (el)	2015-06-10
CA2348993C (fr)	2009-12-29
WO2000025777A1 (fr)	2000-05-11
CA2348993A1 (fr)	2000-05-11
EP2305248B1 (fr)	2013-05-08
ATE350033T1 (de)	2007-01-15
BR9915201A (pt)	2001-10-30
CY1114304T1 (el)	2016-08-31
ES2343744T3 (es)	2010-08-09
BRPI9915201A (pt)	2001-10-30
HK1103224A1 (en)	2007-12-14
DK1126839T3 (da)	2007-05-14
JP2002528496A (ja)	2002-09-03
DE69934708D1 (de)	2007-02-15
NZ511253A (en)	2003-02-28
EP1126839B1 (fr)	2007-01-03
JP4530543B2 (ja)	2010-08-25
EP2305248A1 (fr)	2011-04-06
BRPI9915201B8 (pt)	2021-07-06
HK1038696B (en)	2007-08-03
EP1752148A2 (fr)	2007-02-14
ATE471718T1 (de)	2010-07-15
DK1752148T3 (da)	2010-09-27
ES2421153T3 (es)	2013-08-29
DK2305248T3 (da)	2013-07-29
CY1107499T1 (el)	2013-03-13
ES2278467T3 (es)	2007-08-01
BRPI9915201B1 (pt)	2012-02-22
NO20012021D0 (no)	2001-04-24
DE69934708T2 (de)	2007-10-18
US6011050A (en)	2000-01-04
EP1752148A3 (fr)	2007-03-14
NO20012021L (no)	2001-06-26
AU756308B2 (en)	2003-01-09
PT1752148E (pt)	2010-09-28
US6020358A (en)	2000-02-01
PT1126839E (pt)	2007-03-30
DE69942532D1 (de)	2010-08-05
PT2305248E (pt)	2013-08-22
HK1038696A1 (en)	2002-03-28
EP1752148B1 (fr)	2010-06-23
EP1126839A1 (fr)	2001-08-29
AU1447200A (en)	2000-05-22
EP1126839A4 (fr)	2004-10-27

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Date	Code	Title	Description
2019-11-04	MK1K	Patent expired

Publication	Publication Date	Title
NO319790B1 (no)	2005-09-12	Substituerte fenyletylsulfoner og fremgangsmate for reduksjon av TNF<alfa>-nivaene
EP1462449B9 (fr)	2010-03-10	1,3,4-Oxadiazoles substitués et un procédé de réduction des taux de TNF-alpha
US5798368A (en)	1998-08-25	Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
NO323515B1 (no)	2007-06-04	Substituerte acylhydroksamsyrer samt fremgangsmate for a redusere tnftalfa-nivaet
NO320028B1 (no)	2005-10-10	Substituerte 1-Okso- og 1,3-dioksoisoindoliner og deres anvendelse i farmasoytiske preparater for a redusere inflammatoriske cykotin nivaer
NO331367B1 (no)	2011-12-12	1-okso-2-(2,6 dioksopiperidin-3-yl)-4-aminoisoindolin samt farmasoytisk sammensetning inneholdende en slik forbindelse
NO315043B1 (no)	2003-06-30	Substituerte alkanohydroxaminsyrer og fremgangsmåte for å redusere TNF-<alfa>-nivåer
SK13642000A3 (sk)	2001-04-09	2-(2,6-dioxopiperidin-3-yl)izoindolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
CZ291613B6 (cs)	2003-04-16	Nitrilové sloučeniny jako inhibitory tumor necrosis faktoru alfa, farmaceutický prostředek obsahující tyto sloučeniny a použití těchto sloučenin
AU2006200033B2 (en)	2008-08-14	Substituted phenethylsulfones and methods of reducing TNF-alpha levels
AU2003203681B2 (en)	2005-10-06	Substituted phenethylsulfones and methods of reducing TNF-alpha-levels
HK1103224B (en)	2010-12-03	Substituted phenethylsulfones for the treatment of inflammatory, infectious, immunological or malignant disease
MXPA00008645A (en)	2001-07-31	2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines
HK1069581B (en)	2009-12-04	Substituted 1,3,4-oxadiazoles and a method of reducing tnf-alpha levels