NO324706B1 - Benzodiazepinderivater, fremstilling av disse, medikament inneholdende slike forbindelser samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer - Google Patents

Benzodiazepinderivater, fremstilling av disse, medikament inneholdende slike forbindelser samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer Download PDF

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Publication number
NO324706B1
NO324706B1 NO20032208A NO20032208A NO324706B1 NO 324706 B1 NO324706 B1 NO 324706B1 NO 20032208 A NO20032208 A NO 20032208A NO 20032208 A NO20032208 A NO 20032208A NO 324706 B1 NO324706 B1 NO 324706B1
Authority
NO
Norway
Prior art keywords
benzodiazepine
triazolo
imidazo
ethyl
carboxylate
Prior art date
Application number
NO20032208A
Other languages
English (en)
Norwegian (no)
Other versions
NO20032208D0 (no
NO20032208L (no
Inventor
Juergen Wichmann
Andrew William Thomas
Raffaello Masciadri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20032208D0 publication Critical patent/NO20032208D0/no
Publication of NO20032208L publication Critical patent/NO20032208L/no
Publication of NO324706B1 publication Critical patent/NO324706B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20032208A 2000-11-16 2003-05-15 Benzodiazepinderivater, fremstilling av disse, medikament inneholdende slike forbindelser samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer NO324706B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (3)

Publication Number Publication Date
NO20032208D0 NO20032208D0 (no) 2003-05-15
NO20032208L NO20032208L (no) 2003-05-15
NO324706B1 true NO324706B1 (no) 2007-12-03

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032208A NO324706B1 (no) 2000-11-16 2003-05-15 Benzodiazepinderivater, fremstilling av disse, medikament inneholdende slike forbindelser samt anvendelse av disse for fremstilling av medikament for behandling av sykdommer

Country Status (40)

Country Link
US (1) US6743789B2 (es)
EP (1) EP1337535B1 (es)
JP (1) JP4088151B2 (es)
KR (1) KR100504300B1 (es)
CN (1) CN1191255C (es)
AR (1) AR031345A1 (es)
AT (1) ATE268776T1 (es)
AU (2) AU1700702A (es)
BG (1) BG107817A (es)
BR (1) BR0115393A (es)
CA (1) CA2427576C (es)
CZ (1) CZ295256B6 (es)
DE (1) DE60103776T2 (es)
DK (1) DK1337535T3 (es)
EC (1) ECSP034607A (es)
ES (1) ES2220831T3 (es)
GC (1) GC0000375A (es)
GT (1) GT200100230A (es)
HR (1) HRP20030360A2 (es)
HU (1) HUP0303281A3 (es)
IL (1) IL155813A0 (es)
JO (1) JO2359B1 (es)
MA (1) MA26962A1 (es)
MX (1) MXPA03004251A (es)
MY (1) MY141675A (es)
NO (1) NO324706B1 (es)
NZ (1) NZ525413A (es)
PA (1) PA8532401A1 (es)
PE (1) PE20020583A1 (es)
PL (1) PL362925A1 (es)
PT (1) PT1337535E (es)
RU (1) RU2278865C2 (es)
SI (1) SI1337535T1 (es)
SK (1) SK7232003A3 (es)
TR (1) TR200402073T4 (es)
TW (1) TWI239333B (es)
UY (1) UY27026A1 (es)
WO (1) WO2002040487A2 (es)
YU (1) YU35603A (es)
ZA (1) ZA200303435B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1634879A4 (en) * 2003-06-19 2007-09-05 Daiichi Seiyaku Co METHOD FOR THE SELECTIVE INTRODUCTION OF AN AMINO SUBSTITUENT
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
RU2007112675A (ru) * 2004-10-12 2008-11-20 Ф.Хоффманн-Ля Рош Аг (Ch) ПРОИЗВОДНЫЕ ИМИДАЗО[1,5-a]ТРИАЗОЛО[1,5-d]БЕНЗОДИАЗЕПИНА ДЛЯ ЛЕЧЕНИЯ КОГНИТИВНЫХ РАССТРОЙСТВ
AU2005299031B2 (en) 2004-10-20 2011-11-10 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
MX2007004639A (es) * 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de imidazo-benzodiazepina.
EP1828194B1 (en) 2004-12-14 2008-05-28 F. Hoffmann-Roche AG Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
EP2682481A3 (en) * 2005-08-03 2014-09-17 The Johns-Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
BRPI0617204A2 (pt) 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
RU2510397C2 (ru) 2008-11-18 2014-03-27 Ф. Хоффманн-Ля Рош Аг Алкилциклогексиловые эфиры дигидротетраазабензоазуленов
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
EP3034079B1 (en) 2010-11-15 2018-01-10 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014047413A1 (en) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
NZ760341A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX392119B (es) 2015-06-19 2025-03-11 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo
US10059718B2 (en) 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
CN112601749B (zh) * 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (es) * 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
US6743789B2 (en) 2004-06-01
DE60103776T2 (de) 2005-07-14
NO20032208D0 (no) 2003-05-15
JO2359B1 (en) 2006-12-12
SK7232003A3 (en) 2004-03-02
GC0000375A (en) 2007-03-31
BG107817A (bg) 2004-07-30
CA2427576C (en) 2007-11-06
EP1337535B1 (en) 2004-06-09
UY27026A1 (es) 2002-06-20
SI1337535T1 (en) 2004-10-31
CZ295256B6 (cs) 2005-06-15
JP2004517070A (ja) 2004-06-10
RU2003116895A (ru) 2005-02-20
ZA200303435B (en) 2004-08-05
KR100504300B1 (ko) 2005-07-28
PA8532401A1 (es) 2002-08-26
HRP20030360A2 (en) 2005-04-30
MXPA03004251A (es) 2003-09-22
AU1700702A (en) 2002-05-27
CN1474820A (zh) 2004-02-11
PL362925A1 (en) 2004-11-02
ES2220831T3 (es) 2004-12-16
CA2427576A1 (en) 2002-05-23
DK1337535T3 (da) 2004-10-25
CZ20031597A3 (cs) 2003-11-12
WO2002040487A2 (en) 2002-05-23
ECSP034607A (es) 2003-06-25
MA26962A1 (fr) 2004-12-20
EP1337535A2 (en) 2003-08-27
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
AR031345A1 (es) 2003-09-17
BR0115393A (pt) 2004-07-06
DE60103776D1 (de) 2004-07-15
PT1337535E (pt) 2004-09-30
RU2278865C2 (ru) 2006-06-27
CN1191255C (zh) 2005-03-02
HK1062442A1 (en) 2004-11-05
HUP0303281A3 (en) 2005-05-30
WO2002040487A3 (en) 2002-09-26
US20020103371A1 (en) 2002-08-01
GT200100230A (es) 2002-07-04
ATE268776T1 (de) 2004-06-15
TWI239333B (en) 2005-09-11
PE20020583A1 (es) 2002-07-06
KR20030045192A (ko) 2003-06-09
MY141675A (en) 2010-06-15
IL155813A0 (en) 2003-12-23
HUP0303281A2 (hu) 2004-01-28
AU2002217007B2 (en) 2006-11-30
NO20032208L (no) 2003-05-15
JP4088151B2 (ja) 2008-05-21
YU35603A (sh) 2006-05-25

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