NO327751B1 - Fotosensibilisator og fremgangsmate for fremstilling av samme - Google Patents

Fotosensibilisator og fremgangsmate for fremstilling av samme Download PDF

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Publication number
NO327751B1
NO327751B1 NO20034344A NO20034344A NO327751B1 NO 327751 B1 NO327751 B1 NO 327751B1 NO 20034344 A NO20034344 A NO 20034344A NO 20034344 A NO20034344 A NO 20034344A NO 327751 B1 NO327751 B1 NO 327751B1
Authority
NO
Norway
Prior art keywords
solution
chlorin
mixture
purpurin
chlorine
Prior art date
Application number
NO20034344A
Other languages
English (en)
Norwegian (no)
Other versions
NO20034344D0 (no
NO20034344L (no
Inventor
Andrei Valentinovich Reshetnikov
Igor Dmitrievich Zalevksky
Jury Viktorovich Kemov
Andrei Valentinovich Ivanov
Artashes Vacheevich Karmenyan
Alexandr Tikhonovic Gradjushko
Vladimir Petrovich Laptev
Nataliya Petrovna Neugodova
Olga Yurievna Abakumova
Valery Alexeevich Privalov
Alexandr Vladimirovich Lappa
Vladimir Alexandrovich Romanov
Original Assignee
Obschestvo S Ogranichennoi Otv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Obschestvo S Ogranichennoi Otv filed Critical Obschestvo S Ogranichennoi Otv
Publication of NO20034344D0 publication Critical patent/NO20034344D0/no
Publication of NO20034344L publication Critical patent/NO20034344L/no
Publication of NO327751B1 publication Critical patent/NO327751B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Light Receiving Elements (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO20034344A 2001-03-30 2003-09-29 Fotosensibilisator og fremgangsmate for fremstilling av samme NO327751B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2001108397/14A RU2183956C1 (ru) 2001-03-30 2001-03-30 Фотосенсибилизатор и способ его получения
PCT/RU2001/000399 WO2002078694A1 (en) 2001-03-30 2001-10-04 Photosensitiser and method for production thereof

Publications (3)

Publication Number Publication Date
NO20034344D0 NO20034344D0 (no) 2003-09-29
NO20034344L NO20034344L (no) 2003-11-21
NO327751B1 true NO327751B1 (no) 2009-09-14

Family

ID=20247772

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034344A NO327751B1 (no) 2001-03-30 2003-09-29 Fotosensibilisator og fremgangsmate for fremstilling av samme

Country Status (23)

Country Link
US (2) US6969765B2 (cs)
EP (1) EP1380295B1 (cs)
KR (1) KR100628548B1 (cs)
CN (1) CN1250294C (cs)
AT (1) ATE426403T1 (cs)
AU (1) AU2002212867B2 (cs)
BG (1) BG108534A (cs)
BR (1) BR0116952A (cs)
CA (1) CA2440650C (cs)
CZ (1) CZ304591B6 (cs)
DE (1) DE60138141D1 (cs)
GB (1) GB2389531B (cs)
HR (1) HRP20030876B1 (cs)
HU (1) HU227756B1 (cs)
MX (1) MXPA03008925A (cs)
NO (1) NO327751B1 (cs)
NZ (1) NZ528237A (cs)
PL (1) PL206902B1 (cs)
RU (1) RU2183956C1 (cs)
SI (1) SI1380295T1 (cs)
SK (1) SK287784B6 (cs)
WO (1) WO2002078694A1 (cs)
ZA (1) ZA200308407B (cs)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2228750C1 (ru) * 2002-09-13 2004-05-20 Мещерякова Аделия Леонидовна Способ получения хлорина е6
RU2228775C1 (ru) * 2002-10-01 2004-05-20 Общество с ограниченной ответственностью "РАДА-ФАРМА" Способ фотодинамического лечения острого и хронического гнойного гайморита
WO2004110438A1 (en) * 2003-06-17 2004-12-23 Peter Timofeevich Petrov Agent for photodynamic diagnosis and therapy of oncological diseases
RU2244533C1 (ru) * 2003-07-01 2005-01-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ электрохимической деструкции, хирургического удаления и фотодинамической профилактики рецидивов внутриглазных новообразований в среде перфторорганического соединения (варианты)
RU2244532C1 (ru) * 2003-07-01 2005-01-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ хирургического фотодинамического лечения субретинальных неоваскулярных мембран (варианты)
RU2243753C1 (ru) * 2003-07-01 2005-01-10 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ хирургического фотодинамического лечения хориоидальных гемангиом
RU2243748C1 (ru) * 2003-07-01 2005-01-10 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ хирургического удаления и фотодинамической профилактики рецидивов субретинальных неоваскулярных мембран
RU2243755C1 (ru) * 2003-07-01 2005-01-10 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ хирургической электрохимической деструкции и фотодинамического лечения внутриглазных новообразований
RU2244531C1 (ru) * 2003-07-01 2005-01-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им.акад. С.Н.Федорова Способ электрохимической деструкции, хирургического удаления и фотодинамической профилактики рецидивов внутриглазных новообразований (варианты)
CA2437638A1 (en) * 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
GB0323358D0 (en) * 2003-10-06 2003-11-05 Green Grass Design Ltd Novel compounds and processes
RU2256446C1 (ru) * 2003-10-22 2005-07-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Способ профилактики метастазов после хирургического удаления внутриглазных новообразований
PL368213A1 (en) * 2004-05-25 2005-11-28 ADAMED Sp.z o.o. New coupling, method for its fabrication and its application
KR100841959B1 (ko) * 2006-11-03 2008-06-27 광주과학기술원 클로로필 ａ 및 클로린 ｅ６의 제조방법
RU2345803C2 (ru) * 2006-11-30 2009-02-10 Закрытое Акционерное Общество "Исследовательские лаборатории "РАДА-ФАРМА" Способ фотоиммунотерапии фотосенсибилизатором, активируемым волновой энергией вне организма человека
RU2330037C1 (ru) * 2006-12-28 2008-07-27 Гелий Васильевич Пономарев СПОСОБ ПОЛУЧЕНИЯ ХЛОРИНА e6
KR100808630B1 (ko) * 2006-12-28 2008-02-29 광주과학기술원 클로린 화합물을 포함하는 경구투여용 항종양 조성물
CN100496516C (zh) * 2007-12-03 2009-06-10 贵州圣济堂制药有限公司 一种螺旋藻组合物及其制备方法与应用
RU2367434C1 (ru) * 2008-04-22 2009-09-20 Виктор Александрович Борисов Фотосенсибилизатор и способ его получения
RU2428175C2 (ru) * 2008-06-02 2011-09-10 Закрытое Акционерное Общество "Биокад" Способ получения парентерального фармацевтического раствора
KR100896327B1 (ko) * 2008-09-09 2009-05-07 다이아텍코리아 주식회사 스피루리나로부터 클로로필 ａ 및 클로린을 제조하는 방법
EP2431366B1 (en) 2009-04-29 2014-04-09 Diatech Korea Co., Ltd. New chlorin e6-folic acid conjugated compound, preparation method thereof, and pharmaceutical composition containing the same for treatment of cancer
KR100918810B1 (ko) 2009-04-29 2009-09-25 다이아텍코리아 주식회사 클로린 ｅ６-엽산 결합 화합물을 함유하는 암 치료용 약학적 조성물
ES2354096B1 (es) * 2009-07-27 2012-02-23 Nuevas Tecnologias Cientificas, S.A. Procedimiento para la obtencion de un fotosensibilizante para ser empleado en terapia fotodinamica y fotosensibilizante.
KR100950441B1 (ko) * 2009-09-30 2010-04-02 주식회사 아큐텍 스피루리나로부터 클로로필 ａ 및 포토디타진을 제조하는 방법
RU2428981C1 (ru) * 2010-03-31 2011-09-20 Анатолий Юрьевич Барышников Средство для фотодинамической терапии, способ получения предлагаемого средства и способ проведения фотодинамической терапии с использованием предлагаемого средства
RU2490273C1 (ru) * 2012-02-27 2013-08-20 Оскар Иосифович Койфман Способ получения метилфеофорбида (а)
RS60225B1 (sr) * 2012-12-14 2020-06-30 Rmw Cho Group Ltd Derivat hlorina koristan u fotodinamičkoj terapiji i dijagnostici
RU2523380C1 (ru) * 2013-05-21 2014-07-20 Общество с ограниченной ответственностью "ГЕЛИОХЛОРИН" Фотосенсибилизатор и способ его получения
CN105777760A (zh) * 2014-12-23 2016-07-20 深圳市中兴扬帆生物工程有限公司 四间-羟基苯基二氢卟酚原料药的保存方法
CN106349736A (zh) * 2016-08-05 2017-01-25 雷春生 一种纯有机光敏染料的制备方法
KR102357787B1 (ko) * 2016-12-14 2022-02-03 동성제약주식회사 고순도 트리소듐 클로린 e6(trisodium Chlorin e6)와 PVP (polyvinylpyrrolidone)의 복합체 제조 방법과 Chlorin e6의 제조 방법
RU2670087C1 (ru) * 2018-01-29 2018-10-18 Михаил Александрович Грин Фотосенсибилизатор для лечения рака предстательной железы и способ его получения
RU2691754C1 (ru) * 2018-11-15 2019-06-18 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" ПРОИЗВОДНОЕ ЦИНКОВОГО МЕТАЛЛОКОМПЛЕКСА ХЛОРИНА-e6 И ЕГО ПРИМЕНЕНИЕ
CN112521392A (zh) * 2019-09-18 2021-03-19 康俄(上海)医疗科技有限公司 一种二氢卟吩e6的纯化方法

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US5330741A (en) * 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors
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Also Published As

Publication number Publication date
CN1512881A (zh) 2004-07-14
BG108534A (bg) 2005-02-28
ZA200308407B (en) 2005-02-23
US20060003983A1 (en) 2006-01-05
EP1380295B1 (en) 2009-03-25
HRP20030876A2 (en) 2005-08-31
KR100628548B1 (ko) 2006-09-26
US6969765B2 (en) 2005-11-29
GB0321726D0 (en) 2003-10-15
SK13482003A3 (sk) 2004-05-04
DE60138141D1 (de) 2009-05-07
BR0116952A (pt) 2004-06-01
WO2002078694A1 (en) 2002-10-10
HU227756B1 (en) 2012-02-28
HUP0400298A2 (hu) 2004-07-28
EP1380295A4 (en) 2005-11-30
CA2440650A1 (en) 2002-10-10
RU2183956C1 (ru) 2002-06-27
AU2002212867B2 (en) 2007-07-12
US20040147499A1 (en) 2004-07-29
EP1380295A1 (en) 2004-01-14
NO20034344D0 (no) 2003-09-29
CZ304591B6 (cs) 2014-07-23
EP1380295A9 (en) 2004-04-14
NZ528237A (en) 2006-09-29
GB2389531B (en) 2005-03-16
ATE426403T1 (de) 2009-04-15
CZ20032940A3 (cs) 2004-04-14
HUP0400298A3 (en) 2007-05-29
US7550587B2 (en) 2009-06-23
CN1250294C (zh) 2006-04-12
SK287784B6 (sk) 2011-09-05
PL365102A1 (pl) 2004-12-27
GB2389531A (en) 2003-12-17
KR20040025911A (ko) 2004-03-26
PL206902B1 (pl) 2010-10-29
HRP20030876B1 (en) 2011-10-31
CA2440650C (en) 2009-09-15
MXPA03008925A (es) 2005-03-07
NO20034344L (no) 2003-11-21
SI1380295T1 (sl) 2009-10-31

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