ATE426403T1 - Photosensibilisator und verfahren zu seiner herstellung - Google Patents

Photosensibilisator und verfahren zu seiner herstellung

Info

Publication number: ATE426403T1
Authority: AT; Austria
Prior art keywords: chlorine; photosensitiser; purpurin; aceton; neutralisation
Prior art date: 2001-03-30

Application number

AT01981209T

Other languages

English (en)

Inventor

Andrei Valentinovi Reshetnikov

Igor Dmitrievich Zalevsky

Jury Viktorovich Kemov

Andrei Valentinovich Ivanov

Artashes Vacheevich Karmenyan

Alexandr Tikhonovich Gradjushko

Vladimir Petrovich Laptev

Nataliya Petrovna Neugodova

Olga Yurievna Abakumova

Valery Alexeevich Privalov

Alexandr Vladimirovich Lappa

Vladimir Alexandrovich Romanov

Original Assignee

Obschestvo S Ogranichennoi Otv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-30

Filing date

2001-10-04

Publication date

2009-04-15

2001-10-04 Application filed by Obschestvo S Ogranichennoi Otv filed Critical Obschestvo S Ogranichennoi Otv

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE426403T1 publication Critical patent/ATE426403T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000003504 photosensitizing agent Substances 0.000 title 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
229910052801 chlorine Inorganic materials 0.000 abstract 3
239000000460 chlorine Substances 0.000 abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
239000002028 Biomass Substances 0.000 abstract 2
238000006386 neutralization reaction Methods 0.000 abstract 2
BBNQQADTFFCFGB-UHFFFAOYSA-N purpurin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC(O)=C3C(=O)C2=C1 BBNQQADTFFCFGB-UHFFFAOYSA-N 0.000 abstract 2
OYINILBBZAQBEV-UWJYYQICSA-N (17s,18s)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid Chemical compound N1C2=C(C)C(C=C)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1C(O)=O)=NC1=C(CC(O)=O)C([C@@H](CCC(O)=O)[C@@H]1C)=NC1=C2 OYINILBBZAQBEV-UWJYYQICSA-N 0.000 abstract 1
235000016425 Arthrospira platensis Nutrition 0.000 abstract 1
240000002900 Arthrospira platensis Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
238000010306 acid treatment Methods 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
COWCVGUYIYQWPC-MRZQNBKKSA-N purpurin 18 Chemical compound N1C(C=C2C(=C(CC)C(C=C3C(=C4C(=C5C(=O)OC4=O)N3)C)=N2)C)=C(C=C)C(C)=C1C=C1C(C)C(CCC(=O)OCC(/C)=C/CCC(C)CCCC(C)CCCC(C)CC)C5=N1 COWCVGUYIYQWPC-MRZQNBKKSA-N 0.000 abstract 1
238000001226 reprecipitation Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940082787 spirulina Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Light Receiving Elements (AREA)
Steroid Compounds (AREA)

AT01981209T 2001-03-30 2001-10-04 Photosensibilisator und verfahren zu seiner herstellung ATE426403T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
RU2001108397/14A RU2183956C1 (ru)	2001-03-30	2001-03-30	Фотосенсибилизатор и способ его получения

Publications (1)

Publication Number	Publication Date
ATE426403T1 true ATE426403T1 (de)	2009-04-15

Family

ID=20247772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01981209T ATE426403T1 (de)	2001-03-30	2001-10-04	Photosensibilisator und verfahren zu seiner herstellung

Country Status (23)

Country	Link
US (2)	US6969765B2 (de)
EP (1)	EP1380295B1 (de)
KR (1)	KR100628548B1 (de)
CN (1)	CN1250294C (de)
AT (1)	ATE426403T1 (de)
AU (1)	AU2002212867B2 (de)
BG (1)	BG108534A (de)
BR (1)	BR0116952A (de)
CA (1)	CA2440650C (de)
CZ (1)	CZ304591B6 (de)
DE (1)	DE60138141D1 (de)
GB (1)	GB2389531B (de)
HR (1)	HRP20030876B1 (de)
HU (1)	HU227756B1 (de)
MX (1)	MXPA03008925A (de)
NO (1)	NO327751B1 (de)
NZ (1)	NZ528237A (de)
PL (1)	PL206902B1 (de)
RU (1)	RU2183956C1 (de)
SI (1)	SI1380295T1 (de)
SK (1)	SK287784B6 (de)
WO (1)	WO2002078694A1 (de)
ZA (1)	ZA200308407B (de)

Families Citing this family (35)

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RU2228750C1 (ru) *	2002-09-13	2004-05-20	Мещерякова Аделия Леонидовна	Способ получения хлорина е6
RU2228775C1 (ru) *	2002-10-01	2004-05-20	Общество с ограниченной ответственностью "РАДА-ФАРМА"	Способ фотодинамического лечения острого и хронического гнойного гайморита
WO2004110438A1 (en) *	2003-06-17	2004-12-23	Peter Timofeevich Petrov	Agent for photodynamic diagnosis and therapy of oncological diseases
RU2244533C1 (ru) *	2003-07-01	2005-01-20	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова	Способ электрохимической деструкции, хирургического удаления и фотодинамической профилактики рецидивов внутриглазных новообразований в среде перфторорганического соединения (варианты)
RU2243755C1 (ru) *	2003-07-01	2005-01-10	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова	Способ хирургической электрохимической деструкции и фотодинамического лечения внутриглазных новообразований
RU2243753C1 (ru) *	2003-07-01	2005-01-10	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова	Способ хирургического фотодинамического лечения хориоидальных гемангиом
RU2244532C1 (ru) *	2003-07-01	2005-01-20	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова	Способ хирургического фотодинамического лечения субретинальных неоваскулярных мембран (варианты)
RU2244531C1 (ru) *	2003-07-01	2005-01-20	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им.акад. С.Н.Федорова	Способ электрохимической деструкции, хирургического удаления и фотодинамической профилактики рецидивов внутриглазных новообразований (варианты)
RU2243748C1 (ru) *	2003-07-01	2005-01-10	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова	Способ хирургического удаления и фотодинамической профилактики рецидивов субретинальных неоваскулярных мембран
CA2437638A1 (en) *	2003-08-20	2005-02-20	John Robert North	Photodynamic therapy
GB0323358D0 (en) *	2003-10-06	2003-11-05	Green Grass Design Ltd	Novel compounds and processes
RU2256446C1 (ru) *	2003-10-22	2005-07-20	Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова	Способ профилактики метастазов после хирургического удаления внутриглазных новообразований
PL368213A1 (en) *	2004-05-25	2005-11-28	ADAMED Sp.z o.o.	New coupling, method for its fabrication and its application
US8349335B2 (en) *	2006-11-03	2013-01-08	Gwangju Institute Of Science And Technology	Methods for preparing chlorophyll a and chlorin e6
RU2345803C2 (ru) *	2006-11-30	2009-02-10	Закрытое Акционерное Общество "Исследовательские лаборатории "РАДА-ФАРМА"	Способ фотоиммунотерапии фотосенсибилизатором, активируемым волновой энергией вне организма человека
KR100808630B1 (ko) *	2006-12-28	2008-02-29	광주과학기술원	클로린 화합물을 포함하는 경구투여용 항종양 조성물
RU2330037C1 (ru) *	2006-12-28	2008-07-27	Гелий Васильевич Пономарев	СПОСОБ ПОЛУЧЕНИЯ ХЛОРИНА e6
CN100496516C (zh) *	2007-12-03	2009-06-10	贵州圣济堂制药有限公司	一种螺旋藻组合物及其制备方法与应用
RU2367434C1 (ru) *	2008-04-22	2009-09-20	Виктор Александрович Борисов	Фотосенсибилизатор и способ его получения
RU2428175C2 (ru) *	2008-06-02	2011-09-10	Закрытое Акционерное Общество "Биокад"	Способ получения парентерального фармацевтического раствора
KR100896327B1 (ko) *	2008-09-09	2009-05-07	다이아텍코리아 주식회사	스피루리나로부터 클로로필 ａ 및 클로린을 제조하는 방법
KR100918810B1 (ko)	2009-04-29	2009-09-25	다이아텍코리아 주식회사	클로린 ｅ６-엽산 결합 화합물을 함유하는 암 치료용 약학적 조성물
JP2011518890A (ja)	2009-04-29	2011-06-30	ドイアテクフコリアシーオー．，エルティーディー．	新規のクロリンｅ６−葉酸結合化合物、その製造方法、およびそれを含有する癌治療用薬学的組成物
ES2354096B1 (es) *	2009-07-27	2012-02-23	Nuevas Tecnologias Cientificas, S.A.	Procedimiento para la obtencion de un fotosensibilizante para ser empleado en terapia fotodinamica y fotosensibilizante.
KR100950441B1 (ko) *	2009-09-30	2010-04-02	주식회사 아큐텍	스피루리나로부터 클로로필 ａ 및 포토디타진을 제조하는 방법
RU2428981C1 (ru) *	2010-03-31	2011-09-20	Анатолий Юрьевич Барышников	Средство для фотодинамической терапии, способ получения предлагаемого средства и способ проведения фотодинамической терапии с использованием предлагаемого средства
RU2490273C1 (ru) *	2012-02-27	2013-08-20	Оскар Иосифович Койфман	Способ получения метилфеофорбида (а)
PL2931728T3 (pl) *	2012-12-14	2020-11-02	Rmw Cho Group Limited	Pochodna chloryny przydatna w terapii fotodynamicznej i diagnostyce
RU2523380C1 (ru) *	2013-05-21	2014-07-20	Общество с ограниченной ответственностью "ГЕЛИОХЛОРИН"	Фотосенсибилизатор и способ его получения
CN105777760A (zh) *	2014-12-23	2016-07-20	深圳市中兴扬帆生物工程有限公司	四间-羟基苯基二氢卟酚原料药的保存方法
CN106349736A (zh) *	2016-08-05	2017-01-25	雷春生	一种纯有机光敏染料的制备方法
KR102357787B1 (ko) *	2016-12-14	2022-02-03	동성제약주식회사	고순도 트리소듐 클로린 e6(trisodium Chlorin e6)와 PVP (polyvinylpyrrolidone)의 복합체 제조 방법과 Chlorin e6의 제조 방법
RU2670087C1 (ru) *	2018-01-29	2018-10-18	Михаил Александрович Грин	Фотосенсибилизатор для лечения рака предстательной железы и способ его получения
RU2691754C1 (ru) *	2018-11-15	2019-06-18	Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского"	ПРОИЗВОДНОЕ ЦИНКОВОГО МЕТАЛЛОКОМПЛЕКСА ХЛОРИНА-e6 И ЕГО ПРИМЕНЕНИЕ
CN112521392A (zh) *	2019-09-18	2021-03-19	康俄(上海)医疗科技有限公司	一种二氢卟吩e6的纯化方法

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US5534506A (en) *	1986-01-02	1996-07-09	University Of Toledo	Use of purpurins, chlorins and purpurin- and chlorin-containing compositions
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JP2963178B2 (ja)	1990-09-27	1999-10-12	株式会社エス・エル・ティ・ジャパン	水溶性フェオホーバイドａの製造方法
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RU2054476C1 (ru) *	1993-07-14	1996-02-20	Мещерякова Аделия Леонидовна	Способ получения 18-карбокси-20-(карбоксиметил)-8-этенил-13-этил-2,3-дигидро-3,7-12,17-тетраметил-21н, 23нпорфин-2-пропионовой кислоты или ее солей
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2001
- 2001-03-30 RU RU2001108397/14A patent/RU2183956C1/ru not_active IP Right Cessation
- 2001-10-04 CA CA002440650A patent/CA2440650C/en not_active Expired - Fee Related
- 2001-10-04 NZ NZ528237A patent/NZ528237A/en not_active IP Right Cessation
- 2001-10-04 CZ CZ2003-2940A patent/CZ304591B6/cs not_active IP Right Cessation
- 2001-10-04 EP EP01981209A patent/EP1380295B1/de not_active Expired - Lifetime
- 2001-10-04 DE DE60138141T patent/DE60138141D1/de not_active Expired - Lifetime
- 2001-10-04 HR HR20030876A patent/HRP20030876B1/xx not_active IP Right Cessation
- 2001-10-04 HU HU0400298A patent/HU227756B1/hu not_active IP Right Cessation
- 2001-10-04 PL PL365102A patent/PL206902B1/pl unknown
- 2001-10-04 US US10/473,445 patent/US6969765B2/en not_active Expired - Fee Related
- 2001-10-04 SK SK1348-2003A patent/SK287784B6/sk not_active IP Right Cessation
- 2001-10-04 WO PCT/RU2001/000399 patent/WO2002078694A1/ru not_active Ceased
- 2001-10-04 BR BR0116952-1A patent/BR0116952A/pt not_active IP Right Cessation
- 2001-10-04 GB GB0321726A patent/GB2389531B/en not_active Expired - Fee Related
- 2001-10-04 SI SI200130919T patent/SI1380295T1/sl unknown
- 2001-10-04 MX MXPA03008925A patent/MXPA03008925A/es active IP Right Grant
- 2001-10-04 AT AT01981209T patent/ATE426403T1/de not_active IP Right Cessation
- 2001-10-04 AU AU2002212867A patent/AU2002212867B2/en not_active Ceased
- 2001-10-04 KR KR1020037012876A patent/KR100628548B1/ko not_active Expired - Fee Related
- 2001-10-04 CN CNB018230938A patent/CN1250294C/zh not_active Expired - Fee Related
2003
- 2003-09-29 NO NO20034344A patent/NO327751B1/no not_active IP Right Cessation
- 2003-10-29 ZA ZA2003/08407A patent/ZA200308407B/en unknown
2004
- 2004-01-16 BG BG108534A patent/BG108534A/bg unknown
2005
- 2005-06-30 US US11/171,076 patent/US7550587B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HRP20030876B1 (en)	2011-10-31
CN1250294C (zh)	2006-04-12
CZ20032940A3 (cs)	2004-04-14
HUP0400298A2 (hu)	2004-07-28
HRP20030876A2 (en)	2005-08-31
KR100628548B1 (ko)	2006-09-26
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