NO328655B1 - Morfinonderivat og fremgangsmate for fremstilling av slike samt mellomprodukter - Google Patents

Morfinonderivat og fremgangsmate for fremstilling av slike samt mellomprodukter Download PDF

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Publication number
NO328655B1
NO328655B1 NO20040724A NO20040724A NO328655B1 NO 328655 B1 NO328655 B1 NO 328655B1 NO 20040724 A NO20040724 A NO 20040724A NO 20040724 A NO20040724 A NO 20040724A NO 328655 B1 NO328655 B1 NO 328655B1
Authority
NO
Norway
Prior art keywords
formula
derivative
benzyl
formula iii
morphinone
Prior art date
Application number
NO20040724A
Other languages
English (en)
Norwegian (no)
Other versions
NO20040724L (no
Inventor
Joannes Theodorus Maria Linders
Vrijhof
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of NO20040724L publication Critical patent/NO20040724L/no
Publication of NO328655B1 publication Critical patent/NO328655B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
NO20040724A 2001-08-23 2004-02-19 Morfinonderivat og fremgangsmate for fremstilling av slike samt mellomprodukter NO328655B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203187 2001-08-23
PCT/EP2002/009280 WO2003018588A2 (fr) 2001-08-23 2002-08-15 Oxydation c-14 de derives de morphine

Publications (2)

Publication Number Publication Date
NO20040724L NO20040724L (no) 2004-02-19
NO328655B1 true NO328655B1 (no) 2010-04-19

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040724A NO328655B1 (no) 2001-08-23 2004-02-19 Morfinonderivat og fremgangsmate for fremstilling av slike samt mellomprodukter

Country Status (25)

Country Link
US (1) US7435817B2 (fr)
EP (1) EP1421085B1 (fr)
JP (1) JP4559730B2 (fr)
KR (1) KR100901402B1 (fr)
CN (1) CN1271072C (fr)
AR (1) AR035289A1 (fr)
AT (1) ATE466016T1 (fr)
AU (1) AU2002331163B2 (fr)
BR (1) BRPI0211899B8 (fr)
CA (1) CA2457671C (fr)
DE (1) DE60236171D1 (fr)
EC (1) ECSP044984A (fr)
ES (1) ES2345327T3 (fr)
HR (1) HRP20040161A2 (fr)
HU (1) HUP0401600A3 (fr)
IL (1) IL160193A0 (fr)
IS (1) IS7153A (fr)
MX (1) MXPA04001647A (fr)
NO (1) NO328655B1 (fr)
NZ (1) NZ531152A (fr)
PE (1) PE20030460A1 (fr)
PL (1) PL368732A1 (fr)
RU (1) RU2297419C2 (fr)
WO (1) WO2003018588A2 (fr)
ZA (1) ZA200401016B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (fr) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. Derive de morphinane substitue en position 7 par un carbamoyle et insature en positions 6 et 7
ATE493417T1 (de) 2005-06-16 2011-01-15 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga
EP2125824B2 (fr) * 2007-03-23 2023-11-15 Mallinckrodt LLC Préparation améliorée d'oxymorphone à partir d'oripavine
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
JP5373764B2 (ja) 2007-04-16 2013-12-18 マリンクロッド エルエルシー 触媒性水素転移反応を使用する新規なオピエート還元
NZ611651A (en) * 2007-12-17 2014-11-28 Mallinckrodt Llc Sinomenine derivatives and processes for their synthesis
EP2222642B1 (fr) * 2007-12-17 2014-02-12 Mallinckrodt LLC Procédé et composés de production d'opiacés (+)
CA2709882A1 (fr) 2007-12-17 2009-06-25 Peter X. Wang N-demethylation de n-methyl morphinanes
KR20130030260A (ko) 2010-05-10 2013-03-26 유로-셀티큐 에스.에이. 히드로모르폰 및 날록손을 포함하는 제약 조성물
WO2011141490A1 (fr) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combinaison de granules chargés de principe actif et de principes actifs supplémentaires
NZ603173A (en) 2010-05-10 2014-10-31 Euro Celtique Sa Manufacturing of active-free granules and tablets comprising the same
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
CA2919602C (fr) * 2013-08-02 2018-03-13 Johnson Matthey Public Limited Company Procede de preparation d'oxymorphone
EP3068397A1 (fr) 2013-11-13 2016-09-21 Euro-Celtique S.A. Hydromorphone et naloxone utilisées pour le traitement de la douleur et du syndrome de dysfonctionnement intestinal dû aux opioïdes
CN114621238B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种制备纳呋拉啡的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
FR2562072B1 (fr) 1984-03-27 1989-07-07 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
AU4823900A (en) * 1999-05-05 2000-11-17 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
US7435817B2 (en) 2008-10-14
PE20030460A1 (es) 2003-05-15
CA2457671A1 (fr) 2003-03-06
JP2005502670A (ja) 2005-01-27
BRPI0211899B8 (pt) 2021-05-25
WO2003018588A3 (fr) 2003-11-27
PL368732A1 (en) 2005-04-04
NO20040724L (no) 2004-02-19
CA2457671C (fr) 2011-02-15
JP4559730B2 (ja) 2010-10-13
AR035289A1 (es) 2004-05-05
ECSP044984A (es) 2004-04-28
NZ531152A (en) 2005-11-25
RU2004108210A (ru) 2005-04-10
HK1063803A1 (en) 2005-01-14
BR0211899B1 (pt) 2014-01-21
EP1421085B1 (fr) 2010-04-28
HUP0401600A2 (hu) 2004-11-29
HRP20040161A2 (en) 2004-06-30
MXPA04001647A (es) 2004-05-31
CN1545517A (zh) 2004-11-10
EP1421085A2 (fr) 2004-05-26
BR0211899A (pt) 2004-09-21
KR20040027950A (ko) 2004-04-01
WO2003018588B1 (fr) 2004-02-26
ES2345327T3 (es) 2010-09-21
IS7153A (is) 2004-02-13
CN1271072C (zh) 2006-08-23
KR100901402B1 (ko) 2009-06-05
WO2003018588A2 (fr) 2003-03-06
IL160193A0 (en) 2004-07-25
AU2002331163B2 (en) 2008-02-21
HUP0401600A3 (en) 2008-05-28
DE60236171D1 (de) 2010-06-10
US20050038250A1 (en) 2005-02-17
RU2297419C2 (ru) 2007-04-20
ZA200401016B (en) 2004-10-19
ATE466016T1 (de) 2010-05-15

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