NO329497B1 - Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare. - Google Patents

Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare. Download PDF

Info

Publication number: NO329497B1
Authority: NO; Norway
Prior art keywords: toxin; polymer; mmol; solution; added
Prior art date: 1999-05-13

Application number

NO20015524A

Other languages

English (en)

Norwegian (no)

Other versions

NO20015524D0 (no

NO20015524L (no

Inventor

Caroline Kurtz

Richard Fitzpatrick

Original Assignee

Genzyme Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-13

Filing date

2001-11-12

Publication date

2010-11-01

2001-11-12 Application filed by Genzyme Corp filed Critical Genzyme Corp

2001-11-12 Publication of NO20015524D0 publication Critical patent/NO20015524D0/no

2002-01-11 Publication of NO20015524L publication Critical patent/NO20015524L/no

2010-11-01 Publication of NO329497B1 publication Critical patent/NO329497B1/no

Links

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231100000249 enterotoxic Toxicity 0.000 description 1
230000002242 enterotoxic effect Effects 0.000 description 1
230000008029 eradication Effects 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000003304 gavage Methods 0.000 description 1
239000007863 gel particle Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
230000036541 health Effects 0.000 description 1
230000008588 hemolysis Effects 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
244000000074 intestinal pathogen Species 0.000 description 1
230000003870 intestinal permeability Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
238000005567 liquid scintillation counting Methods 0.000 description 1
230000007774 longterm Effects 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QWOKKHXWFDAJCZ-UHFFFAOYSA-N octane-1-sulfonamide Chemical compound CCCCCCCCS(N)(=O)=O QWOKKHXWFDAJCZ-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
230000036407 pain Effects 0.000 description 1
229940124641 pain reliever Drugs 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
230000008569 process Effects 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000003223 protective agent Substances 0.000 description 1
230000000306 recurrent effect Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
239000012852 risk material Substances 0.000 description 1
238000003345 scintillation counting Methods 0.000 description 1
201000009881 secretory diarrhea Diseases 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
206010040400 serum sickness Diseases 0.000 description 1
230000035939 shock Effects 0.000 description 1
239000011343 solid material Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000011272 standard treatment Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
239000012089 stop solution Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
238000006277 sulfonation reaction Methods 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
HIFJUMGIHIZEPX-UHFFFAOYSA-N sulfuric acid;sulfur trioxide Chemical compound O=S(=O)=O.OS(O)(=O)=O HIFJUMGIHIZEPX-UHFFFAOYSA-N 0.000 description 1
239000013589 supplement Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000008961 swelling Effects 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000007888 toxin activity Effects 0.000 description 1
230000008728 vascular permeability Effects 0.000 description 1
229940118696 vibrio cholerae Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compositions Of Macromolecular Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Detergent Compositions (AREA)
Absorbent Articles And Supports Therefor (AREA)

NO20015524A 1999-05-13 2001-11-12 Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare. NO329497B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13397599P	1999-05-13	1999-05-13
US09/541,268 US6270755B1 (en)	1999-05-13	2000-04-03	Anionic polymers as toxin binders
PCT/US2000/012943 WO2000069428A2 (fr)	1999-05-13	2000-05-11	Polymeres anioniques utilises comme liants de toxines ou agents antibacteriens

Publications (3)

Publication Number	Publication Date
NO20015524D0 NO20015524D0 (no)	2001-11-12
NO20015524L NO20015524L (no)	2002-01-11
NO329497B1 true NO329497B1 (no)	2010-11-01

Family

ID=26831853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20015524A NO329497B1 (no)	1999-05-13	2001-11-12	Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare.

Country Status (23)

Country	Link
US (2)	US6270755B1 (fr)
EP (1)	EP1189622B1 (fr)
JP (1)	JP2002544226A (fr)
KR (1)	KR100742433B1 (fr)
CN (1)	CN100435806C (fr)
AT (1)	ATE367818T1 (fr)
AU (1)	AU768592B2 (fr)
BR (1)	BR0011520A (fr)
CA (1)	CA2374108A1 (fr)
DE (1)	DE60035689T2 (fr)
DK (1)	DK1189622T3 (fr)
ES (1)	ES2288855T3 (fr)
HK (1)	HK1044490A1 (fr)
HU (1)	HUP0201114A3 (fr)
IL (2)	IL146211A0 (fr)
MY (1)	MY132695A (fr)
NO (1)	NO329497B1 (fr)
NZ (1)	NZ515226A (fr)
PL (1)	PL197157B1 (fr)
PT (1)	PT1189622E (fr)
RU (1)	RU2246938C2 (fr)
TW (1)	TW592704B (fr)
WO (1)	WO2000069428A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6290946B1 (en) *	1999-05-13	2001-09-18	Geltex Pharmaceuticals, Inc.	Anionic polymers as toxin binders and antibacterial agents
US6270755B1 (en) *	1999-05-13	2001-08-07	Geltex Pharmaceuticals, Inc.	Anionic polymers as toxin binders
US6805857B2 (en) *	2000-03-06	2004-10-19	Kumarpal A. Shah	Method of modulating factor D, factor H and CD4 cell immune response with a polystyrene sulfonate, alginate, and saline infusion solution
CA2314494A1 (fr) *	2000-05-02	2001-11-02	Geltex Pharmaceuticals, Inc.	Polymeres anioniques utilises comme agents antibacteriens specifiques de certaines especes
US6537538B2 (en) *	2000-12-18	2003-03-25	Rush-Presbyterian-St. Luke's Medical Center	Method for the prevention, inhibition, or treatment of vaginitis and/or bacterial vaginosis using polystyrene sulfonate
EP1542706A1 (fr) *	2002-07-22	2005-06-22	Genzyme Corporation	Poly (potassium et sulfonate styrenique de sodium), procede de fabrication et utilisation associes
US20040106590A1 (en) *	2002-08-29	2004-06-03	Barry Eisenstein	Methods and reagents for treating infections of clostridium difficile and diseases associated therewith
US7682631B2 (en) *	2003-10-01	2010-03-23	Clemson University	Adhesin-specific nanoparticles and process for using same
AU2004285450B2 (en)	2003-10-20	2010-01-14	Gregory K. Frykman	Zeolite molecular sieves for the removal of toxins
US20060099169A1 (en) *	2004-10-13	2006-05-11	Ilypsa, Inc.	Toxin binding compositions
US20060078534A1 (en) *	2004-10-13	2006-04-13	Dominique Charmot	Toxin binding compositions
US8088400B2 (en) *	2005-08-22	2012-01-03	Quick-Med Technologies, Inc.	Disinfectant with quarternary ammonium polymer and copolymers
EP1956899B1 (fr) *	2005-11-02	2015-09-09	Oplon, Pure Science Ltd	Compositions et methodes d'elimination de cellules
RU2308486C1 (ru) *	2006-04-10	2007-10-20	Федеральное Государственное Образовательное Учреждение Высшего Профессионального Образования "Московская Государственная Академия Ветеринарной Медицины И Биотехнологии Имени К.И. Скрябина"	Способ получения иммобилизованной липазы
TW200829286A (en) *	2006-09-06	2008-07-16	Genzyme Corp	Polystyrene sulfonate polymer tablets, their preparation and use
US8809444B2 (en) *	2009-12-23	2014-08-19	Momentive Performance Materials Inc.	Network copolymer crosslinked emulsions and demulsifying compositions comprising the same
JP5820112B2 (ja) *	2010-12-15	2015-11-24	積水化学工業株式会社	インフルエンザウイルス感染阻止剤、インフルエンザウイルス感染阻止塗料及びインフルエンザウイルス感染阻止製品
CN102160870B (zh) *	2011-03-18	2013-04-24	南京欧睿医药科技有限公司	聚（4-苯乙烯磺酸-共聚-马来酸）钠盐的用途及其药物组合物
CN103842083B (zh) *	2011-09-08	2016-12-21	安全Bt股份有限公司	改性的中空纤维材料用于从优选血液和血浆的液体中除去由大肠杆菌产生的外毒素的用途及它们用于治疗伴随疾病的用途
RU2482883C1 (ru) *	2012-03-12	2013-05-27	Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук	Способ получения полимерно-композиционных волокнистых материалов с антимикробной активностью
EP3236940B1 (fr) *	2014-12-23	2020-02-05	Ardelyx, Inc.	Compositions et méthodes de traitement de l'hyperkaliémie
KR101720053B1 (ko)	2015-04-30	2017-03-27	이현국	고주파 열처리 장치 및 고주파 열처리 방법
DE102022132913A1 (de)	2022-12-12	2024-06-13	Forschungszentrum Jülich GmbH	Block-Copolymer, Verfahren zur Herstellung eines Block-Copolymers, Membran und Verwendung einer Membran

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3224941A (en)	1963-01-21	1965-12-21	Lilly Co Eli	Resin compositions and method for controlling diarrhea
US3466365A (en)	1967-07-24	1969-09-09	White Lab Inc	Antiviral compositions and method of use
NL7401542A (fr) *	1973-02-09	1974-08-13
IE44690B1 (en)	1976-02-04	1982-02-24	Rohm & Haas	Pharmaceutical compositions containing polyvinylbenzenosulfonic acids
US4395392A (en)	1980-06-24	1983-07-26	Adria Laboratories Inc.	Method for treating kidney stones
US4362711A (en)	1980-07-11	1982-12-07	Evreka Inc.	Blood cholesterol level reducing agent and method
US5171738A (en)	1982-10-04	1992-12-15	Toray Industries, Inc.	Method of treating malignant tumors
US5435821A (en)	1985-12-12	1995-07-25	Exxon Research & Engineering Co.	Controlled release vegetation enhancement agents coated with sulfonated polymers, method of production and prcesses of use
US5071759A (en)	1986-05-30	1991-12-10	The United States Of America As Represented By The Secretary Of The Army	Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B
US5091171B2 (en) *	1986-12-23	1997-07-15	Tristrata Inc	Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
JPS6422551A (en) *	1987-07-16	1989-01-25	Dainippon Ink & Chemicals	Composite film for lid
IL90388A (en)	1988-05-26	1993-08-18	Duphar Int Res	Pharmaceutical compositions having anti- endotoxic activity containing a novel active fraction from lactulose syrup, and a method for its preparation
JPH02176351A (ja)	1988-12-27	1990-07-09	Matsushita Electric Ind Co Ltd	給湯器
US5149523A (en)	1989-06-20	1992-09-22	Aktiebolaget Hassle	Polystyrenesulfonate-drug complex and solid dosage forms thereof
US5093130A (en)	1989-09-26	1992-03-03	Plant Genetics	Powder coated hydrogel capsules
US5601823A (en)	1989-10-31	1997-02-11	Ophidian Pharmaceuticals, Inc.	Avian antitoxins to clostridium difficle toxin A
US5736139A (en)	1989-10-31	1998-04-07	Ochidian Pharmaceuticals, Inc.	Treatment of Clostridium difficile induced disease
US5231003A (en)	1990-05-11	1993-07-27	Cambridge Bioscience Corporation	Monoclonal antibodies specific for toxin b of clostridium difficile
US5149543A (en)	1990-10-05	1992-09-22	Massachusetts Institute Of Technology	Ionically cross-linked polymeric microcapsules
FR2669535A1 (fr) *	1990-11-26	1992-05-29	Medgenix Group Sa	Utilisation a titre de medicament de macromolecules polysulfonees.
AU2672892A (en) *	1991-09-17	1993-04-27	Alcon Laboratories, Inc.	Compositions containing quinolone antibiotics and sulfonate of polystyrol
US5424063A (en)	1992-01-09	1995-06-13	The Dow Chemical Company	Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process
US5277820A (en)	1992-02-06	1994-01-11	Hemocleanse, Inc.	Device and method for extracorporeal blood treatment
US5474765A (en)	1992-03-23	1995-12-12	Ut Sw Medical Ctr At Dallas	Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5324718A (en)	1992-07-14	1994-06-28	Thorsteinn Loftsson	Cyclodextrin/drug complexation
US5380522A (en) *	1992-08-11	1995-01-10	Day; Charles E.	Method for treatment of irritable bowel syndrome
US5643562A (en)	1993-03-29	1997-07-01	Queen's University Of Kingston	Method for treating amyloidosis
US5614559A (en)	1993-11-23	1997-03-25	Procept Inc.	Compound for inhibiting HIV infectivity
US5484773A (en)	1994-02-14	1996-01-16	Alberta Research Council	Treatment of antibiotic associated diarrhea
US5756810A (en)	1994-03-11	1998-05-26	Pharmacopeia, Inc.	Process of preparing 3-nitro benzoate compounds in lower alkanol
EP0779819A1 (fr)	1994-09-06	1997-06-25	Galagen Inc.	Traitement therapeutique des maladies associees au clostridium difficile
WO1996020042A1 (fr)	1994-12-26	1996-07-04	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	ADSORBANT POUR LES ENDOTOXINES, LE FACTEUR α DE NECROSE TUMORALE OU LES INTERLEUKINES, PROCEDE D'ELIMINATION PAR ADSORPTION ET ADSORBEUR
US5610023A (en)	1995-03-31	1997-03-11	Lee Laboratories, Inc.	Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
DE19515554C2 (de)	1995-04-27	1999-06-17	Braun Melsungen Ag	Verwendung eines Mittels und Vorrichtung zur simultanen extrakorporalen Elimination von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus Vollblut oder/und Blutplasma
AUPN327695A0 (en) *	1995-05-30	1995-06-22	Chemeq Pty. Limited	Chemotherapeutic compositions
US5700458A (en) *	1996-09-20	1997-12-23	Geltex Pharmaceuticals Inc.	Acid-functionalized saccharides as polyvalent anti-infectives
US5800803A (en)	1997-02-10	1998-09-01	Colgate-Palmolive Company	Oral composition exhibiting enhanced uptake by dental tissue of noncationic antibacterial agents
US6060235A (en)	1997-09-19	2000-05-09	Geltex Pharmaceuticals, Inc.	Antiviral polymers comprising acid functional groups and hydrophobic groups
US6007803A (en) *	1997-09-19	1999-12-28	Geltex Pharmaceuticals, Inc.	Ionic polymers as toxin binding agents
WO1999020285A1 (fr)	1997-10-16	1999-04-29	Sanwa Kagaku Kenkyusho Co., Ltd.	Preparations de gels contenant un polystyrenesulfonate
US6270755B1 (en) *	1999-05-13	2001-08-07	Geltex Pharmaceuticals, Inc.	Anionic polymers as toxin binders

2000
- 2000-04-03 US US09/541,268 patent/US6270755B1/en not_active Expired - Lifetime
- 2000-05-09 MY MYPI20001992A patent/MY132695A/en unknown
- 2000-05-10 TW TW089108898A patent/TW592704B/zh not_active IP Right Cessation
- 2000-05-11 IL IL14621100A patent/IL146211A0/xx active IP Right Grant
- 2000-05-11 AU AU48409/00A patent/AU768592B2/en not_active Ceased
- 2000-05-11 PL PL352411A patent/PL197157B1/pl not_active IP Right Cessation
- 2000-05-11 DE DE60035689T patent/DE60035689T2/de not_active Expired - Lifetime
- 2000-05-11 KR KR1020017014459A patent/KR100742433B1/ko not_active Expired - Fee Related
- 2000-05-11 EP EP00930620A patent/EP1189622B1/fr not_active Expired - Lifetime
- 2000-05-11 DK DK00930620T patent/DK1189622T3/da active
- 2000-05-11 RU RU2001133465/15A patent/RU2246938C2/ru not_active IP Right Cessation
- 2000-05-11 CA CA002374108A patent/CA2374108A1/fr not_active Abandoned
- 2000-05-11 ES ES00930620T patent/ES2288855T3/es not_active Expired - Lifetime
- 2000-05-11 HK HK02106350.9A patent/HK1044490A1/zh unknown
- 2000-05-11 HU HU0201114A patent/HUP0201114A3/hu unknown
- 2000-05-11 BR BR0011520-7A patent/BR0011520A/pt not_active Application Discontinuation
- 2000-05-11 JP JP2000617887A patent/JP2002544226A/ja active Pending
- 2000-05-11 WO PCT/US2000/012943 patent/WO2000069428A2/fr not_active Ceased
- 2000-05-11 NZ NZ515226A patent/NZ515226A/en not_active IP Right Cessation
- 2000-05-11 PT PT00930620T patent/PT1189622E/pt unknown
- 2000-05-11 AT AT00930620T patent/ATE367818T1/de not_active IP Right Cessation
- 2000-05-11 CN CNB008075360A patent/CN100435806C/zh not_active Expired - Fee Related
2001
- 2001-06-11 US US09/878,843 patent/US6419914B2/en not_active Expired - Fee Related
- 2001-10-28 IL IL146211A patent/IL146211A/en not_active IP Right Cessation
- 2001-11-12 NO NO20015524A patent/NO329497B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100742433B1 (ko)	2007-07-24
US6419914B2 (en)	2002-07-16
HUP0201114A2 (en)	2002-09-28
PL197157B1 (pl)	2008-03-31
ATE367818T1 (de)	2007-08-15
CA2374108A1 (fr)	2000-11-23
DE60035689D1 (de)	2007-09-06
AU4840900A (en)	2000-12-05
BR0011520A (pt)	2003-06-24
US6270755B1 (en)	2001-08-07
WO2000069428A2 (fr)	2000-11-23
RU2246938C2 (ru)	2005-02-27
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Publication	Publication Date	Title
NO329497B1 (no)	2010-11-01	Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare.
US6290946B1 (en)	2001-09-18	Anionic polymers as toxin binders and antibacterial agents
JPH10505358A (ja)	1998-05-26	クロストリジウム・ディフィシル関連疾患の治療処置
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Deselliers et al.	1997	Effects of Giardia lamblia infection on gastrointestinal transit and contractility in Mongolian gerbils
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US20250281555A1 (en)	2025-09-11	Bacteriophage compositions and methods for treatment of bacterial infections
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Plaut	2000	Clinical pathology of foodborne diseases: notes on the patient with foodborne gastrointestinal illness
EP1800687A2 (fr)	2007-06-27	Polymères anioniques en tant que liants de toxine et agents antibactériens
MXPA01011387A (es)	2002-06-05	Polimeros anionicos como ligantes de toxinas y agentes antibacterianos
ZA200109290B (en)	2002-11-13	Anionic polymers as toxin binders and antibacterial agents.
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Wenisch et al.	1994	Intravenous teicoplanin does not prevent Clostridium difficile associated diarrhea
Gart	2011	Role of colonic epithelial cells in susceptibility and severity of Citrobacter rodentium infection in mice
Madalinski et al.	1989	The role of serum factors and influence of intravenous immunoglobulins on phagocytosis of Campylobacter species
ADLER	1990	Common things are common depending upon where you live
Balabana et al.	2000	Prevention of diseases caused by Staphylococcus aureus using the peptide RIP
Dragstedt	1923	Studies in intestinal obstruction
Dudeja	0	Clostridium difficile Toxins A and B Decrease Intestinal SLC26A3 Protein Expression