NO329497B1 - Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare. - Google Patents

Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare. Download PDF

Info

Publication number: NO329497B1
Authority: NO; Norway
Prior art keywords: toxin; polymer; mmol; solution; added
Prior art date: 1999-05-13

Application number

NO20015524A

Other languages

English (en)

Norwegian (no)

Other versions

NO20015524L (no

NO20015524D0 (no

Inventor

Caroline Kurtz

Richard Fitzpatrick

Original Assignee

Genzyme Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-13

Filing date

2001-11-12

Publication date

2010-11-01

2001-11-12 Application filed by Genzyme Corp filed Critical Genzyme Corp

2001-11-12 Publication of NO20015524D0 publication Critical patent/NO20015524D0/no

2002-01-11 Publication of NO20015524L publication Critical patent/NO20015524L/no

2010-11-01 Publication of NO329497B1 publication Critical patent/NO329497B1/no

Links

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231100000249 enterotoxic Toxicity 0.000 description 1
230000002242 enterotoxic effect Effects 0.000 description 1
230000008029 eradication Effects 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000003304 gavage Methods 0.000 description 1
239000007863 gel particle Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
230000036541 health Effects 0.000 description 1
230000008588 hemolysis Effects 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
244000000074 intestinal pathogen Species 0.000 description 1
230000003870 intestinal permeability Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
238000005567 liquid scintillation counting Methods 0.000 description 1
230000007774 longterm Effects 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QWOKKHXWFDAJCZ-UHFFFAOYSA-N octane-1-sulfonamide Chemical compound CCCCCCCCS(N)(=O)=O QWOKKHXWFDAJCZ-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
230000036407 pain Effects 0.000 description 1
229940124641 pain reliever Drugs 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
229960001412 pentobarbital Drugs 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
230000008569 process Effects 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000003223 protective agent Substances 0.000 description 1
230000000306 recurrent effect Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
239000012852 risk material Substances 0.000 description 1
238000003345 scintillation counting Methods 0.000 description 1
201000009881 secretory diarrhea Diseases 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
206010040400 serum sickness Diseases 0.000 description 1
230000035939 shock Effects 0.000 description 1
239000011343 solid material Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000011272 standard treatment Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
239000012089 stop solution Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
238000006277 sulfonation reaction Methods 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
HIFJUMGIHIZEPX-UHFFFAOYSA-N sulfuric acid;sulfur trioxide Chemical compound O=S(=O)=O.OS(O)(=O)=O HIFJUMGIHIZEPX-UHFFFAOYSA-N 0.000 description 1
239000013589 supplement Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000008961 swelling Effects 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000007888 toxin activity Effects 0.000 description 1
230000008728 vascular permeability Effects 0.000 description 1
229940118696 vibrio cholerae Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Materials For Medical Uses (AREA)
Compositions Of Macromolecular Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Detergent Compositions (AREA)
Absorbent Articles And Supports Therefor (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20015524A 1999-05-13 2001-11-12 Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare. NO329497B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13397599P	1999-05-13	1999-05-13
US09/541,268 US6270755B1 (en)	1999-05-13	2000-04-03	Anionic polymers as toxin binders
PCT/US2000/012943 WO2000069428A2 (fr)	1999-05-13	2000-05-11	Polymeres anioniques utilises comme liants de toxines ou agents antibacteriens

Publications (3)

Publication Number	Publication Date
NO20015524D0 NO20015524D0 (no)	2001-11-12
NO20015524L NO20015524L (no)	2002-01-11
NO329497B1 true NO329497B1 (no)	2010-11-01

Family

ID=26831853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20015524A NO329497B1 (no)	1999-05-13	2001-11-12	Anvendelse av polystyrensulfonat for fremstilling av medikament for behandling av antibiotikumassosiert eller C. difficile-assosiert diare.

Country Status (23)

Country	Link
US (2)	US6270755B1 (fr)
EP (1)	EP1189622B1 (fr)
JP (1)	JP2002544226A (fr)
KR (1)	KR100742433B1 (fr)
CN (1)	CN100435806C (fr)
AT (1)	ATE367818T1 (fr)
AU (1)	AU768592B2 (fr)
BR (1)	BR0011520A (fr)
CA (1)	CA2374108A1 (fr)
DE (1)	DE60035689T2 (fr)
DK (1)	DK1189622T3 (fr)
ES (1)	ES2288855T3 (fr)
HK (1)	HK1044490A1 (fr)
HU (1)	HUP0201114A3 (fr)
IL (2)	IL146211A0 (fr)
MY (1)	MY132695A (fr)
NO (1)	NO329497B1 (fr)
NZ (1)	NZ515226A (fr)
PL (1)	PL197157B1 (fr)
PT (1)	PT1189622E (fr)
RU (1)	RU2246938C2 (fr)
TW (1)	TW592704B (fr)
WO (1)	WO2000069428A2 (fr)

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2000
- 2000-04-03 US US09/541,268 patent/US6270755B1/en not_active Expired - Lifetime
- 2000-05-09 MY MYPI20001992A patent/MY132695A/en unknown
- 2000-05-10 TW TW089108898A patent/TW592704B/zh not_active IP Right Cessation
- 2000-05-11 NZ NZ515226A patent/NZ515226A/en not_active IP Right Cessation
- 2000-05-11 WO PCT/US2000/012943 patent/WO2000069428A2/fr not_active Ceased
- 2000-05-11 CA CA002374108A patent/CA2374108A1/fr not_active Abandoned
- 2000-05-11 AU AU48409/00A patent/AU768592B2/en not_active Ceased
- 2000-05-11 KR KR1020017014459A patent/KR100742433B1/ko not_active Expired - Fee Related
- 2000-05-11 EP EP00930620A patent/EP1189622B1/fr not_active Expired - Lifetime
- 2000-05-11 IL IL14621100A patent/IL146211A0/xx active IP Right Grant
- 2000-05-11 ES ES00930620T patent/ES2288855T3/es not_active Expired - Lifetime
- 2000-05-11 HK HK02106350.9A patent/HK1044490A1/zh unknown
- 2000-05-11 HU HU0201114A patent/HUP0201114A3/hu unknown
- 2000-05-11 PL PL352411A patent/PL197157B1/pl not_active IP Right Cessation
- 2000-05-11 RU RU2001133465/15A patent/RU2246938C2/ru not_active IP Right Cessation
- 2000-05-11 DK DK00930620T patent/DK1189622T3/da active
- 2000-05-11 DE DE60035689T patent/DE60035689T2/de not_active Expired - Lifetime
- 2000-05-11 PT PT00930620T patent/PT1189622E/pt unknown
- 2000-05-11 AT AT00930620T patent/ATE367818T1/de not_active IP Right Cessation
- 2000-05-11 CN CNB008075360A patent/CN100435806C/zh not_active Expired - Fee Related
- 2000-05-11 JP JP2000617887A patent/JP2002544226A/ja active Pending
- 2000-05-11 BR BR0011520-7A patent/BR0011520A/pt not_active Application Discontinuation
2001
- 2001-06-11 US US09/878,843 patent/US6419914B2/en not_active Expired - Fee Related
- 2001-10-28 IL IL146211A patent/IL146211A/en not_active IP Right Cessation
- 2001-11-12 NO NO20015524A patent/NO329497B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1189622T3 (da)	2007-11-05
WO2000069428A2 (fr)	2000-11-23
KR100742433B1 (ko)	2007-07-24
CN1358097A (zh)	2002-07-10
AU4840900A (en)	2000-12-05
IL146211A0 (en)	2002-07-25
AU768592B2 (en)	2003-12-18
HUP0201114A3 (en)	2003-05-28
DE60035689T2 (de)	2008-04-30
NO20015524L (no)	2002-01-11
KR20020005032A (ko)	2002-01-16
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Publication	Publication Date	Title
US6290946B1 (en)	2001-09-18	Anionic polymers as toxin binders and antibacterial agents
AU768592B2 (en)	2003-12-18	Anionic polymers as toxin binders and antibacterial agents
JPH10505358A (ja)	1998-05-26	クロストリジウム・ディフィシル関連疾患の治療処置
Duan et al.	2019	Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea
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Kaya et al.	2016	Can platelet-rich plasma be used safely in intra-abdominal operations?
RU2193407C2 (ru)	2002-11-27	Фармацевтические препараты для лечения гастритов, рефлюкс-эзофагитов, дуоденитов, диспепсии и язвы
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EP1800686A2 (fr)	2007-06-27	Polymères anioniques en tant que liants de toxine et agents antibactériens
MXPA01011387A (es)	2002-06-05	Polimeros anionicos como ligantes de toxinas y agentes antibacterianos
ZA200109290B (en)	2002-11-13	Anionic polymers as toxin binders and antibacterial agents.
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Dragstedt	1923	Studies in intestinal obstruction
Dudeja	0	Clostridium difficile Toxins A and B Decrease Intestinal SLC26A3 Protein Expression