NO330278B1 - Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren - Google Patents

Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren Download PDF

Info

Publication number: NO330278B1
Authority: NO; Norway
Prior art keywords: rantes; mutant; pharmaceutical composition; expression vector; dna molecule
Prior art date: 2000-10-04

Application number

NO20031525A

Other languages

English (en)

Norwegian (no)

Other versions

NO20031525D0 (no

NO20031525L (no

Inventor

Amanda Proudfoot

Timothy N C Wells

Marie Kosco-Vilbois

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-04

Filing date

2003-04-03

Publication date

2011-03-21

2003-04-03 Application filed by Serono Lab filed Critical Serono Lab

2003-04-03 Publication of NO20031525D0 publication Critical patent/NO20031525D0/no

2003-04-03 Publication of NO20031525L publication Critical patent/NO20031525L/no

2011-03-21 Publication of NO330278B1 publication Critical patent/NO330278B1/no

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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
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Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
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Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Enzymes And Modification Thereof (AREA)
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NO20031525A 2000-10-04 2003-04-03 Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren NO330278B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00121665		2000-10-04
PCT/EP2001/011428 WO2002028419A2 (en)	2000-10-04	2001-10-03	Chemokine mutants in the treatment of multiple sclerosis

Publications (3)

Publication Number	Publication Date
NO20031525D0 NO20031525D0 (no)	2003-04-03
NO20031525L NO20031525L (no)	2003-04-03
NO330278B1 true NO330278B1 (no)	2011-03-21

Family

ID=8170011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031525A NO330278B1 (no)	2000-10-04	2003-04-03	Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren

Country Status (30)

Country	Link
US (1)	US7402303B2 (de)
EP (1)	EP1326628B1 (de)
JP (1)	JP3908165B2 (de)
KR (1)	KR100837898B1 (de)
CN (1)	CN1285381C (de)
AR (1)	AR030854A1 (de)
AT (1)	ATE265222T1 (de)
AU (2)	AU2002215919B2 (de)
BG (1)	BG66137B1 (de)
BR (1)	BR0114407A (de)
CA (1)	CA2423616C (de)
CZ (1)	CZ303409B6 (de)
DE (1)	DE60103078T2 (de)
DK (1)	DK1326628T3 (de)
EA (1)	EA006137B1 (de)
EE (1)	EE05174B1 (de)
ES (1)	ES2217199T3 (de)
HR (1)	HRP20030215B1 (de)
HU (1)	HUP0302194A3 (de)
IL (2)	IL155178A0 (de)
MX (1)	MXPA03003008A (de)
NO (1)	NO330278B1 (de)
PL (1)	PL204231B1 (de)
PT (1)	PT1326628E (de)
RS (1)	RS50738B (de)
SI (1)	SI1326628T1 (de)
SK (1)	SK287523B6 (de)
UA (1)	UA77950C2 (de)
WO (1)	WO2002028419A2 (de)
ZA (1)	ZA200302315B (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7553483B2 (en)	2001-12-17	2009-06-30	Merck Serono Sa	Chemokine mutants acting as chemokine antagonists
EP1494703B1 (de)	2002-04-04	2006-03-08	Applied Research Systems ARS Holding N.V.	Chemokin-muntanten mit verbesserter oraler bioverfügbarkeit
ES2305573T3 (es) *	2002-12-23	2008-11-01	Laboratoires Serono Sa	Uso de metantes de quimiocinas cc ccl5/rantes contra transtornos del higado.
WO2005040210A2 (en) *	2003-10-22	2005-05-06	Applied Research Systems Ars Holding N.V.	Novel cxcl8 antagonists
AT412785B (de) *	2003-12-04	2005-07-25	Kungl Andreas J Dr	Gag-bindungsproteine
ATE322506T1 (de) *	2004-01-19	2006-04-15	Ares Trading Sa	Verfahren zur reinigung von in bakterien exprimierten proteinen
GB0412400D0 (en) *	2004-06-03	2004-07-07	Univ Newcastle	Treatment of inflammatory conditions
EP2218748B1 (de) *	2005-09-03	2012-10-10	Samsung SDI Co., Ltd.	Polybenzoxazin Verbindung, Elektrolyt-Membran enthaltend dieser Verbindung und Elektrolyt-Membran benutzende Brenndstofzell
GB0614755D0 (en)	2006-07-25	2006-09-06	Univ Geneve	Cytokine derivatives
US8012474B2 (en)	2007-08-02	2011-09-06	Nov Immune S.A.	Anti-RANTES antibodies
CA2788902C (en) *	2010-02-08	2019-09-03	The Trustees Of The University Of Pennsylvania	Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
CN112469430B (zh)	2018-05-28	2024-12-24	日内瓦大学	抑制大脑炎症的方法
US20250186520A1 (en) *	2020-10-26	2025-06-12	City Of Hope	Oncolytic virus compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5739103A (en)	1993-11-12	1998-04-14	Dana-Farber Cancer Institute	Chemokine N-terminal deletion mutations
WO1998006751A1 (en)	1996-08-16	1998-02-19	Research Corporation Technologies, Inc.	Mcp-3, rantes and mip-1alpha receptor antagonists
EP0906954A1 (de) *	1997-09-29	1999-04-07	Applied Research Systems ARS Holding N.V.	Aminoterminalen verkürzten C-C Chemokine als Chemokine Antagonist
DK1431391T3 (da) *	1997-12-23	2005-12-19	San Raffaele Centro Fond	RANTES-mutanter og terapeutiske anvendelser heraf
AU2740900A (en) *	1999-01-29	2000-08-18	Millennium Pharmaceuticals, Inc.	Method of treating demyelinating inflammatory disease using ccr1 antagonists

2001
- 2001-03-10 UA UA2003044038A patent/UA77950C2/uk unknown
- 2001-10-03 AU AU2002215919A patent/AU2002215919B2/en not_active Ceased
- 2001-10-03 DE DE60103078T patent/DE60103078T2/de not_active Expired - Lifetime
- 2001-10-03 HR HR20030215A patent/HRP20030215B1/xx not_active IP Right Cessation
- 2001-10-03 ZA ZA200302315A patent/ZA200302315B/en unknown
- 2001-10-03 KR KR1020037004599A patent/KR100837898B1/ko not_active Expired - Fee Related
- 2001-10-03 IL IL15517801A patent/IL155178A0/xx unknown
- 2001-10-03 CA CA2423616A patent/CA2423616C/en not_active Expired - Fee Related
- 2001-10-03 AT AT01986265T patent/ATE265222T1/de active
- 2001-10-03 EP EP01986265A patent/EP1326628B1/de not_active Expired - Lifetime
- 2001-10-03 MX MXPA03003008A patent/MXPA03003008A/es active IP Right Grant
- 2001-10-03 RS YUP-257/03A patent/RS50738B/sr unknown
- 2001-10-03 ES ES01986265T patent/ES2217199T3/es not_active Expired - Lifetime
- 2001-10-03 CN CNB018199178A patent/CN1285381C/zh not_active Expired - Fee Related
- 2001-10-03 PT PT01986265T patent/PT1326628E/pt unknown
- 2001-10-03 EE EEP200300139A patent/EE05174B1/xx not_active IP Right Cessation
- 2001-10-03 SK SK406-2003A patent/SK287523B6/sk not_active IP Right Cessation
- 2001-10-03 BR BR0114407-3A patent/BR0114407A/pt not_active IP Right Cessation
- 2001-10-03 WO PCT/EP2001/011428 patent/WO2002028419A2/en not_active Ceased
- 2001-10-03 EA EA200300439A patent/EA006137B1/ru not_active IP Right Cessation
- 2001-10-03 US US10/398,457 patent/US7402303B2/en not_active Expired - Fee Related
- 2001-10-03 PL PL362350A patent/PL204231B1/pl not_active IP Right Cessation
- 2001-10-03 AU AU1591902A patent/AU1591902A/xx active Pending
- 2001-10-03 DK DK01986265T patent/DK1326628T3/da active
- 2001-10-03 JP JP2002532243A patent/JP3908165B2/ja not_active Expired - Fee Related
- 2001-10-03 SI SI200130130T patent/SI1326628T1/xx unknown
- 2001-10-03 HU HU0302194A patent/HUP0302194A3/hu unknown
- 2001-10-03 CZ CZ20030947A patent/CZ303409B6/cs not_active IP Right Cessation
- 2001-10-04 AR ARP010104684A patent/AR030854A1/es unknown
2003
- 2003-03-28 BG BG107685A patent/BG66137B1/bg unknown
- 2003-04-01 IL IL155178A patent/IL155178A/en not_active IP Right Cessation
- 2003-04-03 NO NO20031525A patent/NO330278B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60103078T2 (de)	2005-04-07
CA2423616C (en)	2010-03-16
EE05174B1 (et)	2009-06-15
EA200300439A1 (ru)	2003-08-28
US20040101509A1 (en)	2004-05-27
EE200300139A (et)	2003-06-16
CN1477969A (zh)	2004-02-25
EA006137B1 (ru)	2005-10-27
HRP20030215B1 (en)	2011-09-30
RS50738B (sr)	2010-08-31
IL155178A (en)	2009-07-20
YU25703A (sh)	2006-05-25
BG107685A (bg)	2003-11-28
AR030854A1 (es)	2003-09-03
SI1326628T1 (en)	2004-10-31
PT1326628E (pt)	2004-09-30
HK1062811A1 (en)	2004-11-26
BR0114407A (pt)	2003-07-29
IL155178A0 (en)	2003-11-23
AU1591902A (en)	2002-04-15
SK287523B6 (sk)	2011-01-04
SK4062003A3 (en)	2003-08-05
HUP0302194A3 (en)	2005-12-28
ES2217199T3 (es)	2004-11-01
JP3908165B2 (ja)	2007-04-25
CZ303409B6 (cs)	2012-09-05
KR100837898B1 (ko)	2008-06-13
KR20030034238A (ko)	2003-05-01
WO2002028419A3 (en)	2002-06-13
US7402303B2 (en)	2008-07-22
HUP0302194A2 (hu)	2003-10-28
DE60103078D1 (de)	2004-06-03
ATE265222T1 (de)	2004-05-15
CN1285381C (zh)	2006-11-22
JP2004510426A (ja)	2004-04-08
AU2002215919B2 (en)	2005-11-24
DK1326628T3 (da)	2004-08-09
PL362350A1 (en)	2004-10-18
WO2002028419A2 (en)	2002-04-11
EP1326628A2 (de)	2003-07-16
MXPA03003008A (es)	2003-07-14
HRP20030215A2 (en)	2005-02-28
CA2423616A1 (en)	2002-04-11
EP1326628B1 (de)	2004-04-28
CZ2003947A3 (cs)	2003-11-12
UA77950C2 (en)	2007-02-15
NO20031525D0 (no)	2003-04-03
NO20031525L (no)	2003-04-03
PL204231B1 (pl)	2009-12-31
BG66137B1 (bg)	2011-07-29
ZA200302315B (en)	2004-03-25

Legal Events

Date	Code	Title	Description
2008-01-14	CREP	Change of representative	Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS
2013-05-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
JP4233214B2 (ja)	2009-03-04	ケモカインアンタゴニストとしてのアミノ末端切除型ｒａｎｔｅｓ
NO330278B1 (no)	2011-03-21	Anvendelse av en CC-kjemokinmutant i fremstillingen av en farmasoytisk sammensetning til behandlingen av multippel sklerose og/eller andre demyelinerende sykdommer, farmasoytisk sammensetning omfattende mutantene, trunkert og mutert human RANTES og rekombinant fremgangsmate for fremstilling av samme,DNA-molekyl som koder for dette, ekspresjonsvektor som omfatter DNA-molekylet og vertscelle som omfatter ekspresjonsvektoren
JP2001500382A (ja)	2001-01-16	骨髄前駆体阻害因子―１（ｍｐｉｆ―１）、単球コロニー阻害因子（ｍ―ｃｉｆ）、およびマクロファージ阻害因子―４（ｍｉｐ―４）で疾患状態を処置するための治療組成物および方法
AU2002215919A1 (en)	2002-06-27	Chemokine mutants in the treatment of multiple sclerosis
JP2006505243A (ja)	2006-02-16	Ｍｃｐタンパク質の新規のアンタゴニスト
NO332309B1 (no)	2012-08-20	Antagonister av CXCRX3-bindene CXC-kjemokiner, samt fremgangsmate for fremstilling derav, DNA molekyler kodende for nevnte antagonister, ekspresjonsvektor, vertcelle, farmasoytisk preparat og anvendelse av nevnte antagonister.
AU2002358144B2 (en)	2008-10-02	Chemokine mutants acting as chemokine antagonists
AU711573B2 (en)	1999-10-14	Short forms of chemokine beta-8
Vita et al.	2002	Synthesis and characterization of biologically functional biotinylated RANTES
US20030138400A1 (en)	2003-07-24	Short forms of chemokine beta-8
JP2006516255A (ja)	2006-06-29	治療薬としてのｆ１１受容体（ｆ１１ｒ）拮抗薬
JP3621883B2 (ja)	2005-02-16	ウイルスがコードするセマフォリンタンパク質受容体ｄｎａおよびポリペプチド
CA2233367A1 (en)	1997-04-03	Short forms of chemokine .beta.-8
CN1152315A (zh)	1997-06-18	单核细胞趋化蛋白-4