NO834083L - Antimykotisk middel med hoey virksom stoffrigjoering i form av gelsystemer - Google Patents

Antimykotisk middel med hoey virksom stoffrigjoering i form av gelsystemer

Info

Publication number: NO834083L
Authority: NO; Norway
Prior art keywords: antifungal; approx; gel; mol; gels
Prior art date: 1982-11-27

Application number

NO834083A

Other languages

English (en)

Norwegian (no)

Inventor

Miklos Von Bittera

Dieter Hoff

Karl Heinz Buechel

Manfred Plempel

Erik Regel

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-27

Filing date

1983-11-09

Publication date

1984-05-28

1983-11-09 Application filed by Bayer Ag filed Critical Bayer Ag

1984-05-28 Publication of NO834083L publication Critical patent/NO834083L/no

Links

239000000126 substance Substances 0.000 title description 3
239000003429 antifungal agent Substances 0.000 title 1
239000000499 gel Substances 0.000 claims description 25
239000000203 mixture Substances 0.000 claims description 24
239000013543 active substance Substances 0.000 claims description 14
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 13
230000000843 anti-fungal effect Effects 0.000 claims description 13
229940121375 antifungal agent Drugs 0.000 claims description 13
239000002270 dispersing agent Substances 0.000 claims description 12
238000009472 formulation Methods 0.000 claims description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 10
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 9
150000007980 azole derivatives Chemical class 0.000 claims description 9
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 9
238000003756 stirring Methods 0.000 claims description 9
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 4
229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 3
229920002125 Sokalan® Polymers 0.000 claims description 3
239000004584 polyacrylic acid Substances 0.000 claims description 3
235000019445 benzyl alcohol Nutrition 0.000 claims description 2
230000001857 anti-mycotic effect Effects 0.000 claims 6
239000002543 antimycotic Substances 0.000 claims 6
238000004519 manufacturing process Methods 0.000 claims 6
238000000034 method Methods 0.000 claims 6
229910052757 nitrogen Inorganic materials 0.000 claims 6
DALSNPRWUFOYDT-UHFFFAOYSA-N 1-[(2-chlorophenyl)-(4-phenylphenyl)methyl]imidazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)C1=CC=C(C=2C=CC=CC=2)C=C1 DALSNPRWUFOYDT-UHFFFAOYSA-N 0.000 claims 2
OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 2
229960002206 bifonazole Drugs 0.000 claims 2
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 2
229960004022 clotrimazole Drugs 0.000 claims 2
229950000194 lombazole Drugs 0.000 claims 2
OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 claims 1
229960003344 climbazole Drugs 0.000 claims 1
235000014113 dietary fatty acids Nutrition 0.000 description 10
229930195729 fatty acid Natural products 0.000 description 10
239000000194 fatty acid Substances 0.000 description 10
208000015181 infectious disease Diseases 0.000 description 8
-1 Fatty acid esters Chemical class 0.000 description 7
241001465754 Metazoa Species 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
150000004665 fatty acids Chemical class 0.000 description 5
230000000694 effects Effects 0.000 description 4
150000002191 fatty alcohols Chemical class 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
229920006395 saturated elastomer Polymers 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
229940089456 isopropyl stearate Drugs 0.000 description 3
FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical class CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 3
239000002904 solvent Substances 0.000 description 3
241000272525 Anas platyrhynchos Species 0.000 description 2
241000700198 Cavia Species 0.000 description 2
206010012504 Dermatophytosis Diseases 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
241001460074 Microsporum distortum Species 0.000 description 2
208000031888 Mycoses Diseases 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
208000002474 Tinea Diseases 0.000 description 2
POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 description 2
MVLVMROFTAUDAG-UHFFFAOYSA-N ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC MVLVMROFTAUDAG-UHFFFAOYSA-N 0.000 description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
229940093629 isopropyl isostearate Drugs 0.000 description 2
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229920002521 macromolecule Polymers 0.000 description 2
239000003921 oil Substances 0.000 description 2
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
229920005862 polyol Polymers 0.000 description 2
NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 2
ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 2
229920002545 silicone oil Polymers 0.000 description 2
239000000725 suspension Substances 0.000 description 2
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
XUJLWPFSUCHPQL-UHFFFAOYSA-N 11-methyldodecan-1-ol Chemical compound CC(C)CCCCCCCCCCO XUJLWPFSUCHPQL-UHFFFAOYSA-N 0.000 description 1
LZILFXHGPBJADI-UHFFFAOYSA-N 2-(2-hydroxypropoxy)propan-1-ol;nonanoic acid Chemical compound CC(O)COC(C)CO.CCCCCCCCC(O)=O LZILFXHGPBJADI-UHFFFAOYSA-N 0.000 description 1
ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
201000004384 Alopecia Diseases 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 1
ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical group CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 1
CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
206010039509 Scab Diseases 0.000 description 1
241001045770 Trichophyton mentagrophytes Species 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229960000458 allantoin Drugs 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
235000013405 beer Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
230000007547 defect Effects 0.000 description 1
229910001873 dinitrogen Inorganic materials 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
208000024963 hair loss Diseases 0.000 description 1
230000003676 hair loss Effects 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
150000002780 morpholines Chemical class 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
229940055577 oleyl alcohol Drugs 0.000 description 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000002304 perfume Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
238000005067 remediation Methods 0.000 description 1
238000012154 short term therapy Methods 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229940024986 topical antifungal imidazole and triazole derivative Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO834083A 1982-11-27 1983-11-09 Antimykotisk middel med hoey virksom stoffrigjoering i form av gelsystemer NO834083L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19823244027 DE3244027A1 (de)	1982-11-27	1982-11-27	Antimykotische mittel mit hoher wirkstoff-freisetzung in form von gelsystemen

Publications (1)

Publication Number	Publication Date
NO834083L true NO834083L (no)	1984-05-28

Family

ID=6179276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO834083A NO834083L (no)	1982-11-27	1983-11-09	Antimykotisk middel med hoey virksom stoffrigjoering i form av gelsystemer

Country Status (11)

Country	Link
EP (1)	EP0113009A3 (fr)
JP (1)	JPS59108713A (fr)
KR (1)	KR840006767A (fr)
AR (1)	AR231397A1 (fr)
CA (1)	CA1209916A (fr)
DE (1)	DE3244027A1 (fr)
DK (1)	DK541783A (fr)
ES (1)	ES527566A0 (fr)
HU (1)	HU187612B (fr)
IL (1)	IL70320A0 (fr)
NO (1)	NO834083L (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61151117A (ja) *	1984-12-25	1986-07-09	Bayer Yakuhin Kk	抗真菌ゲル製剤
US4837378A (en) *	1986-01-15	1989-06-06	Curatek Pharmaceuticals, Inc.	Topical metronidazole formulations and therapeutic uses thereof
JPH01242525A (ja) *	1988-03-25	1989-09-27	Nippon Nohyaku Co Ltd	抗真菌外用剤
JPH01246219A (ja) *	1988-03-25	1989-10-02	Nippon Nohyaku Co Ltd	抗真菌外用クリーム組成物
DE4234188C2 (de) *	1992-10-10	1996-01-11	Beiersdorf Ag	Antimycotische kosmetische und dermatologische Verwendungen
IT1284874B1 (it)	1996-08-02	1998-05-22	Farmigea Spa	Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS52117416A (en) *	1976-03-29	1977-10-01	Nippon Kayaku Co Ltd	Novel ointment base
DE3045913A1 (de) *	1980-12-05	1982-07-08	Bayer Ag, 5090 Leverkusen	Antimykotische mittel mit hoher wirkstoff-freisetzung
DE3106635A1 (de) *	1981-02-23	1982-09-09	Bayer Ag	Antimykotisches mittel mit hoher wirkstoff-freisetzung in form von stiften
JPS5815909A (ja) *	1981-07-22	1983-01-29	Toko Yakuhin Kogyo Kk	抗真菌外用剤

1982
- 1982-11-27 DE DE19823244027 patent/DE3244027A1/de not_active Withdrawn
1983
- 1983-11-09 NO NO834083A patent/NO834083L/no unknown
- 1983-11-17 EP EP83111460A patent/EP0113009A3/fr not_active Withdrawn
- 1983-11-24 HU HU834039A patent/HU187612B/hu unknown
- 1983-11-24 IL IL70320A patent/IL70320A0/xx unknown
- 1983-11-25 ES ES527566A patent/ES527566A0/es active Granted
- 1983-11-25 DK DK541783A patent/DK541783A/da not_active Application Discontinuation
- 1983-11-25 CA CA000441948A patent/CA1209916A/fr not_active Expired
- 1983-11-25 AR AR294927A patent/AR231397A1/es active
- 1983-11-25 JP JP58220891A patent/JPS59108713A/ja active Pending
- 1983-11-26 KR KR1019830005598A patent/KR840006767A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
EP0113009A3 (fr)	1985-09-25
EP0113009A2 (fr)	1984-07-11
ES8406192A1 (es)	1984-08-01
ES527566A0 (es)	1984-08-01
AR231397A1 (es)	1984-11-30
DK541783D0 (da)	1983-11-25
DK541783A (da)	1984-05-28
CA1209916A (fr)	1986-08-19
KR840006767A (ko)	1984-12-03
DE3244027A1 (de)	1984-05-30
HU187612B (en)	1986-02-28
JPS59108713A (ja)	1984-06-23
IL70320A0 (en)	1984-02-29

Publication	Publication Date	Title
KR880000724B1 (ko)	1988-04-29	활성화합물의 방출성이 우수한 항진균 조성물의 제조방법
US4457938A (en)	1984-07-03	Antimycotic agent, in the form of sticks, with a high release of active compound
NO813932L (no)	1982-06-07	Antimykotisk middel med hoey virksom stoff-frigjoering i form av elastiske flytende plastere
CA1175354A (fr)	1984-10-02	Agents antimycotiques liberant un compose actif en emplatre liquide elastique
NO834083L (no)	1984-05-28	Antimykotisk middel med hoey virksom stoffrigjoering i form av gelsystemer
EP0719543A1 (fr)	1996-07-03	Activateur dermatologique accelerant la production de glucosaminoglycane
CN1218663A (zh)	1999-06-09	在化妆和药物制剂中稳定维生素a和/或维生素a衍生物的2'-磷酸抗坏血酸酯的使用
DE4110779A1 (de)	1991-10-02	Liposomale formulierungen antimykotischer, antibakterieller und/oder antiphlogistischer arzneimittel fuer die lokale und vaginale anwendung
US20040081677A1 (en)	2004-04-29	Antimycotic gel having high active compound release
EP0294914A2 (fr)	1988-12-14	Nédocromil pour le traitement des maladies dermatologiques
DE3323833A1 (de)	1985-01-03	Etofenamat-zubereitung
DE3311700A1 (de)	1984-10-04	Antimykotische mittel mit hoher wirkstoff-freisetzung in form von loesung und spray
DE3243544A1 (de)	1984-05-30	Antimykotische mittel fuer einmalige gynaekologische behandlung
Itoyama et al.	1997	Therapeutic effects of omoconazole nitrate on guinea-pigs experimentally infected with Trichophyton mentagrophytes.
EP0128459A2 (fr)	1984-12-19	Composition antimycotique pour un traitement gynécologique unique
JPH09309827A (ja)	1997-12-02	抗真菌外用剤
CY1358A (en)	1987-08-07	Antimycotic agent with a high release of active compounds, in the form of a cream
Shankland et al.	1990	Comparative in-vivo activity of clotrimazole and a clotrimazole/hydrocortisone combination in the treatment of experimental dennatophytosis in guinea pigs
JPH0242812B2 (fr)	1990-09-26
JPH0335288B2 (fr)	1991-05-27
BG61329B1 (bg)	1997-06-30	Фармацевтичен мехлем недразнещ кожата и метод заполучаването му