NO843650L - Mikrofase-separerte hydrogeler for regulert frigivelse av bioaktive materialer - Google Patents

Mikrofase-separerte hydrogeler for regulert frigivelse av bioaktive materialer

Info

Publication number: NO843650L
Authority: NO; Norway
Prior art keywords: water; copolymer; weight; soluble; insoluble
Prior art date: 1983-09-15

Application number

NO843650A

Other languages

English (en)

Norwegian (no)

Inventor

Kishore R Shah

Original Assignee

Kendall & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-15

Filing date

1984-09-14

Publication date

1985-03-18

1984-09-14 Application filed by Kendall & Co filed Critical Kendall & Co

1985-03-18 Publication of NO843650L publication Critical patent/NO843650L/no

Links

239000000463 material Substances 0.000 title claims description 23
230000001105 regulatory effect Effects 0.000 title claims description 18
230000000975 bioactive effect Effects 0.000 title description 2
229920001577 copolymer Polymers 0.000 claims description 71
239000000178 monomer Substances 0.000 claims description 49
239000003795 chemical substances by application Substances 0.000 claims description 29
239000003814 drug Substances 0.000 claims description 27
229940079593 drug Drugs 0.000 claims description 26
239000012867 bioactive agent Substances 0.000 claims description 24
239000002253 acid Substances 0.000 claims description 19
229920002554 vinyl polymer Polymers 0.000 claims description 17
230000002209 hydrophobic effect Effects 0.000 claims description 15
229920001519 homopolymer Polymers 0.000 claims description 12
229920002959 polymer blend Polymers 0.000 claims description 9
239000012528 membrane Substances 0.000 claims description 8
229920006037 cross link polymer Polymers 0.000 claims description 4
229920003169 water-soluble polymer Polymers 0.000 claims description 2
229940126601 medicinal product Drugs 0.000 claims 6
229920003176 water-insoluble polymer Polymers 0.000 claims 1
239000000203 mixture Substances 0.000 description 53
239000000017 hydrogel Substances 0.000 description 45
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 23
229920000642 polymer Polymers 0.000 description 19
239000013543 active substance Substances 0.000 description 17
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 15
229960000890 hydrocortisone Drugs 0.000 description 12
238000013270 controlled release Methods 0.000 description 10
-1 polyethylene Polymers 0.000 description 10
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 8
229960003387 progesterone Drugs 0.000 description 8
239000000186 progesterone Substances 0.000 description 8
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 7
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
239000000126 substance Substances 0.000 description 7
239000011159 matrix material Substances 0.000 description 6
150000003431 steroids Chemical class 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
210000004379 membrane Anatomy 0.000 description 5
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 4
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 4
239000011149 active material Substances 0.000 description 4
238000009826 distribution Methods 0.000 description 4
FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 4
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
125000004432 carbon atom Chemical group C* 0.000 description 3
239000003433 contraceptive agent Substances 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
239000002904 solvent Substances 0.000 description 3
QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 2
OLQFXOWPTQTLDP-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl 2-methylprop-2-enoate Chemical group CC(=C)C(=O)OCCOCCO OLQFXOWPTQTLDP-UHFFFAOYSA-N 0.000 description 2
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
MZGMQAMKOBOIDR-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCO MZGMQAMKOBOIDR-UHFFFAOYSA-N 0.000 description 2
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
239000004599 antimicrobial Substances 0.000 description 2
230000008859 change Effects 0.000 description 2
229940124558 contraceptive agent Drugs 0.000 description 2
238000013267 controlled drug release Methods 0.000 description 2
230000007423 decrease Effects 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
238000001647 drug administration Methods 0.000 description 2
238000012377 drug delivery Methods 0.000 description 2
125000005670 ethenylalkyl group Chemical group 0.000 description 2
239000000417 fungicide Substances 0.000 description 2
QBKSWRVVCFFDOT-UHFFFAOYSA-N gossypol Chemical compound CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 QBKSWRVVCFFDOT-UHFFFAOYSA-N 0.000 description 2
229920001477 hydrophilic polymer Polymers 0.000 description 2
239000002917 insecticide Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000000034 method Methods 0.000 description 2
229940088644 n,n-dimethylacrylamide Drugs 0.000 description 2
YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
229940126585 therapeutic drug Drugs 0.000 description 2
229920001169 thermoplastic Polymers 0.000 description 2
ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 description 1
HQGPZXPTJWUDQR-UHFFFAOYSA-N 1-ethenyl-5-methylpyrrolidin-2-one Chemical compound CC1CCC(=O)N1C=C HQGPZXPTJWUDQR-UHFFFAOYSA-N 0.000 description 1
JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 description 1
PBGPBHYPCGDFEZ-UHFFFAOYSA-N 1-ethenylpiperidin-2-one Chemical compound C=CN1CCCCC1=O PBGPBHYPCGDFEZ-UHFFFAOYSA-N 0.000 description 1
GSSDUXHQPXODCN-UHFFFAOYSA-N 1-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C(=C)C1=CC=CC=C1 GSSDUXHQPXODCN-UHFFFAOYSA-N 0.000 description 1
PRAMZQXXPOLCIY-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethanesulfonic acid Chemical compound CC(=C)C(=O)OCCS(O)(=O)=O PRAMZQXXPOLCIY-UHFFFAOYSA-N 0.000 description 1
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 1
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
SSIXTXQCTROADU-UHFFFAOYSA-N 2-methoxyethoxymethyl 2-methylprop-2-enoate Chemical compound COCCOCOC(=O)C(C)=C SSIXTXQCTROADU-UHFFFAOYSA-N 0.000 description 1
YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
GKGOIYMLPJJVQI-UHFFFAOYSA-N 4-ethenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=C(C=C)C=C1 GKGOIYMLPJJVQI-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
240000002024 Gossypium herbaceum Species 0.000 description 1
235000004341 Gossypium herbaceum Nutrition 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000003732 agents acting on the eye Substances 0.000 description 1
125000005250 alkyl acrylate group Chemical group 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
235000019568 aromas Nutrition 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005266 casting Methods 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000000470 constituent Substances 0.000 description 1
230000002254 contraceptive effect Effects 0.000 description 1
239000000599 controlled substance Substances 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
238000004512 die casting Methods 0.000 description 1
150000001993 dienes Chemical class 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
AWMFUEJKWXESNL-JZBHMOKNSA-N erythromycin estolate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(=O)CC)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AWMFUEJKWXESNL-JZBHMOKNSA-N 0.000 description 1
229960003203 erythromycin estolate Drugs 0.000 description 1
MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000013265 extended release Methods 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
150000002222 fluorine compounds Chemical class 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229930000755 gossypol Natural products 0.000 description 1
229950005277 gossypol Drugs 0.000 description 1
229920000578 graft copolymer Polymers 0.000 description 1
239000004009 herbicide Substances 0.000 description 1
229920001480 hydrophilic copolymer Polymers 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
238000010338 mechanical breakdown Methods 0.000 description 1
239000012907 medicinal substance Substances 0.000 description 1
239000002609 medium Substances 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
210000002200 mouth mucosa Anatomy 0.000 description 1
229940087419 nonoxynol-9 Drugs 0.000 description 1
229920004918 nonoxynol-9 Polymers 0.000 description 1
229940023490 ophthalmic product Drugs 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
238000005192 partition Methods 0.000 description 1
230000035699 permeability Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 1
229920000867 polyelectrolyte Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000807 solvent casting Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
229940045136 urea Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L57/00—Compositions of unspecified polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO843650A 1983-09-15 1984-09-14 Mikrofase-separerte hydrogeler for regulert frigivelse av bioaktive materialer NO843650L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53264383A	1983-09-15	1983-09-15
US06/606,794 US4693887A (en)	1983-09-15	1984-05-03	Microphase separated hydrogels for controlled release of bioactive materials

Publications (1)

Publication Number	Publication Date
NO843650L true NO843650L (no)	1985-03-18

Family

ID=27063895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO843650A NO843650L (no)	1983-09-15	1984-09-14	Mikrofase-separerte hydrogeler for regulert frigivelse av bioaktive materialer

Country Status (18)

Country	Link
US (1)	US4693887A (fr)
AT (1)	ATA290884A (fr)
AU (1)	AU577056B2 (fr)
BE (1)	BE900581A (fr)
BR (1)	BR8404409A (fr)
CA (1)	CA1232201A (fr)
CH (1)	CH666415A5 (fr)
DE (1)	DE3432573A1 (fr)
DK (1)	DK410984A (fr)
ES (1)	ES8607357A1 (fr)
FR (1)	FR2551976B1 (fr)
GB (2)	GB2147002B (fr)
IT (1)	IT1178430B (fr)
NL (1)	NL8402833A (fr)
NO (1)	NO843650L (fr)
NZ (1)	NZ209323A (fr)
PT (1)	PT79192B (fr)
SE (1)	SE461502B (fr)

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1984
- 1984-05-03 US US06/606,794 patent/US4693887A/en not_active Expired - Fee Related
- 1984-08-22 AU AU32268/84A patent/AU577056B2/en not_active Ceased
- 1984-08-23 NZ NZ209323A patent/NZ209323A/en unknown
- 1984-08-28 DK DK410984A patent/DK410984A/da not_active Application Discontinuation
- 1984-09-04 BR BR8404409A patent/BR8404409A/pt unknown
- 1984-09-05 DE DE19843432573 patent/DE3432573A1/de not_active Withdrawn
- 1984-09-10 FR FR8413866A patent/FR2551976B1/fr not_active Expired
- 1984-09-11 PT PT79192A patent/PT79192B/pt not_active IP Right Cessation
- 1984-09-11 AT AT842908A patent/ATA290884A/de not_active Application Discontinuation
- 1984-09-12 SE SE8404568A patent/SE461502B/sv not_active IP Right Cessation
- 1984-09-13 IT IT8448836A patent/IT1178430B/it active
- 1984-09-14 BE BE0/213653A patent/BE900581A/fr not_active IP Right Cessation
- 1984-09-14 NL NL8402833A patent/NL8402833A/nl not_active Application Discontinuation
- 1984-09-14 ES ES535923A patent/ES8607357A1/es not_active Expired
- 1984-09-14 CH CH4417/84A patent/CH666415A5/de not_active IP Right Cessation
- 1984-09-14 NO NO843650A patent/NO843650L/no unknown
- 1984-09-14 CA CA000463168A patent/CA1232201A/fr not_active Expired
- 1984-09-17 GB GB08423416A patent/GB2147002B/en not_active Expired
1986
- 1986-08-19 GB GB08620117A patent/GB2177708A/en not_active Withdrawn

Also Published As

Publication number	Publication date
GB8423416D0 (en)	1984-10-24
US4693887A (en)	1987-09-15
GB2147002B (en)	1987-11-11
CH666415A5 (de)	1988-07-29
GB2147002A (en)	1985-05-01
IT1178430B (it)	1987-09-09
FR2551976A1 (fr)	1985-03-22
CA1232201A (fr)	1988-02-02
AU3226884A (en)	1985-03-21
BE900581A (fr)	1985-03-14
NZ209323A (en)	1987-04-30
GB8620117D0 (en)	1986-10-01
IT8448836A0 (it)	1984-09-13
FR2551976B1 (fr)	1988-06-10
DK410984A (da)	1985-03-16
AU577056B2 (en)	1988-09-15
BR8404409A (pt)	1985-07-30
PT79192A (en)	1984-10-01
NL8402833A (nl)	1985-04-01
PT79192B (en)	1986-08-14
ES8607357A1 (es)	1986-05-16
SE8404568L (sv)	1985-03-16
SE8404568D0 (sv)	1984-09-12
ES535923A0 (es)	1986-05-16
DE3432573A1 (de)	1985-04-18
ATA290884A (de)	1991-07-15
SE461502B (sv)	1990-02-26
IT8448836A1 (it)	1986-03-13
GB2177708A (en)	1987-01-28
DK410984D0 (da)	1984-08-28

Publication	Publication Date	Title
NO843650L (no)	1985-03-18	Mikrofase-separerte hydrogeler for regulert frigivelse av bioaktive materialer
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CA1078734A (fr)	1980-06-03	Implant de surfactif a liberation progressive
EP1077678B1 (fr)	2010-12-29	Compositions mucoadhesives pour l'application d'agents biologiquement actifs a des tissus animaux
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CN101983723A (zh)	2011-03-09	缓释释药的药物载体
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Schacht	1984	Hydrogel drug delivery systems physical and ionogenic drug carriers
JPS60100513A (ja)	1985-06-04	生物活性物質を調節して開放するための微小相の分離されたヒドロゲル
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EP0497626B1 (fr)	1999-09-15	Dispositif à libération contrÔlée, activé à la température