NO893471L - Antidepressive n-substituerte nikotinamidforbindelser. - Google Patents
Antidepressive n-substituerte nikotinamidforbindelser.Info
- Publication number
- NO893471L NO893471L NO89893471A NO893471A NO893471L NO 893471 L NO893471 L NO 893471L NO 89893471 A NO89893471 A NO 89893471A NO 893471 A NO893471 A NO 893471A NO 893471 L NO893471 L NO 893471L
- Authority
- NO
- Norway
- Prior art keywords
- chlorine
- fluorine
- compounds
- antidepressive
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/238,951 US4861891A (en) | 1988-08-31 | 1988-08-31 | Antidepressant N-substituted nicotinamide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO893471D0 NO893471D0 (no) | 1989-08-30 |
| NO893471L true NO893471L (no) | 1990-03-01 |
Family
ID=22899998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO89893471A NO893471L (no) | 1988-08-31 | 1989-08-30 | Antidepressive n-substituerte nikotinamidforbindelser. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4861891A (da) |
| EP (1) | EP0357316B1 (da) |
| JP (1) | JPH02115168A (da) |
| KR (1) | KR920000760B1 (da) |
| AT (1) | ATE88182T1 (da) |
| AU (1) | AU609329B2 (da) |
| CA (1) | CA1329605C (da) |
| DE (1) | DE68905979T2 (da) |
| DK (1) | DK426889A (da) |
| FI (1) | FI894066A7 (da) |
| HU (1) | HU208120B (da) |
| IE (1) | IE892775L (da) |
| IL (1) | IL91417A0 (da) |
| MY (1) | MY104179A (da) |
| NO (1) | NO893471L (da) |
| NZ (1) | NZ230493A (da) |
| PT (1) | PT91580B (da) |
| ZA (1) | ZA896626B (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973597A (en) * | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
| US5395935A (en) * | 1992-05-08 | 1995-03-07 | Pfizer Inc. | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents |
| TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| AU738037B2 (en) * | 1997-04-04 | 2001-09-06 | Pfizer Products Inc. | Nicotinamide derivatives |
| GB9715584D0 (en) * | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
| CZ20022413A3 (cs) * | 2000-01-31 | 2003-08-13 | Pfizer Products Inc. | Pyrimidinkarboxamidy užitečné jako inhibitory isozymů PDE4 |
| CZ20022410A3 (cs) * | 2000-01-31 | 2003-08-13 | Pfizer Products Inc. | Benzoanelované heterocyklylové deriváty nikotinamidu užitečné jako selektivní inhibitory isozymů PDE4 |
| KR100661081B1 (ko) * | 2000-06-10 | 2006-12-26 | 동화약품공업주식회사 | 항바이러스제로 유용한 6-메틸니코틴아미드 유도체 |
| CN1489588A (zh) * | 2001-01-31 | 2004-04-14 | �Ʒ� | 用作pde4同功酶抑制剂的噻唑基,噁唑基,吡咯基,和咪唑基羧酸酰胺衍生物 |
| EE200300360A (et) * | 2001-01-31 | 2003-12-15 | Pfizer Products Inc. | PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid |
| ES2248231T3 (es) * | 2001-01-31 | 2006-03-16 | Pfizer Products Inc. | Derivados de eteres utiles como inhibidores de las isozimas pde4. |
| US7250518B2 (en) * | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| GB0317472D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| EP1742627A4 (en) | 2004-05-06 | 2009-08-26 | Plexxikon Inc | PDE4B HEMMER AND ITS USE |
| WO2006026754A2 (en) * | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| ES2597843T3 (es) * | 2005-11-24 | 2017-01-23 | Dompé Farmaceutici S.P.A. | Derivados de (R)-arilalquilamino y composiciones farmacéuticas que los contienen |
| CA2637620A1 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| DE102007057089B4 (de) * | 2006-12-22 | 2010-04-29 | Lg Display Co., Ltd. | Flüssigkristallanzeige mit Photosensor und Herstellungsverfahren derselben |
| US20110105602A2 (en) * | 2007-03-08 | 2011-05-05 | Daria Mochly-Rosen | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof |
| US8354435B2 (en) | 2008-09-08 | 2013-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| CN102202669A (zh) | 2008-10-28 | 2011-09-28 | 利兰·斯坦福青年大学托管委员会 | 醛脱氢酶调节剂及其使用方法 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2014160185A2 (en) | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251263A (en) * | 1979-09-04 | 1981-02-17 | Stauffer Chemical Company | N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof |
| US4270946A (en) * | 1979-10-01 | 1981-06-02 | Stauffer Chemical Company | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof |
| IL64220A (en) * | 1980-11-21 | 1985-06-30 | May & Baker Ltd | Nicotinamide derivatives,their preparation and their use as herbicides |
| US4692185A (en) * | 1986-01-13 | 1987-09-08 | Stauffer Chemical Company | N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides |
-
1988
- 1988-08-31 US US07/238,951 patent/US4861891A/en not_active Expired - Fee Related
-
1989
- 1989-08-22 DE DE8989308481T patent/DE68905979T2/de not_active Expired - Fee Related
- 1989-08-22 EP EP89308481A patent/EP0357316B1/en not_active Expired - Lifetime
- 1989-08-22 AT AT89308481T patent/ATE88182T1/de active
- 1989-08-24 IL IL91417A patent/IL91417A0/xx unknown
- 1989-08-25 MY MYPI89001168A patent/MY104179A/en unknown
- 1989-08-29 CA CA000609655A patent/CA1329605C/en not_active Expired - Fee Related
- 1989-08-30 NO NO89893471A patent/NO893471L/no unknown
- 1989-08-30 NZ NZ230493A patent/NZ230493A/en unknown
- 1989-08-30 JP JP1224342A patent/JPH02115168A/ja active Pending
- 1989-08-30 FI FI894066A patent/FI894066A7/fi not_active IP Right Cessation
- 1989-08-30 KR KR1019890012412A patent/KR920000760B1/ko not_active Expired
- 1989-08-30 ZA ZA896626A patent/ZA896626B/xx unknown
- 1989-08-30 PT PT91580A patent/PT91580B/pt not_active IP Right Cessation
- 1989-08-30 AU AU40913/89A patent/AU609329B2/en not_active Ceased
- 1989-08-30 IE IE892775A patent/IE892775L/xx unknown
- 1989-08-30 DK DK426889A patent/DK426889A/da not_active Application Discontinuation
- 1989-08-30 HU HU894507A patent/HU208120B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK426889A (da) | 1990-03-01 |
| EP0357316B1 (en) | 1993-04-14 |
| IL91417A0 (en) | 1990-04-29 |
| NO893471D0 (no) | 1989-08-30 |
| NZ230493A (en) | 1991-03-26 |
| ZA896626B (en) | 1991-04-24 |
| HU208120B (en) | 1993-08-30 |
| HUT52058A (en) | 1990-06-28 |
| AU4091389A (en) | 1990-06-28 |
| DE68905979D1 (de) | 1993-05-19 |
| US4861891A (en) | 1989-08-29 |
| KR900003154A (ko) | 1990-03-23 |
| PT91580A (pt) | 1990-03-08 |
| DK426889D0 (da) | 1989-08-30 |
| MY104179A (en) | 1994-02-28 |
| IE892775L (en) | 1990-02-28 |
| JPH02115168A (ja) | 1990-04-27 |
| FI894066L (fi) | 1990-03-01 |
| PT91580B (pt) | 1995-05-04 |
| AU609329B2 (en) | 1991-04-26 |
| FI894066A0 (fi) | 1989-08-30 |
| FI894066A7 (fi) | 1990-03-01 |
| DE68905979T2 (de) | 1993-07-22 |
| EP0357316A1 (en) | 1990-03-07 |
| CA1329605C (en) | 1994-05-17 |
| KR920000760B1 (ko) | 1992-01-21 |
| ATE88182T1 (de) | 1993-04-15 |
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