NO914171L - Fremgangsmaate for fremstilling av peptidforbindelser - Google Patents

Fremgangsmaate for fremstilling av peptidforbindelser

Info

Publication number: NO914171L
Authority: NO; Norway
Prior art keywords: alkyl; substituents; preparation; pyridyl; hydrogen
Prior art date: 1990-10-24

Application number

NO91914171A

Other languages

English (en)

Norwegian (no)

Other versions

NO914171D0 (no

Inventor

Masaaki Matsuo

Daijiro Hagiwara

Hiroshi Miyake

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-24

Filing date

1991-10-23

Publication date

1992-04-27

1991-10-23 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1991-10-23 Publication of NO914171D0 publication Critical patent/NO914171D0/no

1992-04-27 Publication of NO914171L publication Critical patent/NO914171L/no

Links

125000001424 substituent group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
102000003141 Tachykinin Human genes 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 pyrazolopyridyl Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108060008037 tachykinin Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Crystallography & Structural Chemistry (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pyridine Compounds (AREA)
Electroluminescent Light Sources (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO91914171A 1990-10-24 1991-10-23 Fremgangsmaate for fremstilling av peptidforbindelser NO914171L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909023116A GB9023116D0 (en)	1990-10-24	1990-10-24	Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

Publications (2)

Publication Number	Publication Date
NO914171D0 NO914171D0 (no)	1991-10-23
NO914171L true NO914171L (no)	1992-04-27

Family

ID=10684270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO91914171A NO914171L (no)	1990-10-24	1991-10-23	Fremgangsmaate for fremstilling av peptidforbindelser

Country Status (19)

Country	Link
EP (1)	EP0482539B1 (fr)
JP (1)	JP3206764B2 (fr)
KR (1)	KR920008065A (fr)
CN (2)	CN1038939C (fr)
AT (1)	ATE146480T1 (fr)
AU (1)	AU647534B2 (fr)
CA (1)	CA2054097A1 (fr)
DE (1)	DE69123697T2 (fr)
DK (1)	DK0482539T3 (fr)
ES (1)	ES2095283T3 (fr)
FI (1)	FI914961A7 (fr)
GB (1)	GB9023116D0 (fr)
GR (1)	GR3022137T3 (fr)
HU (2)	HUT59163A (fr)
IE (1)	IE913599A1 (fr)
NO (1)	NO914171L (fr)
PT (1)	PT99317B (fr)
RU (1)	RU2073683C1 (fr)
ZA (1)	ZA918011B (fr)

Families Citing this family (64)

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US5420297A (en) *	1990-10-24	1995-05-30	Fujisawa Pharmaceutical Co., Ltd.	Peptides having substance P antagonistic activity
ES2149767T5 (es)	1991-09-20	2005-06-16	Glaxo Group Limited	Nuevo uso medico para antagonistas de taquiquininas.
US5328927A (en) *	1992-03-03	1994-07-12	Merck Sharpe & Dohme, Ltd.	Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
DE4243496A1 (de) *	1992-09-03	1994-03-10	Boehringer Ingelheim Kg	Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
JPH07501085A (ja) *	1992-09-03	1995-02-02	ベーリンガー　インゲルハイム　コマンディトゲゼルシャフト	新規なアミノ酸誘導体、その製造方法及びこれらの化合物を含む医薬組成物
IT1256623B (it) *	1992-12-04	1995-12-12	Federico Arcamone	Antagonisti delle tachichinine, procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche
FR2700472B1 (fr)	1993-01-19	1995-02-17	Rhone Poulenc Rorer Sa	Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
WO1994019320A1 (fr) *	1993-02-22	1994-09-01	Merck Sharp & Dohme Limited	Composes aromatiques, compositions les contenant et leur utilisation en therapie
WO1994020126A1 (fr) *	1993-03-03	1994-09-15	Fujisawa Pharmaceutical Co., Ltd.	Utilisation de peptidiques pour la fabrication d'un medicament
US5635510A (en) *	1993-05-06	1997-06-03	Merrell Pharmaceuticals Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines
WO1995000536A1 (fr) *	1993-06-22	1995-01-05	Fujisawa Pharmaceutical Co., Ltd.	Compose a base de peptides
US5455262A (en) *	1993-10-06	1995-10-03	Florida State University	Mercaptosulfide metalloproteinase inhibitors
MX9605128A (es) *	1994-05-07	1997-08-30	Boehringer Ingelheim Kg	Nuevos derivados de aminoacidos, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos.
CN1067385C (zh)	1994-08-25	2001-06-20	默里尔药物公司	用于治疗变应性疾病的新的取代的哌啶类化合物
US5830868A (en) *	1994-09-13	1998-11-03	Warner-Lambert Company	Substituted DI- and tripeptide inhibitors of protein: farnesyl transferase
NZ306022A (en) *	1995-04-13	1998-09-24	Hoechst Marion Roussel Inc	Phenyl, naphthyl or indolyl substituted piperazine derivatives and medicaments
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en)	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US6423689B1 (en)	1997-12-22	2002-07-23	Warner-Lambert Company	Peptidyl calcium channel blockers
TR200100175T2 (tr) *	1998-07-23	2001-09-21	Akzo Nobel N.V.	Otoimmün hastalıkların immünoterapisinde kullanılmak üzere yeni peptitler.
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
DK1246806T3 (da)	1999-11-03	2008-06-16	Amr Technology Inc	Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
MXPA03000275A (es)	2000-07-11	2004-12-13	Albany Molecular Res Inc	Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US7956050B2 (en)	2005-07-15	2011-06-07	Albany Molecular Research, Inc.	Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt)	2007-01-10	2022-01-25	Msd Italia S.R.L.	Compostos de fórmula i e seus usos
US8093268B2 (en)	2007-01-24	2012-01-10	Glaxo Group Limited	Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
WO2009002495A1 (fr)	2007-06-27	2008-12-31	Merck & Co., Inc.	Dérivés de 4-carboxybenzylamino utilisés en tant qu'inhibiteurs de l'histone désacétylase
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
EP2413932A4 (fr)	2009-04-01	2012-09-19	Merck Sharp & Dohme	Inhibiteurs de l'activité akt
JP5739415B2 (ja)	2009-05-12	2015-06-24	ブリストル−マイヤーズスクウィブカンパニー	（Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
CN102595902B (zh)	2009-05-12	2015-04-29	阿尔巴尼分子研究公司	7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
ES2446971T3 (es)	2009-05-12	2014-03-11	Albany Molecular Research, Inc.	Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
CA2777043C (fr)	2009-10-14	2015-12-15	Schering Corporation	Piperidines substituees qui accroissent l'activite de p53, et utilisations de ces composes
US9446029B2 (en)	2010-07-27	2016-09-20	Colorado State University Research Foundation	Use of NK-1 receptor antagonists in management of visceral pain
CN103068980B (zh)	2010-08-02	2017-04-05	瑟纳治疗公司	使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
RU2745848C2 (ru)	2010-08-17	2021-04-01	Сирна Терапьютикс, Инк.	ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (fr)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (fr)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	INHIBITION FACILITÉE PAR L'INTERFÉRENCE D'ARN DE L'EXPRESSION D'UN GÈNE AU MOYEN D'ACIDES NUCLÉIQUES INTERFÉRENTS COURTS (siNA)
WO2012087772A1 (fr)	2010-12-21	2012-06-28	Schering Corporation	Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
WO2012143879A1 (fr)	2011-04-21	2012-10-26	Piramal Healthcare Limited	Forme cristalline d'un sel d'un dérivé de morpholinosulfonylindole et son procédé de préparation
EP2770987B1 (fr)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Nouveaux composés qui sont des inhibiteurs d'erk
EP3919620A1 (fr)	2012-05-02	2021-12-08	Sirna Therapeutics, Inc.	Compositions d'acide nucléique interférent court (sina)
CA2882950A1 (fr)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Nouveaux composes inhibiteurs de erk
SMT201700595T1 (it)	2012-11-28	2018-03-08	Merck Sharp & Dohme	Composizioni e metodi per trattare il cancro
WO2014100065A1 (fr)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Imidazopyridines substituées en tant qu'inhibiteurs de hdm2
WO2014120748A1 (fr)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
WO2015034925A1 (fr)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Polynucléotides circulaires
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
EP3706742B1 (fr)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Inhibiteurs de prmt5
WO2019094312A1 (fr)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Inhibiteurs de prmt5
WO2020033282A1 (fr)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Inhibiteurs de prmt5
CA3108388A1 (fr)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Inhibiteurs de prmt5
EP3833667B1 (fr)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Inhibiteurs de prmt5

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4395401A (en) *	1981-09-09	1983-07-26	Smithkline Beckman Corporation	Renally active dipeptides
US5187156A (en) *	1988-03-16	1993-02-16	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
US5164372A (en) *	1989-04-28	1992-11-17	Fujisawa Pharmaceutical Company, Ltd.	Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same

1990
- 1990-10-24 GB GB909023116A patent/GB9023116D0/en active Pending
1991
- 1991-10-07 ZA ZA918011A patent/ZA918011B/xx unknown
- 1991-10-16 IE IE359991A patent/IE913599A1/en not_active Application Discontinuation
- 1991-10-18 AU AU85925/91A patent/AU647534B2/en not_active Ceased
- 1991-10-20 DE DE69123697T patent/DE69123697T2/de not_active Expired - Fee Related
- 1991-10-20 ES ES91117889T patent/ES2095283T3/es not_active Expired - Lifetime
- 1991-10-20 EP EP91117889A patent/EP0482539B1/fr not_active Expired - Lifetime
- 1991-10-20 DK DK91117889.5T patent/DK0482539T3/da active
- 1991-10-20 AT AT91117889T patent/ATE146480T1/de not_active IP Right Cessation
- 1991-10-22 FI FI914961A patent/FI914961A7/fi not_active Application Discontinuation
- 1991-10-22 HU HU913331A patent/HUT59163A/hu unknown
- 1991-10-22 KR KR1019910018577A patent/KR920008065A/ko not_active Ceased
- 1991-10-23 RU SU915010105A patent/RU2073683C1/ru active
- 1991-10-23 CA CA002054097A patent/CA2054097A1/fr not_active Abandoned
- 1991-10-23 NO NO91914171A patent/NO914171L/no unknown
- 1991-10-23 PT PT99317A patent/PT99317B/pt not_active IP Right Cessation
- 1991-10-23 CN CN91109851A patent/CN1038939C/zh not_active Expired - Lifetime
- 1991-10-24 JP JP34387291A patent/JP3206764B2/ja not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00392P patent/HU211611A9/hu unknown
1996
- 1996-08-14 CN CN96111367A patent/CN1148503A/zh active Pending
- 1996-12-23 GR GR960403576T patent/GR3022137T3/el unknown

Also Published As

Publication number	Publication date
CN1038939C (zh)	1998-07-01
KR920008065A (ko)	1992-05-27
AU647534B2 (en)	1994-03-24
EP0482539B1 (fr)	1996-12-18
DK0482539T3 (da)	1997-01-06
JPH04297492A (ja)	1992-10-21
RU2073683C1 (ru)	1997-02-20
ZA918011B (en)	1992-07-29
PT99317A (pt)	1992-09-30
CN1060848A (zh)	1992-05-06
DE69123697D1 (de)	1997-01-30
CN1148503A (zh)	1997-04-30
PT99317B (pt)	1999-04-30
FI914961A0 (fi)	1991-10-22
ES2095283T3 (es)	1997-02-16
FI914961A7 (fi)	1992-04-25
ATE146480T1 (de)	1997-01-15
GB9023116D0 (en)	1990-12-05
IE913599A1 (en)	1992-05-22
EP0482539A2 (fr)	1992-04-29
GR3022137T3 (en)	1997-03-31
JP3206764B2 (ja)	2001-09-10
HU913331D0 (en)	1992-01-28
NO914171D0 (no)	1991-10-23
DE69123697T2 (de)	1997-04-17
HUT59163A (en)	1992-04-28
HU211611A9 (en)	1995-12-28
CA2054097A1 (fr)	1992-04-25
AU8592591A (en)	1992-04-30
EP0482539A3 (en)	1992-08-26

Publication	Publication Date	Title
NO914171D0 (no)	1991-10-23	Fremgangsmaate for fremstilling av peptidforbindelser
EP0394989A3 (fr)	1991-04-24	Composés peptidiques, leur préparation et médicaments les renfermant
ES8605806A1 (es)	1986-04-01	Procedimiento de preparacion de nuevos derivados de la xan- tina y de sus sales de adicion con acidos apropiados
DK0443132T3 (da)	1994-01-24	Peptider med tachykininantagonistaktivitet, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdende samme
RU95101430A (ru)	1997-02-20	Производные 1-бифенилметилимидазола, их получение, фармацевтическая композиция, способ лечения или профилактики гипертонии
ES8403858A1 (es)	1984-04-01	Procedimiento para la preparacion de dipeptidos carboxialquilicos.
KR870003130A (ko)	1987-04-15	테이코플라닌 화합물의 아미드
NO943093L (no)	1994-12-09	Fremgangsmåte for fremstilling av clavulansyre
RU2001122727A (ru)	2003-05-20	Амиды кислот, способ их получения и фармацевтическая композиция на их основе
PL136015B1 (en)	1986-01-31	Method of obtaining novel imidazolilophenylamidines
CA2053477A1 (fr)	1992-04-17	Derives d'amines heterocycliques, leur production et leur emploi
TW358091B (en)	1999-05-11	Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas
EP0309424A3 (fr)	1990-10-10	Dérivés amidinyls
WO1994004499A1 (fr)	1994-03-03	Des cyanoguanidines, agents bloquants du canal potassium
EP0123962A3 (en)	1987-10-07	Novel benzimidazole derivative, process for the preparation thereof and pharmaceutical composition
RU97110218A (ru)	1999-05-20	Производные 6-метокси-1н-бензотриазол-5-карбоксамида, способы их получения и содержащие их фармацевтические композиции
NO923249L (no)	1993-02-22	Terapeutisk aktive pyrimidinderivater og fremgangsmaate for deres fremstilling
US4912223A (en)	1990-03-27	1,4-Dihydropyridines
EP0703904B1 (fr)	1999-02-24	Cyanoguanidines au pyrimidine utilisees en tant qu'agents bloquant des vannes a potassium
KR950032200A (ko)	1995-12-20	이미다조피리딘 유도체 및 이의 제조방법
WO1997029078A1 (fr)	1997-08-14	Derives d'acides d'amides cycliques
ATE131480T1 (de)	1995-12-15	Pyrimidoindolderivate und verfahren zu ihrer herstellung
HU210248B (en)	1995-03-28	Process for preparing 3-l-(5-thioxo-l-prolyl)-thiazolidine-4-carboxylic acid, derivatives thereof and pharmaceutical compositions containing them
CA2217479A1 (fr)	1996-10-10	Derives de la phenoxyethylamine possedant une haute affinite pour le recepteur 5-ht1a, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant
HU186989B (en)	1985-10-28	Process for preparing new ergoline derivatives