NO923197L - Substituerte heterocykliske forbindelser - Google Patents
Substituerte heterocykliske forbindelserInfo
- Publication number
- NO923197L NO923197L NO92923197A NO923197A NO923197L NO 923197 L NO923197 L NO 923197L NO 92923197 A NO92923197 A NO 92923197A NO 923197 A NO923197 A NO 923197A NO 923197 L NO923197 L NO 923197L
- Authority
- NO
- Norway
- Prior art keywords
- group
- aryl
- formula
- alkyl
- heteroaryl
- Prior art date
Links
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 title 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 102100033174 Neutrophil elastase Human genes 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 102000052502 human ELANE Human genes 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- -1 2,2,2-trifluoroethoxy, amino, methoxyamino, 2,2,2-trifluoroethylamino Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Nonmetallic Welding Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919117641A GB9117641D0 (en) | 1991-08-15 | 1991-08-15 | Substituted heterocycles |
| GB929208378A GB9208378D0 (en) | 1992-04-16 | 1992-04-16 | Substituted heterocycles |
| GB929214447A GB9214447D0 (en) | 1992-07-08 | 1992-07-08 | Substituted heterocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO923197D0 NO923197D0 (no) | 1992-08-14 |
| NO923197L true NO923197L (no) | 1993-02-16 |
Family
ID=27265822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO92923197A NO923197L (no) | 1991-08-15 | 1992-08-14 | Substituerte heterocykliske forbindelser |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5254558A (de) |
| EP (1) | EP0528633B1 (de) |
| JP (1) | JPH05286946A (de) |
| KR (1) | KR930004276A (de) |
| AT (1) | ATE197043T1 (de) |
| CA (1) | CA2076226C (de) |
| CZ (1) | CZ251792A3 (de) |
| DE (1) | DE69231513T2 (de) |
| FI (1) | FI923661A7 (de) |
| GB (1) | GB9216272D0 (de) |
| HU (1) | HUT61732A (de) |
| IE (1) | IE922586A1 (de) |
| IL (1) | IL102805A0 (de) |
| NO (1) | NO923197L (de) |
| NZ (1) | NZ243950A (de) |
| ZW (1) | ZW13292A1 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521179A (en) * | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| DE69314169T2 (de) * | 1992-04-16 | 1998-01-15 | Zeneca Ltd | Peptide mit eine alphaaminoboronaire gruppe and ihre verwendung als elastasehemmer |
| US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
| GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
| GB9214053D0 (en) * | 1992-07-02 | 1992-08-12 | Ici Plc | Heterocyclic amides |
| US6100238A (en) * | 1994-11-21 | 2000-08-08 | Cortech Inc. | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US6001814A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors |
| US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
| US6150334A (en) * | 1994-11-21 | 2000-11-21 | Cortech, Inc. | Serine protease inhibitors-tripeptoid analogs |
| US6015791A (en) * | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
| US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| US6001811A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors--N-substituted derivatives |
| US20020119985A1 (en) | 1994-11-21 | 2002-08-29 | Albert Gyorkos | Serine protease inhibitors |
| US6001813A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Val-pro containing α-keto oxadiazoles as serine protease inhibitors |
| US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
| US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
| CN1188401C (zh) * | 1995-04-27 | 2005-02-09 | 三菱制药株式会社 | 杂环类酰胺化合物及其医药用途 |
| BR9712000A (pt) | 1996-09-06 | 1999-08-24 | Nippon Kayaku Kk | Derivados de acetamida sais dos mesmos composi-Æo farmac-utica inibidores de protease de quimase de desgranula-Æo de mastÄcitos ou de libera-Æo de histamina de mastÄcitos e de ativa-Æo de eosinÄfilo ou de libera-Æo de oxig-nio ativo de eosinÄfilo e processo para produzir os dervados de acetamida |
| US6080738A (en) * | 1996-10-25 | 2000-06-27 | Yoshitomi Pharmaceuticals Industries, Ltd. | Heterocyclic amide compounds and medicinal uses thereof |
| TR199901681T2 (xx) * | 1996-12-06 | 2000-03-21 | Cortech, Inc. | Serin proteas inhibit�rleri. |
| US6656910B2 (en) | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
| WO1999041277A1 (en) | 1998-02-17 | 1999-08-19 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivative and use thereof |
| CN1160075C (zh) | 1998-03-11 | 2004-08-04 | 卫福有限公司 | 杂环酰胺化合物在制备IgE抗体产生抑制剂中的用途 |
| US6255453B1 (en) | 1998-06-03 | 2001-07-03 | Cortech, Inc. | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors |
| KR20020011970A (ko) * | 1999-03-12 | 2002-02-09 | 우에노 도시오 | 피리미딘 유도체 및 그 제조 방법 |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| CA2375229A1 (en) * | 1999-06-17 | 2000-12-28 | Source Precision Medicine, Inc. | Method and compounds for inhibiting activity of serine elastases |
| WO2001023361A1 (en) * | 1999-09-27 | 2001-04-05 | Ono Pharmaceutical Co., Ltd. | Pyrimidine derivatives, process for preparing the derivatives and drugs containing the same as the active ingredient |
| WO2001068605A1 (en) | 2000-03-13 | 2001-09-20 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| ATE289299T1 (de) | 2000-04-05 | 2005-03-15 | Pharmacia Corp | Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess |
| AU2001251315A1 (en) | 2000-04-05 | 2001-10-23 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| EP1274676A2 (de) | 2000-04-17 | 2003-01-15 | Pharmacia Corporation | Polycyclische aryl- und heteroaryl- substuierte 1,4-chinone zur selektiven hemmung des blutgerinnungsprozesses |
| WO2001087851A1 (en) * | 2000-05-18 | 2001-11-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| CA2416248A1 (en) * | 2000-07-18 | 2002-01-24 | Neurogen Corporation | 5-substituted 2-aryl-4-pyrimidinones |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| CA2430037A1 (en) | 2000-11-20 | 2002-05-30 | Michael S. South | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| HUP0303631A2 (hu) * | 2000-12-26 | 2004-03-01 | Ono Pharmaceutical Co., Ltd. | Pirimidinszármazékok és eljárás előállításukra |
| MXPA04003170A (es) | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion. |
| BR0213092A (pt) | 2001-10-03 | 2004-10-19 | Pharmacia Corp | Compostos heterocìclicos de 6 elementos úteis para a inibição seletiva da cascata de coagulação |
| MXPA05002644A (es) * | 2002-09-10 | 2005-09-20 | Bayer Healthcare Ag | Derivados de pirimidinona como agentes terapeuticos contra procesos de remodelacion, isquemicos e inflamatorios agudos y cronicos. |
| TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
-
1992
- 1992-07-30 GB GB929216272A patent/GB9216272D0/en active Pending
- 1992-08-12 AT AT92307389T patent/ATE197043T1/de not_active IP Right Cessation
- 1992-08-12 EP EP92307389A patent/EP0528633B1/de not_active Expired - Lifetime
- 1992-08-12 DE DE69231513T patent/DE69231513T2/de not_active Expired - Fee Related
- 1992-08-14 HU HU9202640A patent/HUT61732A/hu unknown
- 1992-08-14 CA CA002076226A patent/CA2076226C/en not_active Expired - Fee Related
- 1992-08-14 FI FI923661A patent/FI923661A7/fi not_active Application Discontinuation
- 1992-08-14 CZ CS922517A patent/CZ251792A3/cs unknown
- 1992-08-14 KR KR1019920014728A patent/KR930004276A/ko not_active Withdrawn
- 1992-08-14 IL IL102805A patent/IL102805A0/xx unknown
- 1992-08-14 ZW ZW132/92A patent/ZW13292A1/xx unknown
- 1992-08-14 US US07/930,568 patent/US5254558A/en not_active Expired - Lifetime
- 1992-08-14 NO NO92923197A patent/NO923197L/no unknown
- 1992-08-14 IE IE258692A patent/IE922586A1/en not_active IP Right Cessation
- 1992-08-14 NZ NZ243950A patent/NZ243950A/en unknown
- 1992-08-17 JP JP4260490A patent/JPH05286946A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUT61732A (en) | 1993-03-01 |
| FI923661A7 (fi) | 1993-02-16 |
| DE69231513T2 (de) | 2001-03-01 |
| DE69231513D1 (de) | 2000-11-23 |
| EP0528633B1 (de) | 2000-10-18 |
| US5254558A (en) | 1993-10-19 |
| IL102805A0 (en) | 1993-01-31 |
| EP0528633A1 (de) | 1993-02-24 |
| CA2076226A1 (en) | 1993-02-16 |
| CZ251792A3 (en) | 1993-02-17 |
| HU9202640D0 (en) | 1992-10-28 |
| KR930004276A (ko) | 1993-03-22 |
| ZW13292A1 (en) | 1993-05-05 |
| CA2076226C (en) | 2004-09-21 |
| FI923661A0 (fi) | 1992-08-14 |
| NZ243950A (en) | 1995-05-26 |
| JPH05286946A (ja) | 1993-11-02 |
| IE922586A1 (en) | 1993-02-24 |
| ATE197043T1 (de) | 2000-11-15 |
| NO923197D0 (no) | 1992-08-14 |
| GB9216272D0 (en) | 1992-09-09 |
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