NO950075L - Trombininhibitorer - Google Patents

Trombininhibitorer

Info

Publication number
NO950075L
NO950075L NO950075A NO950075A NO950075L NO 950075 L NO950075 L NO 950075L NO 950075 A NO950075 A NO 950075A NO 950075 A NO950075 A NO 950075A NO 950075 L NO950075 L NO 950075L
Authority
NO
Norway
Prior art keywords
pct
sec
date
thrombin inhibitors
pub
Prior art date
Application number
NO950075A
Other languages
English (en)
Other versions
NO950075D0 (no
NO318017B1 (no
Inventor
Jurgen Hemberger
Roy Sawyer
Sabine Wolf
Johannes Dodt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO950075D0 publication Critical patent/NO950075D0/no
Publication of NO950075L publication Critical patent/NO950075L/no
Publication of NO318017B1 publication Critical patent/NO318017B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19950075A 1993-05-07 1995-01-06 Ekstrakt med trombininhibitoraktivitet, polypeptid erholdt fra ekstrakten, fremgangsmater for fremstilling av henholdsvis ekstrakten og polypeptider, farmasoytiske preparater og anvendelse av polypeptidet for fremstilling av preparatene, samt anvendelse av blodigler for fremstilling av trombininhibitorer NO318017B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939309509A GB9309509D0 (en) 1993-05-07 1993-05-07 Thrombin inhibitors
PCT/EP1994/001404 WO1994026777A1 (en) 1993-05-07 1994-05-03 Thrombin inhibitors

Publications (3)

Publication Number Publication Date
NO950075D0 NO950075D0 (no) 1995-01-06
NO950075L true NO950075L (no) 1995-01-06
NO318017B1 NO318017B1 (no) 2005-01-24

Family

ID=10735154

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19950075A NO318017B1 (no) 1993-05-07 1995-01-06 Ekstrakt med trombininhibitoraktivitet, polypeptid erholdt fra ekstrakten, fremgangsmater for fremstilling av henholdsvis ekstrakten og polypeptider, farmasoytiske preparater og anvendelse av polypeptidet for fremstilling av preparatene, samt anvendelse av blodigler for fremstilling av trombininhibitorer

Country Status (22)

Country Link
US (1) US5583111A (no)
EP (1) EP0652900B1 (no)
JP (1) JP3537437B2 (no)
KR (1) KR100335536B1 (no)
AT (1) ATE208793T1 (no)
AU (1) AU682368B2 (no)
CA (1) CA2139652C (no)
CZ (1) CZ287794B6 (no)
DE (1) DE69429062T2 (no)
DK (1) DK0652900T3 (no)
ES (1) ES2167364T3 (no)
GB (1) GB9309509D0 (no)
HU (1) HU226243B1 (no)
NO (1) NO318017B1 (no)
PL (1) PL179215B1 (no)
PT (1) PT652900E (no)
RU (1) RU2138275C1 (no)
SK (1) SK282860B6 (no)
TW (1) TW369541B (no)
UA (1) UA43831C2 (no)
WO (1) WO1994026777A1 (no)
ZA (1) ZA943171B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2380633A1 (en) * 1999-08-06 2001-02-15 Genentech, Inc. Peptide antagonists of factor viia
GB9930659D0 (en) * 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
FR2834293B1 (fr) * 2002-01-03 2005-02-04 Ricarimpex Extraits de sangsues a effet psychosomatique
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US7691839B2 (en) * 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
CN101095697A (zh) * 2006-06-28 2008-01-02 李振国 水蛭和/或地龙分子量5800道尔顿以下的提取物
RU2366441C2 (ru) * 2007-08-03 2009-09-10 Государственное учреждение гематологический научный центр Российской академии медицинских наук (ГУ ГНЦ РАМН) Антикоагулянтное средство на основе биологически активного комплекса из коры кедра сибирского
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
RU2519741C2 (ru) * 2012-06-25 2014-06-20 Общество с ограниченной ответственностью Научно-внедренческая фирма "Гируд И.Н." (ООО НВФ "Гируд И.Н.") Фармацевтическая композиция, обладающая противотромботическим, тромболитическим, иммуномодулирующим, противовоспалительным действиями, нормализующая липидный и углеводный обмен
US8501241B1 (en) 2012-09-17 2013-08-06 Biopep Solutions, Inc. Treating cancer with a whole, leech saliva extract
CN108395475B (zh) * 2018-03-29 2021-09-10 苏州至汇生物科技有限公司 一种基于亲和层析的水蛭素分离纯化方法
CN116987181B (zh) * 2023-09-27 2023-12-08 北京元延医药科技股份有限公司 高生物学活性的天然水蛭素和高收率制备它们的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432596A (en) * 1967-10-13 1969-03-11 Dresden Arzneimittel Method for producing highly pure hirudine
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
DE69127346T2 (de) * 1990-04-06 1998-02-26 Merck Patent Gmbh, 64293 Darmstadt Behandlung thrombotischer ereignisse

Also Published As

Publication number Publication date
EP0652900B1 (en) 2001-11-14
SK282860B6 (sk) 2002-12-03
UA43831C2 (uk) 2002-01-15
ES2167364T3 (es) 2002-05-16
US5583111A (en) 1996-12-10
NO950075D0 (no) 1995-01-06
GB9309509D0 (en) 1993-06-23
AU6795094A (en) 1994-12-12
PL307088A1 (en) 1995-05-02
PT652900E (pt) 2002-05-31
PL179215B1 (pl) 2000-08-31
KR100335536B1 (ko) 2002-11-11
SK895A3 (en) 1995-05-10
ZA943171B (en) 1995-01-11
JPH07508765A (ja) 1995-09-28
CZ4295A3 (en) 1995-10-18
DE69429062D1 (de) 2001-12-20
RU2138275C1 (ru) 1999-09-27
CA2139652A1 (en) 1994-11-24
WO1994026777A1 (en) 1994-11-24
CZ287794B6 (en) 2001-02-14
DK0652900T3 (da) 2002-02-25
EP0652900A1 (en) 1995-05-17
DE69429062T2 (de) 2002-06-20
JP3537437B2 (ja) 2004-06-14
KR950702579A (ko) 1995-07-29
HU9500038D0 (en) 1995-03-28
CA2139652C (en) 2003-03-18
RU95105983A (ru) 1997-02-27
HUT70215A (en) 1995-09-28
HU226243B1 (en) 2008-07-28
AU682368B2 (en) 1997-10-02
ATE208793T1 (de) 2001-11-15
NO318017B1 (no) 2005-01-24
TW369541B (en) 1999-09-11

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