NO950432L - Stereoselektiv syntese av nukleosidanaloger ved anvendelse av bicykliske mellomprodukter - Google Patents

Stereoselektiv syntese av nukleosidanaloger ved anvendelse av bicykliske mellomprodukter

Info

Publication number: NO950432L
Authority: NO; Norway
Prior art keywords: pct; formula; image; nucleoside analogs; stereoselective synthesis
Prior art date: 1993-06-07

Application number

NO950432A

Other languages

English (en)

Other versions

NO950432D0 (no

NO303449B1 (no

Inventor

Tarek S Mansour

Colleen A Evans

Haolun Jin

Arshad M Siddiqui

Alan H L Tse

Original Assignee

Iaf Biochem Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-07

Filing date

1995-02-06

Publication date

1995-03-13

1995-02-06 Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int

1995-02-06 Publication of NO950432D0 publication Critical patent/NO950432D0/no

1995-03-13 Publication of NO950432L publication Critical patent/NO950432L/no

1998-07-13 Publication of NO303449B1 publication Critical patent/NO303449B1/no

Links

125000002619 bicyclic group Chemical group 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
230000000707 stereoselective effect Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
239000002841 Lewis acid Substances 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940127073 nucleoside analogue Drugs 0.000 abstract 1
IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO950432A 1993-06-07 1995-02-06 Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse NO303449B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939311709A GB9311709D0 (en)	1993-06-07	1993-06-07	Stereoselective synthesis of nucleoside analogues using bicycle intermediate
PCT/CA1994/000311 WO1994029301A1 (en)	1993-06-07	1994-06-07	Stereoselective synthesis of nucleoside analogues using bicyclic intermediate

Publications (3)

Publication Number	Publication Date
NO950432D0 NO950432D0 (no)	1995-02-06
NO950432L true NO950432L (no)	1995-03-13
NO303449B1 NO303449B1 (no)	1998-07-13

Family

ID=10736757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO950432A NO303449B1 (no)	1993-06-07	1995-02-06	Stereoselektiv syntese av nukleosidanaloger samt bicyklisk forbindelse

Country Status (21)

Country	Link
US (1)	US5763606A (no)
EP (1)	EP0654031B1 (no)
JP (1)	JP3110461B2 (no)
KR (1)	KR100304072B1 (no)
CN (1)	CN1046720C (no)
AT (1)	ATE188215T1 (no)
AU (1)	AU668829B2 (no)
BR (1)	BR9405423A (no)
CA (1)	CA2141029C (no)
DE (1)	DE69422374T2 (no)
DK (1)	DK0654031T3 (no)
ES (1)	ES2139744T3 (no)
FI (1)	FI112078B (no)
GB (1)	GB9311709D0 (no)
HU (1)	HU219199B (no)
NO (1)	NO303449B1 (no)
NZ (1)	NZ267379A (no)
OA (1)	OA10349A (no)
PL (1)	PL180870B1 (no)
RU (1)	RU2139870C1 (no)
WO (1)	WO1994029301A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6175008B1 (en) *	1988-04-11	2001-01-16	Biochem Pharma Inc.	Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US6034087A (en) *	1994-10-22	2000-03-07	Chong Kun Dang Corp.	Nucleoside derivatives and process for preparing thereof
JP4249393B2 (ja)	1998-08-12	2009-04-02	トライアングル・ファーマシューティカルズ，インコーポレイテッド	１，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en)	1998-10-09	2005-12-27	Gilead Sciences, Inc.	Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en)	2000-05-16	2005-07-26	Brantford Chemicals Inc.	1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
PT1574512E (pt)	2001-03-01	2008-03-05	Abbott Lab	Formas polimórficas e outras formas cristalinas de cis-ftc
EA015145B1 (ru)	2003-01-14	2011-06-30	Джилид Сайэнс, Инк.	Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
CN101044122A (zh) *	2004-02-03	2007-09-26	埃莫里大学	制备1,3－二氧戊环核苷的方法
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047407A (en) *	1989-02-08	1991-09-10	Iaf Biochem International, Inc.	2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) *	1990-05-02	1990-06-27	Glaxo Group Ltd	Chemical compounds
AU9125991A (en) *	1990-12-05	1992-07-08	University Of Georgia Research Foundation, Inc., The	Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
ZA923641B (en) *	1991-05-21	1993-02-24	Iaf Biochem Int	Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) *	1991-08-01	1991-09-18	Iaf Biochem Int	1,3-oxathiolane nucleoside analogues
US5332814A (en) *	1991-11-12	1994-07-26	Ciba-Geigy Corporation	Process for the preparation of carbacyclic nucleosides, and intermediates

1993
- 1993-06-07 GB GB939311709A patent/GB9311709D0/en active Pending
- 1993-11-19 OA OA60438A patent/OA10349A/en unknown
1994
- 1994-06-07 WO PCT/CA1994/000311 patent/WO1994029301A1/en not_active Ceased
- 1994-06-07 BR BR9405423A patent/BR9405423A/pt not_active Application Discontinuation
- 1994-06-07 EP EP94918252A patent/EP0654031B1/en not_active Expired - Lifetime
- 1994-06-07 DK DK94918252T patent/DK0654031T3/da active
- 1994-06-07 PL PL94307350A patent/PL180870B1/pl not_active IP Right Cessation
- 1994-06-07 JP JP07501139A patent/JP3110461B2/ja not_active Expired - Fee Related
- 1994-06-07 ES ES94918252T patent/ES2139744T3/es not_active Expired - Lifetime
- 1994-06-07 CN CN94190356A patent/CN1046720C/zh not_active Expired - Fee Related
- 1994-06-07 CA CA002141029A patent/CA2141029C/en not_active Expired - Fee Related
- 1994-06-07 HU HU9500364A patent/HU219199B/hu not_active IP Right Cessation
- 1994-06-07 US US08/379,644 patent/US5763606A/en not_active Expired - Fee Related
- 1994-06-07 RU RU95108553A patent/RU2139870C1/ru not_active IP Right Cessation
- 1994-06-07 DE DE69422374T patent/DE69422374T2/de not_active Expired - Fee Related
- 1994-06-07 NZ NZ267379A patent/NZ267379A/en not_active IP Right Cessation
- 1994-06-07 AT AT94918252T patent/ATE188215T1/de not_active IP Right Cessation
- 1994-06-07 AU AU69667/94A patent/AU668829B2/en not_active Ceased
- 1994-06-07 KR KR1019950700453A patent/KR100304072B1/ko not_active Expired - Fee Related
1995
- 1995-02-06 NO NO950432A patent/NO303449B1/no unknown
- 1995-02-07 FI FI950535A patent/FI112078B/fi active

Also Published As

Publication number	Publication date
CA2141029C (en)	2000-07-25
PL180870B1 (pl)	2001-04-30
NO950432D0 (no)	1995-02-06
RU2139870C1 (ru)	1999-10-20
DE69422374D1 (de)	2000-02-03
CN1110479A (zh)	1995-10-18
FI950535L (fi)	1995-02-07
BR9405423A (pt)	1999-05-25
DE69422374T2 (de)	2000-06-29
DK0654031T3 (da)	2000-06-13
OA10349A (en)	2001-10-18
GB9311709D0 (en)	1993-07-21
WO1994029301A1 (en)	1994-12-22
JP3110461B2 (ja)	2000-11-20
EP0654031A1 (en)	1995-05-24
HU219199B (en)	2001-03-28
CN1046720C (zh)	1999-11-24
PL307350A1 (en)	1995-05-15
CA2141029A1 (en)	1994-12-22
NO303449B1 (no)	1998-07-13
RU95108553A (ru)	1996-11-20
HK1008673A1 (en)	1999-05-14
KR100304072B1 (ko)	2001-11-22
AU6966794A (en)	1995-01-03
AU668829B2 (en)	1996-05-16
FI950535A0 (fi)	1995-02-07
HU9500364D0 (en)	1995-05-29
ES2139744T3 (es)	2000-02-16
FI112078B (fi)	2003-10-31
ATE188215T1 (de)	2000-01-15
US5763606A (en)	1998-06-09
NZ267379A (en)	1997-04-24
JPH08505643A (ja)	1996-06-18
HUT73630A (en)	1996-08-28
EP0654031B1 (en)	1999-12-29

Publication	Publication Date	Title
TW262474B (no)	1995-11-11
EP0443449A3 (en)	1991-12-04	Process for the preparation of oxetanones
NO950432D0 (no)	1995-02-06	Stereoselektiv syntese av nukleosidanaloger ved anvendelse av bicykliske mellomprodukter
Prugh et al.	1982	Methyl 3-0-benzyl-2, 4, 6-trideoxy-6-iodo-α-d-erythro-hexopyranoside, a chiral synthon for the synthesis of inhibitors of HMG-CoA reductase
HU209977B (en)	1995-01-30	Process for preparing fluorinated bis(hydroxymethyl)-cyclobutyl purines and pyrimidines, and pharmateutical preparations containing them
ES2033203A1 (es)	1993-03-01	Procedimiento para la preparacion de intermediarios utiles para la sintesis de benzotiacepinas.
KR910006288A (ko)	1991-04-29	신규 제조방법
Nishitani et al.	1979	Synthesis of 2-(pyrimidin-1-yl)-and 2-(purin-9-yl)-2-amino acids
ATE229011T1 (de)	2002-12-15	Verfahren zur herstellung von glycidylethern
GR3032285T3 (en)	2000-04-27	Process and intermediates for bis-aza-bicyclic anxiolytic agents.
SE9300455D0 (sv)	1993-02-11	Mellanprodukt vid framstaellning av histamin h2-antagonister
ATE207908T1 (de)	2001-11-15	Verfahren zur herstellung von 2-alkoxy-6- (trifluormethyl)-pyrimidin-4-ol
EP0393611A3 (en)	1991-01-23	Novel process for producing oxetanocin g
ATE132864T1 (de)	1996-01-15	Herstellung von dioxolanderivaten
HUT62867A (en)	1993-06-28	Process for producing uracyl derivatives
ES8500914A1 (es)	1984-11-01	"procedimiento para la obtencion de un compuesto derivado de la 1-pirimidincarboxamida"
KR970042487A (ko)	1997-07-24	알칼리 금속을 촉매로 이용한 아크릴산 에스테르 화합물의 제조방법
IL100129A (en)	1997-04-15	Process for the preparation of 3-(3,4,5,6-tetrahydro- phthalimido) cinnamic esters and intermediates thereof
HUT36094A (en)	1985-08-28	Process for producing 4-quinolinones
JPS6419091A (en)	1989-01-23	Production of (2"r)-4'-o-tetrahydropyranyladriamycin