ATE188215T1 - Stereoselektive synthese von nukleoziden analogen mit hilfe von bicyclischer zwischenverbindung - Google Patents

Stereoselektive synthese von nukleoziden analogen mit hilfe von bicyclischer zwischenverbindung

Info

Publication number: ATE188215T1
Authority: AT; Austria
Prior art keywords: pct; formula; image; nucleocide; analogue
Prior art date: 1993-06-07

Application number

AT94918252T

Other languages

English (en)

Inventor

Tarek S Mansour

Colleen A Evans

Haolun Jin

Arshad M Siddiqui

Allan H L Tse

Original Assignee

Iaf Biochem Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-07

Filing date

1994-06-07

Publication date

2000-01-15

1994-06-07 Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE188215T1 publication Critical patent/ATE188215T1/de

Links

230000015572 biosynthetic process Effects 0.000 title 1
230000000707 stereoselective effect Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
239000002841 Lewis acid Substances 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940127073 nucleoside analogue Drugs 0.000 abstract 1
IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT94918252T 1993-06-07 1994-06-07 Stereoselektive synthese von nukleoziden analogen mit hilfe von bicyclischer zwischenverbindung ATE188215T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939311709A GB9311709D0 (en)	1993-06-07	1993-06-07	Stereoselective synthesis of nucleoside analogues using bicycle intermediate
PCT/CA1994/000311 WO1994029301A1 (en)	1993-06-07	1994-06-07	Stereoselective synthesis of nucleoside analogues using bicyclic intermediate

Publications (1)

Publication Number	Publication Date
ATE188215T1 true ATE188215T1 (de)	2000-01-15

Family

ID=10736757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94918252T ATE188215T1 (de)	1993-06-07	1994-06-07	Stereoselektive synthese von nukleoziden analogen mit hilfe von bicyclischer zwischenverbindung

Country Status (21)

Country	Link
US (1)	US5763606A (de)
EP (1)	EP0654031B1 (de)
JP (1)	JP3110461B2 (de)
KR (1)	KR100304072B1 (de)
CN (1)	CN1046720C (de)
AT (1)	ATE188215T1 (de)
AU (1)	AU668829B2 (de)
BR (1)	BR9405423A (de)
CA (1)	CA2141029C (de)
DE (1)	DE69422374T2 (de)
DK (1)	DK0654031T3 (de)
ES (1)	ES2139744T3 (de)
FI (1)	FI112078B (de)
GB (1)	GB9311709D0 (de)
HU (1)	HU219199B (de)
NO (1)	NO303449B1 (de)
NZ (1)	NZ267379A (de)
OA (1)	OA10349A (de)
PL (1)	PL180870B1 (de)
RU (1)	RU2139870C1 (de)
WO (1)	WO1994029301A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6175008B1 (en) *	1988-04-11	2001-01-16	Biochem Pharma Inc.	Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US6034087A (en) *	1994-10-22	2000-03-07	Chong Kun Dang Corp.	Nucleoside derivatives and process for preparing thereof
JP4249393B2 (ja)	1998-08-12	2009-04-02	トライアングル・ファーマシューティカルズ，インコーポレイテッド	１，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en)	1998-10-09	2005-12-27	Gilead Sciences, Inc.	Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en)	2000-05-16	2005-07-26	Brantford Chemicals Inc.	1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
PT1574512E (pt)	2001-03-01	2008-03-05	Abbott Lab	Formas polimórficas e outras formas cristalinas de cis-ftc
EA015145B1 (ru)	2003-01-14	2011-06-30	Джилид Сайэнс, Инк.	Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
CN101044122A (zh) *	2004-02-03	2007-09-26	埃莫里大学	制备1,3－二氧戊环核苷的方法
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047407A (en) *	1989-02-08	1991-09-10	Iaf Biochem International, Inc.	2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) *	1990-05-02	1990-06-27	Glaxo Group Ltd	Chemical compounds
AU9125991A (en) *	1990-12-05	1992-07-08	University Of Georgia Research Foundation, Inc., The	Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
ZA923641B (en) *	1991-05-21	1993-02-24	Iaf Biochem Int	Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) *	1991-08-01	1991-09-18	Iaf Biochem Int	1,3-oxathiolane nucleoside analogues
US5332814A (en) *	1991-11-12	1994-07-26	Ciba-Geigy Corporation	Process for the preparation of carbacyclic nucleosides, and intermediates

1993
- 1993-06-07 GB GB939311709A patent/GB9311709D0/en active Pending
- 1993-11-19 OA OA60438A patent/OA10349A/en unknown
1994
- 1994-06-07 WO PCT/CA1994/000311 patent/WO1994029301A1/en not_active Ceased
- 1994-06-07 BR BR9405423A patent/BR9405423A/pt not_active Application Discontinuation
- 1994-06-07 EP EP94918252A patent/EP0654031B1/de not_active Expired - Lifetime
- 1994-06-07 DK DK94918252T patent/DK0654031T3/da active
- 1994-06-07 PL PL94307350A patent/PL180870B1/pl not_active IP Right Cessation
- 1994-06-07 JP JP07501139A patent/JP3110461B2/ja not_active Expired - Fee Related
- 1994-06-07 ES ES94918252T patent/ES2139744T3/es not_active Expired - Lifetime
- 1994-06-07 CN CN94190356A patent/CN1046720C/zh not_active Expired - Fee Related
- 1994-06-07 CA CA002141029A patent/CA2141029C/en not_active Expired - Fee Related
- 1994-06-07 HU HU9500364A patent/HU219199B/hu not_active IP Right Cessation
- 1994-06-07 US US08/379,644 patent/US5763606A/en not_active Expired - Fee Related
- 1994-06-07 RU RU95108553A patent/RU2139870C1/ru not_active IP Right Cessation
- 1994-06-07 DE DE69422374T patent/DE69422374T2/de not_active Expired - Fee Related
- 1994-06-07 NZ NZ267379A patent/NZ267379A/en not_active IP Right Cessation
- 1994-06-07 AT AT94918252T patent/ATE188215T1/de not_active IP Right Cessation
- 1994-06-07 AU AU69667/94A patent/AU668829B2/en not_active Ceased
- 1994-06-07 KR KR1019950700453A patent/KR100304072B1/ko not_active Expired - Fee Related
1995
- 1995-02-06 NO NO950432A patent/NO303449B1/no unknown
- 1995-02-07 FI FI950535A patent/FI112078B/fi active

Also Published As

Publication number	Publication date
CA2141029C (en)	2000-07-25
NO950432L (no)	1995-03-13
PL180870B1 (pl)	2001-04-30
NO950432D0 (no)	1995-02-06
RU2139870C1 (ru)	1999-10-20
DE69422374D1 (de)	2000-02-03
CN1110479A (zh)	1995-10-18
FI950535L (fi)	1995-02-07
BR9405423A (pt)	1999-05-25
DE69422374T2 (de)	2000-06-29
DK0654031T3 (da)	2000-06-13
OA10349A (en)	2001-10-18
GB9311709D0 (en)	1993-07-21
WO1994029301A1 (en)	1994-12-22
JP3110461B2 (ja)	2000-11-20
EP0654031A1 (de)	1995-05-24
HU219199B (en)	2001-03-28
CN1046720C (zh)	1999-11-24
PL307350A1 (en)	1995-05-15
CA2141029A1 (en)	1994-12-22
NO303449B1 (no)	1998-07-13
RU95108553A (ru)	1996-11-20
HK1008673A1 (en)	1999-05-14
KR100304072B1 (ko)	2001-11-22
AU6966794A (en)	1995-01-03
AU668829B2 (en)	1996-05-16
FI950535A0 (fi)	1995-02-07
HU9500364D0 (en)	1995-05-29
ES2139744T3 (es)	2000-02-16
FI112078B (fi)	2003-10-31
US5763606A (en)	1998-06-09
NZ267379A (en)	1997-04-24
JPH08505643A (ja)	1996-06-18
HUT73630A (en)	1996-08-28
EP0654031B1 (de)	1999-12-29

Legal Events

Date	Code	Title	Description
2000-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
GR3024420T3 (en)	1997-11-28	Process for the preparation of oxetanones
DE69332577D1 (de)	2003-01-30	Verfahren zur Herstellung von 13-Ether-Derivaten von Milbemycinen und Zwischenprodukte
TW366349B (en)	1999-08-11	Processes for the diastereoselective synthesis of nucleosides
DE69422374D1 (de)	2000-02-03	Stereoselektive synthese von nukleoziden analogen mit hilfe von bicyclischer zwischenverbindung
AU3154993A (en)	1994-07-19	Process for preparing substituted 1,3-oxathiolanes with antiviral properties
DK51087A (da)	1987-08-01	Antihypercholesterolaemiske forbindelser
CA2065008A1 (en)	1991-03-01	Light Activated Acyl-Enzymes
IT1289904B1 (it)	1998-10-19	Composizione cristallina mesoporosa ad alta area superficiale di un metallo tetravalente utile come catalizzatore
Prugh et al.	1982	Methyl 3-0-benzyl-2, 4, 6-trideoxy-6-iodo-α-d-erythro-hexopyranoside, a chiral synthon for the synthesis of inhibitors of HMG-CoA reductase
DK0565558T3 (da)	1995-03-06	Fremgangsmåde og mellemprodukter til fremstilling af azabicyclo(2.2.2)octan-3-iminer
AU2139792A (en)	1993-05-27	Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
KR910006288A (ko)	1991-04-29	신규 제조방법
ES2058047T3 (es)	1998-01-16	Resolucion de acido arilalcanoico.
ATE207908T1 (de)	2001-11-15	Verfahren zur herstellung von 2-alkoxy-6- (trifluormethyl)-pyrimidin-4-ol
EP0393611A3 (de)	1991-01-23	Verfahren zur Herstellung von Oxetanocin G
ES8500914A1 (es)	1984-11-01	"procedimiento para la obtencion de un compuesto derivado de la 1-pirimidincarboxamida"
HUT62867A (en)	1993-06-28	Process for producing uracyl derivatives
JPS6429390A (en)	1989-01-31	Production of pentofuranoside derivative
AR005042A1 (es)	1999-04-07	Procedimiento para la preparacion de un antagonista endotelin.