NO961207L - Tetrahydropyridin-(eller 4-hydroksypiperidin)-alkylazoler som har affinitet for sigma og/eller 5HT1A-reseptorer - Google Patents

Tetrahydropyridin-(eller 4-hydroksypiperidin)-alkylazoler som har affinitet for sigma og/eller 5HT1A-reseptorer

Info

Publication number
NO961207L
NO961207L NO961207A NO961207A NO961207L NO 961207 L NO961207 L NO 961207L NO 961207 A NO961207 A NO 961207A NO 961207 A NO961207 A NO 961207A NO 961207 L NO961207 L NO 961207L
Authority
NO
Norway
Prior art keywords
hydroxypiperidine
tetrahydropyridine
sigma
affinity
5ht1a receptors
Prior art date
Application number
NO961207A
Other languages
English (en)
Other versions
NO961207D0 (no
NO309379B1 (no
Inventor
Ramon Merce-Vidal
Jordi Frigola-Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of NO961207D0 publication Critical patent/NO961207D0/no
Publication of NO961207L publication Critical patent/NO961207L/no
Publication of NO309379B1 publication Critical patent/NO309379B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO961207A 1994-07-29 1996-03-25 Tetrahydropyridin-(eller 4-hydroksypiperidin)-alkylazoler som har affinitet for sigma og/eller 5HT1A-reseptorer NO309379B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9409443A FR2723091B1 (fr) 1994-07-29 1994-07-29 Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
PCT/EP1995/002978 WO1996004287A1 (fr) 1994-07-29 1995-07-26 Tetrahydropyridine-(ou 4-hydroxypiperidine) alkylazoles ayant une activite pour les recepteurs sigma et/ou 5ht1a

Publications (3)

Publication Number Publication Date
NO961207D0 NO961207D0 (no) 1996-03-25
NO961207L true NO961207L (no) 1996-05-29
NO309379B1 NO309379B1 (no) 2001-01-22

Family

ID=9465902

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961207A NO309379B1 (no) 1994-07-29 1996-03-25 Tetrahydropyridin-(eller 4-hydroksypiperidin)-alkylazoler som har affinitet for sigma og/eller 5HT1A-reseptorer

Country Status (22)

Country Link
US (2) US5731331A (no)
EP (1) EP0721455B9 (no)
JP (2) JP4035787B2 (no)
KR (1) KR100389785B1 (no)
CN (1) CN1120167C (no)
AT (1) ATE229530T1 (no)
AU (1) AU712479B2 (no)
BR (1) BR9506292A (no)
CA (1) CA2172986A1 (no)
CZ (1) CZ293123B6 (no)
DE (1) DE69529142T2 (no)
DK (1) DK0721455T3 (no)
FI (1) FI116386B (no)
FR (1) FR2723091B1 (no)
HU (1) HU220088B (no)
NO (1) NO309379B1 (no)
NZ (1) NZ291172A (no)
PL (1) PL183766B1 (no)
PT (1) PT721455E (no)
RU (1) RU2168507C2 (no)
WO (1) WO1996004287A1 (no)
ZA (1) ZA956314B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
FR2742052B1 (fr) * 1995-12-12 1998-04-10 Esteve Labor Dr Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports
GB9613423D0 (en) * 1996-06-26 1996-08-28 Lilly Industries Ltd Pharmaceutical compounds
HUP9602763A3 (en) * 1996-10-09 1999-05-28 Egyt Gyogyszervegyeszeti Gyar 3-phenyl isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
US5919802A (en) * 1997-12-05 1999-07-06 Princeton University Methods of preventing and/or treating temporal lobe epilepsy
ES2151828B1 (es) * 1998-07-10 2001-08-16 Esteve Labor Dr Empleo de derivados de tetrahidropiridinas (ohidroxi-piperidinas)-b utilazoles en la elaboracion de un medicamento para el tratamiento del dolor.
US6046331A (en) * 1998-12-17 2000-04-04 Synaptic Pharmaceutical Corporation Imidazolones and their use in treating benign prostatic hyperplasia and other disorders
GB2355456A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
UA73981C2 (en) * 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
DE10109867A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Verwendung von Triazolverbindungen zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10109866A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
ES2251316B1 (es) * 2004-10-14 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Inhibidores del receptor sigma.
BRPI0514736A (pt) * 2004-08-27 2008-06-24 Esteve Labor Dr inibidores do receptor sigma
ES2251317B1 (es) * 2004-10-14 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Inhibidores del receptor sigma.
KR100893394B1 (ko) * 2007-05-11 2009-04-17 한국화학연구원 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물
KR100895998B1 (ko) * 2007-05-11 2009-05-07 한국화학연구원 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물
KR100871077B1 (ko) * 2007-05-11 2008-11-28 한국화학연구원 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물
JP5514716B2 (ja) * 2007-05-11 2014-06-04 コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物
PT3252057T (pt) 2009-12-04 2024-06-04 Sunovion Pharmaceuticals Inc Compostos multicíclicos e métodos de utilização dos mesmos
MX2019000982A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
EA201990400A1 (ru) 2016-07-29 2019-07-31 Суновион Фармасьютикалз, Инк. Соединения и композиции и их применение
CN116808023A (zh) 2017-02-16 2023-09-29 桑诺维恩药品公司 治疗精神分裂症的方法
CN109280030B (zh) * 2017-07-19 2022-04-22 江苏恩华药业股份有限公司 苯骈氮杂烷基芳基哌嗪衍生物及在制备药物中的应用
JP7191085B2 (ja) 2017-08-02 2022-12-16 サノビオン ファーマシューティカルズ インク イソクロマン化合物およびその使用
MX2020008537A (es) 2018-02-16 2021-01-08 Sunovion Pharmaceuticals Inc Sales, formas cristalinas y metodos de produccion de las mismas.
CN113784755B (zh) 2019-03-14 2024-05-10 赛诺维信制药公司 异色满基化合物的盐及其结晶形式、制备方法、治疗用途和药物组合物
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509153A (en) * 1967-03-24 1970-04-28 Miles Lab 5-phenyl (or 5-phenylalkyl)-2-(omega-(4-phenyl-1-piperazinyl)alkyl)tetrazoles
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
ES378315A1 (es) * 1969-04-11 1972-06-01 Robins Co Inc A H Un procedimiento para la preparacion de 1 - (omega-susti- tuido-alcohil)-2-metilbenzimidazoles.
JPS5011395B1 (no) * 1970-12-29 1975-04-30
NZ181256A (en) * 1975-07-21 1978-04-28 Janssen Pharmaceutica Nv 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives
US3981881A (en) * 1975-08-14 1976-09-21 E. R. Squibb & Sons, Inc. 2-[(4-Phenyl-tetrahydropyridinyl)alkyl]-1H-isoindole-1,3(2H)-diones
US3994904A (en) * 1976-03-08 1976-11-30 Miles Laboratories, Inc. 3-Substituted -5-phenyl-5-pyridyl hydantoins
JPS5746983A (en) * 1980-09-04 1982-03-17 Eisai Co Ltd Theophylline derivative and its preparation
JPS58150511A (ja) * 1982-03-02 1983-09-07 Eisai Co Ltd テオフイリン誘導体を有効成分とする脳循環代謝改善剤
EP0087810B1 (en) * 1982-03-02 1986-06-25 Eisai Co., Ltd. Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient
US4539407A (en) * 1983-12-13 1985-09-03 American Home Products Corporation β-Carboline anticonvulsants
US4675403A (en) * 1985-10-16 1987-06-23 American Home Products Corporation 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity
US4754038A (en) * 1987-02-26 1988-06-28 American Home Products Corporation Carboline histamine H1 antagonists
US5296487A (en) * 1990-01-02 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Quinazoline derivatives and their preparation
ATE126796T1 (de) * 1990-01-02 1995-09-15 Fujisawa Pharmaceutical Co Quinazolinderivate und ihre herstellung.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体
US5149817A (en) * 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
JPH04211059A (ja) * 1990-03-05 1992-08-03 Shionogi & Co Ltd 新規なテトラヒドロピリジン誘導体
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
JP3219281B2 (ja) * 1991-04-03 2001-10-15 聰 竹尾 心筋保護剤
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
AU7195694A (en) * 1993-07-19 1995-02-20 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives useful as dopamine receptor antagonist, 5-ht receptor agonist or alpha1 receptor antagonist
US5411960A (en) * 1993-12-09 1995-05-02 Bayer Aktiengesellschaft Substituted pyrroloanthracenes and -diones
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles

Also Published As

Publication number Publication date
CZ92696A3 (en) 1996-09-11
WO1996004287A1 (fr) 1996-02-15
RU2168507C2 (ru) 2001-06-10
ATE229530T1 (de) 2002-12-15
NO961207D0 (no) 1996-03-25
HUT75645A (en) 1997-05-28
FR2723091B1 (fr) 1996-11-08
FI961412L (fi) 1996-03-28
EP0721455B1 (fr) 2002-12-11
KR100389785B1 (ko) 2003-10-04
AU3222595A (en) 1996-03-04
NO309379B1 (no) 2001-01-22
KR960704900A (ko) 1996-10-09
US5731331A (en) 1998-03-24
FR2723091A1 (fr) 1996-02-02
HU220088B (hu) 2001-10-28
JP2007051154A (ja) 2007-03-01
FI116386B (fi) 2005-11-15
US6232329B1 (en) 2001-05-15
AU712479B2 (en) 1999-11-11
JPH09503230A (ja) 1997-03-31
CZ293123B6 (cs) 2004-02-18
PL183766B1 (pl) 2002-07-31
DE69529142T2 (de) 2003-09-25
EP0721455A1 (fr) 1996-07-17
BR9506292A (pt) 1997-08-12
EP0721455B9 (fr) 2005-04-20
FI961412A0 (fi) 1996-03-28
MX9601191A (es) 1997-12-31
DE69529142D1 (de) 2003-01-23
NZ291172A (en) 1998-02-26
CA2172986A1 (fr) 1996-02-15
CN1166173A (zh) 1997-11-26
PT721455E (pt) 2003-04-30
JP4035787B2 (ja) 2008-01-23
HU9600815D0 (en) 1996-07-29
DK0721455T3 (da) 2003-04-07
PL313716A1 (en) 1996-07-22
ZA956314B (en) 1996-03-25
CN1120167C (zh) 2003-09-03

Similar Documents

Publication Publication Date Title
NO961207D0 (no) Tetrahydropyridin-(eller 4-hydroksypiperidin)-alkylazoler som har affinitet for sigma og/eller 5HT1A-reseptorer
DE60224404D1 (de) Substiuierte piperidine als melanocortinrezeptor-modulatoren
NO20051871L (no) Opioidreseptorantagonister
DE69318854D1 (de) Spiroazacyclischderivate als substanz p antagonisten
DK0841928T3 (da) Sustained release-formulering af d-threo-methylphenidat
GR1002466B (el) Νεες ενωσεις.
DE69516866D1 (de) Stereochemische wortmanninderivate
PT923554E (pt) N-benzilpiperidina e derivados tetrahidropiridina
NO20044764L (no) 1-(aminoalkyl)-3-sulfonylindol og -indazolderivater som 5-hydroksytryptamin-6 ligander
NO973652L (no) 5-(4-subst.-piperidinyl-1)-3-aryl-pentansyrederivater som tachykininreseptor-antagonist
YU63696A (sh) Novi fenilamidin-derivati, postupci za njihovo pripremanje i njihova primena kao lekova
ATE397599T1 (de) Als modulatoren der chemokinrezeptoraktivität geeignete piperidinderivate
ES2090948T3 (es) Derivados de carbinol terciario 2-sustituidos de 1,5-iminoazucares como compuestos antivirales.
NO983860L (no) Nye triazolopuriner, fremgangsmÕte for deres fremstilling og deres anvendelse som legemidler
NO20052172D0 (no) 4-aminopiperidinderivater, fremgangsmate for deres fremstilling og deres anvendelse som medikamenter
NO904135L (no) Fremgangsmaate for fremstilling av nye substituerte alkylpiperidiner og deres anvendelse som inhibitorer av kolesterolsyntese.
DK1000067T3 (da) Thiazolobenzoheterocycliske forbindelser, deres fremstilling og lægemidler indeholdende forbindelserne
NO20000199L (no) Medikamenter inneholdende polyhydroksybutylpyraziner, nye polyhydroksybutylpyraziner og deres fremstilling
AU7695596A (en) Use of 1-hydroxy-2-pyridones for treating mucosa diseases which are difficult to treat
ES2117934A1 (es) Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles.
NO993650L (no) Nye forbindelser med hemoregulerende effekt
ATE204853T1 (de) Schädlingsbekämpfungsmittel