NO961888L - Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer av metallproteinaser - Google Patents

Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer av metallproteinaser

Info

Publication number: NO961888L
Authority: NO; Norway
Prior art keywords: alkyl; aryl; amino; alkenyl; inhibitors
Prior art date: 1993-11-10

Application number

NO961888A

Other languages

English (en)

Norwegian (no)

Other versions

NO961888D0 (no

Inventor

John Montana

Jonathon Dickens

David Alan Owen

Andrew Douglas Baxter

Original Assignee

Chiroscience Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-10

Filing date

1996-05-09

Publication date

1996-05-09

1996-05-09 Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd

1996-05-09 Publication of NO961888D0 publication Critical patent/NO961888D0/no

1996-05-09 Publication of NO961888L publication Critical patent/NO961888L/no

Links

102000035195 Peptidases Human genes 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000002184 metal Substances 0.000 title 1
125000001151 peptidyl group Chemical group 0.000 title 1
235000019833 protease Nutrition 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 16
125000003118 aryl group Chemical group 0.000 abstract 9
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
-1 protected amino Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
102000005741 Metalloproteases Human genes 0.000 abstract 1
108010006035 Metalloproteases Proteins 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Transplantation (AREA)
Nutrition Science (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO961888A 1993-11-10 1996-05-09 Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer av metallproteinaser NO961888L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939323165A GB9323165D0 (en)	1993-11-10	1993-11-10	Compounds
PCT/GB1994/002471 WO1995013289A1 (en)	1993-11-10	1994-11-10	Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases

Publications (2)

Publication Number	Publication Date
NO961888D0 NO961888D0 (no)	1996-05-09
NO961888L true NO961888L (no)	1996-05-09

Family

ID=10744943

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO961888A NO961888L (no)	1993-11-10	1996-05-09	Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer av metallproteinaser

Country Status (21)

Country	Link
US (1)	US5853623A (de)
EP (1)	EP0728144B1 (de)
JP (1)	JPH09505041A (de)
KR (1)	KR960705843A (de)
CN (1)	CN1134705A (de)
AT (1)	ATE188969T1 (de)
AU (1)	AU679286B2 (de)
BR (1)	BR9408025A (de)
CA (1)	CA2173470A1 (de)
CZ (1)	CZ287780B6 (de)
DE (1)	DE69422726T2 (de)
DK (1)	DK0728144T3 (de)
ES (1)	ES2143611T3 (de)
FI (1)	FI961976A0 (de)
GB (1)	GB9323165D0 (de)
GR (1)	GR3033103T3 (de)
HU (1)	HU217344B1 (de)
NO (1)	NO961888L (de)
PL (1)	PL180403B1 (de)
PT (1)	PT728144E (de)
WO (1)	WO1995013289A1 (de)

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JPH09503201A (ja) *	1993-08-23	1997-03-31	イミュネックス・コーポレーション	Ｔｎｆ−アルファ分泌の阻害剤
GB9601042D0 (en) *	1996-01-17	1996-03-20	Smithkline Beecham Plc	Medical use
GB9414157D0 (en) *	1994-07-13	1994-08-31	Smithkline Beecham Plc	Medical use
CZ288436B6 (en) *	1994-10-05	2001-06-13	Darwin Discovery Ltd	Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised
EP0824543A1 (de) *	1995-05-10	1998-02-25	Chiroscience Limited	Peptide, die metalloproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung
AU710502B2 (en) *	1995-05-10	1999-09-23	Darwin Discovery Limited	Peptidyl compounds which inhibit metalloproteinase and TNF liberation and their therapeutic use
EP0826000B1 (de) *	1995-05-10	2002-10-23	Darwin Discovery Limited	Peptide, die metallproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung
US5677282A (en) *	1995-06-07	1997-10-14	Proscript, Inc.	Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase
GB2318353B (en) *	1995-07-20	1999-10-06	British Biotech Pharm	Metalloproteinase inhibitors
GB9514867D0 (en) *	1995-07-20	1995-09-20	British Biotech Pharm	Metalloproteinase inhibitors
JP2008024720A (ja) *	1995-07-26	2008-02-07	Mitsubishi Chemicals Corp	ペニシラミンアミド誘導体
WO1997012861A1 (en) *	1995-10-05	1997-04-10	Chiroscience Limited	Mercaptoamide derivatives and their therapeutic use
WO1997012902A1 (en) *	1995-10-05	1997-04-10	Darwin Discovery Limited	Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation
GB9523066D0 (en) *	1995-11-10	1996-01-10	Chiroscience Ltd	Compounds and their therapeutic use
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BR9707010B1 (pt)	1996-01-23	2009-05-05		compostos, composição farmacêutica e composições para inibir metaloproteinase e colagenase do tipo iv.
GB9607249D0 (en) *	1996-04-04	1996-06-12	Chiroscience Ltd	Compounds
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GB9607119D0 (en) *	1996-04-04	1996-06-12	Chiroscience Ltd	Compounds
GB9609702D0 (en)	1996-05-09	1996-07-10	Royal Free Hosp School Med	Anticoagulant peptides
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JP2001505869A (ja) *	1996-07-22	2001-05-08	モンサントカンパニー	チオールスルホンメタロプロテアーゼ阻害剤
GB9616643D0 (en) *	1996-08-08	1996-09-25	Chiroscience Ltd	Compounds
US6953788B1 (en)	1996-09-19	2005-10-11	Aventis Pharmaceuticals Inc.	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
GB9624817D0 (en) *	1996-11-28	1997-01-15	British Biotech Pharm	Metalloproteinase inhibitors
JP2001513813A (ja) *	1997-03-03	2001-09-04	ダーウィン・ディスカバリー・リミテッド	副作用の少ない選択的ｍｍｐインヒビター
NZ337326A (en)	1997-03-04	2001-05-25	Monsanto Co	Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds to inhibit the activity of matrix metalloproteinases
US6696449B2 (en)	1997-03-04	2004-02-24	Pharmacia Corporation	Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6638952B1 (en)	1997-03-04	2003-10-28	Pharmacia Corporation	Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US6476027B1 (en)	1997-03-04	2002-11-05	Monsanto Company	N-hydroxy 4-sulfonyl butanamide compounds
US6794511B2 (en)	1997-03-04	2004-09-21	G. D. Searle	Sulfonyl aryl or heteroaryl hydroxamic acid compounds
WO1998039326A1 (en)	1997-03-04	1998-09-11	Monsanto Company	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
US7115632B1 (en)	1999-05-12	2006-10-03	G. D. Searle & Co.	Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6034136A (en)	1997-03-20	2000-03-07	Novartis Ag	Certain cyclic thio substituted acylaminoacid amide derivatives
US5756545A (en) *	1997-04-21	1998-05-26	Warner-Lambert Company	Biphenysulfonamide matrix metal alloproteinase inhibitors
WO1999007679A1 (en) *	1997-08-08	1999-02-18	Chiroscience Limited	Peptidyl compounds having mmp and tnf inhibitory activity
WO1999025687A1 (en)	1997-11-14	1999-05-27	G.D. Searle & Co.	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010039287A1 (en)	1997-11-14	2001-11-08	Thomas E Barta	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6750228B1 (en)	1997-11-14	2004-06-15	Pharmacia Corporation	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6329418B1 (en)	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
AUPP508798A0 (en) *	1998-08-05	1998-08-27	Biotech Australia Pty Limited	Method of treating psoriasis
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2000040552A1 (en) *	1998-12-31	2000-07-13	Aventis Pharmaceuticals Inc.	Amidomalonamides and their use as inhibitors of matrix metalloproteinase
US6329550B1 (en)	1998-12-31	2001-12-11	Aventis Pharmaceuticals Inc.	Amidomalonamides useful as inhibitors of MMP of matrix metalloproteinase
HRP20010660A2 (en)	1999-02-08	2005-02-28	G.D. Searle & Co	Sulfamato hydroxamic acid metalloprotease inhibitor
US6800646B1 (en)	1999-02-08	2004-10-05	Pharmacia Corporation	Sulfamato hydroxamic acid metalloprotease inhibitor
JP2003521476A (ja) *	1999-06-15	2003-07-15	メルクエンドカムパニーインコーポレーテッド	チオール誘導体、メタロ−β−ラクタマーゼ阻害剤
US6869951B1 (en)	1999-07-16	2005-03-22	Pharmacia Corporation	Method of changing conformation of a matrix metalloproteinase
US6696456B1 (en)	1999-10-14	2004-02-24	The Procter & Gamble Company	Beta disubstituted metalloprotease inhibitors
WO2001070682A2 (en) *	2000-03-21	2001-09-27	The Procter & Gamble Company	Carbocyclic side chain containing metalloprotease inhibitors
NZ520657A (en) *	2000-03-21	2004-11-26	Procter & Gamble	Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
WO2001070693A2 (en) *	2000-03-21	2001-09-27	The Procter & Gamble Company	Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
US6683093B2 (en)	2000-05-12	2004-01-27	Pharmacia Corporation	Aromatic sulfone hydroxamic acids and their use as protease inhibitors
FR2823212B1 (fr) *	2001-04-10	2005-12-02	Inst Nat Sante Rech Med	Inhibiteurs de la toxine botulique de type b
YU85403A (sh)	2001-05-11	2006-03-03	Pharmacia Corporation	Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora
WO2003091247A2 (en)	2002-04-25	2003-11-06	Pharmacia Corporation	Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
JP4804004B2 (ja) *	2002-08-20	2011-10-26	アステラス製薬株式会社	関節軟骨細胞外マトリクス分解阻害剤
AU2003300076C1 (en)	2002-12-30	2010-03-04	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
US7570250B2 (en) *	2006-05-04	2009-08-04	Yi-Ming Tseng	Control device including a ball that stores data
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US11021514B2 (en)	2016-06-01	2021-06-01	Athira Pharma, Inc.	Compounds

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AU599736B2 (en) *	1986-12-24	1990-07-26	Beecham Group Plc	Thiol-carboxylic acid derivatives
ATE106087T1 (de) *	1987-03-17	1994-06-15	Res Corp Technologies Inc	Synthetische inhibitoren von säugetier- collagenase.
US5144043A (en) *	1988-06-15	1992-09-01	Centocor	Cleavable bifunctional coupling agents
WO1994007481A1 (en) *	1992-10-02	1994-04-14	Merck & Co., Inc.	N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents

1993
- 1993-11-10 GB GB939323165A patent/GB9323165D0/en active Pending
1994
- 1994-11-10 PL PL94314300A patent/PL180403B1/pl unknown
- 1994-11-10 BR BR9408025A patent/BR9408025A/pt not_active Application Discontinuation
- 1994-11-10 HU HU9601244A patent/HU217344B1/hu not_active IP Right Cessation
- 1994-11-10 AU AU81133/94A patent/AU679286B2/en not_active Ceased
- 1994-11-10 KR KR1019960702437A patent/KR960705843A/ko not_active Abandoned
- 1994-11-10 AT AT95900237T patent/ATE188969T1/de not_active IP Right Cessation
- 1994-11-10 PT PT95900237T patent/PT728144E/pt unknown
- 1994-11-10 WO PCT/GB1994/002471 patent/WO1995013289A1/en not_active Ceased
- 1994-11-10 EP EP95900237A patent/EP0728144B1/de not_active Expired - Lifetime
- 1994-11-10 CN CN94194051A patent/CN1134705A/zh active Pending
- 1994-11-10 CZ CZ19961349A patent/CZ287780B6/cs not_active IP Right Cessation
- 1994-11-10 DE DE69422726T patent/DE69422726T2/de not_active Expired - Fee Related
- 1994-11-10 ES ES95900237T patent/ES2143611T3/es not_active Expired - Lifetime
- 1994-11-10 CA CA002173470A patent/CA2173470A1/en not_active Abandoned
- 1994-11-10 DK DK95900237T patent/DK0728144T3/da active
- 1994-11-10 JP JP7513690A patent/JPH09505041A/ja not_active Ceased
1996
- 1996-05-09 NO NO961888A patent/NO961888L/no not_active Application Discontinuation
- 1996-05-09 FI FI961976A patent/FI961976A0/fi unknown
- 1996-05-10 US US08/644,383 patent/US5853623A/en not_active Expired - Fee Related
2000
- 2000-03-29 GR GR20000400792T patent/GR3033103T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5853623A (en)	1998-12-29
NO961888D0 (no)	1996-05-09
PT728144E (pt)	2000-07-31
KR960705843A (ko)	1996-11-08
AU679286B2 (en)	1997-06-26
CZ287780B6 (en)	2001-02-14
JPH09505041A (ja)	1997-05-20
CZ134996A3 (en)	1996-10-16
WO1995013289A1 (en)	1995-05-18
CA2173470A1 (en)	1995-05-18
FI961976A7 (fi)	1996-05-09
ES2143611T3 (es)	2000-05-16
HU9601244D0 (en)	1996-07-29
HUT73799A (en)	1996-09-30
DE69422726D1 (de)	2000-02-24
PL314300A1 (en)	1996-09-02
BR9408025A (pt)	1996-12-17
FI961976A0 (fi)	1996-05-09
GB9323165D0 (en)	1994-01-05
EP0728144A1 (de)	1996-08-28
HK1015139A1 (en)	1999-10-08
AU8113394A (en)	1995-05-29
EP0728144B1 (de)	2000-01-19
DE69422726T2 (de)	2000-06-08
CN1134705A (zh)	1996-10-30
GR3033103T3 (en)	2000-08-31
DK0728144T3 (da)	2000-07-03
PL180403B1 (pl)	2001-01-31
ATE188969T1 (de)	2000-02-15
HU217344B1 (hu)	2002-02-28

Legal Events

Date	Code	Title	Description
2003-07-07	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO961888L (no)	1996-05-09	Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer av metallproteinaser
NO301880B1 (no)	1997-12-22	Substituerte heterocykliske karboksylsyreamider og deres anvendelse for fremstilling av legemidler
ZA918893B (en)	1992-08-26	Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives,process for their production and pharmaceutical agents containing these derivatives
MY108885A (en)	1996-11-30	Heterocyclic-cyclic amine derivatives.
ATE299890T1 (de)	2005-08-15	Inhibitoren von gamma-secretase
NO962540L (no)	1996-06-14	Rapamycinderivater for anvendelse som immunsuppresjonsmidler
MY116539A (en)	2004-02-28	New amino acid derivatives
ATE159945T1 (de)	1997-11-15	Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure
DE69402173D1 (de)	1997-04-24	Hemmung von Thrombin
ES2151156T3 (es)	2000-12-16	Derivados de acidos n-(aroil)glicina hidroxamicos y compuestos relacionados.
AU6049696A (en)	1996-12-30	Amino acid amides of 5-amino-1,3,4-thiadiazones and their use as inhibitors for matrix metalloproteinases
CA2189131A1 (en)	1995-11-30	Use of pteridine derivatives as no-synthase inhibitors
ATE242206T1 (de)	2003-06-15	Substituierte derivate von benzosulphonamiden als hemmer des enzym cyclooxygenase ii
GB9300194D0 (en)	1993-03-03	Piperazine derivatives
NO944918L (no)	1995-06-22	Hemming av seborre og akne
NO982290L (no)	1998-05-20	Merkaptoalkylpeptidyl-forbindelser som har en imidazolsubstituent og deres anvendelse som inhibitorer av matriks-metalloproteinaser (MMP) og/eller tumor nekrosefaktor (TNF)
DK0572635T3 (da)	1997-06-16	Hidtil ukendte forbindelser med guanidinstruktur og farmaceutisk komposition indeholdende forbindelserne
UA27910C2 (uk)	2000-10-16	Засіб для підвищення експресії тромбомодуліну та підвищення активації протеїну с
NO943873D0 (no)	1994-10-13	Hemming av bruskdegradering
AU2223595A (en)	1995-11-10	Aziridine derivatives, their production and use
AU9066498A (en)	1999-02-16	Substituted 6-alkylphenanthridines
EP0774462A4 (de)	1997-10-29	Heterocyclische verbindungen
DE69427807D1 (de)	2001-08-30	Hemmung von Hirsutismus und Alopecia bei Frauen
NO984921L (no)	1998-12-22	Tienopyridinderivater og deres anvendelser
TW353662B (en)	1999-03-01	Cephalosporin salts and process for the preparation thereof