NO972911L - Stabiliserte ribozym-analoger - Google Patents

Stabiliserte ribozym-analoger

Info

Publication number
NO972911L
NO972911L NO972911A NO972911A NO972911L NO 972911 L NO972911 L NO 972911L NO 972911 A NO972911 A NO 972911A NO 972911 A NO972911 A NO 972911A NO 972911 L NO972911 L NO 972911L
Authority
NO
Norway
Prior art keywords
analogues
ribozyme
making
stabilized
stabilized ribozyme
Prior art date
Application number
NO972911A
Other languages
English (en)
Other versions
NO972911D0 (no
Inventor
John Goodchild
Steven M Nesbitt
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of NO972911D0 publication Critical patent/NO972911D0/no
Publication of NO972911L publication Critical patent/NO972911L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Amplifiers (AREA)
  • Oscillators With Electromechanical Resonators (AREA)

Abstract

Det beskrives stabiliserte ribozym-analoger som har evne til endonukleolytisk å spalte en sekvens av 3' til 5' koblede ribonukleotider. Disse ribozym-analogene innbefatter modifikasjoner i bestemte sløyfe-, katalytisk kjerne- og flankerende region-nukleotider, hvilket gjør dem mer resistente overfor nukleaser.Det beskrives også fremgangsmåter for fremstilling og utnyttelse av ribozym-analogen ifølge oppfinnelsen, samt farmasøytiske formuleringer og sett som inneholder slike rjbozym-analoger.
NO972911A 1994-12-22 1997-06-20 Stabiliserte ribozym-analoger NO972911L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/361,687 US5545729A (en) 1994-12-22 1994-12-22 Stabilized ribozyme analogs
PCT/US1995/015871 WO1996019568A2 (en) 1994-12-22 1995-12-05 Stabilized ribozyme analogs

Publications (2)

Publication Number Publication Date
NO972911D0 NO972911D0 (no) 1997-06-20
NO972911L true NO972911L (no) 1997-08-19

Family

ID=23423065

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972911A NO972911L (no) 1994-12-22 1997-06-20 Stabiliserte ribozym-analoger

Country Status (7)

Country Link
US (1) US5545729A (no)
EP (1) EP0795010A2 (no)
JP (1) JPH10510992A (no)
AU (1) AU4417296A (no)
CA (1) CA2208427A1 (no)
NO (1) NO972911L (no)
WO (1) WO1996019568A2 (no)

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US6656730B1 (en) 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
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US20030124196A1 (en) 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
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CA2562151C (en) 2004-04-30 2016-09-06 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a c5-modified pyrimidine
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EP2385141B1 (en) 2005-10-07 2013-08-07 SpeeDx Pty Ltd Multicomponent nucleic acid enzymes and methods for their use
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Also Published As

Publication number Publication date
WO1996019568A3 (en) 1996-09-06
CA2208427A1 (en) 1996-06-27
NO972911D0 (no) 1997-06-20
WO1996019568A2 (en) 1996-06-27
JPH10510992A (ja) 1998-10-27
US5545729A (en) 1996-08-13
EP0795010A2 (en) 1997-09-17
AU4417296A (en) 1996-07-10

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