NO973482L - Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider - Google Patents

Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider

Info

Publication number
NO973482L
NO973482L NO973482A NO973482A NO973482L NO 973482 L NO973482 L NO 973482L NO 973482 A NO973482 A NO 973482A NO 973482 A NO973482 A NO 973482A NO 973482 L NO973482 L NO 973482L
Authority
NO
Norway
Prior art keywords
parathyroid hormone
analogues
synthesis
related peptides
hormone related
Prior art date
Application number
NO973482A
Other languages
English (en)
Norwegian (no)
Other versions
NO973482D0 (no
Inventor
Humberto Arzeno
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO973482D0 publication Critical patent/NO973482D0/no
Publication of NO973482L publication Critical patent/NO973482L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO973482A 1996-07-30 1997-07-29 Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider NO973482L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2332296P 1996-07-30 1996-07-30

Publications (2)

Publication Number Publication Date
NO973482D0 NO973482D0 (no) 1997-07-29
NO973482L true NO973482L (no) 1998-02-02

Family

ID=21814418

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973482A NO973482L (no) 1996-07-30 1997-07-29 Fremgangsmåte ved syntese av analoger av paratyroihormon og paratyroidhormonrelaterte peptider

Country Status (30)

Country Link
US (1) US6849710B1 (ja)
EP (1) EP0822200B1 (ja)
JP (1) JP4229992B2 (ja)
KR (1) KR100518982B1 (ja)
CN (1) CN1293096C (ja)
AR (2) AR008094A1 (ja)
AT (1) ATE277080T1 (ja)
AU (1) AU731160B2 (ja)
BR (1) BR9704138A (ja)
CA (1) CA2206008C (ja)
CO (1) CO4650046A1 (ja)
CZ (1) CZ239697A3 (ja)
DE (1) DE69730787T2 (ja)
DK (1) DK0822200T3 (ja)
ES (1) ES2227639T3 (ja)
HR (1) HRP970416A2 (ja)
HU (1) HUP9701277A3 (ja)
IL (1) IL121391A0 (ja)
MA (1) MA24353A1 (ja)
MX (1) MX9705719A (ja)
NO (1) NO973482L (ja)
NZ (1) NZ328411A (ja)
PE (1) PE91998A1 (ja)
PL (1) PL321391A1 (ja)
SG (1) SG67408A1 (ja)
TR (1) TR199700714A2 (ja)
TW (1) TW505654B (ja)
UY (1) UY24651A1 (ja)
YU (1) YU32197A (ja)
ZA (1) ZA976555B (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1531855A4 (en) * 2002-01-10 2009-07-22 Osteotrophin Llc TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA
US7378495B2 (en) * 2002-10-21 2008-05-27 Pevion Biotech, Ltd. PTH-rP related peptide cancer therapeutics
CA2628945A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
BRPI0706400A2 (pt) * 2006-01-17 2011-03-29 Organon Nv processos para a hidrólise enzimática seletiva de terc-butil ésteres c-terminais de substratos de peptìdeo, para a sìntese convergente de um peptìdeo de dois ou mais fragmentos de peptìdeo, para a sìntese enzimática por etapas de um peptìdeo na direção do terminal c, e para a sìntese de peptìdeo
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
BRPI0719821B8 (pt) 2006-10-03 2021-05-25 Ipsen Pharma Sas composição estável na armazenagem apropriada para administração a pacientes
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
BR112012013725A2 (pt) 2009-12-07 2017-01-10 Univ Michigan Tech paratormônio de urso preto e métodos de usar o paratormônio de uso preto.
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
CN102993293B (zh) * 2012-12-05 2014-05-07 深圳翰宇药业股份有限公司 一种特立帕肽醋酸盐的纯化方法
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
CN104530198B (zh) * 2014-12-09 2017-09-15 兰州大学 一种片段缩合制备醋酸去氨加压素的方法
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3765488A1 (en) * 2018-03-12 2021-01-20 Fresenius Kabi iPSUM S.r.l. Process for the manufacture of pthrp analogue
MX2020013713A (es) 2018-07-04 2021-03-02 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
CN111057139B (zh) * 2018-10-17 2023-12-22 南京华威医药科技集团有限公司 一种制备特立帕肽的新工艺
EP3924328A1 (en) 2019-02-12 2021-12-22 Radius Pharmaceuticals, Inc. Processes and compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
AU667662B2 (en) * 1990-07-13 1996-04-04 Regents Of The University Of California, The Parathyroid hormone analogues modified at positions 3, 6 or 9
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

Also Published As

Publication number Publication date
JP4229992B2 (ja) 2009-02-25
MX9705719A (es) 1998-02-28
PL321391A1 (en) 1998-02-02
ZA976555B (en) 1998-01-30
BR9704138A (pt) 1998-12-29
DK0822200T3 (da) 2005-01-31
TW505654B (en) 2002-10-11
JPH1077295A (ja) 1998-03-24
KR100518982B1 (ko) 2006-05-29
AR016981A2 (es) 2001-08-01
TR199700714A2 (xx) 1998-02-21
CO4650046A1 (es) 1998-09-03
DE69730787T2 (de) 2005-10-13
HRP970416A2 (en) 1998-08-31
US6849710B1 (en) 2005-02-01
ATE277080T1 (de) 2004-10-15
CN1174845A (zh) 1998-03-04
AR008094A1 (es) 1999-12-09
YU32197A (sh) 1999-07-28
AU3236297A (en) 1998-02-05
EP0822200B1 (en) 2004-09-22
KR980009282A (ko) 1998-04-30
EP0822200A1 (en) 1998-02-04
SG67408A1 (en) 1999-09-21
UY24651A1 (es) 2000-12-29
PE91998A1 (es) 1998-12-31
CA2206008A1 (en) 1998-01-30
HU9701277D0 (en) 1997-09-29
CN1293096C (zh) 2007-01-03
CA2206008C (en) 2008-09-23
CZ239697A3 (cs) 1998-04-15
NO973482D0 (no) 1997-07-29
NZ328411A (en) 1998-12-23
HUP9701277A3 (en) 2001-02-28
HUP9701277A2 (hu) 1998-11-30
ES2227639T3 (es) 2005-04-01
DE69730787D1 (de) 2004-10-28
MA24353A1 (fr) 1998-07-01
IL121391A0 (en) 1998-01-04
AU731160B2 (en) 2001-03-22

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Legal Events

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