NO975758D0 - Heterosykliske frie metylradikaler som bildeforbedrende milder - Google Patents
Heterosykliske frie metylradikaler som bildeforbedrende milderInfo
- Publication number
- NO975758D0 NO975758D0 NO975758A NO975758A NO975758D0 NO 975758 D0 NO975758 D0 NO 975758D0 NO 975758 A NO975758 A NO 975758A NO 975758 A NO975758 A NO 975758A NO 975758 D0 NO975758 D0 NO 975758D0
- Authority
- NO
- Norway
- Prior art keywords
- mild
- image enhancing
- methyl radicals
- radicals
- free methyl
- Prior art date
Links
- 230000002708 enhancing effect Effects 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 239000002872 contrast media Substances 0.000 abstract 2
- 229940039231 contrast media Drugs 0.000 abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000005039 triarylmethyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C07B61/02—Generation of organic free radicals; Organic free radicals per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/467,273 US5728370A (en) | 1993-04-02 | 1995-06-06 | Free Radicals |
| PCT/GB1995/002151 WO1996039367A1 (en) | 1994-03-31 | 1995-09-08 | Heterocyclic methyl free radicals as image enhancing agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO975758L NO975758L (no) | 1997-12-05 |
| NO975758D0 true NO975758D0 (no) | 1997-12-05 |
Family
ID=23855069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO975758A NO975758D0 (no) | 1995-06-06 | 1997-12-05 | Heterosykliske frie metylradikaler som bildeforbedrende milder |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5728370A (es) |
| EP (1) | EP0832054B1 (es) |
| JP (1) | JP4054376B2 (es) |
| KR (1) | KR19990022477A (es) |
| CN (1) | CN1193952A (es) |
| AT (1) | ATE198313T1 (es) |
| AU (1) | AU709532B2 (es) |
| CA (1) | CA2222331A1 (es) |
| CZ (1) | CZ390197A3 (es) |
| DE (1) | DE69519752T2 (es) |
| ES (1) | ES2153046T3 (es) |
| HU (1) | HUT78020A (es) |
| NO (1) | NO975758D0 (es) |
| NZ (1) | NZ292582A (es) |
| PL (1) | PL323919A1 (es) |
| WO (1) | WO1996039367A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063360A (en) * | 1993-04-02 | 2000-05-16 | Nycomed Imaging A/S | Free radicals comprising benzodithiole derivatives |
| GB9704669D0 (en) * | 1997-03-06 | 1997-04-23 | Nycomed Imaging As | Free radicals |
| AU6506598A (en) * | 1997-03-06 | 1998-09-22 | Nycomed Imaging As | Triarylmethyl free radicals as image enhancing agents |
| US7122736B2 (en) * | 2001-08-16 | 2006-10-17 | Midwest Research Institute | Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique |
| US7351402B2 (en) * | 2003-08-21 | 2008-04-01 | Massachusetts Institute Of Technology | Polarizing agents for dynamic nuclear polarization |
| PL1805186T3 (pl) * | 2004-07-30 | 2015-10-30 | Ge Healthcare As | Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej |
| WO2006011809A1 (en) | 2004-07-30 | 2006-02-02 | Ge Healthcare As | Method of producing a composition, composition and its use |
| JP5475995B2 (ja) | 2005-12-01 | 2014-04-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極(dnp)法 |
| US20090004114A1 (en) | 2005-12-08 | 2009-01-01 | Koninklijke Philips Electronics N. V. | System and Method for Monitoring in Vivo Drug Release Using Overhauser-Enhanced Nmr |
| PL1962912T3 (pl) * | 2005-12-16 | 2013-03-29 | Ge Healthcare As | Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych |
| US7985594B2 (en) | 2006-05-12 | 2011-07-26 | Massachusetts Institute Of Technology | Biradical polarizing agents for dynamic nuclear polarization |
| JP5269791B2 (ja) | 2006-08-30 | 2013-08-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極(dnp)方法並びに該方法で使用するための化合物及び組成物 |
| EP2902041A1 (en) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| US8697034B2 (en) | 2008-10-10 | 2014-04-15 | The Board Of Regents Of The University Of Texas System | Hyperpolarized 89-yttrium and methods relating thereto |
| SG179067A1 (en) | 2009-09-10 | 2012-04-27 | Ge Healthcare Ltd | 13c-mr detection using hyperpolarised 13c-fructose |
| WO2011124672A1 (en) | 2010-04-08 | 2011-10-13 | Bracco Imaging Spa | Process for preparing hyperpolarized substrates and method for mri |
| FR2967158A1 (fr) | 2010-11-08 | 2012-05-11 | Phosphoenix Sarl | Nouveaux radicaux triarylmethyle: leur preparation et application |
| JP6010118B2 (ja) * | 2011-06-30 | 2016-10-19 | ゴーダーヴァリ バイオリファイナリーズ リミテッド | クレイスタンチンaおよびその誘導体の合成 |
| WO2013053839A1 (en) | 2011-10-12 | 2013-04-18 | Bracco Imaging Spa | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| WO2013083535A1 (en) | 2011-12-05 | 2013-06-13 | Bracco Imaging Spa | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis |
| US8715621B2 (en) | 2012-03-15 | 2014-05-06 | Massachusetts Institute Of Technology | Radical polarizing agents for dynamic nuclear polarization |
| US9925280B2 (en) | 2012-04-02 | 2018-03-27 | Bracco Imaging S.P.A. | Hyperpolarized amino acids |
| EP2872520B1 (en) | 2012-07-13 | 2016-09-14 | Bracco Imaging S.p.A | Triarylmethyl radicals |
| US20160216351A1 (en) * | 2013-05-29 | 2016-07-28 | Kyushu University, National University Corporation | Method for detecting oxidation/reduction reaction in vivo |
| CN103951613A (zh) * | 2014-04-21 | 2014-07-30 | 南开大学 | 用于蛋白质顺磁标记的dtpa类似物的设计与合成 |
| CN104610138A (zh) * | 2015-01-09 | 2015-05-13 | 南开大学 | 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法 |
| WO2019018655A1 (en) * | 2017-07-19 | 2019-01-24 | West Virginia University | SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS |
| DE102017122275B4 (de) * | 2017-09-26 | 2021-03-11 | Universität Potsdam | Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol) |
| DE102018126261A1 (de) | 2018-10-22 | 2020-04-23 | Universität Bielefeld | Tritylverbindungen vom Finland-Typ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991012024A1 (en) * | 1990-02-12 | 1991-08-22 | Hafslund Nycomed Innovation Ab | Triarylmethyl radicals and the use of inert carbon free radicals in mri |
| JPH06507904A (ja) * | 1991-05-23 | 1994-09-08 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 磁気共鳴画像形成用の油脂可溶化合物 |
| AU668691B2 (en) * | 1991-08-09 | 1996-05-16 | Nycomed Innovation Ab | Use of persistent free-radicals in magnetic resonance imaging |
| GB9117258D0 (en) * | 1991-08-09 | 1991-09-25 | Hafslund Nycomed Innovation | Use of radicals |
| GB9307027D0 (en) * | 1993-04-02 | 1993-05-26 | Nycomed Innovation Ab | Free radicals |
-
1995
- 1995-06-06 US US08/467,273 patent/US5728370A/en not_active Expired - Fee Related
- 1995-09-08 PL PL95323919A patent/PL323919A1/xx unknown
- 1995-09-08 EP EP95931302A patent/EP0832054B1/en not_active Expired - Lifetime
- 1995-09-08 CA CA002222331A patent/CA2222331A1/en not_active Abandoned
- 1995-09-08 JP JP51933896A patent/JP4054376B2/ja not_active Expired - Lifetime
- 1995-09-08 NZ NZ292582A patent/NZ292582A/xx unknown
- 1995-09-08 KR KR1019970708958A patent/KR19990022477A/ko not_active Withdrawn
- 1995-09-08 AU AU34790/95A patent/AU709532B2/en not_active Ceased
- 1995-09-08 ES ES95931302T patent/ES2153046T3/es not_active Expired - Lifetime
- 1995-09-08 WO PCT/GB1995/002151 patent/WO1996039367A1/en not_active Ceased
- 1995-09-08 CZ CZ973901A patent/CZ390197A3/cs unknown
- 1995-09-08 AT AT95931302T patent/ATE198313T1/de not_active IP Right Cessation
- 1995-09-08 HU HU9802729A patent/HUT78020A/hu unknown
- 1995-09-08 DE DE69519752T patent/DE69519752T2/de not_active Expired - Lifetime
-
1996
- 1996-09-08 CN CN95197926A patent/CN1193952A/zh active Pending
-
1997
- 1997-12-05 NO NO975758A patent/NO975758D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2153046T3 (es) | 2001-02-16 |
| AU3479095A (en) | 1996-12-24 |
| HUT78020A (hu) | 1999-05-28 |
| NZ292582A (en) | 1998-12-23 |
| KR19990022477A (ko) | 1999-03-25 |
| DE69519752T2 (de) | 2001-08-02 |
| CA2222331A1 (en) | 1996-12-12 |
| AU709532B2 (en) | 1999-09-02 |
| CZ390197A3 (cs) | 1998-06-17 |
| US5728370A (en) | 1998-03-17 |
| NO975758L (no) | 1997-12-05 |
| JP4054376B2 (ja) | 2008-02-27 |
| WO1996039367A1 (en) | 1996-12-12 |
| PL323919A1 (en) | 1998-04-27 |
| ATE198313T1 (de) | 2001-01-15 |
| CN1193952A (zh) | 1998-09-23 |
| JPH11505510A (ja) | 1999-05-21 |
| EP0832054A1 (en) | 1998-04-01 |
| EP0832054B1 (en) | 2000-12-27 |
| DE69519752D1 (de) | 2001-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |