NO975758D0 - Heterosykliske frie metylradikaler som bildeforbedrende milder - Google Patents

Heterosykliske frie metylradikaler som bildeforbedrende milder

Info

Publication number
NO975758D0
NO975758D0 NO975758A NO975758A NO975758D0 NO 975758 D0 NO975758 D0 NO 975758D0 NO 975758 A NO975758 A NO 975758A NO 975758 A NO975758 A NO 975758A NO 975758 D0 NO975758 D0 NO 975758D0
Authority
NO
Norway
Prior art keywords
mild
image enhancing
methyl radicals
radicals
free methyl
Prior art date
Application number
NO975758A
Other languages
English (en)
Norwegian (no)
Other versions
NO975758L (no
Inventor
Sven Andersson
Anna Rydbeck
Rolf Servin
Lars-Goeran Wistrand
Finn Radner
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO975758L publication Critical patent/NO975758L/no
Publication of NO975758D0 publication Critical patent/NO975758D0/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00Other general methods
    • C07B61/02Generation of organic free radicals; Organic free radicals per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
NO975758A 1995-06-06 1997-12-05 Heterosykliske frie metylradikaler som bildeforbedrende milder NO975758D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,273 US5728370A (en) 1993-04-02 1995-06-06 Free Radicals
PCT/GB1995/002151 WO1996039367A1 (en) 1994-03-31 1995-09-08 Heterocyclic methyl free radicals as image enhancing agents

Publications (2)

Publication Number Publication Date
NO975758L NO975758L (no) 1997-12-05
NO975758D0 true NO975758D0 (no) 1997-12-05

Family

ID=23855069

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975758A NO975758D0 (no) 1995-06-06 1997-12-05 Heterosykliske frie metylradikaler som bildeforbedrende milder

Country Status (16)

Country Link
US (1) US5728370A (es)
EP (1) EP0832054B1 (es)
JP (1) JP4054376B2 (es)
KR (1) KR19990022477A (es)
CN (1) CN1193952A (es)
AT (1) ATE198313T1 (es)
AU (1) AU709532B2 (es)
CA (1) CA2222331A1 (es)
CZ (1) CZ390197A3 (es)
DE (1) DE69519752T2 (es)
ES (1) ES2153046T3 (es)
HU (1) HUT78020A (es)
NO (1) NO975758D0 (es)
NZ (1) NZ292582A (es)
PL (1) PL323919A1 (es)
WO (1) WO1996039367A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063360A (en) * 1993-04-02 2000-05-16 Nycomed Imaging A/S Free radicals comprising benzodithiole derivatives
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
AU6506598A (en) * 1997-03-06 1998-09-22 Nycomed Imaging As Triarylmethyl free radicals as image enhancing agents
US7122736B2 (en) * 2001-08-16 2006-10-17 Midwest Research Institute Method and apparatus for fabricating a thin-film solar cell utilizing a hot wire chemical vapor deposition technique
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
PL1805186T3 (pl) * 2004-07-30 2015-10-30 Ge Healthcare As Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej
WO2006011809A1 (en) 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極(dnp)法
US20090004114A1 (en) 2005-12-08 2009-01-01 Koninklijke Philips Electronics N. V. System and Method for Monitoring in Vivo Drug Release Using Overhauser-Enhanced Nmr
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych
US7985594B2 (en) 2006-05-12 2011-07-26 Massachusetts Institute Of Technology Biradical polarizing agents for dynamic nuclear polarization
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極(dnp)方法並びに該方法で使用するための化合物及び組成物
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
SG179067A1 (en) 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
JP6010118B2 (ja) * 2011-06-30 2016-10-19 ゴーダーヴァリ バイオリファイナリーズ リミテッド クレイスタンチンaおよびその誘導体の合成
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
EP2872520B1 (en) 2012-07-13 2016-09-14 Bracco Imaging S.p.A Triarylmethyl radicals
US20160216351A1 (en) * 2013-05-29 2016-07-28 Kyushu University, National University Corporation Method for detecting oxidation/reduction reaction in vivo
CN103951613A (zh) * 2014-04-21 2014-07-30 南开大学 用于蛋白质顺磁标记的dtpa类似物的设计与合成
CN104610138A (zh) * 2015-01-09 2015-05-13 南开大学 用于蛋白质顺磁标记的乙二胺四乙酸类探针的合成方法
WO2019018655A1 (en) * 2017-07-19 2019-01-24 West Virginia University SYNTHESIS OF BIOCOMPATIBLE TRITYLE RADICALS FOR APPLICATIONS AS HYPERPOLARIZATION AGENTS
DE102017122275B4 (de) * 2017-09-26 2021-03-11 Universität Potsdam Fluoreszenzfarbstoffe basierend auf Benzo[1,2-d:4,5- d']bis([1,3]dithiol)
DE102018126261A1 (de) 2018-10-22 2020-04-23 Universität Bielefeld Tritylverbindungen vom Finland-Typ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) * 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
JPH06507904A (ja) * 1991-05-23 1994-09-08 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 磁気共鳴画像形成用の油脂可溶化合物
AU668691B2 (en) * 1991-08-09 1996-05-16 Nycomed Innovation Ab Use of persistent free-radicals in magnetic resonance imaging
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals

Also Published As

Publication number Publication date
ES2153046T3 (es) 2001-02-16
AU3479095A (en) 1996-12-24
HUT78020A (hu) 1999-05-28
NZ292582A (en) 1998-12-23
KR19990022477A (ko) 1999-03-25
DE69519752T2 (de) 2001-08-02
CA2222331A1 (en) 1996-12-12
AU709532B2 (en) 1999-09-02
CZ390197A3 (cs) 1998-06-17
US5728370A (en) 1998-03-17
NO975758L (no) 1997-12-05
JP4054376B2 (ja) 2008-02-27
WO1996039367A1 (en) 1996-12-12
PL323919A1 (en) 1998-04-27
ATE198313T1 (de) 2001-01-15
CN1193952A (zh) 1998-09-23
JPH11505510A (ja) 1999-05-21
EP0832054A1 (en) 1998-04-01
EP0832054B1 (en) 2000-12-27
DE69519752D1 (de) 2001-02-01

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