NO982132L - Biologisk funksjonelt plasmid eller virus-DNA-vektor som koder for en analog av granulocyttkolonistimulerende faktor (hpG-CSF), samt prokaryot eller eukaryot vertscelle - Google Patents
Biologisk funksjonelt plasmid eller virus-DNA-vektor som koder for en analog av granulocyttkolonistimulerende faktor (hpG-CSF), samt prokaryot eller eukaryot vertscelleInfo
- Publication number
- NO982132L NO982132L NO982132A NO982132A NO982132L NO 982132 L NO982132 L NO 982132L NO 982132 A NO982132 A NO 982132A NO 982132 A NO982132 A NO 982132A NO 982132 L NO982132 L NO 982132L
- Authority
- NO
- Norway
- Prior art keywords
- hpg
- csf
- stimulating factor
- granulocyte colony
- prokaryotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76895985A | 1985-08-23 | 1985-08-23 | |
| US06/835,548 US4810643A (en) | 1985-08-23 | 1986-03-03 | Production of pluripotent granulocyte colony-stimulating factor |
| PCT/US1986/001708 WO1987001132A1 (en) | 1985-08-23 | 1986-08-22 | Production of pluripotent granulocyte colony-stimulating factor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982132L true NO982132L (no) | 1987-04-22 |
| NO982132D0 NO982132D0 (no) | 1998-05-11 |
| NO314902B1 NO314902B1 (no) | 2003-06-10 |
Family
ID=27118107
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO871679A NO303544B1 (no) | 1985-08-23 | 1987-04-22 | FremgangsmÕte for fremstilling av et polypeptid med Ún eller flere av de hematopoietiske biologiske egenskaper til granulocyttkolonistimulerende faktor (hpG-CSF) |
| NO19982132A NO314902B1 (no) | 1985-08-23 | 1998-05-11 | Biologisk funksjonelt plasmid eller virus-DNA-vektor som koder for en analog av granulocyttkolonistimulerende faktor (hpG-CSF), samtprokaryot eller eukaryot vertscelle |
| NO20032250A NO318755B1 (no) | 1985-08-23 | 2003-05-19 | Anvendelse av et hpG-CSF-polypeptid til fremstilling av et medikament for a stanse proliferasjon av leukemiceller |
| NO2003008C NO2003008I1 (no) | 1985-08-23 | 2003-11-13 | Fremgangsmaate for fremstilling av et polypeptid med én eller flere av de hematopoietiske biologiskeegenskaper til grnulocyttkolonistimulerende faktor(hpg-csf) |
| NO2003010C NO2003010I2 (no) | 1985-08-23 | 2003-12-09 | Pegfilgrastim |
| NO20045548A NO20045548L (no) | 1985-08-23 | 2004-12-17 | Fremgangsmate for fremstilling av et hpG-CSF-polypeptidprodukt, samt anvendelse derav til fremstilling av et medikament for induksjon av proliferasjonen av humane benmargsceller |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO871679A NO303544B1 (no) | 1985-08-23 | 1987-04-22 | FremgangsmÕte for fremstilling av et polypeptid med Ún eller flere av de hematopoietiske biologiske egenskaper til granulocyttkolonistimulerende faktor (hpG-CSF) |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20032250A NO318755B1 (no) | 1985-08-23 | 2003-05-19 | Anvendelse av et hpG-CSF-polypeptid til fremstilling av et medikament for a stanse proliferasjon av leukemiceller |
| NO2003008C NO2003008I1 (no) | 1985-08-23 | 2003-11-13 | Fremgangsmaate for fremstilling av et polypeptid med én eller flere av de hematopoietiske biologiskeegenskaper til grnulocyttkolonistimulerende faktor(hpg-csf) |
| NO2003010C NO2003010I2 (no) | 1985-08-23 | 2003-12-09 | Pegfilgrastim |
| NO20045548A NO20045548L (no) | 1985-08-23 | 2004-12-17 | Fremgangsmate for fremstilling av et hpG-CSF-polypeptidprodukt, samt anvendelse derav til fremstilling av et medikament for induksjon av proliferasjonen av humane benmargsceller |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US4810643A (no) |
| EP (1) | EP0237545B2 (no) |
| JP (11) | JPH0231675A (no) |
| KR (1) | KR880700071A (no) |
| CN (1) | CN1020924C (no) |
| AT (1) | ATE332375T1 (no) |
| AU (1) | AU6334686A (no) |
| CA (1) | CA1341537C (no) |
| CY (1) | CY1642A (no) |
| DE (1) | DE3650788T2 (no) |
| DK (1) | DK174980B1 (no) |
| ES (1) | ES2001883A6 (no) |
| FI (3) | FI105191B (no) |
| GR (1) | GR862185B (no) |
| IL (1) | IL79805A (no) |
| MX (1) | MX9202992A (no) |
| NL (1) | NL930127I1 (no) |
| NO (6) | NO303544B1 (no) |
| NZ (1) | NZ217334A (no) |
| PT (1) | PT83242B (no) |
| SA (1) | SA92130186B1 (no) |
| SG (2) | SG48964A1 (no) |
| WO (1) | WO1987001132A1 (no) |
Families Citing this family (346)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU594014B2 (en) * | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
| US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| EP0215126B1 (en) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| US5532341A (en) * | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
| US5078996A (en) * | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US6004548A (en) * | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
| NZ218336A (en) * | 1985-12-09 | 1991-08-27 | Kirin Amgen Inc | Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf) |
| DK203187A (da) * | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| GR871067B (en) * | 1986-07-18 | 1987-11-19 | Chugai Pharmaceutical Co Ltd | Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor |
| US5186931A (en) * | 1986-08-06 | 1993-02-16 | Ajinomoto Co., Inc. | Composition and method for supporting bone marrow transplantation |
| AU7675487A (en) * | 1986-08-11 | 1988-05-19 | Cetus Corporation | Expression of granulocyte colony-stimulating factor |
| JPH0618781B2 (ja) * | 1986-10-18 | 1994-03-16 | 中外製薬株式会社 | 感染症治療剤 |
| US6238889B1 (en) * | 1986-12-16 | 2001-05-29 | Dsm N.V. | Molecular cloning and expression of the Pro8 isoform of human IL-3 |
| US5714581A (en) * | 1986-12-23 | 1998-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| JP2618618B2 (ja) * | 1988-03-04 | 1997-06-11 | 協和醗酵工業株式会社 | 抗g−csf誘導体、nd28モノクローナル抗体 |
| US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| DK174044B1 (da) | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
| US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5194592A (en) * | 1986-12-23 | 1993-03-16 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor |
| US6384194B1 (en) * | 1987-12-16 | 2002-05-07 | Dsm N.V. | Expression and purification of human interleukin-3 and muteins thereof |
| GB2213821B (en) * | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
| US5599690A (en) * | 1988-02-01 | 1997-02-04 | Amgen Inc. | Control of norleucine incorporation into recombinant proteins |
| CA1329119C (en) * | 1988-03-29 | 1994-05-03 | Milton David Goldenberg | Cytotoxic therapy |
| US20030232010A2 (en) * | 1988-03-29 | 2003-12-18 | Immunomedics, Inc. | Improved cytotoxic therapy |
| JP2796388B2 (ja) * | 1988-05-13 | 1998-09-10 | アムジエン・インコーポレーテツド | G−csfの精製方法 |
| US5070013A (en) * | 1988-05-31 | 1991-12-03 | Schering Corporation | Immunochemical assay for human granulocyte-macrophage colony stimulating factor |
| US5082774A (en) * | 1988-08-30 | 1992-01-21 | The General Hospital Corporation | Recombinant human nerve growth factor |
| US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| EP0401384B1 (en) * | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| US6254861B1 (en) * | 1989-05-23 | 2001-07-03 | Chandra Choudhury | Hematopoietic growth factor derived from T lymphocytes |
| US5605822A (en) * | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5763266A (en) * | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| JPH04506153A (ja) * | 1989-06-15 | 1992-10-29 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・ミシガン | 細胞増殖方法、細胞増殖用組成物及び装置 |
| US5635386A (en) * | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5665543A (en) * | 1989-07-18 | 1997-09-09 | Oncogene Science, Inc. | Method of discovering chemicals capable of functioning as gene expression modulators |
| US6203976B1 (en) | 1989-07-18 | 2001-03-20 | Osi Pharmaceuticals, Inc. | Methods of preparing compositions comprising chemicals capable of transcriptional modulation |
| US5776502A (en) | 1989-07-18 | 1998-07-07 | Oncogene Science, Inc. | Methods of transcriptionally modulating gene expression |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
| EP0648501A1 (en) * | 1989-10-10 | 1995-04-19 | Amgen Inc. | Compositions comprising G-CSF for treating or preventing infections in canine and feline animals |
| CA2025181A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting fungi |
| US6852313B1 (en) | 1989-10-16 | 2005-02-08 | Amgen Inc. | Method of stimulating growth of melanocyte cells by administering stem cell factor |
| RU2212411C2 (ru) * | 1989-10-16 | 2003-09-20 | Эмджен Инк. | Полипептид, обладающий гемопоэтической биологической активностью фактора стволовых клеток (варианты), днк (варианты), экспрессирующий вектор (варианты), фармацевтическая композиция для гемопоэтической терапии, способ получения полипептида и способ его использования (варианты) |
| ZA907921B (en) | 1989-10-16 | 1991-08-28 | Amgen Inc | Stem cell factor |
| SG59931A1 (en) * | 1989-10-16 | 1999-02-22 | Amgen Inc | Stem cell factor |
| US7144731B2 (en) | 1989-10-16 | 2006-12-05 | Amgen Inc. | SCF antibody compositions and methods of using the same |
| US20040181044A1 (en) * | 1989-10-16 | 2004-09-16 | Zsebo Krisztina M. | Method of stimulating growth of epithelial cells by administering stem cell factor |
| US5214133A (en) * | 1989-11-17 | 1993-05-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SCL: a hematopoietic growth and differentiation factor |
| US5132212A (en) * | 1989-11-17 | 1992-07-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Scl gene, and a hematopoietic growth and differentiation factor encoded thereby |
| JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5147799A (en) * | 1990-04-25 | 1992-09-15 | Isia Bursuker | Repopulation of macrophages and granulocytes using transforming growth factor-beta |
| GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| US5399345A (en) * | 1990-05-08 | 1995-03-21 | Boehringer Mannheim, Gmbh | Muteins of the granulocyte colony stimulating factor |
| US5258367A (en) * | 1990-06-29 | 1993-11-02 | University Of Florida | Uteroferrin and rose proteins for stimulating hematopoietic cells |
| IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| FI924778A0 (fi) * | 1991-02-22 | 1992-10-21 | Amgen Inc | Anvaendning av gm-csf och g-csf foer foersnabbande av saorlaekning |
| GB2253852B (en) * | 1991-02-26 | 1995-03-22 | Ici Plc | Vector for expression of heterologous polypeptide comprising inducible selection system |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US7091319B1 (en) | 1992-11-24 | 2006-08-15 | Bauer S Christopher | IL-3 variant hematopoiesis fusion protein |
| US5772992A (en) * | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US6057133A (en) * | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
| US6403076B1 (en) | 1992-11-24 | 2002-06-11 | S. Christopher Bauer | Compositions for increasing hematopoiesis with interleukin-3 mutants |
| US6361977B1 (en) | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Methods of using multivariant IL-3 hematopoiesis fusion protein |
| US6153183A (en) * | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
| US6361976B1 (en) * | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production |
| US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US6413509B1 (en) | 1992-11-24 | 2002-07-02 | S. Christopher Bauer | Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors |
| AU2007200247B2 (en) * | 1993-01-28 | 2011-03-10 | Amgen Inc. | G-CSF analog compositions |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| ES2328424T3 (es) | 1993-09-15 | 2009-11-12 | Novartis Vaccines And Diagnostics, Inc. | Vectores de alfavirus recombinantes. |
| US5874075A (en) * | 1993-10-06 | 1999-02-23 | Amgen Inc. | Stable protein: phospholipid compositions and methods |
| US20050059149A1 (en) * | 1993-11-22 | 2005-03-17 | Bauer S. Christopher | Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins |
| CA2139385C (en) * | 1994-02-04 | 2001-12-25 | Gottfried Alber | Products containing g-csf and tnf binding protein |
| US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
| US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| CN1229385C (zh) * | 1994-03-31 | 2005-11-30 | 安姆根有限公司 | 刺激巨核细胞生长和分化的组合物及方法 |
| US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
| US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
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| EP0215126B1 (en) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| JPH0615477B2 (ja) * | 1985-02-08 | 1994-03-02 | 中外製薬株式会社 | 感染防禦剤 |
| JPH01110629A (ja) * | 1985-04-05 | 1989-04-27 | Chugai Pharmaceut Co Ltd | 感染防禦剤 |
| JPS63500636A (ja) * | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするdna |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPH0657152B2 (ja) * | 1985-09-17 | 1994-08-03 | 中外製薬株式会社 | Csf遺伝子類 |
| DE3681551D1 (de) * | 1985-09-30 | 1991-10-24 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| JP2976258B2 (ja) * | 1992-07-07 | 1999-11-10 | 株式会社名機製作所 | ホットプレスの断熱材取付け構造 |
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1986
- 1986-03-03 US US06/835,548 patent/US4810643A/en not_active Expired - Lifetime
- 1986-08-22 IL IL79805A patent/IL79805A/xx not_active IP Right Cessation
- 1986-08-22 EP EP86905530A patent/EP0237545B2/en not_active Expired - Lifetime
- 1986-08-22 NZ NZ217334A patent/NZ217334A/en unknown
- 1986-08-22 KR KR870700352A patent/KR880700071A/ko not_active Ceased
- 1986-08-22 WO PCT/US1986/001708 patent/WO1987001132A1/en not_active Ceased
- 1986-08-22 AT AT00101091T patent/ATE332375T1/de not_active IP Right Cessation
- 1986-08-22 GR GR862185A patent/GR862185B/el unknown
- 1986-08-22 DE DE3650788T patent/DE3650788T2/de not_active Expired - Lifetime
- 1986-08-22 PT PT83242A patent/PT83242B/pt unknown
- 1986-08-22 AU AU63346/86A patent/AU6334686A/en not_active Abandoned
- 1986-08-22 SG SG1996004322A patent/SG48964A1/en unknown
- 1986-08-23 ES ES8601318A patent/ES2001883A6/es not_active Expired
- 1986-08-23 CN CN86106234A patent/CN1020924C/zh not_active Expired - Lifetime
- 1986-08-25 CA CA000516737A patent/CA1341537C/en not_active Expired - Lifetime
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1987
- 1987-04-16 FI FI871700A patent/FI105191B/fi not_active IP Right Cessation
- 1987-04-22 NO NO871679A patent/NO303544B1/no not_active IP Right Cessation
- 1987-04-22 DK DK198702044A patent/DK174980B1/da not_active IP Right Cessation
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1989
- 1989-05-02 JP JP1113513A patent/JPH0231675A/ja active Granted
- 1989-05-02 JP JP1113512A patent/JP2527365B2/ja not_active Expired - Lifetime
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1991
- 1991-05-17 JP JP3141402A patent/JP2660178B2/ja not_active Expired - Lifetime
- 1991-09-27 JP JP3277149A patent/JP2660179B2/ja not_active Expired - Lifetime
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1992
- 1992-03-26 SG SG358/92A patent/SG35892G/en unknown
- 1992-06-18 MX MX9202992A patent/MX9202992A/es unknown
- 1992-10-21 SA SA92130186A patent/SA92130186B1/ar unknown
- 1992-11-06 CY CY1642A patent/CY1642A/xx unknown
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1993
- 1993-07-01 NL NL930127C patent/NL930127I1/nl unknown
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1995
- 1995-05-26 US US08/452,135 patent/US5582823A/en not_active Expired - Lifetime
- 1995-06-02 US US08/459,298 patent/US5580755A/en not_active Expired - Lifetime
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1996
- 1996-03-12 JP JP8055077A patent/JP2718426B2/ja not_active Expired - Lifetime
- 1996-07-11 US US08/678,692 patent/US5676941A/en not_active Expired - Fee Related
- 1996-07-15 US US08/679,897 patent/US5830705A/en not_active Expired - Fee Related
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1997
- 1997-02-18 JP JP9033849A patent/JP2952203B2/ja not_active Expired - Lifetime
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1998
- 1998-05-11 NO NO19982132A patent/NO314902B1/no active Protection Beyond IP Right Term
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1999
- 1999-02-12 JP JP11034848A patent/JP3115561B2/ja not_active Expired - Lifetime
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2000
- 2000-01-04 FI FI20000014A patent/FI107540B/fi not_active IP Right Cessation
- 2000-03-08 JP JP2000064219A patent/JP2000279185A/ja active Pending
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2001
- 2001-02-21 FI FI20010334A patent/FI110576B/fi not_active IP Right Cessation
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2002
- 2002-03-28 JP JP2002092947A patent/JP2002315578A/ja active Pending
-
2003
- 2003-05-19 NO NO20032250A patent/NO318755B1/no not_active IP Right Cessation
- 2003-11-13 NO NO2003008C patent/NO2003008I1/no unknown
- 2003-11-26 JP JP2003394905A patent/JP2004041242A/ja not_active Withdrawn
- 2003-12-09 NO NO2003010C patent/NO2003010I2/no not_active IP Right Cessation
-
2004
- 2004-12-17 NO NO20045548A patent/NO20045548L/no unknown
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2006
- 2006-01-11 JP JP2006004052A patent/JP2006101889A/ja active Pending
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