NO982960L - Radicikol derivater - Google Patents
Radicikol derivaterInfo
- Publication number
- NO982960L NO982960L NO982960A NO982960A NO982960L NO 982960 L NO982960 L NO 982960L NO 982960 A NO982960 A NO 982960A NO 982960 A NO982960 A NO 982960A NO 982960 L NO982960 L NO 982960L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- unsubstituted
- lower alkyl
- alkanoyl
- tert
- Prior art date
Links
- AECPBJMOGBFQDN-YMYQVXQQSA-N radicicol Chemical class C1CCCC(=O)C[C@H]2[C@H](Cl)C(=O)CC(=O)[C@H]2C(=O)O[C@H](C)C[C@H]2O[C@@H]21 AECPBJMOGBFQDN-YMYQVXQQSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28443996 | 1996-10-25 | ||
| JP357897 | 1997-01-13 | ||
| PCT/JP1997/003874 WO1998018780A1 (en) | 1996-10-25 | 1997-10-24 | Radicicol derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO982960D0 NO982960D0 (no) | 1998-06-25 |
| NO982960L true NO982960L (no) | 1998-08-25 |
Family
ID=26337204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO982960A NO982960L (no) | 1996-10-25 | 1998-06-25 | Radicikol derivater |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6316491B1 (de) |
| EP (1) | EP0889042B1 (de) |
| KR (1) | KR19990076764A (de) |
| CN (1) | CN1211244A (de) |
| AT (1) | ATE266017T1 (de) |
| AU (1) | AU727722B2 (de) |
| CA (1) | CA2241624A1 (de) |
| DE (1) | DE69728974T2 (de) |
| ES (1) | ES2216130T3 (de) |
| NO (1) | NO982960L (de) |
| NZ (1) | NZ331062A (de) |
| WO (1) | WO1998018780A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6838810B1 (en) * | 1997-03-21 | 2005-01-04 | Chunghwa Picture Tubes, Ltd. | Flat-panel display mounting system for portable computer |
| JP4903922B2 (ja) | 1997-05-14 | 2012-03-28 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 選択された蛋白質を分解する複合化合物 |
| AU3534499A (en) * | 1998-04-24 | 1999-11-16 | Kyowa Hakko Kogyo Co. Ltd. | Radicicol derivatives |
| CA2356622A1 (en) | 1998-12-24 | 2000-07-06 | Novation Pharmaceuticals Inc. | Compounds which affect mrna stability and uses therefor |
| AU2986800A (en) * | 1999-02-08 | 2000-08-25 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods of inhibiting the hgf-met-upa-plasmin network |
| US7238682B1 (en) | 1999-04-09 | 2007-07-03 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of HER-family tyrosine kinases |
| WO2000061578A1 (en) | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
| US6979574B1 (en) * | 1999-08-06 | 2005-12-27 | Institut Fuer Diagnostik Forshung Gmbh | Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles |
| US6946456B2 (en) * | 2000-07-28 | 2005-09-20 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
| EP1315732B1 (de) * | 2000-08-25 | 2006-06-07 | Sloan-Kettering Institute For Cancer Research | Radicicol und monocillin und ihre analogen und ihre anwendungen |
| CA2447066A1 (en) * | 2001-05-23 | 2002-11-28 | Sloan Kettering Institute For Cancer Research | Method of treatment for cancers associated with elevated |
| WO2003034995A2 (en) * | 2001-10-22 | 2003-05-01 | The Scripps Research Institute | Integrin targeting compounds |
| JP4750360B2 (ja) | 2001-10-22 | 2011-08-17 | ザ スクリプス リサーチ インスティチュート | 抗体ターゲッティング化合物 |
| JP4575294B2 (ja) | 2003-06-27 | 2010-11-04 | 協和発酵キリン株式会社 | Ｈｓｐ９０ファミリー蛋白質阻害剤 |
| US20080108694A1 (en) * | 2003-12-19 | 2008-05-08 | Samuel J Danishefsky | Novel Macrocycles and Uses Thereof |
| EP1768662A2 (de) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Immunstimulatoren kleiner moleküle und assays für deren nachweis |
| EP1945262A2 (de) * | 2005-10-20 | 2008-07-23 | The Scripps Research Institute | Fc-etikettierung für immunostaining und immunotargeting |
| GB0526615D0 (en) * | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
| WO2008021213A1 (en) * | 2006-08-11 | 2008-02-21 | Nicolas Winssinger | Macrocyclic compounds useful as inhibitors of kinases and hsp90 |
| US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
| MX2010007755A (es) | 2008-01-15 | 2010-12-21 | Univ Strasbourg | Sintesis de lactonas de acido resorcilico utiles como agentes terapeuticos. |
| EP2254880B8 (de) * | 2008-02-21 | 2016-09-21 | OncoSynergy, Inc. | Als Therapeutika geeignete makrocyclische Prodrugverbindungen |
| LT5623B (lt) | 2008-04-30 | 2010-01-25 | Biotechnologijos Institutas, , | 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti |
| US8518927B2 (en) | 2009-02-10 | 2013-08-27 | The Scripps Research Institute | Chemically programmed vaccination |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE911915A1 (en) | 1990-06-06 | 1991-12-18 | Sankyo Co | Radicicol derivatives, their preparation and their¹anti-tumor activity |
| US5650430A (en) | 1990-06-06 | 1997-07-22 | Sankyo Company, Limited | Radicicol derivatives, their preparation and their anti-tumor activity |
| JP3055967B2 (ja) | 1990-06-06 | 2000-06-26 | 三共株式会社 | ラディシコール誘導体 |
| JPH06279279A (ja) * | 1993-03-26 | 1994-10-04 | Tsumura & Co | 血管新生阻害剤 |
| JPH06298764A (ja) | 1993-04-15 | 1994-10-25 | Kyowa Hakko Kogyo Co Ltd | 免疫抑制剤 |
| JPH0840893A (ja) * | 1993-08-31 | 1996-02-13 | Takeda Chem Ind Ltd | インターロイキン−１産生抑制剤 |
| US5731343A (en) * | 1995-02-24 | 1998-03-24 | The Scripps Research Institute | Method of use of radicicol for treatment of immunopathological disorders |
| JP3938936B2 (ja) * | 1995-04-26 | 2007-06-27 | 協和醗酵工業株式会社 | ラディシコール誘導体 |
| JPH09202781A (ja) * | 1996-01-25 | 1997-08-05 | Sankyo Co Ltd | ラディシコール誘導体 |
-
1997
- 1997-10-24 AT AT97909629T patent/ATE266017T1/de not_active IP Right Cessation
- 1997-10-24 WO PCT/JP1997/003874 patent/WO1998018780A1/ja not_active Ceased
- 1997-10-24 EP EP97909629A patent/EP0889042B1/de not_active Expired - Lifetime
- 1997-10-24 CN CN97192375A patent/CN1211244A/zh active Pending
- 1997-10-24 DE DE69728974T patent/DE69728974T2/de not_active Expired - Fee Related
- 1997-10-24 CA CA002241624A patent/CA2241624A1/en not_active Abandoned
- 1997-10-24 ES ES97909629T patent/ES2216130T3/es not_active Expired - Lifetime
- 1997-10-24 KR KR1019980704887A patent/KR19990076764A/ko not_active Withdrawn
- 1997-10-24 NZ NZ331062A patent/NZ331062A/xx unknown
- 1997-10-24 US US09/091,752 patent/US6316491B1/en not_active Expired - Fee Related
- 1997-10-24 AU AU47239/97A patent/AU727722B2/en not_active Ceased
-
1998
- 1998-06-25 NO NO982960A patent/NO982960L/no unknown
-
2000
- 2000-02-25 US US09/513,472 patent/US6239168B1/en not_active Expired - Fee Related
-
2001
- 2001-02-26 US US09/791,602 patent/US6635662B2/en not_active Expired - Fee Related
-
2003
- 2003-07-30 US US10/629,655 patent/US20040053990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2216130T3 (es) | 2004-10-16 |
| KR19990076764A (ko) | 1999-10-15 |
| NZ331062A (en) | 2000-05-26 |
| US20010027208A1 (en) | 2001-10-04 |
| DE69728974D1 (de) | 2004-06-09 |
| EP0889042A4 (de) | 1999-10-06 |
| NO982960D0 (no) | 1998-06-25 |
| CA2241624A1 (en) | 1998-05-07 |
| EP0889042B1 (de) | 2004-05-06 |
| US20040053990A1 (en) | 2004-03-18 |
| US6316491B1 (en) | 2001-11-13 |
| DE69728974T2 (de) | 2005-03-31 |
| CN1211244A (zh) | 1999-03-17 |
| AU727722B2 (en) | 2000-12-21 |
| US6239168B1 (en) | 2001-05-29 |
| AU4723997A (en) | 1998-05-22 |
| ATE266017T1 (de) | 2004-05-15 |
| WO1998018780A1 (en) | 1998-05-07 |
| EP0889042A1 (de) | 1999-01-07 |
| US6635662B2 (en) | 2003-10-21 |
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