NO984481L - 4-((thien-3-yl)metyl) imidazolderivater med <alfa>-2-adrenoceptor agonistisk aktivitet - Google Patents

4-((thien-3-yl)metyl) imidazolderivater med <alfa>-2-adrenoceptor agonistisk aktivitet

Info

Publication number
NO984481L
NO984481L NO984481A NO984481A NO984481L NO 984481 L NO984481 L NO 984481L NO 984481 A NO984481 A NO 984481A NO 984481 A NO984481 A NO 984481A NO 984481 L NO984481 L NO 984481L
Authority
NO
Norway
Prior art keywords
methyl
thien
alpha
imidazole derivatives
agonistic activity
Prior art date
Application number
NO984481A
Other languages
English (en)
Other versions
NO984481D0 (no
Inventor
Robert E Boyd
Chris Royce Rasmussen
Jeffrey B Press
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of NO984481D0 publication Critical patent/NO984481D0/no
Publication of NO984481L publication Critical patent/NO984481L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

4-[(thien-3-yl)metyl]-imidazoler med formel (I), hvor R er hydrogen eller metyl, og X er Calkyl, brom eller klor; eller (II), hvor Y er hydrogen; Calkyl, brom eller klor, og Z er Calkyl, brom eller klor, har eksepsjonell analgetisk aktivitet.
NO984481A 1996-03-28 1998-09-25 4-((thien-3-yl)metyl) imidazolderivater med <alfa>-2-adrenoceptor agonistisk aktivitet NO984481L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/625,442 US5750720A (en) 1996-03-28 1996-03-28 4- (thien-3-yl)methyl!-imidazole analgesics
PCT/US1997/004773 WO1997035858A1 (en) 1996-03-28 1997-03-26 4-[(THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING α2-ADRENOCEPTOR AGONISTIC ACTIVITY

Publications (2)

Publication Number Publication Date
NO984481D0 NO984481D0 (no) 1998-09-25
NO984481L true NO984481L (no) 1998-11-23

Family

ID=24506097

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984481A NO984481L (no) 1996-03-28 1998-09-25 4-((thien-3-yl)metyl) imidazolderivater med <alfa>-2-adrenoceptor agonistisk aktivitet

Country Status (14)

Country Link
US (1) US5750720A (no)
EP (1) EP0954521B1 (no)
JP (1) JP2000507549A (no)
AT (1) ATE240321T1 (no)
AU (1) AU721867B2 (no)
DE (1) DE69722031T2 (no)
DK (1) DK0954521T3 (no)
ES (1) ES2198567T3 (no)
NO (1) NO984481L (no)
NZ (1) NZ332012A (no)
PT (1) PT954521E (no)
TW (1) TW504512B (no)
WO (1) WO1997035858A1 (no)
ZA (1) ZA972778B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841684B2 (en) * 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
BR9813381A (pt) * 1997-12-04 2000-10-03 Allergan Sales Inc "derivados de imidazol substituìdo possuindo atividade semelhante a agonista em receptores adrenérgicos alfa 2b ou 2b/2c"
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
AU2002254265B2 (en) * 1997-12-04 2008-05-15 Allergan, Inc. Imidiazole derivatives and their use as agonists selective at alpha 2B or 2B/2C adrenergic receptors
US6426356B1 (en) 1998-11-18 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Imidazoethyl thiophenes
US6465486B1 (en) 1999-03-12 2002-10-15 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl/quinolinyl imidazoles
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
US7893191B2 (en) 2007-02-28 2011-02-22 Corning Incorporated Fused thiophenes, methods for making fused thiophenes, and uses thereof
TW200621789A (en) 2004-09-14 2006-07-01 Corning Inc Fused thiophenes, methods for making fused thiophens, and uses thereof
US7838623B2 (en) 2004-09-14 2010-11-23 Corning Incorporated Fused thiophenes, methods for making fused thiophenes, and uses thereof
BRPI0620079A2 (pt) * 2005-12-19 2011-11-01 Syngenta Ltd compostos heterocìclicos aromáticos substituìdos como fungicidas
CA2687303C (en) * 2007-05-14 2015-05-05 Allergan, Inc. ((phenyl)imidazolyl)methylheteroaryl compounds
WO2009123695A1 (en) 2008-03-31 2009-10-08 Corning Incorporated Fused thiophenes and methods for making and using same
EP2595985A1 (en) * 2010-07-19 2013-05-29 Syngenta Participations AG Isoxazole, isothiazole, furane and thiophene compounds as microbicides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01242571A (ja) * 1988-03-22 1989-09-27 Mitsui Petrochem Ind Ltd イミダゾール誘導体の製造方法
FI894911A0 (fi) * 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
CA2104873C (en) * 1991-02-26 2000-05-23 James N. Campbell Compositions and methods of treatment of sympathetically maintained pain
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics

Also Published As

Publication number Publication date
PT954521E (pt) 2003-09-30
NO984481D0 (no) 1998-09-25
ES2198567T3 (es) 2004-02-01
US5750720A (en) 1998-05-12
EP0954521B1 (en) 2003-05-14
WO1997035858A1 (en) 1997-10-02
NZ332012A (en) 2000-07-28
DE69722031D1 (en) 2003-06-18
ATE240321T1 (de) 2003-05-15
JP2000507549A (ja) 2000-06-20
TW504512B (en) 2002-10-01
EP0954521A1 (en) 1999-11-10
DK0954521T3 (da) 2003-09-15
ZA972778B (en) 1998-10-01
AU2422997A (en) 1997-10-17
AU721867B2 (en) 2000-07-13
DE69722031T2 (de) 2004-01-29

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